Tobramycin (BioDeep_00000002096)

human metabolite blood metabolite Chemicals and Drugs Antibiotics

代谢物信息卡片

(2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol

化学式: C18H37N5O9 (467.2591152)
中文名称: 托普霉素, 妥布霉素
谱图信息: 最多检出来源 Homo sapiens(blood) 3.13%

Reviewed

Last reviewed on 2024-10-31.

Cite this Page

Tobramycin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/tobramycin (retrieved 2024-11-08) (BioDeep RN: BioDeep_00000002096). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(C(C(C(C1N)OC2C(C(C(C(O2)CO)O)N)O)O)OC3C(CC(C(O3)CN)O)N)N
InChI: InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1-6(21)16(14(15)28)32-18-13(27)11(23)12(26)10(4-24)30-18/h5-18,24-28H,1-4,19-23H2/t5-,6+,7+,8-,9+,10+,11-,12+,13+,14-,15+,16-,17+,18+/m0/s1

描述信息

Tobramycin is only found in individuals that have used or taken this drug. It is an aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the pseudomonas species. It is a 10\\\% component of the antibiotic complex, nebramycin, produced by the same species. [PubChem]Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01G - Aminoglycoside antibacterials
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AA - Antibiotics
C784 - Protein Synthesis Inhibitor > C2363 - Aminoglycoside Antibiotic
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
C254 - Anti-Infective Agent > C258 - Antibiotic
Tobramycin (Nebramycin Factor 6) is a parenterally administered, broad spectrum aminoglycoside antibiotic that is widely used in the treatment of moderate to severe bacterial infections due to sensitive organisms[1].Tobramycin can be used to pneumonia research caused by Pseudomonas aeruginosa[2][3].

同义名列表

24 个代谢物同义名

(2S,3R,4S,5S,6R)-4-amino-2-{[(1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2R,3R,5S,6R)-3-amino-6-(aminomethyl)-5-hydroxyoxan-2-yl]oxy}-2-hydroxycyclohexyl]oxy}-6-(hydroxymethyl)oxane-3,5-diol; O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-alpha-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine; O-3-Amino-3-deoxy-a-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-a-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine; O-3-Amino-3-deoxy-α-D-glucopyranosyl-(1-4)-O-(2,6-diamino-2,3,6-trideoxy-α-D-ribohexopyranosyl-(1-4))-2-deoxy-D-streptamine; Tobramycin solution for inhalation; Nebramycin factor 6; Nebramycin factir 6; Sulfate, tobramycin; 3-Deoxykanamycin b; Tobramycin sulfate; Tenebrimycin; Nebramycin 6; Brulamycin; Tobramycin; SPRC-AB01; Tobracin; Bethkis; Nebicin; Obracin; Tobrex; Nebcin; Tobi; TOB; Deoxykanamycin B

数据库引用编号

19 个数据库交叉引用编号

ChEBI: CHEBI:28864
KEGG: C00397
KEGGdrug: D00063
PubChem: 36294
PubChem: 5496
HMDB: HMDB0014822
Metlin: METLIN2863
DrugBank: DB00684
ChEMBL: CHEMBL1747
Wikipedia: Tobramycin
MeSH: Tobramycin
chemspider: 33377
CAS: 32986-56-4
PMhub: MS000001828
PubChem: 3687
PDB-CCD: TOY
NIKKAJI: J4.533K
RefMet: Tobramycin
medchemexpress: HY-B0441

