Cystathione (BioDeep_00000227898)
Main id: BioDeep_00000001337
human metabolite PANOMIX_OTCML-2023
代谢物信息卡片
2-amino-4-[(2-amino-2-carboxyethyl)sulfanyl]butanoic acid
化学式: C7H14N2O4S (222.0674244)
中文名称: DL-胱硫醚
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CSCC(C(=O)O)N)C(C(=O)O)N
InChI: InChI=1S/C7H14N2O4S/c8-4(6(10)11)1-2-14-3-5(9)7(12)13/h4-5H,1-3,8-9H2,(H,10,11)(H,12,13)
描述信息
Cystathione, also known as dl-cystathionine, belongs to cysteine and derivatives class of compounds. Those are compounds containing cysteine or a derivative thereof resulting from reaction of cysteine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom. Cystathione is soluble (in water) and a moderately acidic compound (based on its pKa). Cystathione can be found in corn, which makes cystathione a potential biomarker for the consumption of this food product. Cystathione may be a unique E.coli metabolite.
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:17755
- KEGG: C00542
- PubChem: 834
- HMDB: HMDB0303077
- ChEMBL: CHEMBL209241
- MeSH: Cystathionine
- KNApSAcK: C00001392
- foodb: FDB007661
- chemspider: 811
- CAS: 535-34-2
- ChEBI: CHEBI:165853
- PubChem: 3823
- 3DMET: B01284
- NIKKAJI: J410.855H
分类词条
相关代谢途径
BioCyc(6)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alan Cunningham, Lieve Oudejans, Marjan Geugien, Diego A Pereira-Martins, Albertus Tj Wierenga, Ayşegül Erdem, Dominique Sternadt, Gerwin A Huls, Jan Jacob Schuringa. The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia.
Blood advances.
2023 Oct; ?(?):. doi:
10.1182/bloodadvances.2023010786. [PMID: 37906522] - Rafael Rosell, Anisha Jain, Jordi Codony-Servat, Eloisa Jantus-Lewintre, Blake Morrison, Jordi Barretina Ginesta, María González-Cao. Biological insights in non-small cell lung cancer.
Cancer biology & medicine.
2023 Jun; ?(?):. doi:
10.20892/j.issn.2095-3941.2023.0108. [PMID: 37381723] - Elena C Tore, Simone J P M Eussen, Nasser E Bastani, Pieter C Dagnelie, Amany K Elshorbagy, Pol Grootswagers, Viktor Kožich, Thomas Olsen, Helga Refsum, Kjetil Retterstøl, Coen DA Stehouwer, Emma T K Stolt, Kathrine J Vinknes, Marleen M J van Greevenbroek. The Associations of Habitual Intake of Sulfur Amino Acids, Proteins and Diet Quality with Plasma Sulfur Amino Acid Concentrations: The Maastricht Study.
The Journal of nutrition.
2023 May; ?(?):. doi:
10.1016/j.tjnut.2023.05.008. [PMID: 37164267] - Chau M Tran, Shoko Mihara, Keisuke Yoshida, Toru Hisabori. Cystathionine-β-synthase X proteins negatively regulate NADPH-thioredoxin reductase C activity.
Biochemical and biophysical research communications.
2023 04; 653(?):47-52. doi:
10.1016/j.bbrc.2023.02.055. [PMID: 36857899] - Fei Duan, Man-Man Li, Wei-Xia Li, Jin-Fa Tang, Zhi-Wan Wang. [Serum metabolomics of chronic obstructive pulmonary disease with lung-Qi deficiency syndrome].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Apr; 47(8):2251-2256. doi:
10.19540/j.cnki.cjcmm.20211203.501. [PMID: 35531742] - N Mota-Martorell, M Jové, R Berdún, R Pamplona. Plasma methionine metabolic profile is associated with longevity in mammals.
Communications biology.
2021 06; 4(1):725. doi:
10.1038/s42003-021-02254-3. [PMID: 34117367] - Ferran Comas, Jèssica Latorre, Francisco Ortega, Núria Oliveras-Cañellas, Aina Lluch, Wifredo Ricart, José Manuel Fernández-Real, José María Moreno-Navarrete. Permanent cystathionine-β-Synthase gene knockdown promotes inflammation and oxidative stress in immortalized human adipose-derived mesenchymal stem cells, enhancing their adipogenic capacity.
Redox biology.
2021 06; 42(?):101668. doi:
10.1016/j.redox.2020.101668. [PMID: 32800520] - Ingrid Kvestad, Adrian McCann, Ram K Chandyo, Lasse M Giil, Merina Shrestha, Manjeswori Ulak, Mari Hysing, Per M Ueland, Tor A Strand. One-Carbon Metabolism in Nepalese Infant-Mother Pairs and Child Cognition at 5 Years Old.
The Journal of nutrition.
2021 04; 151(4):883-891. doi:
10.1093/jn/nxaa403. [PMID: 33484134] - Laurent Ouerdane, Eszter Borbála Both, Jiqian Xiang, Hongqing Yin, Yu Kang, Shuxun Shao, Katalin Kiszelák, Zsuzsa Jókai, Mihály Dernovics. Water soluble selenometabolome of Cardamine violifolia.
Metallomics : integrated biometal science.
2020 12; 12(12):2032-2048. doi:
10.1039/d0mt00216j. [PMID: 33165451] - Mads M Svenningsson, Gard F T Svingen, Vegard Lysne, Per M Ueland, Grethe S Tell, Eva R Pedersen, Indu Dhar, Dennis W Nilsen, Ottar Nygård. Transsulfuration metabolites and the association with incident atrial fibrillation - An observational cohort study among Norwegian patients with stable angina pectoris.
