Ochratoxin A (BioDeep_00000001398)
Secondary id: BioDeep_00000298194
human metabolite Endogenous Toxin
代谢物信息卡片
化学式: C20H18ClNO6 (403.08225980000003)
中文名称: 曲霉素A
谱图信息:
最多检出来源 Escherichia coli(natural_products) 57.14%
分子结构信息
SMILES: CC1CC2=C(C=C(C(=C2C(=O)O1)O)C(=O)NC(CC3=CC=CC=C3)C(=O)O)Cl
InChI: InChI=1S/C20H18ClNO6/c1-10-7-12-14(21)9-13(17(23)16(12)20(27)28-10)18(24)22-15(19(25)26)8-11-5-3-2-4-6-11/h2-6,9-10,15,23H,7-8H2,1H3,(H,22,24)(H,25,26)
描述信息
Ochratoxin A is found in barley. Mycotoxin. Ochratoxin A is produced by Aspergillus melleus, Aspergillus sulphureus and Penicillium viridicatum.Potential contaminant of foodstuffs, especially cereals. Ochratoxin A is found in stored grain products in UK (1997).Ochratoxin A, a toxin produced by Aspergillus ochraceus and Penicillium verrucosum, is one of the most abundant food-contaminating mycotoxins in the world. Human exposure occurs mainly through consumption of improperly stored food products, particularly contaminated grain and pork products, as well as coffee, wine grapes and dried grapes. The toxin has been found in the tissues and organs of animals, including human blood and breast milk. Ochratoxin A toxicity has large species- and sex-specific differences
Mycotoxin. Production by Aspergillus melleus, Aspergillus sulphureus and Penicillium viridicatum.Potential contaminant of foodstuffs, especially cereals. Found in stored grain products in UK (1997)
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D009676 - Noxae > D011042 - Poisons > D009793 - Ochratoxins
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D000077264 - Calcium-Regulating Hormones and Agents
D009676 - Noxae > D002273 - Carcinogens
D049990 - Membrane Transport Modulators
同义名列表
12 个代谢物同义名
(2S)-2-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]amino}-3-phenylpropanoic acid; (2S)-2-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-yl]formamido}-3-phenylpropanoic acid; (2S)-2-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]amino}-3-phenylpropanoate; N-{[(3R)-5-chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-isochromen-7-yl]carbonyl}-L-phenylalanine; N-[(5-chloro-3,4-dihydro-8-Hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]phenylalanine, 9ci; N-[(3R)-5-Chloro-8-hydroxy-3-methyl-1-oxo-3,4-dihydro-1H-2-benzopyran-7-carbonyl]-L-phenylalanine; (R)-N-((5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl)phenylalanine; Ochratoxin a-bsa conjugate from aspergillus ochraceus; Phenylalanine - ochratoxin a; Antibiotic 9663; Ochratoxin A; OTA
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:7719
- KEGG: C09955
- PubChem: 442530
- PubChem: 4580
- HMDB: HMDB0029399
- Metlin: METLIN68042
- ChEMBL: CHEMBL589366
- Wikipedia: Ochratoxin_A
- KNApSAcK: C00003008
- foodb: FDB000488
- chemspider: 390954
- CAS: 1448049-50-0
- CAS: 303-47-9
- PMhub: MS000000445
- PubChem: 12141
- PDB-CCD: 97U
- NIKKAJI: J1.519I
- RefMet: Ochratoxin A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
8 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 138277 - Aspergillus melleus: 10.1007/S10295-003-0048-Y
- 5061 - Aspergillus niger: 10.1128/AEM.60.7.2650-2652.1994
- 40380 - Aspergillus ochraceus:
- 40380 - Aspergillus ochraceus: 10.1016/S0031-9422(01)00316-8
- 9606 - Homo sapiens: -
- 229535 - Penicillium nordicum: 10.1016/J.SYAPM.2005.03.008
- 60171 - Penicillium verrucosum: 10.1016/S0953-7562(10)80017-6
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yue Wang, Buda Su, Xingxu Yan, Chenlei Geng, Tingting Lian, Xiaomeng Li, Yanyan Xu, Yubo Li. Studies of Mycotoxins in Medicinal Plants Conducted Worldwide over the Last Decade: A Systematic Review, Meta-Analysis, and Exposure Risk Assessment.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155367. doi:
10.1016/j.phymed.2024.155367
. [PMID: 38493720] - Bu-Da Su, Xiao-Meng Li, Zhi-Wei Huang, Yue Wang, Jia Shao, Yan-Yan Xu, Le-Xin Shu, Yu-Bo Li. Development and application of the physiologically-based toxicokinetic (PBTK) model for ochratoxin A (OTA) in rats and humans.
Ecotoxicology and environmental safety.
2024 May; 276(?):116277. doi:
10.1016/j.ecoenv.2024.116277
. [PMID: 38604061] - Xuanjun Zhang, Na Li, Han Luo, Yu Zhou. A discussion on N-terminal signal peptide removed ADH3 and the hydrolytic activity on ochratoxin A in the published paper by Dai et al. (2023).
Journal of hazardous materials.
2024 Apr; 468(?):133767. doi:
10.1016/j.jhazmat.2024.133767
. [PMID: 38377903] - Hangbin Yan, Weifan Zhao, Asma Parveen, Ziling Ye, Qingru Fei, Xu Wang, Yu Zhou. Comprehensive and cumulative risk evaluation of dietary exposure to aflatoxins and ochratoxin A on fermented teas worldwide by a new assessment model.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2024 Feb; 184(?):114321. doi:
10.1016/j.fct.2023.114321
. [PMID: 38072213] - Sen Wang, Hui Ren, Chen Fan, Qian Lin, Man Liu, Jun Tian. Ochratoxin A Induces Renal Cell Ferroptosis by Disrupting Iron Homeostasis and Increasing ROS.
Journal of agricultural and food chemistry.