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
3708 - Brassica napus: 10.3389/FNUT.2022.822033
9606 - Homo sapiens: -
2017 - Streptoalloteichus hindustanus: 10.1038/JA.2006.51
66881 - Streptomyces cremeus:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Xianwen Xiao, Yuan Lin, Xie Fang, Zhiwen Xie, Shunrong Luo, Huping Wu. Clinical features and comprehensive treatment of persistent corneal epithelial dysfunction after cataract surgery. BMC ophthalmology. 2024 Apr; 24(1):197. doi: 10.1186/s12886-024-03466-x. [PMID: 38671418]
Jiaojiao Fu, Fangting He, Jinming Xiao, Zhengyue Liao, Liying He, Jing He, Jinlin Guo, Sijing Liu. Rapid AMR prediction in Pseudomonas aeruginosa combining MALDI-TOF MS with DNN model. Journal of applied microbiology. 2023 Nov; 134(11):. doi: 10.1093/jambio/lxad248. [PMID: 37930836]
Aleksandra Gostyńska, Katarzyna Dettlaff, Anna Jelińska, Maciej Stawny. Improving the Safety of Clinical Management of COVID-19 Patients Receiving Aminoglycosides and Parenteral Nutrition: Y-site Compatibility Studies. Journal of pharmaceutical sciences. 2023 10; 112(10):2597-2603. doi: 10.1016/j.xphs.2023.08.007. [PMID: 37595749]
Santhni Subramaniam, Paul Joyce, Clive A Prestidge. Liquid crystalline lipid nanoparticles improve the antibacterial activity of tobramycin and vancomycin against intracellular Pseudomonas aeruginosa and Staphylococcus aureus. International journal of pharmaceutics. 2023 Apr; 639(?):122927. doi: 10.1016/j.ijpharm.2023.122927. [PMID: 37059243]
Wenjuan Liu, Minglong Yan, Wenjie Zhao. Antibacterial-renew dual-function anti-biofouling strategy: Self-assembled Schiff-base metal complex coatings built from natural products. Journal of colloid and interface science. 2023 Jan; 629(Pt A):496-507. doi: 10.1016/j.jcis.2022.08.178. [PMID: 36088695]
Noelia Perez, María Julia Altube, Leandro Ramos Souza Barbosa, Eder Lilia Romero, Ana Paula Perez. Thymus vulgaris essential oil + tobramycin within nanostructured archaeolipid carriers: A new approach against Pseudomonas aeruginosa biofilms. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154179. doi: 10.1016/j.phymed.2022.154179. [PMID: 35671606]
Christian Emmanuel Mahavy, Adeline Mol, Blandine Andrianarisoa, Pierre Duez, Mondher El Jaziri, Marie Baucher, Tsiry Rasamiravaka. The Xanthophyll Carotenoid Lutein Reduces the Invasive Potential of Pseudomonas aeruginosa and Increases Its Susceptibility to Tobramycin. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137199. [PMID: 35806201]
Mehdi El Hassani, Chantale Simard, Sylvie Pilote, Isabelle Cloutier, Sara Soufsaf, Amélie Marsot. Consideration of height-based tobramycin dosing regimens for the treatment of adult cystic fibrosis pulmonary exacerbations. British journal of clinical pharmacology. 2022 05; 88(5):2246-2255. doi: 10.1111/bcp.15154. [PMID: 34820875]
Chelsea R Thorn, Anthony Wignall, Zlatko Kopecki, Anita Kral, Clive A Prestidge, Nicky Thomas. Liquid Crystal Nanoparticles Enhance Tobramycin Efficacy in a Murine Model of Pseudomonas aeruginosa Biofilm Wound Infection. ACS infectious diseases. 2022 04; 8(4):841-854. doi: 10.1021/acsinfecdis.1c00606. [PMID: 35255215]
Chie Inoue, Hideharu Hagiya. Anti-Glomerular Basement Membrane Nephritis Potentially Induced by Nebulized Tobramycin Inhalation. Journal of aerosol medicine and pulmonary drug delivery. 2022 04; 35(2):104-106. doi: 10.1089/jamp.2021.0053. [PMID: 34870476]
Roxane Rohani, Brian Hoff, Manu Jain, Alexander Philbrick, Sara Salama, Joanne F Cullina, Nathaniel J Rhodes. Defining the Importance of Age-Related Changes in Drug Clearance to Optimizing Aminoglycoside Dosing Regimens for Adult Patients with Cystic Fibrosis. European journal of drug metabolism and pharmacokinetics. 2022 Mar; 47(2):199-209. doi: 10.1007/s13318-021-00734-9. [PMID: 34882292]
