Aesculetin (BioDeep_00000000120)

 

Secondary id: BioDeep_00000398645

natural product human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


6,7-dihydroxychromen-2-one

化学式: C9H6O4 (178.0266)
中文名称: 七叶亭, 6,7-二羟基香豆素, 七叶苷, 七叶内酯, 秦皮乙素
谱图信息: 最多检出来源 Viridiplantae(plant) 16.52%

Reviewed

Last reviewed on 2024-09-04.

Cite this Page

Aesculetin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/aesculetin (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000120). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1(c(cc2c(c1)ccc(=O)o2)O)O
InChI: InChI=1/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11H

描述信息

Aesculetin, also known as cichorigenin or cichoriin aglucon, belongs to the class of organic compounds known as 6,7-dihydroxycoumarins. These are coumarins bearing two hydroxyl groups at positions 6 and 7 of the coumarin skeleton, respectively. Aesculetin is found, on average, in the highest concentration within sherries. Aesculetin has also been detected, but not quantified, in several different foods, such as horseradish, carrots, dandelions, grape wines, and highbush blueberries. This could make aesculetin a potential biomarker for the consumption of these foods.
Esculetin is a hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light. It has a role as an antioxidant, an ultraviolet filter and a plant metabolite.
Esculetin is a natural product found in Artemisia eriopoda, Euphorbia decipiens, and other organisms with data available.
A hydroxycoumarin that is umbelliferone in which the hydrogen at position 6 is substituted by a hydroxy group. It is used in filters for absorption of ultraviolet light.
Metabolite of infected sweet potato. Aesculetin is found in many foods, some of which are root vegetables, wild carrot, sweet basil, and carrot.
D020011 - Protective Agents > D000975 - Antioxidants
Acquisition and generation of the data is financially supported in part by CREST/JST.
[Raw Data] CB031_Aesculetin_pos_20eV_CB000017.txt
[Raw Data] CB031_Aesculetin_pos_10eV_CB000017.txt
[Raw Data] CB031_Aesculetin_pos_40eV_CB000017.txt
[Raw Data] CB031_Aesculetin_pos_50eV_CB000017.txt
[Raw Data] CB031_Aesculetin_pos_30eV_CB000017.txt
[Raw Data] CB031_Aesculetin_neg_10eV_000010.txt
[Raw Data] CB031_Aesculetin_neg_20eV_000010.txt
[Raw Data] CB031_Aesculetin_neg_30eV_000010.txt
CONFIDENCE standard compound; ML_ID 39
Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].
Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].
Esculetin is an active ingredient extracted mainly from the bark of Fraxinus rhynchophylla. Esculetin inhibits platelet-derived growth factor (PDGF)-induced airway smooth muscle cells (ASMCs) phenotype switching through inhibition of PI3K/Akt pathway. Esculetin has antioxidant, antiinflammatory, and antitumor activities[1].

同义名列表

67 个代谢物同义名

InChI=1/C9H6O4/c10-6-3-5-1-2-9(12)13-8(5)4-7(6)11/h1-4,10-11; Esculetin, European Pharmacopoeia (EP) Reference Standard; 5-18-03-00202 (Beilstein Handbook Reference); 2H-1-Benzopyran-2-one, 6,7-dihydroxy- (9CI); 2H-1-Benzopyran-2-one, 6,7-dihydroxy-; Esculetin [Matrix for MALDI-TOF/MS]; 6,7-Dihydroxy-2H-1-benzopyran-2-one; 2,6-Dihydroxy-7H-1-benzopyran-7-one; Coumarin, 6,7-dihydroxy- Esculetin; 6,7-Dihydroxy-2H-chromen-2-one #; 6,7-dihydroxy-1-benzopyran-2-one; 6,7-bis(oxidanyl)chromen-2-one; 2,6-Dihydroxy-7H-chromen-7-one; Esculetin, analytical standard; 6,7-Dihydroxy-2H-chromen-2-one; ILEDWLMCKZNDJK-UHFFFAOYSA-N; 6,7-Dihydroxy-2-benzopyrone; 6,7-Dihydroxycoumarin, 98\\%; 6,7-dihydroxychromen-2-one; 6,7-Dihydroxy-2-chromenone; 6,7-Dihydroxycoumarin, 8CI; Coumarin, 6,7-dihydroxy-; Aesculetin (cichorigenin; Cichorigenin|Aesculetin; 6,7-Dihydroxycounmarin; 6,7-dihydroxy-coumarin; 6,7-dihydroxycoumarin; Cichoriin aglucon; Prestwick1_000940; Prestwick3_000940; Cichoriin aglycon; Prestwick2_000940; Prestwick0_000940; ESCULETIN [INCI]; Spectrum4_001886; Spectrum3_000752; Spectrum2_000586; Spectrum5_000512; UNII-SM2XD6V944; Aesculetin ,(S); Esculin aglycon; Esculin aglucon; ESCULETIN [MI]; BPBio1_000968; Oprea1_719746; DivK1c_006430; KSC-11-243-1; KBio2_004214; KBio2_001646; KBio3_001584; KBio2_006782; KBio1_001374; Cichorigenin; NCI60_002119; SMP2_000093; Esculetol); SM2XD6V944; Asculetine; esculetine; aesculetin; Esculetin; 1ST157072; Esculetol; Esculatin; HFC; Esculetin; Esculetin