International journal of cardiology.
2020 Oct; 317(?):75-80. doi:
10.1016/j.ijcard.2020.05.010. [PMID: 32389762] - Yasuyuki Matoba, Masafumi Noda, Tomoki Yoshida, Kosuke Oda, Yuka Ezumi, Chiaki Yasutake, Hisae Izuhara-Kihara, Narandarai Danshiitsoodol, Takanori Kumagai, Masanori Sugiyama. Catalytic specificity of the Lactobacillus plantarum cystathionine γ-lyase presumed by the crystallographic analysis.
Scientific reports.
2020 09; 10(1):14886. doi:
10.1038/s41598-020-71756-7. [PMID: 32913258] - X M Yuan, B Zhuan, P Li, X Zhao, T Wang, Z Yang. [Expression of nicotinamide adenine dinucleotide phosphate-reduced oxidase-4/reactive oxygen species and cystathionine-γ-lyase/hydrogen sulfide in patients with chronic obstructive pulmonary disease-related pulmonary hypertension].
Zhonghua nei ke za zhi.
2019 Oct; 58(10):770-776. doi:
10.3760/cma.j.issn.0578-1426.2019.10.009. [PMID: 31594176] - Laura Kasak, Constantina Bakolitsa, Zhiqiang Hu, Changhua Yu, Jasper Rine, Dago F Dimster-Denk, Gaurav Pandey, Greet De Baets, Yana Bromberg, Chen Cao, Emidio Capriotti, Rita Casadio, Joost Van Durme, Manuel Giollo, Rachel Karchin, Panagiotis Katsonis, Emanuela Leonardi, Olivier Lichtarge, Pier Luigi Martelli, David Masica, Sean D Mooney, Ayodeji Olatubosun, Predrag Radivojac, Frederic Rousseau, Lipika R Pal, Castrense Savojardo, Joost Schymkowitz, Janita Thusberg, Silvio C E Tosatto, Mauno Vihinen, Jouni Väliaho, Susanna Repo, John Moult, Steven E Brenner, Iddo Friedberg. Assessing computational predictions of the phenotypic effect of cystathionine-beta-synthase variants.
Human mutation.
2019 09; 40(9):1530-1545. doi:
10.1002/humu.23868. [PMID: 31301157] - Antonio Belardo, Federica Gevi, Lello Zolla. The concomitant lower concentrations of vitamins B6, B9 and B12 may cause methylation deficiency in autistic children.
The Journal of nutritional biochemistry.
2019 08; 70(?):38-46. doi:
10.1016/j.jnutbio.2019.04.004. [PMID: 31151052] - Maria F Mujica-Coopman, Dayana R Farias, Ana B Franco-Sena, Juliana S Vaz, Gilberto Kac, Yvonne Lamers. Maternal Plasma Pyridoxal 5'-Phosphate Concentration Is Inversely Associated with Plasma Cystathionine Concentration across All Trimesters in Healthy Pregnant Women.
The Journal of nutrition.
2019 08; 149(8):1354-1362. doi:
10.1093/jn/nxz082. [PMID: 31098628] - Indu Dhar, Vegard Lysne, Gard F T Svingen, Per M Ueland, Jesse F Gregory, Kaare H Bønaa, Ottar K Nygård. Elevated plasma cystathionine is associated with increased risk of mortality among patients with suspected or established coronary heart disease.
The American journal of clinical nutrition.
2019 06; 109(6):1546-1554. doi:
10.1093/ajcn/nqy391. [PMID: 31005968] - Lili Shi, Chao Han, Shuai Liu, Yiqun Liu, Xuesong Xiang. [Effects of methionine on the activity of cystathionine-β-synthase].
Wei sheng yan jiu = Journal of hygiene research.
2019 May; 48(3):463-467. doi:
. [PMID: 31133135] - Thomas Olsen, Bente Øvrebø, Cheryl Turner, Nasser E Bastani, Helga Refsum, Kathrine J Vinknes. Combining Dietary Sulfur Amino Acid Restriction with Polyunsaturated Fatty Acid Intake in Humans: A Randomized Controlled Pilot Trial.
Nutrients.
2018 Nov; 10(12):. doi:
10.3390/nu10121822. [PMID: 30477080] - Indu Dhar, Gard F T Svingen, Per M Ueland, Vegard Lysne, Mads M Svenningsson, Grethe S Tell, Ottar K Nygård. Plasma Cystathionine and Risk of Incident Stroke in Patients With Suspected Stable Angina Pectoris.
Journal of the American Heart Association.
2018 09; 7(17):e008824. doi:
10.1161/jaha.118.008824. [PMID: 30371177] - Indu Dhar, Gard F T Svingen, Eva R Pedersen, Barbara DeRatt, Arve Ulvik, Elin Strand, Per M Ueland, Kaare H Bønaa, Jesse F Gregory, Ottar K Nygård. Plasma cystathionine and risk of acute myocardial infarction among patients with coronary heart disease: Results from two independent cohorts.
International journal of cardiology.
2018 Sep; 266(?):24-30. doi:
10.1016/j.ijcard.2018.04.083. [PMID: 29728335] - Shozo Tomonaga, Hirofumi Okuyama, Tetsuya Tachibana, Ryosuke Makino. Effects of high ambient temperature on plasma metabolomic profiles in chicks.
Animal science journal = Nihon chikusan Gakkaiho.
