L-Cystathionine (BioDeep_00000001337)
Secondary id: BioDeep_00000027581, BioDeep_00000227898, BioDeep_00000399916, BioDeep_00000400228, BioDeep_00000405277
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
(2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid
化学式: C7H14N2O4S (222.0674244)
中文名称: L-胱硫醚, DL-胱硫醚, DL-胱硫醚, 胱硫醚
谱图信息:
最多检出来源 Homo sapiens(blood) 0.1%
Reviewed
Last reviewed on 2024-09-13.
Cite this Page
L-Cystathionine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/cystathionine (retrieved
2024-09-17) (BioDeep RN: BioDeep_00000001337). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CSCC(C(=O)O)N)C(C(=O)O)N
InChI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
描述信息
Cystathionine is a dipeptide formed by serine and homocysteine. Cystathioninuria is a prominent manifestation of vitamin-B6 deficiency. The transsulfuration of methionine yields homocysteine, which combines with serine to form cystathionine, the proximate precursor of cysteine through the enzymatic activity of cystathionase. In conditions in which cystathionine gamma-synthase or cystathionase is deficient, for example, there is cystathioninuria. Although cystathionine has not been detected in normal human serum or plasma by most conventional methods, gas chromatographic/mass spectrometric methodology detected a mean concentration of cystathionine in normal human serum of 140 nM, with a range of 65 to 301 nM. Cystathionine concentrations in CSF have been 10, 1, and 0.5 uM, and "not detected". Only traces (i.e., <1 uM) of cystathionine are present in normal CSF.587. Gamma-cystathionase deficiency (also known as Cystathioninuria), which is an autosomal recessive disorder (NIH: 2428), provided the first instance in which, in a human, the major biochemical abnormality due to a defined enzyme defect was clearly shown to be alleviated by administration of large doses of pyridoxine. The response in gamma-cystathionase-deficient patients is not attributable to correction of a preexisting deficiency of this vitamin (OMMBID, Chap. 88).
Isolated from Phallus impudicus (common stinkhorn)
CONFIDENCE standard compound; INTERNAL_ID 146
KEIO_ID C019; [MS2] KO008910
KEIO_ID C047
KEIO_ID C019
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE standard compound; ML_ID 30
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].
同义名列表
23 个代谢物同义名
(2S)-2-amino-4-{[(2R)-2-amino-2-carboxyethyl]sulfanyl}butanoic acid; [R-(R*,s*)]-2-amino-4-[(2-amino-2-carboxyethyl)thio]-butanoic acid; (2S)-2-amino-4-[(2R)-2-amino-2-carboxyethyl]sulfanylbutanoic acid; [R-(R*,s*)]-2-amino-4-[(2-amino-2-carboxyethyl)thio]-butanoate; S-[(2R)-2-Amino-2-carboxyethyl]-L-homocysteine; (R)-S-(2-Amino-2-carboxyethyl)-L-homocysteine; S-(beta-Amino-beta-carboxyethyl)homocysteine; S-(Β-amino-β-carboxyethyl)homocysteine; S-(b-Amino-b-carboxyethyl)homocysteine; L-(+)-Cystathionine; L(+)-Cystathionine; L-Cystathionine; L-Cystathione; Cystathionine; α-amino-γ-(2-amino-2-carboxyethylmercapto)-Butyric acid; 2-amino-4-(2-amino-2-carboxyethyl)sulfanylbutanoic acid; a-Amino-g-(2-amino-2-carboxyethylmercapto)-butyric acid; DL-S-(2-Amino-2-carboxyethyl)-homocysteine; Homocysteine,S-(2-amino-2-carboxyethyl)-; S-(2-Amino-2-carboxyethyl)homocysteine; DL,DL-allo-Cystathionine; DL-Allocystathionine; Cystathionine
数据库引用编号
55 个数据库交叉引用编号
- ChEBI: CHEBI:17482
- ChEBI: CHEBI:17755
- KEGG: C02291
- KEGG: C00542
- PubChem: 439258
- PubChem: 5347
- PubChem: 834
- HMDB: HMDB0000099
- Metlin: METLIN39
- Metlin: METLIN63300
- ChEMBL: CHEMBL209241
- Wikipedia: Cystathionine