2024 Jan; 72(3):1734-1744. doi:
10.1021/acs.jafc.3c04495
. [PMID: 38133486] - Yang Yang, Linjie Lv, Shanshan Shi, Gaofeng Cai, Lin Yu, Shuwen Xu, Tianyu Zhu, Xinyue Su, Ningning Mao, Yue Zhang, Song Peng, Jin He, Zhenguang Liu, Deyun Wang. Polysaccharide from walnut green husk alleviates liver inflammation and gluconeogenesis dysfunction by altering gut microbiota in ochratoxin A-induced mice.
Carbohydrate polymers.
2023 Dec; 322(?):121362. doi:
10.1016/j.carbpol.2023.121362
. [PMID: 37839834] - G A Domínguez-Gutiérrez, I Perraud-Gaime, H Escalona-Buendía, N Durand, E I Champion-Martínez, R R Fernández-Soto, G Saucedo-Castañeda, G Rodríguez-Serrano. Inhibition of Aspergillus carbonarius growth and Ochratoxin A production using lactic acid bacteria cultivated in an optimized medium.
International journal of food microbiology.
2023 Nov; 404(?):110320. doi:
10.1016/j.ijfoodmicro.2023.110320
. [PMID: 37490784] - Zhentao Tang, Fang Fang, Tingting Lou, Bakhetgul Manatbai, Cheng Peng, Zhiguo Gong, Jinlin Guo. Determination of ochratoxin A in licorice extract based on modified immunoaffinity column clean-up and HPLC analysis.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2023 Nov; 40(11):1470-1481. doi:
10.1080/19440049.2023.2266042
. [PMID: 37862446] - Wiem Chtioui, Sandrina Heleno, Quirico Migheli, Paula Rodrigues. Plant extracts as biocontrol agents against Aspergillus carbonarius growth and ochratoxin A production in grapes.
International journal of food microbiology.
2023 Oct; 407(?):110425. doi:
10.1016/j.ijfoodmicro.2023.110425
. [PMID: 37804776] - Jiangyu Tang, Junya Zeng, Li Chen, Mengmeng Wang, Suibin He, Azhar Muhmood, Xingxiang Chen, Kehe Huang, Fang Gan. Farnesoid X Receptor Plays a Key Role in Ochratoxin A-Induced Nephrotoxicity by Targeting Ferroptosis In Vivo and In Vitro.
Journal of agricultural and food chemistry.
2023 Oct; 71(39):14365-14378. doi:
10.1021/acs.jafc.3c04560
. [PMID: 37750412] - Huifeng Xu, Rui Pan, Weihua Huang, Xi Zhu. Label-free dual-mode sensing platform based on target-regulated CRISPR-Cas12a activity for ochratoxin A in Morinda officinalis.
Analytical methods : advancing methods and applications.
2023 09; 15(35):4518-4523. doi:
10.1039/d3ay01025b
. [PMID: 37622284] - Lijuan Ding, Meihua Han, Xiangtao Wang, Yifei Guo. Ochratoxin A: Overview of Prevention, Removal, and Detoxification Methods.
Toxins.
2023 09; 15(9):. doi:
10.3390/toxins15090565
. [PMID: 37755991] - Yujiao Hou, Qingbin Xu, Ying Li, Nan Long, Peng Li, Jiabo Wang, Lidong Zhou, Ping Sheng, Weijun Kong. Ultrasensitive electrochemical aptasensor with Nafion-stabilized f-MWCNTs as signal enhancers for OTA detection.
Bioelectrochemistry (Amsterdam, Netherlands).
2023 Jun; 151(?):108399. doi:
10.1016/j.bioelechem.2023.108399
. [PMID: 36805204] - Xinyu Cai, Boqiang Li, Xue Li, Hui Dang, Di Wang, Zhifei Pei, Xuan Feng, Xueyan Ren, Qingjun Kong. Characteristic Structures of Different Stilbenes Distinguish the Impact on Ochratoxin A Biosynthesis Intermediate Pathway and Metabolites of Aspergillus carbonarius.
Journal of agricultural and food chemistry.
2023 May; 71(21):7996-8007. doi:
10.1021/acs.jafc.3c00717
. [PMID: 37192315] - Ying Zhang, Dongmei Wei, Xiaohu Wu, Tingting Duan, Jun Xu, Fengshou Dong, Xinglu Pan, Yongquan Zheng. Occurrence and impact of carbendazim and hymexazol residues on yeast and ochratoxin A contamination during wine production.
Journal of the science of food and agriculture.
2023 May; ?(?):. doi:
10.1002/jsfa.12699
. [PMID: 37177869] - Roua Gabriela Popescu, George Cătălin Marinescu, Andreea Luminița Rădulescu, Daniela Eliza Marin, Ionelia Țăranu, Anca Dinischiotu. Natural Antioxidant By-Product Mixture Counteracts the Effects of Aflatoxin B1 and Ochratoxin A Exposure of Piglets after Weaning: A Proteomic Survey on Liver Microsomal Fraction.
Toxins.
2023 04; 15(4):. doi:
10.3390/toxins15040299
. [PMID: 37104237] - Meilin Wei, Solairaj Dhanasekaran, Qihao Ji, Qiya Yang, Hongyin Zhang. Sustainable and efficient method utilizing N-acetyl-L-cysteine for complete and enhanced ochratoxin A clearance by antagonistic yeast.
Journal of hazardous materials.
2023 04; 448(?):130975. doi:
10.1016/j.jhazmat.2023.130975
. [PMID: 36860082] - Nii Korley Kortei, Peter Oman Ayiku, John Nsor-Atindana, Leslie Owusu Ansah, Michael Wiafe-Kwagyan, Vincent Kyei-Baffour, Isaac Delali Kottoh, George Tawia Odamtten. Toxicogenic fungal profile, Ochratoxin A exposure and cancer risk characterization through maize (Zea mays) consumed by different age populations in the Volta region of Ghana.
