Syringetin (BioDeep_00000017653)

Main id: BioDeep_00000004340

 

human metabolite PANOMIX_OTCML-2023 natural product


代谢物信息卡片


4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-

化学式: C17H14O8 (346.0689)
中文名称: 丁香亭
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1(O)=CC2OC(C3C=C(OC)C(O)=C(OC)C=3)=C(O)C(=O)C=2C(O)=C1
InChI: InChI=1S/C17H14O8/c1-23-11-3-7(4-12(24-2)14(11)20)17-16(22)15(21)13-9(19)5-8(18)6-10(13)25-17/h3-6,18-20,22H,1-2H3

描述信息

Syringetin is a dimethoxyflavone that is myricetin in which the hydroxy groups at positions 3 and 5 have been replaced by methoxy groups. It has a role as a platelet aggregation inhibitor and a metabolite. It is a tetrahydroxyflavone, a dimethoxyflavone, a 7-hydroxyflavonol, a member of 3-methoxyflavones and a 3,5-dimethoxyflavone. It is functionally related to a myricetin. It is a conjugate acid of a syringetin(1-).
Syringetin is a natural product found in Lysimachia congestiflora, Chondropetalum, and other organisms with data available.
A dimethoxyflavone that is myricetin in which the hydroxy groups at positions 3 and 5 have been replaced by methoxy groups.
Syringetin,?a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts[1].
Syringetin,?a flavonoid derivative, is associated with increased BMP-2 production. Syringetin stimulates osteoblast differentiation at various stages, from maturation to terminally differentiated osteoblasts[1].

同义名列表

19 个代谢物同义名

4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-; 3,5,7-Trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)-4H-chromen-4-one; 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxy-phenyl)chromen-4-one; 3,5,7-trihydroxy-2-(4-hydroxy-3,5-dimethoxyphenyl)chromen-4-one; FLAVONE, 3,4,5,7-TETRAHYDROXY-3,5-DIMETHOXY-; 3,5-DIMETHOXY-3,5,7,4-TETRAHYDROXYFLAVONE; 3,5-Dimethoxy-3,5,7,4-tetrahydroxyflavone; 3,5,7,4-Tetrahydroxy-3,5-dimethoxyflavone; 3,5,7,4-tetrahydroxy-3,5dimethoxyflavone; Myricetin-3,5-dimethyl ether; MYRICETIN-3,5-DIMETHYL ETHER; UZMAPBJVXOGOFT-UHFFFAOYSA-N; 3,5-O-Dimethylmyricetin; UNII-J68JG79B9W; DIBOA trihexose; Syringetin; J68JG79B9W; Syringetin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