2018 Feb; 89(2):448-455. doi:
10.1111/asj.12951. [PMID: 29154397] - Barbara N DeRatt, Maria A Ralat, Vegard Lysne, Fariba Tayyari, Indu Dhar, Arthur S Edison, Timothy J Garrett, Øivind Midttun, Per Magne Ueland, Ottar Kjell Nygård, Jesse F Gregory. Metabolomic Evaluation of the Consequences of Plasma Cystathionine Elevation in Adults with Stable Angina Pectoris.
The Journal of nutrition.
2017 09; 147(9):1658-1668. doi:
10.3945/jn.117.254029. [PMID: 28794210] - Yasuyuki Matoba, Tomoki Yoshida, Hisae Izuhara-Kihara, Masafumi Noda, Masanori Sugiyama. Crystallographic and mutational analyses of cystathionine β-synthase in the H2 S-synthetic gene cluster in Lactobacillus plantarum.
Protein science : a publication of the Protein Society.
2017 04; 26(4):763-783. doi:
10.1002/pro.3123. [PMID: 28127810] - Wupeng Yan, Everett Stone, Yan Jessie Zhang. Structural Snapshots of an Engineered Cystathionine-γ-lyase Reveal the Critical Role of Electrostatic Interactions in the Active Site.
Biochemistry.
2017 02; 56(6):876-885. doi:
10.1021/acs.biochem.6b01172. [PMID: 28106980] - Angelo D'Alessandro, Travis Nemkov, Lori K Bogren, Sandra L Martin, Kirk C Hansen. Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.
Journal of proteome research.
2017 02; 16(2):958-969. doi:
10.1021/acs.jproteome.6b00884. [PMID: 27991798] - Han Li, Mu Wang, Qiande Liang, Shuna Jin, Xiaojie Sun, Yangqian Jiang, Xingyun Pan, Yanqiu Zhou, Yang Peng, Bin Zhang, Aifen Zhou, Yiming Zhang, Zhong Chen, Jiangxia Cao, Hongling Zhang, Wei Xia, Tongzhang Zheng, Zongwei Cai, Yuanyuan Li, Shunqing Xu. Urinary metabolomics revealed arsenic exposure related to metabolic alterations in general Chinese pregnant women.
Journal of chromatography. A.
2017 Jan; 1479(?):145-152. doi:
10.1016/j.chroma.2016.12.007. [PMID: 27988079] - Zheng Zhou, Mario Vailati-Riboni, Daniel N Luchini, Juan J Loor. Methionine and Choline Supply during the Periparturient Period Alter Plasma Amino Acid and One-Carbon Metabolism Profiles to Various Extents: Potential Role in Hepatic Metabolism and Antioxidant Status.
Nutrients.
2016 Dec; 9(1):. doi:
10.3390/nu9010010. [PMID: 28036059] - Mélanie Pouget, Marie Perrot, Philippe Denis, Jacques Vuichoud, Dominique Dardevet, Karine Vidal, Denis Breuillé, Isabelle Papet. Long-term dietary supplementation with cystathionine improves tissue glutathione in ageing rats.
Aging clinical and experimental research.
2016 Aug; 28(4):781-5. doi:
10.1007/s40520-015-0465-6. [PMID: 26514972] - Viktor Kožich, Jakub Krijt, Jitka Sokolová, Petra Melenovská, Pavel Ješina, Roman Vozdek, Tomáš Majtán, Jan P Kraus. Thioethers as markers of hydrogen sulfide production in homocystinurias.
Biochimie.
2016 Jul; 126(?):14-20. doi:
10.1016/j.biochi.2016.01.001. [PMID: 26791043] - Clemens C Stoffregen, Elisabeth A Odin, Göran U Carlsson, Göran K Kurlberg, Hillevi G Björkqvist, Maria T Tångefjord, Bengt G Gustavsson. Reduced folate and serum vitamin metabolites in patients with rectal carcinoma: an open-label feasibility study of pemetrexed with folic acid and vitamin B12 supplementation.
Anti-cancer drugs.
2016 Jun; 27(5):439-46. doi:
10.1097/cad.0000000000000345. [PMID: 26825869] - Rima Obeid, Susanne H Kirsch, Sarah Dilmann, Cosima Klein, Rudolf Eckert, Jürgen Geisel, Wolfgang Herrmann. Folic acid causes higher prevalence of detectable unmetabolized folic acid in serum than B-complex: a randomized trial.
European journal of nutrition.
2016 Apr; 55(3):1021-8. doi:
10.1007/s00394-015-0916-z. [PMID: 25943647] - Kim M Holwerda, M Susanne Weedon-Fekjær, Anne C Staff, Ilja M Nolte, Harry van Goor, A Titia Lely, Marijke M Faas. The association of single nucleotide polymorphisms of the maternal cystathionine-β-synthase gene with early-onset preeclampsia.
Pregnancy hypertension.
2016 Jan; 6(1):60-5. doi:
10.1016/j.preghy.2015.12.001. [PMID: 26955774] - Shyamchand Mayengbam, Sara Raposo, Michel Aliani, James D House. A Vitamin B-6 Antagonist from Flaxseed Perturbs Amino Acid Metabolism in Moderately Vitamin B-6-Deficient Male Rats.
The Journal of nutrition.