Jacob P Counts, Jessica L Elefritz, Erica E Reed, Marilly Palettas, Connor Aossey, Julia J Beatty. Risk Factors Associated with Suboptimal Tobramycin Levels in the Medical Intensive Care Unit. European journal of drug metabolism and pharmacokinetics. 2022 Mar; 47(2):271-278. doi: 10.1007/s13318-021-00749-2. [PMID: 35029839]
Parisa Tavakoli, Seyed Mohammad Taghdisi, Parvaneh Maghami, Khalil Abnous. A novel aptasensor for colorimetric monitoring of tobramycin: Strategy of enzyme-like activity of AuNPs controlled by three-way junction DNA pockets. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Feb; 267(Pt 2):120626. doi: 10.1016/j.saa.2021.120626. [PMID: 34815175]
Han-Wen Zhang, Hong-Kai Li, Zhang-Ye Han, Rongrong Yuan, Hongming He. Incorporating Fullerenes in Nanoscale Metal-Organic Matrixes: An Ultrasensitive Platform for Impedimetric Aptasensing of Tobramycin. ACS applied materials & interfaces. 2022 Feb; 14(5):7350-7357. doi: 10.1021/acsami.1c23320. [PMID: 35076206]
Joseph Jeffry Borick, Shuba Balan, Paola Lichtenberger, Lauren Bjork. Timely explantation of tobramycin-impregnated beads and bone cement to avoid haemodialysis in a patient with worsening renal failure. BMJ case reports. 2022 Feb; 15(2):. doi: 10.1136/bcr-2021-242760. [PMID: 35131767]
Scott Marston, Gudrun Mirick Mueller, Arick Sabin, Glen T Hansen, Bruce Lindgren, Conrado Aparicio, Alexandra R Armstrong, Ole H Larsen, Andrew Schmidt, Richard Kyle, Ramon Gustilo, Dean Tsukayama, Joan Bechtold, Mats Bue. Systemic versus free antibiotic delivery in preventing acute exogenous implant related infection in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 2022 02; 40(2):429-438. doi: 10.1002/jor.25052. [PMID: 33913540]
Yi-Zhong Gu, Larry Handt, Katerina Vlasakova, Vasudevan Bakthavatchalu, Roger Smith, Guillermo E Fernandez, Stephanie L Born, Warren E Glaab, Frank D Sistare. Kidney Injury Monitoring in Tobramycin-Treated Rhesus Monkeys: Supplementing Urinary Kidney Biomarkers With Kidney Biopsy Gene Expression Profiling. Toxicologic pathology. 2022 01; 50(1):35-46. doi: 10.1177/01926233211049171. [PMID: 34657537]
Charles Murray Lawrie, Gregory S Kazarian, Toby Barrack, Ryan M Nunley, Robert L Barrack. Intra-articular administration of vancomycin and tobramycin during primary cementless total knee arthroplasty : determination of intra-articular and serum elution profiles. The bone & joint journal. 2021 Nov; 103-B(11):1702-1708. doi: 10.1302/0301-620x.103b11.bjj-2020-2453.r1. [PMID: 34719272]
Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Janis Kuka, Jon Hansen, Klara Haldimann, Solveiga Grinberga, Talia Berruga-Fernández, Douglas L Huseby, Reza Shariatgorji, Evelina Lindmark, Björn Platzack, Erik C Böttger, David Crich, Lena E Friberg, Carina Vingsbo Lundberg, Diarmaid Hughes, Mark Brönstrup, Per E Andrén, Edgars Liepinsh, Sven N Hobbie. Antibacterial activity of apramycin at acidic pH warrants wide therapeutic window in the treatment of complicated urinary tract infections and acute pyelonephritis. EBioMedicine. 2021 Nov; 73(?):103652. doi: 10.1016/j.ebiom.2021.103652. [PMID: 34740109]
Katherine B Landmesser, Elizabeth B Autry, Brian M Gardner, Katherine A Bosko, Aric Schadler, Robert J Kuhn. Comparison of the predictive value of area under the curve versus maximum serum concentration of intravenous tobramycin in cystic fibrosis patients treated for an acute pulmonary exacerbation. Pediatric pulmonology. 2021 10; 56(10):3209-3216. doi: 10.1002/ppul.25569. [PMID: 34241975]