- MeSH: Cystathionine
- MetaCyc: L-CYSTATHIONINE
- KNApSAcK: C00007498
- foodb: FDB001976
- chemspider: 388392
- CAS: 56-88-2
- CAS: 535-34-2
- MoNA: KO002573
- MoNA: KO002574
- MoNA: RP014612
- MoNA: RP014602
- MoNA: PS066503
- MoNA: PS066506
- MoNA: RP014603
- MoNA: PS066504
- MoNA: KO002575
- MoNA: PS066502
- MoNA: PS066501
- MoNA: KO008911
- MoNA: RP014601
- MoNA: KO002572
- MoNA: KO002576
- MoNA: KO008910
- MoNA: RP014611
- MoNA: PS066505
- MoNA: PS018702
- MoNA: PR100113
- MoNA: PS018704
- MoNA: PS018703
- MoNA: PR100535
- MoNA: ML003051
- MoNA: ML003001
- MoNA: PS018701
- MoNA: PS018705
- MoNA: PR100114
- PMhub: MS000000352
- ChEBI: CHEBI:165853
- PubChem: 3823
- 3DMET: B01284
- NIKKAJI: J410.855H
- 3DMET: B01559
- NIKKAJI: J4.574H
- medchemexpress: HY-W009749
分类词条
相关代谢途径
Reactome(6)
BioCyc(6)
PlantCyc(0)
代谢反应
412 个相关的代谢反应过程信息。
Reactome(71)
- Mycobacterium tuberculosis biological processes:
CYSTA + H2O ⟶ 2OBUTA + L-Cys + ammonia - Sulfur compound metabolism:
CYSTA + H2O ⟶ 2OBUTA + L-Cys + ammonia - Sulfur amino acid metabolism:
CYSTA + H2O ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
MTAD + Pi ⟶ Ade + MTRIBP - Cysteine formation from homocysteine:
HCYS + Ser ⟶ H2O + L-Cystathionine - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Sulfur amino acid metabolism:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia - Cysteine formation from homocysteine:
H2O + L-Cystathionine ⟶ 2OBUTA + L-Cys + ammonia
BioCyc(9)
- homocysteine and cysteine interconversion:
O-acetyl-L-homoserine + cys ⟶ H+ + L-cystathionine + acetate - cysteine biosynthesis/homocysteine degradation:
H2O + L-cystathionine ⟶ 2-oxobutanoate + H+ + ammonia + cys - methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - cysteine biosynthesis/homocysteine degradation:
H2O + L-cystathionine ⟶ 2-oxobutanoate + H+ + ammonia + cys - aspartate superpathway:
ATP + ammonia + nicotinate adenine dinucleotide ⟶ AMP + H+ + NAD+ + diphosphate - superpathway of lysine, threonine and methionine biosynthesis II:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - superpathway of lysine, threonine and methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - methionine biosynthesis II:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate
WikiPathways(6)
- One-carbon metabolism and related pathways:
5-oxoproline ⟶ Glutamate - Methionine metabolism leading to sulfur amino acids and related disorders:
Adenosine ⟶ AMP - Folate-alcohol and cancer pathway hypotheses:
Cysteine ⟶ Cystathionine - Trans-sulfuration and one-carbon metabolism:
Methionine ⟶ Decarboxylated SAM - One-carbon metabolism and related pathways:
L-Cystathionine ⟶ 2-oxobutanoate - Metabolic Epileptic Disorders:
P-enolpyruvate ⟶ Pyruvate
Plant Reactome(324)
- Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid metabolism:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid biosynthesis:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia
INOH(2)
- Glycine and Serine metabolism ( Glycine and Serine metabolism ):
Guanidino-acetic acid + S-Adenosyl-L-methionine ⟶ Creatine + S-Adenosyl-L-homocysteine - Methionine and Cysteine metabolism ( Methionine and Cysteine metabolism ):
H2O + L-Cystathionine ⟶ 2-Oxo-butanoic acid + L-Cysteine + NH3
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alan Cunningham, Lieve Oudejans, Marjan Geugien, Diego A Pereira-Martins, Albertus Tj Wierenga, Ayşegül Erdem, Dominique Sternadt, Gerwin A Huls, Jan Jacob Schuringa. The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia.
Blood advances.