2016 Jan; 146(1):14-20. doi:
10.3945/jn.115.219378. [PMID: 26581680] - Luisa Rios-Avila, Bonnie Coats, Maria Ralat, Yueh-Yun Chi, Øivind Midttun, Per M Ueland, Peter W Stacpoole, Jesse F Gregory. Pyridoxine supplementation does not alter in vivo kinetics of one-carbon metabolism but modifies patterns of one-carbon and tryptophan metabolites in vitamin B-6-insufficient oral contraceptive users.
The American journal of clinical nutrition.
2015 Sep; 102(3):616-25. doi:
10.3945/ajcn.115.113159. [PMID: 26201817] - Shoichiro Funatsu, Takashi Kondoh, Takahiro Kawase, Hiromi Ikeda, Mao Nagasawa, D Michael Denbow, Mitsuhiro Furuse. Long-term consumption of dried bonito dashi (a traditional Japanese fish stock) reduces anxiety and modifies central amino acid levels in rats.
Nutritional neuroscience.
2015 Aug; 18(6):256-64. doi:
10.1179/1476830514y.0000000124. [PMID: 24701973] - Shyamchand Mayengbam, Sara Raposo, Michel Aliani, James D House. Oral exposure to the anti-pyridoxine compound 1-amino D-proline further perturbs homocysteine metabolism through the transsulfuration pathway in moderately vitamin B₆ deficient rats.
The Journal of nutritional biochemistry.
2015 Mar; 26(3):241-9. doi:
10.1016/j.jnutbio.2014.10.014. [PMID: 25524630] - P Alcaide, J Krijt, P Ruiz-Sala, P Ješina, M Ugarte, V Kožich, B Merinero. Enzymatic diagnosis of homocystinuria by determination of cystathionine-ß-synthase activity in plasma using LC-MS/MS.
Clinica chimica acta; international journal of clinical chemistry.
2015 Jan; 438(?):261-5. doi:
10.1016/j.cca.2014.09.009. [PMID: 25218699] - Josef Bártl, Petr Chrastina, Jakub Krijt, Jakub Hodík, Karolína Pešková, Viktor Kožich. Simultaneous determination of cystathionine, total homocysteine, and methionine in dried blood spots by liquid chromatography/tandem mass spectrometry and its utility for the management of patients with homocystinuria.
Clinica chimica acta; international journal of clinical chemistry.
2014 Nov; 437(?):211-7. doi:
10.1016/j.cca.2014.07.028. [PMID: 25086281] - Noriyuki Akahoshi, Shotaro Kamata, Masashi Kubota, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Chiho Yamazaki, Yuka Yoshida, Hidenori Yamada, Yasuki Ishizaki, Makoto Suematsu, Tadashi Kasahara, Isao Ishii. Neutral aminoaciduria in cystathionine β-synthase-deficient mice; an animal model of homocystinuria.
American journal of physiology. Renal physiology.
2014 Jun; 306(12):F1462-76. doi:
10.1152/ajprenal.00623.2013. [PMID: 24761004] - Vanessa R da Silva, Luisa Rios-Avila, Yvonne Lamers, Maria A Ralat, Øivind Midttun, Eoin P Quinlivan, Timothy J Garrett, Bonnie Coats, Meena N Shankar, Susan S Percival, Yueh-Yun Chi, Keith E Muller, Per Magne Ueland, Peter W Stacpoole, Jesse F Gregory. Metabolite profile analysis reveals functional effects of 28-day vitamin B-6 restriction on one-carbon metabolism and tryptophan catabolic pathways in healthy men and women.
The Journal of nutrition.
2013 Nov; 143(11):1719-27. doi:
10.3945/jn.113.180588. [PMID: 23966327] - Heather B Roman, Lawrence L Hirschberger, Jakub Krijt, Alessandro Valli, Viktor Kožich, Martha H Stipanuk. The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H2S/HS(-) production and evidence of pancreatic and lung toxicity.
Antioxidants & redox signaling.
2013 Oct; 19(12):1321-36. doi:
10.1089/ars.2012.5010. [PMID: 23350603] - K J Vinknes, J M Dekker, C A Drevon, H Refsum, E Nurk, G Nijpels, C D A Stehouwer, T Teerlink, G S Tell, O Nygård, S E Vollset, P M Ueland, A K Elshorbagy. Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two Caucasian populations.
Prostaglandins, leukotrienes, and essential fatty acids.
2013 Oct; 89(5):297-303. doi:
10.1016/j.plefa.2013.09.007. [PMID: 24120123] - Moemen S Hanafy, Shaikh M Rahman, Yumi Nakamoto, Toru Fujiwara, Satoshi Naito, Kyo Wakasa, Masao Ishimoto. Differential response of methionine metabolism in two grain legumes, soybean and azuki bean, expressing a mutated form of Arabidopsis cystathionine γ-synthase.
Journal of plant physiology.
2013 Feb; 170(3):338-45. doi:
10.1016/j.jplph.2012.10.018. [PMID: 23286999] - Jesse F Gregory, Youngja Park, Yvonne Lamers, Nirmalya Bandyopadhyay, Yueh-Yun Chi, Kichen Lee, Steven Kim, Vanessa da Silva, Nikolas Hove, Sanjay Ranka, Tamer Kahveci, Keith E Muller, Robert D Stevens, Christopher B Newgard, Peter W Stacpoole, Dean P Jones. Metabolomic analysis reveals extended metabolic consequences of marginal vitamin B-6 deficiency in healthy human subjects.
PloS one.
2013; 8(6):e63544. doi:
10.1371/journal.pone.0063544. [PMID: 23776431] - J M Biselli, B L Zampieri, E M Goloni-Bertollo, R Haddad, M F R Fonseca, M N Eberlin, H Vannucchi, V M Carvalho, E C Pavarino. Genetic polymorphisms modulate the folate metabolism of Brazilian individuals with Down syndrome.
