PUROMYCIN (BioDeep_00000001635)

   

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


CHEMBL320467

化学式: C22H29N7O5 (471.22300640000003)
中文名称: 嘌呤霉素
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.14%

分子结构信息

SMILES: CN(C)C1=NC=NC2=C1N=CN2C3C(C(C(O3)CO)NC(=O)C(CC4=CC=C(C=C4)OC)N)O
InChI: InChI=1S/C22H29N7O5/c1-28(2)19-17-20(25-10-24-19)29(11-26-17)22-18(31)16(15(9-30)34-22)27-21(32)14(23)8-12-4-6-13(33-3)7-5-12/h4-7,10-11,14-16,18,22,30-31H,8-9,23H2,1-3H3,(H,27,32)/t14-,15+,16+,18+,22+/m0/s1

描述信息

An aminonucleoside antibiotic, derived from the Streptomyces alboniger bacterium, that causes premature chain termination during translation taking place in the ribosome.
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D009676 - Noxae > D000963 - Antimetabolites
C784 - Protein Synthesis Inhibitor
D000970 - Antineoplastic Agents
KEIO_ID P075; [MS2] KO009213
KEIO_ID P075

同义名列表

4 个代谢物同义名

PUROMYCIN; CHEMBL320467; Puromycin dihydrochloride; Puromycin



数据库引用编号

38 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Bing Zhang, Shiying Huang, Zhuoting Liu, Xinhui Liu, Zilan Jiang, Jianping Chen, Youjia Zeng. Investigation of the Metabolism of Astragaloside IV in a Puromycin-Damaged Rat Model by UPLC-Q-TOF-MS/MS Analysis. Planta medica. 2023 Nov; ?(?):. doi: 10.1055/a-2186-3182. [PMID: 37931776]
  • Ming Lyu, Yongsen Sun, Nana Yan, Qiang Chen, Xin Wang, Zehui Wei, Zhiying Zhang, Kun Xu. Efficient CRISPR/Cas9-mediated gene editing in mammalian cells by the novel selectable traffic light reporters. International journal of biological macromolecules. 2023 Jul; 243(?):124926. doi: 10.1016/j.ijbiomac.2023.124926. [PMID: 37217056]
  • Baowei Ji, Junchao Liu, Yanli Ma, Ye Yin, Hong Xu, Qian Shen, Jian Yu. Minnelide Markedly Reduces Proteinuria in Mice with Adriamycin Nephropathy by Protecting Against Podocyte Injury. Applied biochemistry and biotechnology. 2023 Mar; ?(?):. doi: 10.1007/s12010-023-04333-z. [PMID: 37000351]
  • Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis. Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations. Journal of natural products. 2023 03; 86(3):557-565. doi: 10.1021/acs.jnatprod.2c01041. [PMID: 36799121]
  • Saaya Hatakeyama, Akihiro Tojo, Hiroshi Satonaka, Nami O Yamada, Takao Senda, Toshihiko Ishimitsu. Decreased Podocyte Vesicle Transcytosis and Albuminuria in APC C-Terminal Deficiency Mice with Puromycin-Induced Nephrotic Syndrome. International journal of molecular sciences. 2021 Dec; 22(24):. doi: 10.3390/ijms222413412. [PMID: 34948207]
  • Yong Huang, Yaqian Huang, Yehua Zhou, Jie Cheng, Chanjun Wan, Maohong Wang, Chiheng Pi, Guoqing Wu, Weiguo Song. Shensu IV prevents glomerular podocyte injury in nephrotic rats via promoting lncRNA H19/DIRAS3-mediated autophagy. Bioscience reports. 2021 05; 41(5):. doi: 10.1042/bsr20203362. [PMID: 33881140]
  • Rémi Roumanille, Barbara Vernus, Thomas Brioche, Vincent Descossy, Christophe Tran Van Ba, Sarah Campredon, Antony G Philippe, Pierre Delobel, Christelle Bertrand-Gaday, Angèle Chopard, Anne Bonnieu, Guillaume Py, Pascale Fança-Berthon. Acute and chronic effects of Rhaponticum carthamoides and Rhodiola rosea extracts supplementation coupled to resistance exercise on muscle protein synthesis and mechanical power in rats. Journal of the International Society of Sports Nutrition. 2020 Nov; 17(1):58. doi: 10.1186/s12970-020-00390-5. [PMID: 33198764]