Sawsan M A El-Sheikh, Abd El-Alim F Abd El-Alim, Hosny A Ibrahim, Elham A Mobarez, Walaa A El-Sayed, Azza A A Galal, Naglaa F S Awad. Chitosan propolis nanocomposite alone or in combination with apramycin: an alternative therapy for multidrug-resistant Salmonella Typhimurium in rabbits: in vitro and in vivo study. Journal of medical microbiology. 2021 Oct; 70(10):. doi: 10.1099/jmm.0.001412. [PMID: 34612810]
Katja Becker, Vincent Aranzana-Climent, Sha Cao, Anna Nilsson, Reza Shariatgorji, Klara Haldimann, Björn Platzack, Diarmaid Hughes, Per E Andrén, Erik C Böttger, Lena E Friberg, Sven N Hobbie. Efficacy of EBL-1003 (apramycin) against Acinetobacter baumannii lung infections in mice. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2021 Sep; 27(9):1315-1321. doi: 10.1016/j.cmi.2020.12.004. [PMID: 33316399]
Chelsea R Thorn, Cristiane de Souza Carvalho-Wodarz, Justus C Horstmann, Claus-Michael Lehr, Clive A Prestidge, Nicky Thomas. Tobramycin Liquid Crystal Nanoparticles Eradicate Cystic Fibrosis-Related Pseudomonas aeruginosa Biofilms. Small (Weinheim an der Bergstrasse, Germany). 2021 06; 17(24):e2100531. doi: 10.1002/smll.202100531. [PMID: 33978317]
Louis Dagneaux, Afton K Limberg, Douglas R Osmon, Nelson Leung, Daniel J Berry, Matthew P Abdel. Acute Kidney Injury When Treating Periprosthetic Joint Infections After Total Knee Arthroplasties with Antibiotic-Loaded Spacers: Incidence, Risks, and Outcomes. The Journal of bone and joint surgery. American volume. 2021 05; 103(9):754-760. doi: 10.2106/jbjs.20.01825. [PMID: 33780403]
Steven L Taylor, Lex E X Leong, Sarah K Sims, Rebecca L Keating, Lito E Papanicolas, Alyson Richard, Fredrick M Mobegi, Steve Wesselingh, Lucy D Burr, Geraint B Rogers. The cystic fibrosis gut as a potential source of multidrug resistant pathogens. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2021 05; 20(3):413-420. doi: 10.1016/j.jcf.2020.11.009. [PMID: 33250435]
Constanza Toledo, Rocío C Gambaro, Gisel Padula, María E Vela, Guillermo R Castro, Cecilia Y Chain, Germán A Islan. Binary Medical Nanofluids by Combination of Polymeric Eudragit Nanoparticles for Vehiculization of Tobramycin and Resveratrol: Antimicrobial, Hemotoxicity and Protein Corona Studies. Journal of pharmaceutical sciences. 2021 04; 110(4):1739-1748. doi: 10.1016/j.xphs.2021.01.005. [PMID: 33428918]
Tomás Sou, Jon Hansen, Edgars Liepinsh, Maria Backlund, Onur Ercan, Solveiga Grinberga, Sha Cao, Paraskevi Giachou, Anna Petersson, Magdalena Tomczak, Malgorzata Urbas, Dorota Zabicka, Carina Vingsbo Lundberg, Diarmaid Hughes, Sven N Hobbie, Lena E Friberg. Model-Informed Drug Development for Antimicrobials: Translational PK and PK/PD Modeling to Predict an Efficacious Human Dose for Apramycin. Clinical pharmacology and therapeutics. 2021 04; 109(4):1063-1073. doi: 10.1002/cpt.2104. [PMID: 33150591]
Jayesh A Dhanani, Steven Goodman, Benjamin Ahern, Jeremy Cohen, John F Fraser, Adrian Barnett, Sara Diab, Manoj Bhatt, Jason A Roberts. Comparative lung distribution of radiolabeled tobramycin between nebulized and intravenous administration in a mechanically-ventilated ovine model, an observational study. International journal of antimicrobial agents. 2021 Feb; 57(2):106232. doi: 10.1016/j.ijantimicag.2020.106232. [PMID: 33232733]
Zeren Liang, Kai Gao, Mengdi Lu, Wei Peng, Shenggeng Zhu, Yixiu Huang, Long Hong, Jean-Francois Masson. Comparative study of serum sample preparation methods in aggregation-based plasmonic sensing. The Analyst. 2021 Jan; 145(24):7946-7955. doi: 10.1039/d0an01348j. [PMID: 33034308]
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Traci M Grucz, Rachel M Kruer, Fidelia Bernice, Pamela A Lipsett, Todd Dorman, David Sugrue, Andrew S Jarrell. Aminoglycoside Dosing and Volume of Distribution in Critically Ill Surgery Patients. Surgical infections. 2020 Dec; 21(10):859-864. doi: 10.1089/sur.2020.012. [PMID: 32302517]