Molecular biology reports.
2012 Oct; 39(10):9277-84. doi:
10.1007/s11033-012-1629-5. [PMID: 22903356] - Dengqun Liao, Agnieszka Pajak, Steven R Karcz, B Patrick Chapman, Andrew G Sharpe, Ryan S Austin, Raju Datla, Sangeeta Dhaubhadel, Frédéric Marsolais. Transcripts of sulphur metabolic genes are co-ordinately regulated in developing seeds of common bean lacking phaseolin and major lectins.
Journal of experimental botany.
2012 Oct; 63(17):6283-95. doi:
10.1093/jxb/ers280. [PMID: 23066144] - Kenneth N Maclean, Lori S Greiner, Jeffrey R Evans, Sudesh K Sood, Sarka Lhotak, Neil E Markham, Sally P Stabler, Robert H Allen, Richard C Austin, Vivek Balasubramaniam, Hua Jiang. Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death.
The Journal of biological chemistry.
2012 Sep; 287(38):31994-2005. doi:
10.1074/jbc.m112.355172. [PMID: 22854956] - A L Miranda-Vilela. Role of polymorphisms in factor V (FV Leiden), prothrombin, plasminogen activator inhibitor type-1 (PAI-1), methylenetetrahydrofolate reductase (MTHFR) and cystathionine β-synthase (CBS) genes as risk factors for thrombophilias.
Mini reviews in medicinal chemistry.
2012 Sep; 12(10):997-1006. doi:
10.2174/138955712802762338. [PMID: 22512572] - S Givvimani, C Munjal, N Narayanan, F Aqil, G Tyagi, N Metreveli, S C Tyagi. Hyperhomocysteinemia decreases intestinal motility leading to constipation.
American journal of physiology. Gastrointestinal and liver physiology.
2012 Aug; 303(3):G281-90. doi:
10.1152/ajpgi.00423.2011. [PMID: 22595990] - Niikee C Schoendorfer, Rima Obeid, Leith Moxon-Lester, Nita Sharp, Luis Vitetta, Roslyn N Boyd, Peter S W Davies. Methylation capacity in children with severe cerebral palsy.
European journal of clinical investigation.
2012 Jul; 42(7):768-76. doi:
10.1111/j.1365-2362.2011.02644.x. [PMID: 22299647] - Daqing Zhang, Pu Fang, Xiaohua Jiang, Jun Nelson, Jodene K Moore, Warren D Kruger, Remus M Berretta, Steven R Houser, Xiaofeng Yang, Hong Wang. Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr/CBS-deficient mice.
Circulation research.
2012 Jun; 111(1):37-49. doi:
10.1161/circresaha.112.269472. [PMID: 22628578] - Monica S Rocha, Tom Teerlink, Mirian C H Janssen, Leo A J Kluijtmans, Yvo Smulders, Cornelis Jakobs, Isabel Tavares de Almeida, Isabel Rivera, Rita Castro, Henk J Blom. Asymmetric dimethylarginine in adults with cystathionine β-synthase deficiency.
Atherosclerosis.
2012 Jun; 222(2):509-11. doi:
10.1016/j.atherosclerosis.2012.03.009. [PMID: 22484094] - Young S Jung, Sun J Kim, Do Y Kwon, Young C Kim. Metabolomic analysis of sulfur-containing substances and polyamines in regenerating rat liver.
Amino acids.
2012 Jun; 42(6):2095-102. doi:
10.1007/s00726-011-0946-7. [PMID: 21626405] - Hidenori Yamada, Noriyuki Akahoshi, Shotaro Kamata, Yoshifumi Hagiya, Takako Hishiki, Yoshiko Nagahata, Tomomi Matsuura, Naoharu Takano, Masatomo Mori, Yasuki Ishizaki, Takashi Izumi, Yoshito Kumagai, Tadashi Kasahara, Makoto Suematsu, Isao Ishii. Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Free radical biology & medicine.
2012 May; 52(9):1716-26. doi:
10.1016/j.freeradbiomed.2012.02.033. [PMID: 22387178] - Jeroen H F de Baaij, Marchel Stuiver, Iwan C Meij, Sergio Lainez, Kathrin Kopplin, Hanka Venselaar, Dominik Müller, René J M Bindels, Joost G J Hoenderop. Membrane topology and intracellular processing of cyclin M2 (CNNM2).
The Journal of biological chemistry.
2012 Apr; 287(17):13644-55. doi:
10.1074/jbc.m112.342204. [PMID: 22399287] - Amany K Elshorbagy, Chris Church, Maria Valdivia-Garcia, A David Smith, Helga Refsum, Roger Cox. Dietary cystine level affects metabolic rate and glycaemic control in adult mice.
The Journal of nutritional biochemistry.
2012 Apr; 23(4):332-40. doi:
10.1016/j.jnutbio.2010.12.009. [PMID: 21543215] - Romain Vuillefroy de Silly, Flora Coulon, Nicolas Poirier, Vojislav Jovanovic, Sophie Brouard, Véronique Ferchaud-Roucher, Gilles Blancho, Bernard Vanhove. Transplant tolerance is associated with reduced expression of cystathionine-γ-lyase that controls IL-12 production by dendritic cells and TH-1 immune responses.
Blood.