  • Gasper Maeda, Joan J E Munissi, Sofia Lindblad, Sandra Duffy, Jerry Pelletier, Vicky M Avery, Stephen S Nyandoro, Máté Erdélyi. A Meroisoprenoid, Heptenolides, and C-Benzylated Flavonoids from Sphaerocoryne gracilis ssp. gracilis. Journal of natural products. 2020 02; 83(2):316-322. doi: 10.1021/acs.jnatprod.9b00721. [PMID: 32067457]
  • Luke P Robertson, Leonardo Lucantoni, Sandra Duffy, Vicky M Avery, Anthony R Carroll. Acrotrione: An Oxidized Xanthene from the Roots of Acronychia pubescens. Journal of natural products. 2019 04; 82(4):1019-1023. doi: 10.1021/acs.jnatprod.8b00956. [PMID: 30865443]
  • Takumi Kagawa, Tomáš Zárybnický, Takanao Omi, Yuji Shirai, Shinya Toyokuni, Shingo Oda, Tsuyoshi Yokoi. A scrutiny of circulating microRNA biomarkers for drug-induced tubular and glomerular injury in rats. Toxicology. 2019 03; 415(?):26-36. doi: 10.1016/j.tox.2019.01.011. [PMID: 30682439]
  • Vitalina Gryshkova, Mabel Cotter, Portia McGhan, Jana Obajdin, Renaud Fleurance, Andre Nogueira da Costa. Phosphoprotein expression profiles in rat kidney injury: Source for potential mechanistic biomarkers. Journal of cellular and molecular medicine. 2019 03; 23(3):2251-2255. doi: 10.1111/jcmm.14103. [PMID: 30636369]
  • Jana Obajdin, Mabel Cotter, Sara Snelling, Sarah Dremier, Pierrette De Ron, Renaud Fleurance, Jean-Pierre Valentin, André Nogueira da Costa, Vitalina Gryshkova. Fatty-Acid Binding Protein 4 (FABP4) as a Potential Preclinical Biomarker of Drug-Induced Kidney Injury. Toxicological sciences : an official journal of the Society of Toxicology. 2018 Dec; 166(2):441-450. doi: 10.1093/toxsci/kfy204. [PMID: 30215792]
  • Stéphanie F Glineur, Etienne Hanon, Sarah Dremier, Sara Snelling, Caroline Berteau, Pierrette De Ron, André Nogueira da Costa. Assessment of a Urinary Kidney MicroRNA Panel as Potential Nephron Segment-Specific Biomarkers of Subacute Renal Toxicity in Preclinical Rat Models. Toxicological sciences : an official journal of the Society of Toxicology. 2018 12; 166(2):409-419. doi: 10.1093/toxsci/kfy213. [PMID: 30169741]
  • Sarath P D Senadeera, Leonardo Lucantoni, Sandra Duffy, Vicky M Avery, Anthony R Carroll. Antiplasmodial β-Triketone-Flavanone Hybrids from the Flowers of the Australian Tree Corymbia torelliana. Journal of natural products. 2018 07; 81(7):1588-1597. doi: 10.1021/acs.jnatprod.8b00154. [PMID: 29969262]
  • Sebastien Andrew Rider, Finnius Austin Bruton, Richard George Collins, Bryan Ronald Conway, John James Mullins. The Efficacy of Puromycin and Adriamycin for Induction of Glomerular Failure in Larval Zebrafish Validated by an Assay of Glomerular Permeability Dynamics. Zebrafish. 2018 06; 15(3):234-242. doi: 10.1089/zeb.2017.1527. [PMID: 29480793]
  • Rohitesh Kumar, Sandra Duffy, Vicky M Avery, Anthony R Carroll, Rohan A Davis. Microthecaline A, a Quinoline Serrulatane Alkaloid from the Roots of the Australian Desert Plant Eremophila microtheca. Journal of natural products. 2018 04; 81(4):1079-1083. doi: 10.1021/acs.jnatprod.7b00992. [PMID: 29533611]