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(5)

代谢反应

134 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(9)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(125)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

194 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 AKT1, ANXA5, APOE, BCL2, CASP3, CASP9, CAT, CCND1, MAPK14, NFE2L2, PIK3CA, PTGS2, STAT3, TP53
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 10 AKT1, APOE, BCL2, CASP3, CASP9, CCND1, MAPK14, NFE2L2, STAT3, TP53
cytosol 13 AKT1, ANXA5, BCL2, CASP3, CASP9, CAT, CCND1, GPT, MAPK14, NFE2L2, PIK3CA, STAT3, TP53
dendrite 1 APOE
centrosome 3 CCND1, NFE2L2, TP53
nucleoplasm 7 AKT1, CASP3, CCND1, MAPK14, NFE2L2, STAT3, TP53
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 2 AKT1, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 2 AKT1, PIK3CA
Golgi apparatus membrane 1 GORASP1
cell cortex 1 AKT1
cell surface 1 TNF
glutamatergic synapse 4 AKT1, APOE, CASP3, MAPK14
Golgi apparatus 3 APOE, GORASP1, NFE2L2
Golgi membrane 2 GORASP1, INS
neuronal cell body 3 APOE, CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NFE2L2
plasma membrane 6 AKT1, APOE, NFE2L2, PIK3CA, STAT3, TNF
Membrane 6 AKT1, ANXA5, APOE, BCL2, CAT, TP53
caveola 1 PTGS2
extracellular exosome 4 ANXA5, APOE, CAT, GPT
endoplasmic reticulum 4 APOE, BCL2, PTGS2, TP53
extracellular space 4 APOE, IL6, INS, TNF
perinuclear region of cytoplasm 1 PIK3CA
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CASP9, CAT, MAPK14, TP53
protein-containing complex 6 AKT1, BCL2, CASP9, CAT, PTGS2, TP53
intracellular membrane-bounded organelle 1 CAT
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Secreted 3 APOE, IL6, INS
extracellular region 7 ANXA5, APOE, CAT, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TP53
mitochondrial matrix 2 CAT, TP53
transcription regulator complex 2 STAT3, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 2 ANXA5, TNF
Endosome, multivesicular body 1 APOE
Extracellular vesicle 1 APOE
Secreted, extracellular space, extracellular matrix 1 APOE
chylomicron 1 APOE
high-density lipoprotein particle 1 APOE
low-density lipoprotein particle 1 APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 1 APOE
microtubule cytoskeleton 1 AKT1
nucleolus 1 TP53
Early endosome 1 APOE
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 2 ANXA5, CAT
spindle 1 AKT1
cis-Golgi network 1 GORASP1
extracellular matrix 1 APOE
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 TP53
PML body 1 TP53
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ANXA5, APOE
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 NFE2L2, STAT3, TP53
mediator complex 1 NFE2L2
phagocytic cup 1 TNF
Secreted, extracellular space 1 APOE
spindle pole 1 MAPK14
blood microparticle 1 APOE
site of double-strand break 1 TP53
endosome lumen 1 INS
Melanosome 1 APOE
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 APOE, IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 2 CCND1, TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 APOE
[Isoform 1]: Nucleus 1 TP53
synaptic cleft 1 APOE
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
discoidal high-density lipoprotein particle 1 APOE