2023 Oct; ?(?):. doi:
10.1182/bloodadvances.2023010786. [PMID: 37906522] - Rafael Rosell, Anisha Jain, Jordi Codony-Servat, Eloisa Jantus-Lewintre, Blake Morrison, Jordi Barretina Ginesta, María González-Cao. Biological insights in non-small cell lung cancer.
Cancer biology & medicine.
2023 Jun; ?(?):. doi:
10.20892/j.issn.2095-3941.2023.0108. [PMID: 37381723] - Elena C Tore, Simone J P M Eussen, Nasser E Bastani, Pieter C Dagnelie, Amany K Elshorbagy, Pol Grootswagers, Viktor Kožich, Thomas Olsen, Helga Refsum, Kjetil Retterstøl, Coen DA Stehouwer, Emma T K Stolt, Kathrine J Vinknes, Marleen M J van Greevenbroek. The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study.
The Journal of nutrition.
2023 May; ?(?):. doi:
10.1016/j.tjnut.2023.05.008. [PMID: 37164267] - Chau M Tran, Shoko Mihara, Keisuke Yoshida, Toru Hisabori. Cystathionine-β-synthase X proteins negatively regulate NADPH-thioredoxin reductase C activity.
Biochemical and biophysical research communications.
2023 04; 653(?):47-52. doi:
10.1016/j.bbrc.2023.02.055. [PMID: 36857899] - Fei Duan, Man-Man Li, Wei-Xia Li, Jin-Fa Tang, Zhi-Wan Wang. [Serum metabolomics of chronic obstructive pulmonary disease with lung-Qi deficiency syndrome].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(8):2251-2256. doi:
10.19540/j.cnki.cjcmm.20211203.501. [PMID: 35531742] - N Mota-Martorell, M Jové, R Berdún, R Pamplona. Plasma methionine metabolic profile is associated with longevity in mammals.
Communications biology.
2021 06; 4(1):725. doi:
10.1038/s42003-021-02254-3. [PMID: 34117367] - Ferran Comas, Jèssica Latorre, Francisco Ortega, Núria Oliveras-Cañellas, Aina Lluch, Wifredo Ricart, José Manuel Fernández-Real, José María Moreno-Navarrete. Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.
Redox biology.
2021 06; 42(?):101668. doi:
10.1016/j.redox.2020.101668. [PMID: 32800520] - Ingrid Kvestad, Adrian McCann, Ram K Chandyo, Lasse M Giil, Merina Shrestha, Manjeswori Ulak, Mari Hysing, Per M Ueland, Tor A Strand. One-Carbon Metabolism in Nepalese Infant-Mother Pairs and Child Cognition at 5 Years Old.
The Journal of nutrition.
2021 04; 151(4):883-891. doi:
10.1093/jn/nxaa403. [PMID: 33484134] - Laurent Ouerdane, Eszter Borbála Both, Jiqian Xiang, Hongqing Yin, Yu Kang, Shuxun Shao, Katalin Kiszelák, Zsuzsa Jókai, Mihály Dernovics. Water soluble selenometabolome of Cardamine violifolia.
Metallomics : integrated biometal science.
2020 12; 12(12):2032-2048. doi:
10.1039/d0mt00216j. [PMID: 33165451] - Mads M Svenningsson, Gard F T Svingen, Vegard Lysne, Per M Ueland, Grethe S Tell, Eva R Pedersen, Indu Dhar, Dennis W Nilsen, Ottar Nygård. Transsulfuration metabolites and the association with incident atrial fibrillation - An observational cohort study among Norwegian patients with stable angina pectoris.
International journal of cardiology.
2020 Oct; 317(?):75-80. doi:
10.1016/j.ijcard.2020.05.010. [PMID: 32389762] - Yasuyuki Matoba, Masafumi Noda, Tomoki Yoshida, Kosuke Oda, Yuka Ezumi, Chiaki Yasutake, Hisae Izuhara-Kihara, Narandarai Danshiitsoodol, Takanori Kumagai, Masanori Sugiyama. Catalytic specificity of the Lactobacillus plantarum cystathionine γ-lyase presumed by the crystallographic analysis.
Scientific reports.
2020 09; 10(1):14886. doi:
10.1038/s41598-020-71756-7. [PMID: 32913258] - X M Yuan, B Zhuan, P Li, X Zhao, T Wang, Z Yang. [Expression of nicotinamide adenine dinucleotide phosphate-reduced oxidase-4/reactive oxygen species and cystathionine-γ-lyase/hydrogen sulfide in patients with chronic obstructive pulmonary disease-related pulmonary hypertension].