51 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ABCB1, AIMP2, ASL, BGLAP, CASP3, CYP3A4, MAPK3, MTOR, NCOA3, TNFSF11, VDR
Peripheral membrane protein 1 MTOR
Endosome membrane 2 BACE1, CD14
Endoplasmic reticulum membrane 4 CYP3A4, CYP3A5, MTOR, SPP1
Nucleus 7 AIMP2, CASP3, MAPK3, MTOR, NCOA3, NR1I2, VDR
cytosol 7 AIMP2, ASL, CASP3, MAPK3, MTOR, NCOA3, VDR
dendrite 3 BACE1, BGLAP, MTOR
nuclear body 1 NR1I2
phagocytic vesicle 1 MTOR
trans-Golgi network 1 BACE1
nucleoplasm 6 CASP3, MAPK3, MTOR, NCOA3, NR1I2, VDR
RNA polymerase II transcription regulator complex 1 VDR
Cell membrane 5 ABCB1, BACE1, CD14, SPP1, TNFSF11
Cytoplasmic side 1 MTOR
Cell projection, axon 1 BACE1
Multi-pass membrane protein 3 ABCB1, CATSPER3, SPP1
Golgi apparatus membrane 1 MTOR
cell surface 3 ABCB1, BACE1, BMP2
glutamatergic synapse 2 CASP3, MAPK3
Golgi apparatus 4 BACE1, CD14, MAPK3, SPP1
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
mitochondrial inner membrane 1 CYP24A1
neuronal cell body 2 BACE1, CASP3
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 1 AIMP2
Lysosome 2 BACE1, MTOR
acrosomal vesicle 1 CATSPER3
endosome 1 BACE1
plasma membrane 9 ABCB1, BACE1, BMP2, CATSPER3, CD14, MAPK3, SPP1, TNFRSF11B, TNFSF11
Membrane 7 ABCB1, AIMP2, BACE1, CYP3A4, CYP3A5, MTOR, TNFSF11
apical plasma membrane 1 ABCB1
axon 1 BACE1
caveola 1 MAPK3
extracellular exosome 5 ABCB1, ASL, CD14, NCOA3, SPP1
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 BACE1, CATSPER3
extracellular space 6 BGLAP, BMP2, CD14, SPP1, TNFRSF11B, TNFSF11
perinuclear region of cytoplasm 1 SPP1
mitochondrion 2 CYP24A1, MAPK3
protein-containing complex 1 NCOA3
intracellular membrane-bounded organelle 3 BMP2, CYP3A4, CYP3A5
Microsome membrane 3 CYP3A4, CYP3A5, MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 BACE1
Secreted 6 BGLAP, BMP2, CD14, SPP1, TNFRSF11B, TNFSF11
extracellular region 6 BGLAP, BMP2, CD14, SPP1, TNFRSF11B, TNFSF11
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
hippocampal mossy fiber to CA3 synapse 1 BACE1
transcription regulator complex 1 NR1I2
motile cilium 1 CATSPER3
external side of plasma membrane 1 CD14
multivesicular body 1 BACE1
perikaryon 1 BGLAP
Early endosome 2 BACE1, MAPK3
recycling endosome 1 BACE1
Single-pass type II membrane protein 1 TNFSF11
vesicle 1 BGLAP
Apical cell membrane 1 ABCB1
Membrane raft 2 BACE1, CD14
Cell junction, focal adhesion 1 MAPK3
focal adhesion 1 MAPK3
extracellular matrix 1 TNFRSF11B
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Late endosome 2 BACE1, MAPK3
receptor complex 2 TNFRSF11B, VDR
chromatin 3 NCOA3, NR1I2, VDR
cell projection 1 SPP1
cytoskeleton 1 MAPK3
Golgi apparatus, trans-Golgi network 1 BACE1
Lipid-anchor, GPI-anchor 1 CD14
nuclear envelope 2 MAPK3, MTOR
Endomembrane system 2 BACE1, MTOR
Membrane, caveola 1 MAPK3
Cell projection, cilium, flagellum membrane 1 CATSPER3
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
side of membrane 1 CD14
pseudopodium 1 MAPK3
intermediate filament cytoskeleton 1 NR1I2
lipopolysaccharide receptor complex 1 CD14
secretory granule membrane 1 CD14
Golgi lumen 1 BGLAP
endoplasmic reticulum lumen 4 BACE1, BGLAP, MAPK3, SPP1
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
BMP receptor complex 1 BMP2
CatSper complex 1 CATSPER3
Golgi-associated vesicle lumen 1 BACE1


文献列表

  • Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
  • Bin Wu, Hui-Peng Song, Xu Zhou, Xin-Guang Liu, Wen Gao, Xin Dong, Hui-Jun Li, Ping Li, Hua Yang. Screening of minor bioactive compounds from herbal medicines by in silico docking and the trace peak exposure methods. Journal of chromatography. A. 2016 Mar; 1436(?):91-9. doi: 10.1016/j.chroma.2016.01.062. [PMID: 26852619]
  • Maja Mikulic-Petkovsek, Ana Slatnar, Franci Stampar, Robert Veberic. HPLC-MSn identification and quantification of flavonol glycosides in 28 wild and cultivated berry species. Food chemistry. 2012 Dec; 135(4):2138-46. doi: 10.1016/j.foodchem.2012.06.115. [PMID: 22980782]
  • Anja K Lätti, Laura Jaakola, Kaisu R Riihinen, Pirjo S Kainulainen. Anthocyanin and flavonol variation in bog bilberries (Vaccinium uliginosum L.) in Finland. Journal of agricultural and food chemistry. 2010 Jan; 58(1):427-33. doi: 10.1021/jf903033m. [PMID: 20000402]
  • Alberto Bertolini, Carlo Peresson, Elisa Petrussa, Enrico Braidot, Sabina Passamonti, Francesco Macrì, Angelo Vianello. Identification and localization of the bilitranslocase homologue in white grape berries (Vitis vinifera L.) during ripening. Journal of experimental botany. 2009; 60(13):3861-71. doi: 10.1093/jxb/erp225. [PMID: 19596699]
  • Jianping Zhao, Rahul S Pawar, Zulfiqar Ali, Ikhlas A Khan. Phytochemical investigation of Turnera diffusa. Journal of natural products. 2007 Feb; 70(2):289-92. doi: 10.1021/np060253r. [PMID: 17284070]
  • Lawrence O Arot Manguro, Ivar Ugi, Rudolf Hermann, Peter Lemmen. Flavonol and drimane-type sesquiterpene glycosides of Warburgia stuhlmannii leaves. Phytochemistry. 2003 Jun; 63(4):497-502. doi: 10.1016/s0031-9422(03)00105-5. [PMID: 12770606]
  • . . . . doi: . [PMID: 21343428]