endocytic vesicle lumen 1 APOE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Sriravali Pulipaka, Hridya Chempon, Gajalakshmi Singuru, Shashikanta Sahoo, Altab Shaikh, Sunita Kumari, Rajamannar Thennati, Srigiridhar Kotamraju. Mitochondria-targeted esculetin and metformin delay endothelial senescence by promoting fatty acid β-oxidation: Relevance in age-associated atherosclerosis. Mechanisms of ageing and development. 2024 Jun; 219(?):111931. doi: 10.1016/j.mad.2024.111931. [PMID: 38554949]
  • Mehmet Güvenç, Murat Yüksel, Tuncer Kutlu, Muhammed Etyemez, İshak Gökçek, Mustafa Cellat. Protective effects of esculetin against ovary ischemia-reperfusion injury model in rats. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23528. doi: 10.1002/jbt.23528. [PMID: 37661762]
  • Zheng Lv, Boyang Wang, Bianli Wang, Huimin Zhang. In vivo comprehensive metabolite profiling of esculetin and esculin derived from chicory in hyperuricemia rats using ultra-high-performance liquid chromatography coupled with quadrupole-orbitrap high-resolution mass spectrometry. Journal of separation science. 2024 Jan; 47(1):e2300664. doi: 10.1002/jssc.202300664. [PMID: 38010472]
  • Gajalakshmi Singuru, Sriravali Pulipaka, Altab Shaikh, Sai Balaji Andugulapati, Rajamannar Thennati, Srigiridhar Kotamraju. Therapeutic efficacy of mitochondria-targeted esculetin in the improvement of NAFLD-NASH via modulating AMPK-SIRT1 axis. International immunopharmacology. 2023 Nov; 124(Pt B):111070. doi: 10.1016/j.intimp.2023.111070. [PMID: 37862737]
  • Zheng-Ming Qian, Meng-Qi Wu, Guo-Ying Tan, Li-Ling Jin, Ning Li, Ju-Ying Xie. [Rapid determination of aesculin and aesculetin in Fraxini Cortex by high performance liquid chromatography-ultraviolet at equal absorption wavelength]. Se pu = Chinese journal of chromatography. 2023 Aug; 41(8):690-697. doi: 10.3724/sp.j.1123.2023.03018. [PMID: 37534556]
  • Luana Eloísa Leal, Evelyn Silva Moreira, Bruna Lopes Correia, Paulo Sérgio Alves Bueno, Jurandir Fernando Comar, Anacharis Babeto de Sá-Nakanishi, Roberto Kenji Nakamura Cuman, Adelar Bracht, Ciomar Aparecida Bersani-Amado, Lívia Bracht. Comparative study of the antioxidant and anti-inflammatory effects of the natural coumarins 1,2-benzopyrone, umbelliferone and esculetin: in silico, in vitro and in vivo analyses. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Jul; ?(?):. doi: 10.1007/s00210-023-02606-2. [PMID: 37395795]
  • Feng Shi, Wenxiong Yin, Michael Adu-Frimpong, Xiaoxiao Li, Xiaoli Xia, Weigang Sun, Hao Ji, Elmurat Toreniyazov, Wang Qilong, Xia Cao, Jiangnan Yu, Ximing Xu. In-vitro and in-vivo evaluation and anti-colitis activity of esculetin-loaded nanostructured lipid carrier decorated with DSPE-MPEG2000. Journal of microencapsulation. 2023 May; ?(?):1-17. doi: 10.1080/02652048.2023.2215345. [PMID: 37191893]
  • Xiaoqing Li, Lisi Wang, Lijun Yan, Xiao Han, Zejun Zhang, Xiaoping Zhang, Wei Sun. A Portable Wireless Intelligent Nanosensor for 6,7-Dihydroxycoumarin Analysis with A Black Phosphorene and Nano-Diamond Nanocomposite-Modified Electrode. Biosensors. 2023 Jan; 13(2):. doi: 10.3390/bios13020153. [PMID: 36831920]
  • Ji Ma, Yang Deng, Tingting Yang, Maoru Li, Jing Shang. Esculetin Alleviates Nonalcoholic Fatty Liver Disease on High-Cholesterol-Diet-Induced Larval Zebrafish and FFA-Induced BRL-3A Hepatocyte. International journal of molecular sciences. 2023 Jan; 24(2):. doi: 10.3390/ijms24021593. [PMID: 36675107]
  • Sourbh Suren Garg, Jeena Gupta, Debasis Sahu, Chuan-Ju Liu. Pharmacological and Therapeutic Applications of Esculetin. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012643. [PMID: 36293500]