2012 Mar; 119(11):2633-43. doi:
10.1182/blood-2011-04-350546. [PMID: 22262763] - Jeffrey G Dickhout, Rachel E Carlisle, Danielle E Jerome, Zahraa Mohammed-Ali, Hua Jiang, Guangdong Yang, Sarathi Mani, Sanjay K Garg, Ruma Banerjee, Randal J Kaufman, Kenneth N Maclean, Rui Wang, Richard C Austin. Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism.
The Journal of biological chemistry.
2012 Mar; 287(10):7603-14. doi:
10.1074/jbc.m111.304576. [PMID: 22215680] - Kenneth N Maclean, Hua Jiang, Lori S Greiner, Robert H Allen, Sally P Stabler. Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk.
Molecular genetics and metabolism.
2012 Mar; 105(3):395-403. doi:
10.1016/j.ymgme.2011.11.190. [PMID: 22192524] - Sara R Zwart, C Robert Gibson, Thomas H Mader, Karen Ericson, Robert Ploutz-Snyder, Martina Heer, Scott M Smith. Vision changes after spaceflight are related to alterations in folate- and vitamin B-12-dependent one-carbon metabolism.
The Journal of nutrition.
2012 Mar; 142(3):427-31. doi:
10.3945/jn.111.154245. [PMID: 22298570] - Hak Joo Lee, Meenalakshmi M Mariappan, Denis Feliers, Rita C Cavaglieri, Kavithalakshmi Sataranatarajan, Hanna E Abboud, Goutam Ghosh Choudhury, Balakuntalam S Kasinath. Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells.
The Journal of biological chemistry.
2012 Feb; 287(7):4451-61. doi:
10.1074/jbc.m111.278325. [PMID: 22158625] - Steinar Hustad, Simone Eussen, Øivind Midttun, Arve Ulvik, Puck M van de Kant, Lars Mørkrid, Randi Gislefoss, Per M Ueland. Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism.
Clinical chemistry.
2012 Feb; 58(2):402-10. doi:
10.1373/clinchem.2011.174490. [PMID: 22194632] - Kelly T Williams, Kevin L Schalinske. Tissue-specific alterations of methyl group metabolism with DNA hypermethylation in the Zucker (type 2) diabetic fatty rat.
Diabetes/metabolism research and reviews.
2012 Feb; 28(2):123-31. doi:
10.1002/dmrr.1281. [PMID: 21818837] - Mohammad A Aminzadeh, Nosratola D Vaziri. Downregulation of the renal and hepatic hydrogen sulfide (H2S)-producing enzymes and capacity in chronic kidney disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Feb; 27(2):498-504. doi:
10.1093/ndt/gfr560. [PMID: 22036943] - S Harvey Mudd, Conrad Wagner, Zigmund Luka, Sally P Stabler, Robert H Allen, Richard Schroer, Timothy Wood, Jing Wang, Lee-Jun Wong. Two patients with hepatic mtDNA depletion syndromes and marked elevations of S-adenosylmethionine and methionine.
Molecular genetics and metabolism.
2012 Feb; 105(2):228-36. doi:
10.1016/j.ymgme.2011.11.006. [PMID: 22137549] - Alessandra F Perna, Diego Ingrosso. Low hydrogen sulphide and chronic kidney disease: a dangerous liaison.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Feb; 27(2):486-93. doi:
10.1093/ndt/gfr737. [PMID: 22323660] - Tao Huang, Mark L Wahlqvist, Duo Li. Effect of n-3 polyunsaturated fatty acid on gene expression of the critical enzymes involved in homocysteine metabolism.
Nutrition journal.
2012 Jan; 11(?):6. doi:
10.1186/1475-2891-11-6. [PMID: 22260268] - Yi-qun Liu, Ying Liu, Tatsuya Morita, Makoto Mori, Kimio Sugiyama. Factors contributing to the resistivity of a higher casein diet against choline deficiency-induced hyperhomocysteinemia in rats.
Journal of nutritional science and vitaminology.
2012; 58(2):78-87. doi:
10.3177/jnsv.58.78. [PMID: 22790565] - Amany K Elshorbagy, Viktor Kozich, A David Smith, Helga Refsum. Cysteine and obesity: consistency of the evidence across epidemiologic, animal and cellular studies.
Current opinion in clinical nutrition and metabolic care.
2012 Jan; 15(1):49-57. doi:
10.1097/mco.0b013e32834d199f. [PMID: 22108094] - Alexander Roy, Abdul H Khan, Mohammed T Islam, Minolfa C Prieto, Dewan S A Majid. Interdependency of cystathione γ-lyase and cystathione β-synthase in hydrogen sulfide-induced blood pressure regulation in rats.
American journal of hypertension.
2012 Jan; 25(1):74-81. doi:
10.1038/ajh.2011.149. [PMID: 21866187] - Waja Wegner, Birgitta Christina Burckhardt, Gerhard Burckhardt, Maja Henjakovic. Male-dominant activation of rat renal organic anion transporter 1 (Oat1) and 3 (Oat3) expression by transcription factor BCL6.
PloS one.
2012; 7(4):e35556. doi:
10.1371/journal.pone.0035556. [PMID: 22530049] - Mohsin Yakub, Naushad Moti, Siddiqa Parveen, Bushra Chaudhry, Iqbal Azam, Mohammad Perwaiz Iqbal. Polymorphisms in MTHFR, MS and CBS genes and homocysteine levels in a Pakistani population.
PloS one.
2012; 7(3):e33222. doi:
10.1371/journal.pone.0033222. [PMID: 22470444] - Ying Liu, Yi-Qun Liu, Tatsuya Morita, Makoto Mori, Kimio Sugiyama. Effect of dietary supplementation with folate on choline deficiency-induced hyperhomocysteinemia in rats.
