Saccharopine (BioDeep_00000001373)

 

Secondary id: BioDeep_00000400291

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acid

化学式: C11H20N2O6 (276.13213)
中文名称: L-酵母氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 0.04%

Reviewed

Last reviewed on 2024-07-29.

Cite this Page

Saccharopine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/saccharopine (retrieved 2024-11-22) (BioDeep RN: BioDeep_00000001373). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CCNC(CCC(=O)O)C(=O)O)CC(C(=O)O)N
InChI: InChI=1S/C11H20N2O6/c12-7(10(16)17)3-1-2-6-13-8(11(18)19)4-5-9(14)15/h7-8,13H,1-6,12H2,(H,14,15)(H,16,17)(H,18,19)

描述信息

Saccharopine is an intermediate in the degradation of lysine, formed by the condensation of lysine and alpha-ketoglutarate. The saccharopine pathway is the main route for lysine degradation in mammals, and its first two reactions are catalyzed by enzymatic activities known as lysine-oxoglutarate reductase (LOR) and saccharopine dehydrogenase (SDH), which reside on a single bifunctional polypeptide (LOR/SDH) (EC 1.5.1.8). The reactions involved with saccharopine dehydrogenases have very strict substrate specificity for L-lysine, 2-oxoglutarate, and NADPH. LOR/SDH has been detected in a number of mammalian tissues, mainly in the liver and kidney, contributing not only to the general nitrogen balance in the organism but also to the controlled conversion of lysine into ketone bodies. A tetrameric form has also been observed in human liver and placenta. LOR activity has also been detected in brain mitochondria during embryonic development, and this opens up the question of whether or not lysine degradation has any functional significance during brain development. As a result, there is now a new focus on the nutritional requirements for lysine in gestation and infancy. Finally, LOR and/or SDH deficiencies seem to be involved in a human autosomal genetic disorder known as familial hyperlysinemia, which is characterized by serious defects in the functioning of the nervous system and characterized by a deficiency in lysine-ketoglutarate reductase, saccharopine dehydrogenase, and saccharopine oxidoreductase activities. Saccharopinuria (high amounts of saccharopine in the urine) and saccharopinemia (an excess of saccharopine in the blood) are conditions present in some inherited disorders of lysine degradation (PMID: 463877, 10567240, 10772957, 4809305). If present in sufficiently high levels, saccharopine can act as an acidogen and a metabotoxin. An acidogen is an acidic compound that induces acidosis, which has multiple adverse effects on many organ systems. A metabotoxin is an endogenously produced metabolite that causes adverse health effects at chronically high levels. Saccharopine is an organic acid. Abnormally high levels of organic acids in the blood (organic acidemia), urine (organic aciduria), the brain, and other tissues lead to general metabolic acidosis. Acidosis typically occurs when arterial pH falls below 7.35. In infants with acidosis, the initial symptoms include poor feeding, vomiting, loss of appetite, weak muscle tone (hypotonia), and lack of energy (lethargy). Many affected children with organic acidemias experience intellectual disability or delayed development.
Amino acid from Saccharomyces cerevisiae and Neurospora crassaand is also found in mushrooms and seeds

同义名列表

19 个代谢物同义名

(2S)-2-{[(5S)-5-amino-5-carboxypentyl]amino}pentanedioic acid; (2S)-2-[[(5S)-5-amino-5-carboxypentyl]amino]pentanedioic acid; N-[(5S)-5-Amino-5-carboxypentyl]-L-glutamic acid; (S)-N-(5-Amino-5-carboxypentyl)-L-glutamic acid; N-[(S)-5-Amino-5-carboxypentyl]-L-glutamic acid; N-[(S)-5-Amino-5-carboxypentyl]-L-glutamate; L-N-(5-Amino-5-carboxypentyl)-glutamic acid; N-(5-Amino-5-carboxypentyl)-L-glutamic acid; N-(5-Amino-5-carboxypentyl)-glutamic acid; N(6)-(L-1,3-Dicarboxypropyl)-L-lysine; N6-(L-1,3-dicarboxylpropyl)-L-lysine; ε-N-(L-glutar-2-yl)-L-lysine; N6-(L-1,3-Dicarboxypropyl)-L-lysine; epsilon-N-(L-Glutar-2-yl)-L-lysine; L-Saccharopine; L-Saccharopin; Saccharopine; Saccharopin; N6-(L-1,3-Dicarboxypropyl)-L-lysine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