  • Santosh Karnewar, Sriravali Pulipaka, Sujana Katta, Devayani Panuganti, Praveen Kumar Neeli, Rajamannar Thennati, Mahesh Kumar Jerald, Srigiridhar Kotamraju. Mitochondria-targeted esculetin mitigates atherosclerosis in the setting of aging via the modulation of SIRT1-mediated vascular cell senescence and mitochondrial function in Apoe-/- mice. Atherosclerosis. 2022 09; 356(?):28-40. doi: 10.1016/j.atherosclerosis.2022.07.012. [PMID: 35961209]
  • Ying Zhang, Zhaojun Li, Haijie Wu, Jing Wang, Sen Zhang. Esculetin alleviates murine lupus nephritis by inhibiting complement activation and enhancing Nrf2 signaling pathway. Journal of ethnopharmacology. 2022 Apr; 288(?):115004. doi: 10.1016/j.jep.2022.115004. [PMID: 35051603]
  • Changhao Bao, Min Shi, Wenwen Ma, Jun Li, Xianju Huang, Han Cheng. Simultaneous determination of aesculin and aesculetin and their interactions with DNA using carbon fiber microelectrode modified by Pt-Au bimetallic nanoparticles. Analytica chimica acta. 2022 Apr; 1202(?):339664. doi: 10.1016/j.aca.2022.339664. [PMID: 35341516]
  • Authors Leah H Knoor, George R Du Laney, Isaac B Jonker, Liam P Hoogewerf, Yukun Tu, Hunter T Pham, Joy Yoo, Mark A Muyskens. Aesculetin Exhibits Strong Fluorescent Photoacid Character. Journal of fluorescence. 2022 Jan; 32(1):307-318. doi: 10.1007/s10895-021-02842-w. [PMID: 34787776]
  • Weijie Jiao, Nan Qin, Kun Wang, Dongmei Wu, Hongyan Yu, Lei Du, Guiyue Wu, Hong Wu, Xu Zhao. LC-MS/MS for determination of aesculetin in rat plasma and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2022 Jan; 36(1):e5233. doi: 10.1002/bmc.5233. [PMID: 34519055]
  • Linlin Zhang, Qingxuan Xie, Xiaofang Li. Esculetin: A review of its pharmacology and pharmacokinetics. Phytotherapy research : PTR. 2022 Jan; 36(1):279-298. doi: 10.1002/ptr.7311. [PMID: 34808701]
  • Woojin Na, Min-Kyung Kang, Sin-Hye Park, Dong Yeon Kim, Su Yeon Oh, Moon-Sik Oh, Sohyun Park, Ii-Jun Kang, Young-Hee Kang. Aesculetin Accelerates Osteoblast Differentiation and Matrix-Vesicle-Mediated Mineralization. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212391. [PMID: 34830274]
  • Parikshit Kumar, S C Sati. Chemical composition, antioxidant and antimicrobial activities of Himalayan Fraxinus micrantha Lingelsh leaf extract. Natural product research. 2021 Oct; 35(20):3519-3523. doi: 10.1080/14786419.2019.1710706. [PMID: 31920103]
  • Aiman Masroor, Tajalli Ilm Chandel, Sadia Malik, Qazi Noorul Mateen, Vladimir N Uversky, Rizwan Hasan Khan. Evaluation of ThT augmentation and RLS inner filter effect caused by highly fluorescent coumarin derivative and establishing it as true inhibitor of amyloid fibrillation. Archives of biochemistry and biophysics. 2021 09; 709(?):108981. doi: 10.1016/j.abb.2021.108981. [PMID: 34214556]
  • Seyed-Mahdi Mohamadi-Zarch, Tourandokht Baluchnejadmojarad, Davood Nourabadi, Samira Ramazi, Morteza Nazari-Serenjeh, Mehrdad Roghani. Esculetin Alleviates Acute Liver Failure following Lipopolysaccharide/D-Galactosamine in Male C57BL/6 Mice. Iranian journal of medical sciences. 2021 09; 46(5):373-382. doi: 10.30476/ijms.2020.84909.1474. [PMID: 34539012]