Journal of nutritional science and vitaminology.
2012; 58(1):20-8. doi:
10.3177/jnsv.58.20. [PMID: 23007063] - Krishna M Boini, Min Xia, Justine M Abais, Ming Xu, Cai-xia Li, Pin-Lan Li. Acid sphingomyelinase gene knockout ameliorates hyperhomocysteinemic glomerular injury in mice lacking cystathionine-β-synthase.
PloS one.
2012; 7(9):e45020. doi:
10.1371/journal.pone.0045020. [PMID: 23024785] - Simon G Lamarre, Anne M Molloy, Stacey N Reinke, Brian D Sykes, Margaret E Brosnan, John T Brosnan. Formate can differentiate between hyperhomocysteinemia due to impaired remethylation and impaired transsulfuration.
American journal of physiology. Endocrinology and metabolism.
2012 Jan; 302(1):E61-7. doi:
10.1152/ajpendo.00345.2011. [PMID: 21934042] - Sara R Zwart, J Milburn Jessup, Jiuping Ji, Scott M Smith. Saturation diving alters folate status and biomarkers of DNA damage and repair.
PloS one.
2012; 7(2):e31058. doi:
10.1371/journal.pone.0031058. [PMID: 22347427] - Sishuo Cao, Wentao Xu, Nan Zhang, Yan Wang, YunBo Luo, Xiaoyun He, Kunlun Huang. A mitochondria-dependent pathway mediates the apoptosis of GSE-induced yeast.
PloS one.
2012; 7(3):e32943. doi:
10.1371/journal.pone.0032943. [PMID: 22403727] - Ernesto Cuevasanta, Ana Denicola, Beatriz Alvarez, Matías N Möller. Solubility and permeation of hydrogen sulfide in lipid membranes.
PloS one.
2012; 7(4):e34562. doi:
10.1371/journal.pone.0034562. [PMID: 22509322] - Jenab N Sidhapuriwala, Akhil Hegde, Abel D Ang, Yi Zhun Zhu, Madhav Bhatia. Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice.
PloS one.
2012; 7(3):e32574. doi:
10.1371/journal.pone.0032574. [PMID: 22396778] - Sanjoy Ghosh, Dian C Sulistyoningrum, Melissa B Glier, C Bruce Verchere, Angela M Devlin. Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice.
The Journal of biological chemistry.
2011 Dec; 286(49):42483-42493. doi:
10.1074/jbc.m111.304592. [PMID: 22021075] - Carlo Chiarla, Ivo Giovannini, John H Siegel. Characterization of alpha-amino-n-butyric acid correlations in sepsis.
Translational research : the journal of laboratory and clinical medicine.
2011 Dec; 158(6):328-33. doi:
10.1016/j.trsl.2011.06.005. [PMID: 22061040] - Aline A da Cunha, Andréa G K Ferreira, Maira J da Cunha, Carolina D Pederzolli, Débora L Becker, Juliana G Coelho, Carlos S Dutra-Filho, Angela T S Wyse. Chronic hyperhomocysteinemia induces oxidative damage in the rat lung.
Molecular and cellular biochemistry.
2011 Dec; 358(1-2):153-60. doi:
10.1007/s11010-011-0930-2. [PMID: 21717134] - Ana Marta Silva, Anabela Cordeiro-da-Silva, Graham H Coombs. Metabolic variation during development in culture of Leishmania donovani promastigotes.
PLoS neglected tropical diseases.
2011 Dec; 5(12):e1451. doi:
10.1371/journal.pntd.0001451. [PMID: 22206037] - Yunliu Zeng, Zhiyong Pan, Yuduan Ding, Andan Zhu, Hongbo Cao, Qiang Xu, Xiuxin Deng. A proteomic analysis of the chromoplasts isolated from sweet orange fruits [Citrus sinensis (L.) Osbeck].
Journal of experimental botany.
2011 Nov; 62(15):5297-309. doi:
10.1093/jxb/err140. [PMID: 21841170] - Kyoung Shin Yoo, Sung Han Ok, Byung-Cheon Jeong, Kwang Wook Jung, Mei Hua Cui, Sujin Hyoung, Myeong-Ryeol Lee, Hyun Kyu Song, Jeong Sheop Shin. Single cystathionine β-synthase domain-containing proteins modulate development by regulating the thioredoxin system in Arabidopsis.
The Plant cell.
2011 Oct; 23(10):3577-94. doi:
10.1105/tpc.111.089847. [PMID: 22021414] - Erzsébet Zavaczki, Viktória Jeney, Anupam Agarwal, Abolfazl Zarjou, Melinda Oros, Mónika Katkó, Zsuzsa Varga, György Balla, József Balla. Hydrogen sulfide inhibits the calcification and osteoblastic differentiation of vascular smooth muscle cells.
Kidney international.
2011 Oct; 80(7):731-9. doi:
10.1038/ki.2011.212. [PMID: 21716261] - Elena Lissina, Brian Young, Malene L Urbanus, Xue Li Guan, Jonathan Lowenson, Shawn Hoon, Anastasia Baryshnikova, Isabelle Riezman, Magali Michaut, Howard Riezman, Leah E Cowen, Markus R Wenk, Steven G Clarke, Guri Giaever, Corey Nislow. A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis.
PLoS genetics.