Zhonghua nei ke za zhi.
2019 Oct; 58(10):770-776. doi:
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Human mutation.
2019 09; 40(9):1530-1545. doi:
10.1002/humu.23868. [PMID: 31301157] - Maria F Mujica-Coopman, Dayana R Farias, Ana B Franco-Sena, Juliana S Vaz, Gilberto Kac, Yvonne Lamers. Maternal Plasma Pyridoxal 5'-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women.
The Journal of nutrition.
2019 08; 149(8):1354-1362. doi:
10.1093/jn/nxz082. [PMID: 31098628] - Antonio Belardo, Federica Gevi, Lello Zolla. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children.
The Journal of nutritional biochemistry.
2019 08; 70(?):38-46. doi:
10.1016/j.jnutbio.2019.04.004. [PMID: 31151052] - Indu Dhar, Vegard Lysne, Gard F T Svingen, Per M Ueland, Jesse F Gregory, Kaare H Bønaa, Ottar K Nygård. Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease.
The American journal of clinical nutrition.
2019 06; 109(6):1546-1554. doi:
10.1093/ajcn/nqy391. [PMID: 31005968] - Lili Shi, Chao Han, Shuai Liu, Yiqun Liu, Xuesong Xiang. [Effects of methionine on the activity of cystathionine-β-synthase].
Wei sheng yan jiu = Journal of hygiene research.
2019 May; 48(3):463-467. doi:
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Nutrients.
2018 Nov; 10(12):. doi:
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Journal of the American Heart Association.
2018 09; 7(17):e008824. doi:
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International journal of cardiology.
2018 Sep; 266(?):24-30. doi:
10.1016/j.ijcard.2018.04.083. [PMID: 29728335] - Shozo Tomonaga, Hirofumi Okuyama, Tetsuya Tachibana, Ryosuke Makino. Effects of high ambient temperature on plasma metabolomic profiles in chicks.
Animal science journal = Nihon chikusan Gakkaiho.
2018 Feb; 89(2):448-455. doi:
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The Journal of nutrition.
2017 09; 147(9):1658-1668. doi:
10.3945/jn.117.254029. [PMID: 28794210] - Yasuyuki Matoba, Tomoki Yoshida, Hisae Izuhara-Kihara, Masafumi Noda, Masanori Sugiyama. Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum.
Protein science : a publication of the Protein Society.
2017 04; 26(4):763-783. doi:
10.1002/pro.3123. [PMID: 28127810] - Wupeng Yan, Everett Stone, Yan Jessie Zhang. Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry.
2017 02; 56(6):876-885. doi:
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Journal of proteome research.
2017 02; 16(2):958-969. doi:
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Journal of chromatography. A.
2017 Jan; 1479(?):145-152. doi:
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Nutrients.
2016 Dec; 9(1):. doi:
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Aging clinical and experimental research.
2016 Aug; 28(4):781-5. doi:
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Biochimie.
2016 Jul; 126(?):14-20. doi:
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Anti-cancer drugs.
2016 Jun; 27(5):439-46. doi:
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European journal of nutrition.
2016 Apr; 55(3):1021-8. doi:
10.1007/s00394-015-0916-z. [PMID: 25943647] - Lei Yin, Kevin Shengyang Yu, Kun Lu, Xiaozhong Yu. Benzyl butyl phthalate promotes adipogenesis in 3T3-L1 preadipocytes: A High Content Cellomics and metabolomic analysis.
Toxicology in vitro : an international journal published in association with BIBRA.
2016 Apr; 32(?):297-309. doi:
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Pregnancy hypertension.
2016 Jan; 6(1):60-5. doi:
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The Journal of nutrition.
2016 Jan; 146(1):14-20. doi:
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The American journal of clinical nutrition.
2015 Sep; 102(3):616-25. doi:
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Nutritional neuroscience.
2015 Aug; 18(6):256-64. doi:
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The Journal of nutritional biochemistry.
2015 Mar; 26(3):241-9. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2015 Jan; 438(?):261-5. doi:
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Clinica chimica acta; international journal of clinical chemistry.
2014 Nov; 437(?):211-7. doi:
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American journal of physiology. Renal physiology.
2014 Jun; 306(12):F1462-76. doi:
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The Journal of nutrition.