Toxicon : official journal of the International Society on Toxinology.
2023 Apr; 226(?):107085. doi:
10.1016/j.toxicon.2023.107085
. [PMID: 36921906] - Yujiao Hou, Nan Long, Qingbin Xu, Ying Li, Pengyue Song, Minghan Yang, Jiabo Wang, Lidong Zhou, Ping Sheng, Weijun Kong. Development of a Nafion-MWCNTs and in-situ generated Au nanopopcorns dual-amplification electrochemical aptasensor for ultrasensitive detection of OTA.
Food chemistry.
2023 Mar; 403(?):134375. doi:
10.1016/j.foodchem.2022.134375
. [PMID: 36162268] - Marcin Bryła, Krzysztof Damaziak, Magdalena Twarużek, Agnieszka Waśkiewicz, Łukasz Stępień, Marek Roszko, Adam Pierzgalski, Ewelina Soszczyńska, Monika Łukasiewicz-Mierzejewska, Marta Chmiel, Wojciech Wójcik. Toxico-pathological effects of ochratoxin A and its diastereoisomer under in ovo conditions and in vitro evaluation of the toxicity of these toxins against the embryo Gallus gallus fibroblast cell line.
Poultry science.
2023 Feb; 102(2):102413. doi:
10.1016/j.psj.2022.102413
. [PMID: 36566659] - Limin Guo, Yun Li, Shichao Gao, Lei Ren. Detection of ochratoxin A using a 'turn-on' fluorescence assay based on guanine quenching of the aptamer.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2023 Jan; 39(1):51-57. doi:
10.1007/s44211-022-00199-z
. [PMID: 36242755] - Yuanshan Chen, Jiang Chen, Qiujin Zhu, Jing Wan. Ochratoxin A in Dry-Cured Ham: OTA-Producing Fungi, Prevalence, Detection Methods, and Biocontrol Strategies-A Review.
Toxins.
2022 10; 14(10):. doi:
10.3390/toxins14100693
. [PMID: 36287962] - Nan Chen, Qingru Fei, Han Luo, Zemin Fang, Yazhong Xiao, Zhengjun Du, Yu Zhou. Isoenzyme N-Acyl-l-Amino Acid Amidohydrolase NA Increases Ochratoxin A Degradation Efficacy of Stenotrophomonas sp. CW117 by Enhancing Amidohydrolase ADH3 Stability.
Microbiology spectrum.
2022 08; 10(4):e0220522. doi:
10.1128/spectrum.02205-22
. [PMID: 35924842] - Piao Zhao, Xin Liu, Wei-Dan Jiang, Pei Wu, Yang Liu, Jun Jiang, Lu Zhang, Hai-Feng Mi, Sheng-Yao Kuang, Ling Tang, Xiao-Qiu Zhou, Lin Feng. The multiple biotoxicity integrated study in grass carp (Ctenopharyngodon idella) caused by Ochratoxin A: Oxidative damage, apoptosis and immunosuppression.
Journal of hazardous materials.
2022 08; 436(?):129268. doi:
10.1016/j.jhazmat.2022.129268
. [PMID: 35739783] - Wen-Chao Liu, Karthika Pushparaj, Arun Meyyazhagan, Vijaya Anand Arumugam, Manikantan Pappuswamy, Haripriya Kuchi Bhotla, Rathinasamy Baskaran, Utthapon Issara, Balamuralikrishnan Balasubramanian, Amin Mousavi Khaneghah. Ochratoxin A as an alarming health threat for livestock and human: A review on molecular interactions, mechanism of toxicity, detection, detoxification, and dietary prophylaxis.
Toxicon : official journal of the International Society on Toxinology.
2022 Jul; 213(?):59-75. doi:
10.1016/j.toxicon.2022.04.012
. [PMID: 35452686] - Raquel Penalva-Olcina, Cristina Juan, Mónica Fernández-Franzón, Ana Juan-García. Effectiveness of beetroot extract in SH-SY5Y neuronal cell protection against Fumonisin B1, Ochratoxin A and its combination.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jul; 165(?):113164. doi:
10.1016/j.fct.2022.113164
. [PMID: 35605710] - Consiglia Longobardi, Gianmarco Ferrara, Emanuela Andretta, Serena Montagnaro, Sara Damiano, Roberto Ciarcia. Ochratoxin A and Kidney Oxidative Stress: The Role of Nutraceuticals in Veterinary Medicine-A Review.
Toxins.
2022 06; 14(6):. doi:
10.3390/toxins14060398
. [PMID: 35737059] - Massimo Frangiamone, Manuel Alonso-Garrido, Guillermina Font, Alessandra Cimbalo, Lara Manyes. Pumpkin extract and fermented whey individually and in combination alleviated AFB1- and OTA-induced alterations on neuronal differentiation invitro.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Jun; 164(?):113011. doi:
10.1016/j.fct.2022.113011
. [PMID: 35447289] - Yin Zhu, Shaomin Wang, Xiaohui Xu, Lingling Wang, Heng Zhou, Xuanyu Ying, Qing Hu, Xinglong Wang, Shen Ji, Qiang Cai. Exposure assessment and risk-based limit levels evaluation of ochratoxin A in Astragali Radix in China.
Ecotoxicology and environmental safety.
2022 Jun; 237(?):113517. doi:
10.1016/j.ecoenv.2022.113517
. [PMID: 35429800] - Indra Dev, Saurabh Pal, Onila Lugun, Neha Singh, Kausar Mahmood Ansari. Ochratoxin A treated rat derived urinary exosomes enhanced cell growth and extracellular matrix production in normal kidney cells through modulation of TGF-β1/smad2/3 signaling pathway.
Life sciences.