  • Chitikela P Pullaiah, Vinod K Nelson, Sushma Rayapu, Narasimha Kumar G V, Thyagaraju Kedam. Exploring cardioprotective potential of esculetin against isoproterenol induced myocardial toxicity in rats: in vivo and in vitro evidence. BMC pharmacology & toxicology. 2021 07; 22(1):43. doi: 10.1186/s40360-021-00510-0. [PMID: 34266475]
  • Jae-Hwan Kwak, Younghwa Kim, Christine E Staatz, In-Hwan Baek. Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Jul; 51(7):811-817. doi: 10.1080/00498254.2021.1925774. [PMID: 33949288]
  • Bi Wang, Pirui Li, Shu Xu, Lanying Liu, Yannan Xu, Xu Feng, Xingzeng Zhao, Yu Chen. Inhibitory Effects of the Natural Product Esculetin on Phytophthora capsici and Its Possible Mechanism. Plant disease. 2021 Jun; 105(6):1814-1822. doi: 10.1094/pdis-09-20-2054-re. [PMID: 33332162]
  • Smita Prajapati, Bhawna Tomar, Anjali Srivastava, Yogesh B Narkhede, Anil N Gaikwad, Amit Lahiri, Shrikant R Mulay. 6,7-Dihydroxycoumarin ameliorates crystal-induced necroptosis during crystal nephropathies by inhibiting MLKL phosphorylation. Life sciences. 2021 Apr; 271(?):119193. doi: 10.1016/j.lfs.2021.119193. [PMID: 33577856]
  • Prajitha Mohandas Edathara, Shivakanth Chintalapally, Venkata Krishna Kanth Makani, Chitrakshi Pant, Suresh Yerramsetty, Manohar D Rao, Manika Pal Bhadra. Inhibitory role of oleanolic acid and esculetin in HeLa cells involve multiple signaling pathways. Gene. 2021 Mar; 771(?):145370. doi: 10.1016/j.gene.2020.145370. [PMID: 33346097]
  • Aaro Jalkanen, Veera Lassheikki, Tommi Torsti, Elham Gharib, Marko Lehtonen, Risto O Juvonen. Tissue and interspecies comparison of catechol-O-methyltransferase mediated catalysis of 6-O-methylation of esculetin to scopoletin and its inhibition by entacapone and tolcapone. Xenobiotica; the fate of foreign compounds in biological systems. 2021 Mar; 51(3):268-278. doi: 10.1080/00498254.2020.1853850. [PMID: 33289420]
  • Yang-Liu Xia, Jing-Jing Wang, Shi-Yang Li, Yong Liu, Frank J Gonzalez, Ping Wang, Guang-Bo Ge. Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment. Bioorganic & medicinal chemistry. 2021 01; 29(?):115851. doi: 10.1016/j.bmc.2020.115851. [PMID: 33218896]
  • Yiming Wang, Weikaixin Kong, Liang Wang, Tianyu Zhang, Boyue Huang, Jia Meng, Baoxue Yang, Zhengwei Xie, Hong Zhou. Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis. International journal of molecular sciences. 2020 Oct; 21(20):. doi: 10.3390/ijms21207695. [PMID: 33080936]
  • Lovedeep Singh, Anudeep Kaur, Saweta Garg, Amrit Pal Singh, Rajbir Bhatti. Protective Effect of Esculetin, Natural Coumarin in Mice Model of Fibromyalgia: Targeting Pro-Inflammatory Cytokines and MAO-A. Neurochemical research. 2020 Oct; 45(10):2364-2374. doi: 10.1007/s11064-020-03095-y. [PMID: 32676949]
  • Beom Zoo Lee, Ik Soo Lee, Chau Ha Pham, Soon-Kyu Jeong, Sulhae Lee, KwangWon Hong, Hee Min Yoo. Apoptosis in Leukemic Cells Induced by Anti-proliferative Coumarin Isolated from the Stem Bark of Fraxinus rhynchophylla. Journal of microbiology and biotechnology. 2020 Aug; 30(8):1214-1221. doi: 10.4014/jmb.2006.06022. [PMID: 32699201]
  • Junyao Duan, Jing Shi, Xin Ma, Yundong Xuan, Pin Li, Hanfeng Wang, Yang Fan, Huijie Gong, Ling Wang, Yuewen Pang, Shaoqiang Pang, Yongji Yan. Esculetin inhibits proliferation, migration, and invasion of clear cell renal cell carcinoma cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 May; 125(?):110031. doi: 10.1016/j.biopha.2020.110031. [PMID: 32164951]
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