388 个相关的代谢反应过程信息。

Reactome(65)

BioCyc(0)

WikiPathways(1)

Plant Reactome(296)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(24)

PharmGKB(0)

63 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Brian J Koos, Jeffrey A Gornbein. Early pregnancy metabolites predict gestational diabetes mellitus: implications for fetal programming. American journal of obstetrics and gynecology. 2021 02; 224(2):215.e1-215.e7. doi: 10.1016/j.ajog.2020.07.050. [PMID: 32739399]
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  • Junxiang Zhou, Xin Wang, Min Wang, Yuwei Chang, Fengxia Zhang, Zhaonan Ban, Ruofeng Tang, Qiwen Gan, Shaohuan Wu, Ye Guo, Qian Zhang, Fengyang Wang, Liyuan Zhao, Yudong Jing, Wenfeng Qian, Guodong Wang, Weixiang Guo, Chonglin Yang. The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis. The Journal of cell biology. 2019 02; 218(2):580-597. doi: 10.1083/jcb.201807204. [PMID: 30573525]
  • Izabella Agostinho Pena, Lygia Azevedo Marques, Ângelo B A Laranjeira, José A Yunes, Marcos N Eberlin, Alex MacKenzie, Paulo Arruda. Mouse lysine catabolism to aminoadipate occurs primarily through the saccharopine pathway; implications for pyridoxine dependent epilepsy (PDE). Biochimica et biophysica acta. Molecular basis of disease. 2017 01; 1863(1):121-128. doi: 10.1016/j.bbadis.2016.09.006. [PMID: 27615426]
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  • Guilherme Coutinho de Mello Serrano, Thaís Rezende e Silva Figueira, Eduardo Kiyota, Natalia Zanata, Paulo Arruda. Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes. FEBS letters. 2012 Mar; 586(6):905-11. doi: 10.1016/j.febslet.2012.02.023. [PMID: 22449979]
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  • Julien Bouchoux, Frauke Beilstein, Thomas Pauquai, I Chiara Guerrera, Danielle Chateau, Nathalie Ly, Malik Alqub, Christophe Klein, Jean Chambaz, Monique Rousset, Jean-Marc Lacorte, Etienne Morel, Sylvie Demignot. The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics. Biology of the cell. 2011 Nov; 103(11):499-517. doi: 10.1042/bc20110024. [PMID: 21787361]
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  • Raquel González-Fernández, Elena Prats, Jesús V Jorrín-Novo. Proteomics of plant pathogenic fungi. Journal of biomedicine & biotechnology. 2010; 2010(?):932527. doi: 10.1155/2010/932527. [PMID: 20589070]
  • Banzragch Battur, Damdinsuren Boldbaatar, Rika Umemiya-Shirafuji, Min Liao, Badgar Battsetseg, DeMar Taylor, Badarch Baymbaa, Kozo Fujisaki. LKR/SDH plays important roles throughout the tick life cycle including a long starvation period. PloS one. 2009 Sep; 4(9):e7136. doi: 10.1371/journal.pone.0007136. [PMID: 19774086]
  • Sun-Jung Kwon, Sang-Yun Cho, Kyung-Mi Lee, Jisuk Yu, Moonil Son, Kook-Hyung Kim. Proteomic analysis of fungal host factors differentially expressed by Fusarium graminearum infected with Fusarium graminearum virus-DK21. Virus research. 2009 Sep; 144(1-2):96-106. doi: 10.1016/j.virusres.2009.04.004. [PMID: 19374926]
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  • Kaoru Urano, Kyonoshin Maruyama, Yoshiyuki Ogata, Yoshihiko Morishita, Migiwa Takeda, Nozomu Sakurai, Hideyuki Suzuki, Kazuki Saito, Daisuke Shibata, Masatomo Kobayashi, Kazuko Yamaguchi-Shinozaki, Kazuo Shinozaki. Characterization of the ABA-regulated global responses to dehydration in Arabidopsis by metabolomics. The Plant journal : for cell and molecular biology. 2009 Mar; 57(6):1065-78. doi: 10.1111/j.1365-313x.2008.03748.x. [PMID: 19036030]
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