  • Michelle L DeBoer, Krishona M Martinson, Mary S Pampusch, Abigail M Hansen, Scott M Wells, Christie Ward, Marcia Hathaway. Cultured equine satellite cells as a model system to assess leucine stimulated protein synthesis in horse muscle. Journal of animal science. 2018 Feb; 96(1):143-153. doi: 10.1093/jas/skx028. [PMID: 29444251]
  • Luke P Robertson, Sandra Duffy, Yun Wang, Dongdong Wang, Vicky M Avery, Anthony R Carroll. Pimentelamines A-C, Indole Alkaloids Isolated from the Leaves of the Australian Tree Flindersia pimenteliana. Journal of natural products. 2017 12; 80(12):3211-3217. doi: 10.1021/acs.jnatprod.7b00587. [PMID: 29236492]
  • Hannah Crossland, Kenneth Smith, Philip J Atherton, Daniel J Wilkinson. A novel puromycin decorporation method to quantify skeletal muscle protein breakdown: A proof-of-concept study. Biochemical and biophysical research communications. 2017 12; 494(3-4):608-614. doi: 10.1016/j.bbrc.2017.10.085. [PMID: 29054406]
  • Olivier Delézay, Zhiguo He, Sophie Hodin, Moin A Saleem, Patrick Mismetti, Nathalie Perek, Xavier Delavenne. Glomerular filtration drug injury: In vitro evaluation of functional and morphological podocyte perturbations. Experimental cell research. 2017 12; 361(2):300-307. doi: 10.1016/j.yexcr.2017.10.031. [PMID: 29107066]
  • Ryan A West, Oran G O'Doherty, Trevor Askwith, John Atack, Paul Beswick, Jamie Laverick, Michael Paradowski, Lewis E Pennicott, Srinivasa P S Rao, Gareth Williams, Simon E Ward. African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase. European journal of medicinal chemistry. 2017 Dec; 141(?):676-689. doi: 10.1016/j.ejmech.2017.09.067. [PMID: 29107420]
  • Rohitesh Kumar, Sandra Duffy, Vicky M Avery, Rohan A Davis. Synthesis of antimalarial amide analogues based on the plant serrulatane diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid. Bioorganic & medicinal chemistry letters. 2017 09; 27(17):4091-4095. doi: 10.1016/j.bmcl.2017.07.039. [PMID: 28774427]
  • Sarath P D Senadeera, Sandra Duffy, Vicky M Avery, Anthony R Carroll. Antiplasmodial β-triketones from the flowers of the Australian tree Angophora woodsiana. Bioorganic & medicinal chemistry letters. 2017 06; 27(11):2602-2607. doi: 10.1016/j.bmcl.2017.03.065. [PMID: 28400231]
  • Sandra Bodeau, Chloé Sauzay, Rémy Nyga, Christophe Louandre, Véronique Descamps, Catherine François, Corinne Godin, Gabriel Choukroun, Antoine Galmiche. Targeting the Unfolded Protein Response as a Potential Therapeutic Strategy in Renal Carcinoma Cells Exposed to Cyclosporine A. Anticancer research. 2017 03; 37(3):1049-1057. doi: 10.21873/anticanres.11416. [PMID: 28314264]
  • Stephen S Nyandoro, Joan J E Munissi, Amra Gruhonjic, Sandra Duffy, Fangfang Pan, Rakesh Puttreddy, John P Holleran, Paul A Fitzpatrick, Jerry Pelletier, Vicky M Avery, Kari Rissanen, Máté Erdélyi. Polyoxygenated Cyclohexenes and Other Constituents of Cleistochlamys kirkii Leaves. Journal of natural products. 2017 01; 80(1):114-125. doi: 10.1021/acs.jnatprod.6b00759. [PMID: 28001067]