2022 Jun; 298(?):120506. doi:
10.1016/j.lfs.2022.120506
. [PMID: 35364054] - Alexandra Jaus, Peter Rhyn, Max Haldimann, Beat J Brüschweiler, Céline Fragnière Rime, Judith Jenny-Burri, Otmar Zoller. Biomonitoring of ochratoxin A, 2'R-ochratoxin A and citrinin in human blood serum from Switzerland.
Mycotoxin research.
2022 May; 38(2):147-161. doi:
10.1007/s12550-022-00456-0
. [PMID: 35446004] - Muhamed N H Eeza, Narmin Bashirova, Zain Zuberi, Jörg Matysik, John P Berry, A Alia. An integrated systems-level model of ochratoxin A toxicity in the zebrafish (Danio rerio) embryo based on NMR metabolic profiling.
Scientific reports.
2022 04; 12(1):6341. doi:
10.1038/s41598-022-09726-4
. [PMID: 35428752] - Dubravka Rašić, Srđan Stefanović, Dragan Milićević, Marin Mladinić, Davor Želježić, Alica Pizent, Paško Konjevoda, Maja Peraica. Ochratoxin A potentiates citrinin accumulation in kidney and liver of rats.
Arhiv za higijenu rada i toksikologiju.
2022 Apr; 73(1):43-47. doi:
10.2478/aiht-2022-73-3605
. [PMID: 35390240] - Jian Zhang, Linlin Li, Yan Yang, Chaofan Zhao, Jiuju Hu, Xianli Xue, Qiang Gao, Depei Wang, Zhenhong Zhuang, Ying Zhang. Deletion and Overexpression of the AnOTAbzip Gene, a Positive Regulator of Ochratoxin A Biosynthesis in Aspergillus niger.
Journal of agricultural and food chemistry.
2022 Feb; 70(7):2169-2178. doi:
10.1021/acs.jafc.1c08160
. [PMID: 35143724] - Dean Karaica, Vedran Micek, Dubravka Rašić, Maja Peraica, Maja Šegvić Klarić, Davorka Breljak. Subchronic exposure of individual and combined ochratoxin A and citrinin selectively affects the expression of rat renal organic cation transporters.
Mycotoxin research.
2022 Feb; 38(1):61-70. doi:
10.1007/s12550-022-00450-6
. [PMID: 35028911] - Han Luo, Gan Wang, Nan Chen, Zemin Fang, Yazhong Xiao, Min Zhang, Khishigjargal Gerelt, Yingying Qian, Ren Lai, Yu Zhou. A Superefficient Ochratoxin A Hydrolase with Promising Potential for Industrial Applications.
Applied and environmental microbiology.
2022 01; 88(2):e0196421. doi:
10.1128/aem.01964-21
. [PMID: 34788069] - Mikela Vlachou, Andreana Pexara, Nikolaos Solomakos, Alexander Govaris. Ochratoxin A in Slaughtered Pigs and Pork Products.
Toxins.
2022 01; 14(2):. doi:
10.3390/toxins14020067
. [PMID: 35202095] - Rehab E Abdelrahman, Abdel Azeim A Khalaf, Mohamed A Elhady, Marwa A Ibrahim, Eman I Hassanen, Peter A Noshy. Quercetin ameliorates ochratoxin A-Induced immunotoxicity in broiler chickens by modulation of PI3K/AKT pathway.
Chemico-biological interactions.
2022 Jan; 351(?):109720. doi:
10.1016/j.cbi.2021.109720
. [PMID: 34717913] - Xinru Mao, Hu Li, Lei Ge, Shuiping Liu, Lili Hou, Dongmei Yue, Heng Du, Cuiling Pan, Fang Gan, Yunhuan Liu, Kehe Huang, Xingxiang Chen. Selenomethionine alleviated Ochratoxin A induced pyroptosis and renal fibrotic factors expressions in MDCK cells.
Journal of biochemical and molecular toxicology.
2022 Jan; 36(1):e22933. doi:
10.1002/jbt.22933
. [PMID: 34676619] - Mingxuan Jia, Boyu Jia, Xiaofang Liao, Linchun Shi, Zheng Zhang, Miao Liu, Lidong Zhou, Donghui Li, Weijun Kong. A CdSe@CdS quantum dots based electrochemiluminescence aptasensor for sensitive detection of ochratoxin A.
Chemosphere.
2022 Jan; 287(Pt 1):131994. doi:
10.1016/j.chemosphere.2021.131994
. [PMID: 34478969] - Guannan Le, Lulu Yang, Heng Du, Lili Hou, Lei Ge, Ardache Sylia, Azhar Muhmood, Xinxiang Chen, Bo Han, Kehe Huang. Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2022 Jan; 69(?):126881. doi:
10.1016/j.jtemb.2021.126881
. [PMID: 34751137] - Agnieszka Zapaśnik, Marcin Bryła, Agnieszka Waśkiewicz, Edyta Ksieniewicz-Woźniak, Grażyna Podolska. Ochratoxin A and 2'R-Ochratoxin A in Selected Foodstuffs and Dietary Risk Assessment.
Molecules (Basel, Switzerland).
2021 Dec; 27(1):. doi:
10.3390/molecules27010188
. [PMID: 35011417] - Paul Gerard Bruinenberg, Mathieu Castex. Evaluation of a Yeast Hydrolysate from a Novel Strain of Saccharomyces cerevisiae for Mycotoxin Mitigation using In Vitro and In Vivo Models.
Toxins.
