Bufadienolide (BioDeep_00000011481)
Main id: BioDeep_00000176863
代谢物信息卡片
Bufadienolide
化学式: C24H34O2 (354.2558664)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCCCC1CCC1C2CCC2(C)C(c3ccc(=O)oc3)CCC12
InChI: InChI=1S/C24H34O2/c1-23-13-4-3-5-17(23)7-8-18-20-10-9-19(16-6-11-22(25)26-15-16)24(20,2)14-12-21(18)23/h6,11,15,17-21H,3-5,7-10,12-14H2,1-2H3/t17?,18-,19+,20+,21-,23-,24+/m0/s1
描述信息
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002018 - Bufanolides
同义名列表
1 个代谢物同义名
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:80798
- KEGG: C16921
- PubChem: 46173848
- Metlin: METLIN71434
- CAS: 29565-35-3
- PMhub: MS000025486
- PubChem: 96023413
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaolai Lei, Xiaozheng Wang, Weiliang Xiong, Han Xiao, Yingchun Wu, Tingting Huang, Rubing Liang, Yiming Li, Shuangjun Lin. Cytochrome P450 Mining for Bufadienolide Diversification.
ACS chemical biology.
2024 May; 19(5):1169-1179. doi:
10.1021/acschembio.4c00089. [PMID: 38624108] - Candelario Rodriguez, Roberto Ibáñez, Luis Mojica, Michelle Ng, Carmenza Spadafora, Armando A Durant-Archibold, Marcelino Gutiérrez. Bufadienolides from the Skin Secretions of the Neotropical Toad Rhinella alata (Anura: Bufonidae): Antiprotozoal Activity against Trypanosoma cruzi.
Molecules (Basel, Switzerland).
2021 Jul; 26(14):. doi:
10.3390/molecules26144217. [PMID: 34299492] - János Ujszegi, Balázs Vajna, Ágnes M Móricz, Dániel Krüzselyi, Kristóf Korponai, Gergely Krett, Attila Hettyey. Relationships Between Chemical Defenses of Common Toad (Bufo bufo) Tadpoles and Bacterial Community Structure of their Natural Aquatic Habitat.
Journal of chemical ecology.
2020 Jun; 46(5-6):534-543. doi:
10.1007/s10886-020-01184-4. [PMID: 32468489] - Khadije Saket, Jalil T Afshari, Ehsan Saburi, Mahdi Yousefi, Roshanak Salari. Therapeutic Aspects of Squill; An Evidence-Based Review.
Current drug discovery technologies.
2020; 17(3):318-324. doi:
10.2174/1570163816666190125154745. [PMID: 30686259] - Hamza Ibrahim Isa, Gezina Catharina Helena Ferreira, Jan Ernst Crafford, Christoffel Jacobus Botha. Evaluation of in vitro neutralization of epoxyscillirosidine by antibodies raised in sheep.
Toxicon : official journal of the International Society on Toxinology.
2019 Jun; 164(?):20-25. doi:
10.1016/j.toxicon.2019.03.023. [PMID: 30946914] - Zoltán Tóth, Anikó Kurali, Ágnes M Móricz, Attila Hettyey. Changes in Toxin Quantities Following Experimental Manipulation of Toxin Reserves in Bufo bufo Tadpoles.
Journal of chemical ecology.
2019 Mar; 45(3):253-263. doi:
10.1007/s10886-019-01045-9. [PMID: 30684072] - Stefanie Santos, Christian Haslinger, Kristian Klaic, Maria T Faleschini, Mónica Mennet, Olivier Potterat, Ursula von Mandach, Matthias Hamburger, Ana Paula Simões-Wüst. A Bufadienolide-Enriched Fraction of Bryophyllum pinnatum Inhibits Human Myometrial Contractility In Vitro.
Planta medica.
2019 Mar; 85(5):385-393. doi:
10.1055/a-0810-7704. [PMID: 30562827] - Denglang Zou, Xuelin Zhu, Fan Zhang, Yurong Du, Jianbin Ma, Renwang Jiang. An Efficient Strategy Based on Liquid-Liquid Extraction with Three-Phase Solvent System and High Speed Counter-Current Chromatography for Rapid Enrichment and Separation of Epimers of Minor Bufadienolide from Toad Meat.
Journal of agricultural and food chemistry.
2018 Jan; 66(4):1008-1014. doi:
10.1021/acs.jafc.7b05310. [PMID: 29300475] - Simon Bachmann, Cornelia Betschart, Julia Gerber, Karin Fürer, Mónica Mennet, Matthias Hamburger, Olivier Potterat, Ursula von Mandach, Ana Paula Simões-Wüst. Potential of Bryophyllum pinnatum as a Detrusor Relaxant: An in Vitro Exploratory Study.
Planta medica.
2017 Nov; 83(16):1274-1280. doi:
10.1055/s-0043-109097. [PMID: 28437806] - Li-Juan Deng, Long-Hai Wang, Cheng-Kang Peng, Yi-Bin Li, Mao-Hua Huang, Min-Feng Chen, Xue-Ping Lei, Ming Qi, Yun Cen, Wen-Cai Ye, Dong-Mei Zhang, Wei-Min Chen. Fibroblast Activation Protein α Activated Tripeptide Bufadienolide Antitumor Prodrug with Reduced Cardiotoxicity.
Journal of medicinal chemistry.