  • Yoshikazu Muroya, Osamu Ito. Effect of clofibrate on fatty acid metabolism in the kidney of puromycin-induced nephrotic rats. Clinical and experimental nephrology. 2016 Dec; 20(6):862-870. doi: 10.1007/s10157-016-1253-0. [PMID: 26949064]
  • Fraser J Scott, Abedawn I Khalaf, Sandra Duffy, Vicky M Avery, Colin J Suckling. Selective anti-malarial minor groove binders. Bioorganic & medicinal chemistry letters. 2016 07; 26(14):3326-3329. doi: 10.1016/j.bmcl.2016.05.039. [PMID: 27212070]
  • Zhe Lyu, Rachit Jain, Peyton Smith, Travis Fetchko, Yajun Yan, William B Whitman. Engineering the Autotroph Methanococcus maripaludis for Geraniol Production. ACS synthetic biology. 2016 07; 5(7):577-81. doi: 10.1021/acssynbio.5b00267. [PMID: 26886063]
  • Melanie Adler, Susanne Ramm, Marc Hafner, Jeremy L Muhlich, Esther Maria Gottwald, Elijah Weber, Alenka Jaklic, Amrendra Kumar Ajay, Daniel Svoboda, Scott Auerbach, Edward J Kelly, Jonathan Himmelfarb, Vishal S Vaidya. A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro. Journal of the American Society of Nephrology : JASN. 2016 Apr; 27(4):1015-28. doi: 10.1681/asn.2015010060. [PMID: 26260164]
  • Tsegaye Deyou, Ivan Gumula, Fangfang Pang, Amra Gruhonjic, Michael Mumo, John Holleran, Sandra Duffy, Paul A Fitzpatrick, Matthias Heydenreich, Göran Landberg, Solomon Derese, Vicky Avery, Kari Rissanen, Máté Erdélyi, Abiy Yenesew. Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis. Journal of natural products. 2015 Dec; 78(12):2932-9. doi: 10.1021/acs.jnatprod.5b00581. [PMID: 26651537]
  • Edgar Maquigussa, Carine P Arnoni, Luciana G Pereira, Mirian A Boim. Calcitriol ameliorates renal damage in a pre-established proteinuria model. Molecular medicine reports. 2015 Jul; 12(1):1009-15. doi: 10.3892/mmr.2015.3555. [PMID: 25823676]
  • De-shu Dai, Xiang Liu, Yang Yang, Xiao-mei Luo, Ren-xian Tang, Zhong-cheng Yin, Hong-qi Ren. Protective Effect of Salvia Przewalskii Extract on Puromycin-Induced Podocyte Injury. American journal of nephrology. 2015; 42(3):216-27. doi: 10.1159/000440851. [PMID: 26439819]
  • Ellen T McCarthy, Jianping Zhou, Ryan Eckert, David Genochio, Rishi Sharma, Olurinde Oni, Alok De, Tarak Srivastava, Ram Sharma, Virginia J Savin, Mukut Sharma. Ethanol at low concentrations protects glomerular podocytes through alcohol dehydrogenase and 20-HETE. Prostaglandins & other lipid mediators. 2015 Jan; 116-117(?):88-98. doi: 10.1016/j.prostaglandins.2014.10.006. [PMID: 25447342]
  • Christiane Sippl, Ludwig F Zeilbeck, Rudolf Fuchshofer, Ernst R Tamm. Optineurin associates with the podocyte Golgi complex to maintain its structure. Cell and tissue research. 2014 Nov; 358(2):567-83. doi: 10.1007/s00441-014-1968-8. [PMID: 25096716]
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  • V N Karavana, H Gakiopoulou, E A Lianos. Expression of Ser729 phosphorylated PKCepsilon in experimental crescentic glomerulonephritis: an immunohistochemical study. European journal of histochemistry : EJH. 2014 Apr; 58(2):2308. doi: 10.4081/ejh.2014.2308. [PMID: 24998921]
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