2021 12; 14(1):. doi:
10.3390/toxins14010007
. [PMID: 35050984] - Frantisek Malir, Miroslav Louda, Jakub Toman, Vladimir Ostry, Darina Pickova, Jaroslav Pacovsky, Milos Brodak, Annie Pfohl-Leszkowicz. Investigation of ochratoxin A biomarkers in biological materials obtained from patients suffering from renal cell carcinoma.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Dec; 158(?):112669. doi:
10.1016/j.fct.2021.112669
. [PMID: 34774926] - Zsolt Csenki, Edina Garai, Zelma Faisal, Rita Csepregi, Kitti Garai, Dóra Kánainé Sipos, István Szabó, Tamás Kőszegi, Árpád Czéh, Tamás Czömpöly, Krisztián Kvell, Miklós Poór. The individual and combined effects of ochratoxin A with citrinin and their metabolites (ochratoxin B, ochratoxin C, and dihydrocitrinone) on 2D/3D cell cultures, and zebrafish embryo models.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Dec; 158(?):112674. doi:
10.1016/j.fct.2021.112674
. [PMID: 34800554] - Xianjiang Li, Wen Ma, Zhiyong Ma, Qinghe Zhang, Hongmei Li. The Occurrence and Contamination Level of Ochratoxin A in Plant and Animal-Derived Food Commodities.
Molecules (Basel, Switzerland).
2021 Nov; 26(22):. doi:
10.3390/molecules26226928
. [PMID: 34834020] - Qian-Wen Zheng, Xu-Fen Ding, Hui-Jun Cao, Qian-Zhi Ni, Bing Zhu, Ning Ma, Feng-Kun Zhang, Yi-Kang Wang, Sheng Xu, Tian-Wei Chen, Ji Xia, Xiao-Song Qiu, Dian-Zhen Yu, Dong Xie, Jing-Jing Li. Ochratoxin A Induces Steatosis via PPARγ-CD36 Axis.
Toxins.
2021 11; 13(11):. doi:
10.3390/toxins13110802
. [PMID: 34822586] - Manar Al Ayoubi, Mohammad Salman, Lucia Gambacorta, Nada El Darra, Michele Solfrizzo. Assessment of Dietary Exposure to Ochratoxin A in Lebanese Students and Its Urinary Biomarker Analysis.
Toxins.
2021 11; 13(11):. doi:
10.3390/toxins13110795
. [PMID: 34822578] - Hanrui Qing, Xueting Huo, Shimeng Huang, Lihong Zhao, Jianyun Zhang, Cheng Ji, Qiugang Ma. Bacillus subtilis ANSB168 Producing d-alanyl-d-alanine Carboxypeptidase Could Alleviate the Immune Injury and Inflammation Induced by Ochratoxin A.
International journal of molecular sciences.
2021 Nov; 22(21):. doi:
10.3390/ijms222112059
. [PMID: 34769489] - Enrique García-Pérez, Dojin Ryu, Hwa-Young Kim, Hae Dun Kim, Hyun Jung Lee. Human Proximal Tubule Epithelial Cells (HK-2) as a Sensitive In Vitro System for Ochratoxin A Induced Oxidative Stress.
Toxins.
2021 11; 13(11):. doi:
10.3390/toxins13110787
. [PMID: 34822571] - Husam Ibrahem Aroud, Bianca May, Helmut Dietrich, Ralf Schweiggert, Sabine Kemmlein. Influence of processing steps on the fate of ochratoxin A, patulin, and alternariol during production of cloudy and clear apple juices.
Mycotoxin research.
2021 Nov; 37(4):341-354. doi:
10.1007/s12550-021-00443-x
. [PMID: 34693499] - Zahra Khoshbin, Khalil Abnous, Seyed Mohammad Taghdisi, Asma Verdian. A novel liquid crystal-based aptasensor for ultra-low detection of ochratoxin a using a π-shaped DNA structure: Promising for future on-site detection test strips.
Biosensors & bioelectronics.
2021 Nov; 191(?):113457. doi:
10.1016/j.bios.2021.113457
. [PMID: 34175647] - Agnieszka Tkaczyk, Piotr Jedziniak, Łukasz Zielonka, Michał Dąbrowski, Piotr Ochodzki, Adrianna Rudawska. Biomarkers of Deoxynivalenol, Citrinin, Ochratoxin A and Zearalenone in Pigs after Exposure to Naturally Contaminated Feed Close to Guidance Values.
Toxins.
2021 10; 13(11):. doi:
10.3390/toxins13110750
. [PMID: 34822534] - Chong-Sun Khoi, Jia-Huang Chen, Tzu-Yu Lin, Chih-Kang Chiang, Kuan-Yu Hung. Ochratoxin A-Induced Nephrotoxicity: Up-to-Date Evidence.
International journal of molecular sciences.
2021 Oct; 22(20):. doi:
10.3390/ijms222011237
. [PMID: 34681895] - Hangbin Yan, Liang Zhang, Ziling Ye, Aibo Wu, Dianzhen Yu, You Wu, Yu Zhou. Determination and Comprehensive Risk Assessment of Dietary Exposure to Ochratoxin A on Fermented Teas.
Journal of agricultural and food chemistry.
2021 Oct; 69(40):12021-12029. doi:
10.1021/acs.jafc.1c04824
. [PMID: 34606275] - Chong-Sun Khoi, Yu-Wen Lin, Jia-Huang Chen, Biing-Hui Liu, Tzu-Yu Lin, Kuan-Yu Hung, Chih-Kang Chiang. Selective Activation of Endoplasmic Reticulum Stress by Reactive-Oxygen-Species-Mediated Ochratoxin A-Induced Apoptosis in Tubular Epithelial Cells.
International journal of molecular sciences.
2021 Oct; 22(20):. doi:
10.3390/ijms222010951
. [PMID: 34681610] - Fang Gan, Lili Hou, Ziman Lin, Lei Ge, Dandan Liu, Haolei Li, Xingxiang Chen, Kehe Huang. Effects of Selenium-enriched probiotics on ochratoxin A-induced kidney injury and DNMTs expressions in piglets.
Research in veterinary science.