2017 07; 60(13):5320-5333. doi:
10.1021/acs.jmedchem.6b01755. [PMID: 28595013] - Joanna Kolodziejczyk-Czepas, Malgorzata Sieradzka, Barbara Moniuszko-Szajwaj, Łukasz Pecio, Michal B Ponczek, Pawel Nowak, Anna Stochmal. Bufadienolides from Kalanchoe daigremontiana as thrombin inhibitors-In vitro and in silico study.
International journal of biological macromolecules.
2017 Jun; 99(?):141-150. doi:
10.1016/j.ijbiomac.2017.02.051. [PMID: 28223215] - Hai-Yan Tian, Li-Jun Ruan, Tong Yu, Qing-Fei Zheng, Nan-Hao Chen, Rui-Bo Wu, Xiao-Qi Zhang, Lei Wang, Ren-Wang Jiang, Wen-Cai Ye. Bufospirostenin A and Bufogargarizin C, Steroids with Rearranged Skeletons from the Toad Bufo bufo gargarizans.
Journal of natural products.
2017 04; 80(4):1182-1186. doi:
10.1021/acs.jnatprod.6b01018. [PMID: 28256122] - Veronika Bókony, Ágnes M Móricz, Zsófia Tóth, Zoltán Gál, Anikó Kurali, Zsanett Mikó, Katalin Pásztor, Márk Szederkényi, Zoltán Tóth, János Ujszegi, Bálint Üveges, Dániel Krüzselyi, Robert J Capon, Herbert Hoi, Attila Hettyey. Variation in Chemical Defense Among Natural Populations of Common Toad, Bufo bufo, Tadpoles: the Role of Environmental Factors.
Journal of chemical ecology.
2016 Apr; 42(4):329-38. doi:
10.1007/s10886-016-0690-2. [PMID: 27059330] - Xiu-Lan Xin, Pei-Pei Dong, Xiao-Hong Sun, Sa Deng, Ning Zhang, Chao Wang, Xiao-Kui Huo, Ye Li, Rong Lan, Liang Chen, Guang-Jun Fan. Identification of the hydroxylated derivatives of bufalin: phase I metabolites in rats.
Journal of Asian natural products research.
2016; 18(3):239-47. doi:
10.1080/10286020.2015.1071358. [PMID: 26577491] - Jing Zhou, Yan Gong, Hongyue Ma, Honglan Wang, Dawei Qian, Hongmei Wen, Rui Liu, Jinao Duan, Qinan Wu. Effect of drying methods on the free and conjugated bufadienolide content in toad venom determined by ultra-performance liquid chromatography-triple quadrupole mass spectrometry coupled with a pattern recognition approach.
Journal of pharmaceutical and biomedical analysis.
2015 Oct; 114(?):482-7. doi:
10.1016/j.jpba.2015.05.032. [PMID: 26186722] - Mouhssin Oufir, Christina Seiler, Manon Gerodetti, Julia Gerber, Karin Fürer, Monica Mennet-von Eiff, Siegward-M Elsas, Rudolf Brenneisen, Ursula von Mandach, Matthias Hamburger, Olivier Potterat. Quantification of Bufadienolides in Bryophyllum pinnatum Leaves and Manufactured Products by UHPLC-ESIMS/MS.
Planta medica.
2015 Aug; 81(12-13):1190-7. doi:
10.1055/s-0035-1546126. [PMID: 26132852] - Hai-Yan Tian, Xiao-Feng Yuan, Lu Jin, Juan Li, Cheng Luo, Wen-Cai Ye, Ren-Wang Jiang. A bufadienolide derived androgen receptor antagonist with inhibitory activities against prostate cancer cells.
Chemico-biological interactions.
2014 Jan; 207(?):16-22. doi:
10.1016/j.cbi.2013.10.020. [PMID: 24211617] - Karin Fürer, Melanie Raith, Rudolf Brenneisen, Monica Mennet, Ana Paula Simões-Wüst, Ursula von Mandach, Matthias Hamburger, Olivier Potterat. Two new flavonol glycosides and a metabolite profile of Bryophyllum pinnatum, a phytotherapeutic used in obstetrics and gynaecology.
Planta medica.
2013 Nov; 79(16):1565-71. doi:
10.1055/s-0033-1350808. [PMID: 24072500] - Kazuki Watanabe, Yoshihiro Mimaki, Hiroshi Sakagami, Yutaka Sashida. Bufadienolide and spirostanol glycosides from the rhizomes of helleborusorientalis.
Journal of natural products.
2003 Feb; 66(2):236-41. doi:
10.1021/np0203638. [PMID: 12608856] - B Sich, U Kirch, M Tepel, W Zidek, W Schoner. Pulse pressure correlates in humans with a proscillaridin A immunoreactive compound.
Hypertension (Dallas, Tex. : 1979).
1996 May; 27(5):1073-8. doi:
10.1161/01.hyp.27.5.1073. [PMID: 8621199] - B Kopp, L Krenn, M Draxler, A Hoyer, R Terkola, P Vallaster, W Robien. Bufadienolides from Urginea maritima from Egypt.
Phytochemistry.
1996 May; 42(2):513-22. doi:
10.1016/0031-9422(95)00876-4. [PMID: 8688179] - G E Swan, R A Schultz, T S Kellerman, M S Mülders, B P Maartens, J J Van der Walt. In vivo effects of a novel calcium antagonist (R56865) against induced epoxyscillirosidin and tulp poisoning in sheep.
The Onderstepoort journal of veterinary research.
1995 Sep; 62(3):163-6. doi:
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