L-Cystathionine (BioDeep_00000399916)

Main id: BioDeep_00000001337

 

natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


L-Cystathionine

化学式: C7H14N2O4S (222.0674)
中文名称: L-胱硫醚
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(CSCC(C(=O)O)N)C(C(=O)O)N
InChI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)

描述信息

A modified amino acid generated by enzymic means from L-homocysteine and L-serine.
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].
L-Cystathionine is a nonprotein thioether and is a key amino acid associated with the metabolic state of sulfur-containing amino acids. L-Cystathionine protects against Homocysteine-induced mitochondria-dependent apoptosis of vascular endothelial cells (HUVECs). L-Cystathionine plays an important role in cardiovascular protection[1][2].

同义名列表

3 个代谢物同义名

L-Cystathionine; L-Cystathionine; L-cystathionine



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(4)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

82 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ALB, BCL2, CASP3, CAT, CBS, HPGDS, KYAT1, MPST, MTOR, MTR, RELA, SDS
Peripheral membrane protein 1 MTOR
Endoplasmic reticulum membrane 2 BCL2, MTOR
Nucleus 7 ALB, BCL2, BHMT, CASP3, CBS, MTOR, RELA
cytosol 14 ALB, BCL2, BHMT, CASP3, CAT, CBS, GPT, HPGDS, KYAT1, MTHFR, MTOR, MTR, RELA, SDS
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 ALB
nucleoplasm 5 CASP3, HPGDS, MTOR, RELA, SCNN1G
Cytoplasmic side 1 MTOR
Multi-pass membrane protein 1 SCNN1G
Golgi apparatus membrane 1 MTOR
Synapse 1 MPST
glutamatergic synapse 2 CASP3, RELA
Golgi apparatus 1 ALB
Golgi membrane 3 C1GALT1, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 CASP3
Cytoplasm, cytosol 2 BHMT, KYAT1
Lysosome 1 MTOR
plasma membrane 1 SCNN1G
Membrane 4 BCL2, C1GALT1, CAT, MTOR
apical plasma membrane 1 SCNN1G
extracellular exosome 6 ALB, BHMT, CAT, GPT, MPST, SCNN1G
Lysosome membrane 1 MTOR
endoplasmic reticulum 2 ALB, BCL2
extracellular space 4 ALB, CRP, INS, TST
mitochondrion 6 BCL2, CAT, KYAT1, MPST, SDS, TST
protein-containing complex 3 ALB, BCL2, CAT
intracellular membrane-bounded organelle 2 CAT, HPGDS
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 ALB, CRP, INS
extracellular region 4 ALB, CAT, CRP, INS
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 TST
mitochondrial matrix 3 CAT, MPST, TST
anchoring junction 1 ALB
transcription regulator complex 1 RELA
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 SCNN1G
Single-pass type II membrane protein 1 C1GALT1
Apical cell membrane 1 SCNN1G
pore complex 1 BCL2
focal adhesion 1 CAT
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 MTOR
PML body 1 MTOR
neuron projection 1 MPST
ciliary basal body 1 ALB
chromatin 1 RELA
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
endosome lumen 1 INS
sodium channel complex 1 SCNN1G
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Synapse, synaptosome 1 MPST
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
catalase complex 1 CAT
BAD-BCL-2 complex 1 BCL2
NF-kappaB p50/p65 complex 1 RELA
NF-kappaB complex 1 RELA
ciliary transition fiber 1 ALB


文献列表

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  • Thomas Olsen, Bente Øvrebø, Cheryl Turner, Nasser E Bastani, Helga Refsum, Kathrine J Vinknes. Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial. Nutrients. 2018 Nov; 10(12):. doi: 10.3390/nu10121822. [PMID: 30477080]
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