2021 Oct; 139(?):94-101. doi:
10.1016/j.rvsc.2021.07.007
. [PMID: 34273745] - Gamal M Hamad, Adel Abdelrazek Abdelazim Mohdaly, Baher Ali El-Nogoumy, Mohamed Fawzy Ramadan, Sabria A Hassan, Ahmed M Zeitoun. Detoxification of Aflatoxin B1 and Ochratoxin A Using Salvia farinacea and Azadirachta indica Water Extract and Application in Meat Products.
Applied biochemistry and biotechnology.
2021 Oct; 193(10):3098-3120. doi:
10.1007/s12010-021-03581-1
. [PMID: 34028665] - Alana Greaves, Kyle Maddison, Marney Doran, Sarah Lin, Ben Geiling. Single-Laboratory Validation of an Immunoaffinity Column Cleanup LC Method for the Analysis of Aflatoxins and Ochratoxin A in Cannabis Plant Material, Resins, Vapes, Isolates, and Edible Products.
Journal of AOAC International.
2021 Sep; 104(5):1264-1271. doi:
10.1093/jaoacint/qsab057
. [PMID: 33881521] - Sheraz Ahmed Bhatti, Muhammad Zargham Khan, Muhammad Kashif Saleemi, Zahoor Ul Hassan. Dietary Trichosporon mycotoxinivoron modulates ochratoxin-A induced altered performance, hepatic and renal antioxidant capacity and tissue injury in broiler chickens.
Chemico-biological interactions.
2021 Sep; 347(?):109614. doi:
10.1016/j.cbi.2021.109614
. [PMID: 34364835] - Magdalena Cuciureanu, Cristina Tuchiluș, Anca Vartolomei, Bogdan Ionel Tamba, Lorena Filip. An Immunoenzymatic Method for the Determination of Ochratoxin A in Biological Liquids (Colostrum and Cow's Milk).
Toxins.
2021 09; 13(10):. doi:
10.3390/toxins13100673
. [PMID: 34678966] - Ge Wu, Zhengwei Xiong, Suk-Heung Oh, Yanrong Ren, Qiang Wang, Lizhu Yang. Two-color, ultra-sensitive fluorescent strategy for Ochratoxin A detection based on hybridization chain reaction and DNA tweezers.
Food chemistry.
2021 Sep; 356(?):129663. doi:
10.1016/j.foodchem.2021.129663
. [PMID: 33812184] - Roua Gabriela Popescu, Sorin Avramescu, Daniela Eliza Marin, Ionelia Țăranu, Sergiu Emil Georgescu, Anca Dinischiotu. The Reduction of the Combined Effects of Aflatoxin and Ochratoxin A in Piglet Livers and Kidneys by Dietary Antioxidants.
Toxins.
2021 09; 13(9):. doi:
10.3390/toxins13090648
. [PMID: 34564652] - Rouaa Daou, Karine Joubrane, Lydia Rabbaa Khabbaz, Richard G Maroun, Ali Ismail, André El Khoury. Aflatoxin B1 and ochratoxin A in imported and Lebanese wheat and -products.
Food additives & contaminants. Part B, Surveillance.
2021 Sep; 14(3):227-235. doi:
10.1080/19393210.2021.1933203
. [PMID: 34109907] - Yanyan Song, Wei Liu, Yao Zhao, Junting Zang, Hang Gao. Ochratoxin A induces human kidney tubular epithelial cell apoptosis through regulating lipid raft/PTEN/AKT signaling pathway.
Environmental toxicology.
2021 Sep; 36(9):1880-1885. doi:
10.1002/tox.23308
. [PMID: 34101318] - Xinge Xu, Min Pang, Jiawei Liu, Yuping Wang, Xiaoyan Wu, KunLun Huang, Zhihong Liang. Genome mining reveals the genes of carboxypeptidase for OTA-detoxification in Bacillus subtilis CW14.
International journal of biological macromolecules.
2021 Sep; 186(?):800-810. doi:
10.1016/j.ijbiomac.2021.07.085
. [PMID: 34284053] - Liye Zhu, Haomiao Wang, Jieyu Yuhan, Boyang Zhang, Hongyu Li, Charles Asakiya, Kunlun Huang, Xiaoyun He, Wentao Xu. Exosomes mediated the delivery of ochratoxin A-induced cytotoxicity in HEK293 cells.
Toxicology.
2021 09; 461(?):152926. doi:
10.1016/j.tox.2021.152926
. [PMID: 34481902] - Robert Kosicki, Joanna Buharowska-Donten, Magdalena Twarużek. Ochratoxin A levels in serum of Polish dialysis patients with chronic renal failure.
Toxicon : official journal of the International Society on Toxinology.
2021 Sep; 200(?):183-188. doi:
10.1016/j.toxicon.2021.08.002
. [PMID: 34375657] - Elif Darbuka, Can Gürkaşlar, Ibrahim Yaman. Ochratoxin A induces ERK1/2 phosphorylation-dependent apoptosis through NF-κB/ERK axis in human proximal tubule HK-2 cell line.
Toxicon : official journal of the International Society on Toxinology.
2021 Aug; 199(?):79-86. doi:
10.1016/j.toxicon.2021.06.005
. [PMID: 34116085] - Dionisia Carballo, Noelia Pallarés, Emilia Ferrer, Francisco J Barba, Houda Berrada. Assessment of Human Exposure to Deoxynivalenol, Ochratoxin A, Zearalenone and Their Metabolites Biomarker in Urine Samples Using LC-ESI-qTOF.
Toxins.
2021 07; 13(8):. doi:
10.3390/toxins13080530
. [PMID: 34437401] - Yingying Qian, Xuanjun Zhang, Qingru Fei, Yu Zhou. Comments on the ochratoxin A degradation mechanism by Lysobacter sp. CW239 - Wei Wei et al. (2020).
Environmental pollution (Barking, Essex : 1987).