2011 Oct; 7(10):e1002332. doi:
10.1371/journal.pgen.1002332. [PMID: 22028670] - C C Tangney, N T Aggarwal, H Li, R S Wilson, C Decarli, D A Evans, M C Morris. Vitamin B12, cognition, and brain MRI measures: a cross-sectional examination.
Neurology.
2011 Sep; 77(13):1276-82. doi:
10.1212/wnl.0b013e3182315a33. [PMID: 21947532] - Chan Woo Park, Ae Ra Han, Joanne Kwak-Kim, So Yeon Park, Jung Yeol Han, Mi Kyoung Koong, In Ok Song, Kwang Moon Yang. The role of methylenetetrahydrofolate reductase C677T polymorphism on the peripheral blood natural killer cell proportion in women with unexplained recurrent miscarriages.
Clinical and experimental reproductive medicine.
2011 Sep; 38(3):168-73. doi:
10.5653/cerm.2011.38.3.168. [PMID: 22384438] - Guangdong Yang, Guanghua Tang, Ling Zhang, Lingyun Wu, Rui Wang. The pathogenic role of cystathionine γ-lyase/hydrogen sulfide in streptozotocin-induced diabetes in mice.
The American journal of pathology.
2011 Aug; 179(2):869-79. doi:
10.1016/j.ajpath.2011.04.028. [PMID: 21718679] - Juan Chen, Fei-Hua Wu, Wen-Hua Wang, Chen-Juan Zheng, Guang-Hui Lin, Xue-Jun Dong, Jun-Xian He, Zhen-Ming Pei, Hai-Lei Zheng. Hydrogen sulphide enhances photosynthesis through promoting chloroplast biogenesis, photosynthetic enzyme expression, and thiol redox modification in Spinacia oleracea seedlings.
Journal of experimental botany.
2011 Aug; 62(13):4481-93. doi:
10.1093/jxb/err145. [PMID: 21624977] - Erlend T Aasheim, Amany K Elshorbagy, Lien My Diep, Torgeir T Søvik, Tom Mala, Maria Valdivia-Garcia, Torsten Olbers, Thomas Bøhmer, Kåre I Birkeland, Helga Refsum. Effect of bariatric surgery on sulphur amino acids and glutamate.
The British journal of nutrition.
2011 Aug; 106(3):432-40. doi:
10.1017/s0007114511000201. [PMID: 21554803] - Katsunori Murota, Yuka Hagiwara-Komoda, Keisuke Komoda, Hitoshi Onouchi, Masayuki Ishikawa, Satoshi Naito. Arabidopsis cell-free extract, ACE, a new in vitro translation system derived from Arabidopsis callus cultures.
Plant & cell physiology.
2011 Aug; 52(8):1443-53. doi:
10.1093/pcp/pcr080. [PMID: 21677046] - Omer Kabil, Victor Vitvitsky, Peter Xie, Ruma Banerjee. The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues.
Antioxidants & redox signaling.
2011 Jul; 15(2):363-72. doi:
10.1089/ars.2010.3781. [PMID: 21254839] - Bartosz T Grobelny, Andrew F Ducruet, Peter A DeRosa, Ivan S Kotchetkov, Brad E Zacharia, Zachary L Hickman, Luis Fernandez, Reshma Narula, Jan Claassen, Kiwon Lee, Neeraj Badjatia, Stephan A Mayer, E Sander Connolly. Gain-of-function polymorphisms of cystathionine β-synthase and delayed cerebral ischemia following aneurysmal subarachnoid hemorrhage.
Journal of neurosurgery.
2011 Jul; 115(1):101-7. doi:
10.3171/2011.2.jns101414. [PMID: 21417705] - Ping Yuan, Hong Xue, Li Zhou, Linping Qu, Cheng Li, Zhen Wang, Jun Ni, Chen Yu, Tai Yao, Yu Huang, Rui Wang, Limin Lu. Rescue of mesangial cells from high glucose-induced over-proliferation and extracellular matrix secretion by hydrogen sulfide.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Jul; 26(7):2119-26. doi:
10.1093/ndt/gfq749. [PMID: 21208996] - Agata Chmurzynska, Anna M Malinowska. Homocysteine homeostasis in the rat is maintained by compensatory changes in cystathionine β-synthase, betaine-homocysteine methyltransferase, and phosphatidylethanolamine N-methyltransferase gene transcription occurring in response to maternal protein and folic acid intake during pregnancy and fat intake after weaning.
Nutrition research (New York, N.Y.).
2011 Jul; 31(7):572-8. doi:
10.1016/j.nutres.2011.07.001. [PMID: 21840474] - Jana Strakova, Sapna Gupta, Warren D Kruger, Ryan N Dilger, Katherine Tryon, Lucas Li, Timothy A Garrow. Inhibition of betaine-homocysteine S-methyltransferase in rats causes hyperhomocysteinemia and reduces liver cystathionine β-synthase activity and methylation capacity.
Nutrition research (New York, N.Y.).
2011 Jul; 31(7):563-71. doi:
10.1016/j.nutres.2011.06.004. [PMID: 21840473] - James B Adams, Tapan Audhya, Sharon McDonough-Means, Robert A Rubin, David Quig, Elizabeth Geis, Eva Gehn, Melissa Loresto, Jessica Mitchell, Sharon Atwood, Suzanne Barnhouse, Wondra Lee. Nutritional and metabolic status of children with autism vs. neurotypical children, and the association with autism severity.
Nutrition & metabolism.
2011 Jun; 8(1):34. doi:
10.1186/1743-7075-8-34. [PMID: 21651783]