2013 Nov; 143(11):1719-27. doi:
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Antioxidants & redox signaling.
2013 Oct; 19(12):1321-36. doi:
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Prostaglandins, leukotrienes, and essential fatty acids.
2013 Oct; 89(5):297-303. doi:
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Chemico-biological interactions.
2013 Jul; 204(2):80-7. doi:
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Journal of plant physiology.
2013 Feb; 170(3):338-45. doi:
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PloS one.
2013; 8(6):e63544. doi:
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Journal of experimental botany.
2012 Oct; 63(17):6283-95. doi:
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Molecular biology reports.
2012 Oct; 39(10):9277-84. doi:
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The Journal of biological chemistry.
2012 Sep; 287(38):31994-2005. doi:
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Mini reviews in medicinal chemistry.
2012 Sep; 12(10):997-1006. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2012 Aug; 303(3):G281-90. doi:
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European journal of clinical investigation.
2012 Jul; 42(7):768-76. doi:
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Circulation research.
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Atherosclerosis.
2012 Jun; 222(2):509-11. doi:
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Amino acids.
2012 Jun; 42(6):2095-102. doi:
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Free radical biology & medicine.
2012 May; 52(9):1716-26. doi:
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The Journal of biological chemistry.
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The Journal of nutritional biochemistry.
2012 Apr; 23(4):332-40. doi:
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Blood.
2012 Mar; 119(11):2633-43. doi:
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The Journal of biological chemistry.
2012 Mar; 287(10):7603-14. doi:
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The Journal of nutrition.
2012 Mar; 142(3):427-31. doi:
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Molecular genetics and metabolism.
2012 Mar; 105(3):395-403. doi:
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The Journal of biological chemistry.
2012 Feb; 287(7):4451-61. doi:
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Diabetes/metabolism research and reviews.
2012 Feb; 28(2):123-31. doi:
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Clinical chemistry.
2012 Feb; 58(2):402-10. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Feb; 27(2):486-93. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Feb; 27(2):498-504. doi:
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Molecular genetics and metabolism.
2012 Feb; 105(2):228-36. doi:
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Nutrition journal.
2012 Jan; 11(?):6. doi:
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PloS one.
2012; 7(3):e33222. doi:
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American journal of hypertension.
2012 Jan; 25(1):74-81. doi:
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PloS one.
2012; 7(9):e45020. doi:
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Journal of nutritional science and vitaminology.
2012; 58(2):78-87. doi:
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Journal of nutritional science and vitaminology.
2012; 58(1):20-8. doi:
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PloS one.
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PloS one.
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PloS one.
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PloS one.
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Current opinion in clinical nutrition and metabolic care.
2012 Jan; 15(1):49-57. doi:
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PloS one.
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American journal of physiology. Endocrinology and metabolism.
2012 Jan; 302(1):E61-7. doi:
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The Journal of biological chemistry.
2011 Dec; 286(49):42483-42493. doi:
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PLoS neglected tropical diseases.
2011 Dec; 5(12):e1451. doi:
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Translational research : the journal of laboratory and clinical medicine.
2011 Dec; 158(6):328-33. doi:
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Molecular and cellular biochemistry.
2011 Dec; 358(1-2):153-60. doi:
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Journal of experimental botany.
2011 Nov; 62(15):5297-309. doi:
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PLoS genetics.
2011 Oct; 7(10):e1002332. doi:
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The Plant cell.
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Kidney international.
2011 Oct; 80(7):731-9. doi:
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Neurology.
2011 Sep; 77(13):1276-82. doi:
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Clinical and experimental reproductive medicine.
2011 Sep; 38(3):168-73. doi:
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The American journal of pathology.
2011 Aug; 179(2):869-79. doi:
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Journal of experimental botany.
2011 Aug; 62(13):4481-93. doi:
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Plant & cell physiology.
2011 Aug; 52(8):1443-53. doi:
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The British journal of nutrition.
2011 Aug; 106(3):432-40. doi:
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Antioxidants & redox signaling.
2011 Jul; 15(2):363-72. doi:
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Nutrition research (New York, N.Y.).
2011 Jul; 31(7):563-71. doi:
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Nutrition research (New York, N.Y.).
2011 Jul; 31(7):572-8. doi:
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Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Jul; 26(7):2119-26. doi:
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