2021 Jul; 281(?):117063. doi:
10.1016/j.envpol.2021.117063
. [PMID: 33857714] - Beatriz Arce-López, Lydia Alvarez-Erviti, Barbara De Santis, María Izco, Silvia López-Calvo, Maria Eugenia Marzo-Sola, Francesca Debegnach, Elena Lizarraga, Adela López de Cerain, Elena González-Peñas, Ariane Vettorazzi. Biomonitoring of Mycotoxins in Plasma of Patients with Alzheimer's and Parkinson's Disease.
Toxins.
2021 07; 13(7):. doi:
10.3390/toxins13070477
. [PMID: 34357949] - M Alonso-Garrido, M Frangiamone, G Font, A Cimbalo, L Manyes. In vitro blood brain barrier exposure to mycotoxins and carotenoids pumpkin extract alters mitochondrial gene expression and oxidative stress.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jul; 153(?):112261. doi:
10.1016/j.fct.2021.112261
. [PMID: 34015425] - G S Bondy, I H C Curran, L C Coady, C Armstrong, C Bourque, S Bugiel, D Caldwell, K Kwong, D E Lefebvre, C Maurice, F Marchetti, P P Pantazopoulos, N Ross, A M Gannon. A one-generation reproductive toxicity study of the mycotoxin ochratoxin A in Fischer rats.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 Jul; 153(?):112247. doi:
10.1016/j.fct.2021.112247
. [PMID: 33951485] - Ziwei Wang, Yanan Gao, Xin Huang, Shengnan Huang, Xue Yang, Jiaqi Wang, Nan Zheng. Metabolomics analysis underlay mechanisms in the renal impairment of mice caused by combination of aflatoxin M1 and ochratoxin A.
Toxicology.
2021 06; 458(?):152835. doi:
10.1016/j.tox.2021.152835
. [PMID: 34126166] - Csaba Fernye, Zsolt Ancsin, Krisztián Balogh, Miklós Mézes, Márta Erdélyi. Role of the glutathione redox system in the susceptibility of pheasants (Phasianus colchicus) to ochratoxin A.
Acta veterinaria Hungarica.
2021 06; 69(2):125-133. doi:
10.1556/004.2021.00021
. [PMID: 34170843] - Benedikt Bauer, Daniel Liedtke, Sebastian Jarzina, Emilia Stammler, Katrin Kreisel, Viola Lalomia, Markus Diefenbacher, Eva Klopocki, Angela Mally. Exploration of zebrafish larvae as an alternative whole-animal model for nephrotoxicity testing.
Toxicology letters.
2021 Jun; 344(?):69-81. doi:
10.1016/j.toxlet.2021.03.005
. [PMID: 33722575] - Haolei Li, Mengmeng Wang, Weili Kang, Ziman Lin, Fang Gan, Kehe Huang. Non-cytotoxic dosage of fumonisin B1 aggravates ochratoxin A-induced nephrocytotoxicity and apoptosis via ROS-dependent JNK/MAPK signaling pathway.
Toxicology.
2021 06; 457(?):152802. doi:
10.1016/j.tox.2021.152802
. [PMID: 33905761] - Yahui Wang, Wei Song, Haiyan Zhao, Xin Ma, Shuying Yang, Xiujuan Qiao, Qinglin Sheng, Tianli Yue. DNA walker-assisted aptasensor for highly sensitive determination of Ochratoxin A.
Biosensors & bioelectronics.
2021 Jun; 182(?):113171. doi:
10.1016/j.bios.2021.113171
. [PMID: 33773380] - Charalampos Templalexis, Paola Giorni, Diamanto Lentzou, Sabrina Mesisca, Dimitrios I Tsitsigiannis, Paola Battilani, Georgios Xanthopoulos. Environmental Conditions Affecting Ochratoxin A during Solar Drying of Grapes: The Case of Tunnel and Open Air-Drying.
Toxins.
2021 06; 13(6):. doi:
10.3390/toxins13060400
. [PMID: 34205222] - Ahmed Ghallab, Reham Hassan, Maiju Myllys, Wiebke Albrecht, Adrian Friebel, Stefan Hoehme, Ute Hofmann, Abdel-Latif Seddek, Albert Braeuning, Lars Kuepfer, Benedikt Cramer, Hans-Ulrich Humpf, Peter Boor, Gisela H Degen, Jan G Hengstler. Subcellular spatio-temporal intravital kinetics of aflatoxin B1 and ochratoxin A in liver and kidney.
Archives of toxicology.
2021 06; 95(6):2163-2177. doi:
10.1007/s00204-021-03073-5
. [PMID: 34003344] - Sophie Ndaw, Aurélie Remy, Danièle Jargot, Guillaume Antoine, Flavien Denis, Alain Robert. Mycotoxins Exposure of French Grain Elevator Workers: Biomonitoring and Airborne Measurements.
Toxins.
2021 05; 13(6):. doi:
10.3390/toxins13060382
. [PMID: 34071776] - Agnieszka Tkaczyk, Piotr Jedziniak. Development of a multi-mycotoxin LC-MS/MS method for the determination of biomarkers in pig urine.
Mycotoxin research.
2021 May; 37(2):169-181. doi:
10.1007/s12550-021-00428-w
. [PMID: 33772455] - Wei Wei, Chong Liu, Ping Ke, Xiaoyun Chen, Ting Zhou, Junfeng Xu, Yu Zhou. Toxicological and physiological effects of successive exposure to ochratoxin A at food regulatory limits.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2021 May; 151(?):112128. doi:
10.1016/j.fct.2021.112128
. [PMID: 33727177] - Mohamed Raafat, Ashraf S A El-Sayed, Manal T El-Sayed. Biosynthesis and Anti-Mycotoxigenic Activity of Zingiber officinale Roscoe-Derived Metal Nanoparticles.
Molecules (Basel, Switzerland).
2021 Apr; 26(8):. doi:
10.3390/molecules26082290
. [PMID: 33920949] - Hu Li, Xinru Mao, Kai Liu, Jiahao Sun, Benrui Li, Rahmani Mohammad Malyar, Dandan Liu, Cuiling Pan, Fang Gan, Yunhuan Liu, Kehe Huang, Xingxiang Chen. Ochratoxin A induces nephrotoxicity in vitro and in vivo via pyroptosis.
Archives of toxicology.
2021 04; 95(4):1489-1502. doi:
10.1007/s00204-021-02993-6
. [PMID: 33543323] - Flávio Fonseca Veras, Bruna Dachery, Vitor Manfroi, Juliane Elisa Welke. Colonization of Aspergillus carbonarius and accumulation of ochratoxin A in Vitis vinifera, Vitis labrusca, and hybrid grapes - research on the most promising alternatives for organic viticulture.
Journal of the science of food and agriculture.
2021 Apr; 101(6):2414-2421. doi:
10.1002/jsfa.10865
. [PMID: 33012097] - Haiyong Zhang, Gang Wang, Qingli Yang, Xu Yang, Yongquan Zheng, Yang Liu, Fuguo Xing. Effects of Light on the Ochratoxigenic Fungi Aspergillus ochraceus and A. carbonarius.
Toxins.
2021 03; 13(4):. doi:
10.3390/toxins13040251
. [PMID: 33807312] - Yasmin Alhamoud, Yingying Li, Haibo Zhou, Ragwa Al-Wazer, Yiying Gong, Shuai Zhi, Danting Yang. Label-Free and Highly-Sensitive Detection of Ochratoxin A Using One-Pot Synthesized Reduced Graphene Oxide/Gold Nanoparticles-Based Impedimetric Aptasensor.
Biosensors.
2021 Mar; 11(3):. doi:
10.3390/bios11030087
. [PMID: 33808613] - Gerald Schwerdt, Michael Kopf, Michael Gekle. The Impact of the Nephrotoxin Ochratoxin A on Human Renal Cells Studied by a Novel Co-Culture Model Is Influenced by the Presence of Fibroblasts.
Toxins.
2021 03; 13(3):. doi:
10.3390/toxins13030219
. [PMID: 33803529] - Yuhao Mao, Mingna Sun, Xia Hong, Sagnik Chakraborty, Jinsheng Duan, Ming Li, Daolin Du. Semi-quantitative and quantitative detection of ochratoxin A in agricultural by-products using a self-assembling immunochromatographic strip.
Journal of the science of food and agriculture.
2021 Mar; 101(4):1659-1665. doi:
10.1002/jsfa.10786
. [PMID: 32892405] - Diana Herman, Peter Mantle. Rat Tumour Histopathology Associated with Experimental Chronic Dietary Exposure to Ochratoxin A in Prediction of the Mycotoxin's Risk for Human Cancers.
Toxins.
2021 03; 13(3):. doi:
10.3390/toxins13030205
. [PMID: 33808971] - Min Cheol Pyo, In-Geol Choi, Kwang-Won Lee. Transcriptome Analysis Reveals the AhR, Smad2/3, and HIF-1α Pathways as the Mechanism of Ochratoxin A Toxicity in Kidney Cells.
Toxins.
2021 03; 13(3):. doi:
10.3390/toxins13030190
. [PMID: 33800744] - Qipeng Zhang, Wenying Chen, Boyang Zhang, Chen Li, Xunyao Zhang, Qian Wang, Yan Wang, Qian Zhou, Xiaohong Li, Xiao Li Shen. Central role of TRAP1 in the ameliorative effect of oleanolic acid on the mitochondrial-mediated and endoplasmic reticulum stress-excitated apoptosis induced by ochratoxin A.
Toxicology.
2021 02; 450(?):152681. doi:
10.1016/j.tox.2021.152681
. [PMID: 33465424] - Laura Pastor, Ariane Vettorazzi, Elizabeth Guruceaga, López de Cerain A. Time Course of Renal Transcriptomics after Subchronic Exposure to Ochratoxin A in Fisher Rats.
Toxins.
2021 02; 13(3):. doi:
10.3390/toxins13030177
. [PMID: 33652839] - Ling Zhao, Yue Feng, Jing-Tao Wei, Meng-Xiang Zhu, Lei Zhang, Jia-Cai Zhang, Niel Alexander Karrow, Yan-Ming Han, Yuan-Yuan Wu, Yu-Ming Guo, Lv-Hui Sun. Mitigation Effects of Bentonite and Yeast Cell Wall Binders on AFB1, DON, and OTA Induced Changes in Laying Hen Performance, Egg Quality, and Health.
Toxins.
2021 02; 13(2):. doi:
10.3390/toxins13020156
. [PMID: 33671260] - Zhengwei Xiong, Qiang Wang, Yuejie Xie, Ning Li, Wen Yun, Lizhu Yang. Simultaneous detection of aflatoxin B1 and ochratoxin A in food samples by dual DNA tweezers nanomachine.
Food chemistry.
2021 Feb; 338(?):128122. doi:
10.1016/j.foodchem.2020.128122
. [PMID: 33091999] - Beatriz Arce-López, Elena Lizarraga, Reyes López de Mesa, Elena González-Peñas. Assessment of Exposure to Mycotoxins in Spanish Children through the Analysis of Their Levels in Plasma Samples.
Toxins.
2021 02; 13(2):. doi:
10.3390/toxins13020150
. [PMID: 33672088] - Roua Gabriela Popescu, Cristina Bulgaru, Arabela Untea, Mihaela Vlassa, Miuta Filip, Anca Hermenean, Daniela Marin, Ionelia Țăranu, Sergiu Emil Georgescu, Anca Dinischiotu. The Effectiveness of Dietary Byproduct Antioxidants on Induced CYP Genes Expression and Histological Alteration in Piglets Liver and Kidney Fed with Aflatoxin B1 and Ochratoxin A.
Toxins.
2021 02; 13(2):. doi:
10.3390/toxins13020148
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