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Paul Skorup, Lisa Maudsdotter, Miklós Lipcsey, Anders Larsson, Jan Sjölin. Mode of bacterial killing affects the inflammatory response and associated organ dysfunctions in a porcine E. coli intensive care sepsis model. Critical care (London, England). 2020 11; 24(1):646. doi: 10.1186/s13054-020-03303-9. [PMID: 33189146]
Lars Christophersen, Franziska Angelika Schwartz, Christian Johann Lerche, Trine Svanekjær, Kasper Nørskov Kragh, Anne Sofie Laulund, Kim Thomsen, Kaj-Åge Henneberg, Thomas Sams, Niels Høiby, Claus Moser. In vivo demonstration of Pseudomonas aeruginosa biofilms as independent pharmacological microcompartments. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2020 11; 19(6):996-1003. doi: 10.1016/j.jcf.2020.01.009. [PMID: 32067957]
Mengya Li, Lingyun Ma, Chaoyang Chen, Lili Lei, Xingyu Zhai, Daohuang Luo, Ying Zhou, Yimin Cui. Evaluation of Assays to Measure Aminoglycosides in Serum: Comparison of Accuracy and Precision Based on External Quality Assessment. Therapeutic drug monitoring. 2020 10; 42(5):710-715. doi: 10.1097/ftd.0000000000000752. [PMID: 32118804]
Man Zhu, Shaoguang Li, Hongxing Li, Hui Li, Fan Xia. Employing an Intercalated Redox Reporter in Electrochemical Aptamer-Based Biosensors to Enable Calibration-Free Molecular Measurements in Undiluted Serum. Analytical chemistry. 2020 09; 92(18):12437-12441. doi: 10.1021/acs.analchem.0c02205. [PMID: 32786211]
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Gerhard E Maale, John J Eager, Daniel K Mohammadi, Flavio A Calderon. Elution Profiles of Synthetic CaSO4 Hemihydrate Beads Loaded with Vancomycin and Tobramycin. European journal of drug metabolism and pharmacokinetics. 2020 Aug; 45(4):547-555. doi: 10.1007/s13318-020-00622-8. [PMID: 32328932]
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Brian M Hoff, Marc H Scheetz, Manu Jain, Joanne F Cullina, Nathaniel J Rhodes. Exploring the Relationship between FEV1 Loss and Recovery and Aminoglycoside Pharmacokinetics in Adult Patients with Cystic Fibrosis: Implications for Clinical Dosing Strategies. Pharmacotherapy. 2020 06; 40(6):584-591. doi: 10.1002/phar.2399. [PMID: 32259317]
Wei-Jia Cheng, Jin-Wei Zhou, Ping-Ping Zhang, Huai-Zhi Luo, Shi Tang, Jun-Jian Li, Shi-Ming Deng, Ai-Qun Jia. Quorum sensing inhibition and tobramycin acceleration in Chromobacterium violaceum by two natural cinnamic acid derivatives. Applied microbiology and biotechnology. 2020 Jun; 104(11):5025-5037. doi: 10.1007/s00253-020-10593-0. [PMID: 32248442]
Tomás Sou, Irena Kukavica-Ibrulj, Roger C Levesque, Lena E Friberg, Christel A S Bergström. Model-Informed Drug Development in Pulmonary Delivery: Semimechanistic Pharmacokinetic-Pharmacodynamic Modeling for Evaluation of Treatments against Chronic Pseudomonas aeruginosa Lung Infections. Molecular pharmaceutics. 2020 05; 17(5):1458-1469. doi: 10.1021/acs.molpharmaceut.9b00968. [PMID: 31951139]
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Matthijs D Kruizinga, Willem A J Birkhoff, Michiel J van Esdonk, Naomi B Klarenbeek, Tomasz Cholewinski, Tessa Nelemans, Melloney J Dröge, Adam F Cohen, Rob G J A Zuiker. Pharmacokinetics of intravenous and inhaled salbutamol and tobramycin: An exploratory study to investigate the potential of exhaled breath condensate as a matrix for pharmacokinetic analysis. British journal of clinical pharmacology. 2020 01; 86(1):175-181. doi: 10.1111/bcp.14156. [PMID: 31658494]
Jonathon R Lindner, David Seligson, Ernest Chisena, Saeed A Jortani, Erik A Korte. Does an antibiotic nail made in a lubricated tube release antibiotic?. European journal of orthopaedic surgery & traumatology : orthopedie traumatologie. 2020 Jan; 30(1):153-156. doi: 10.1007/s00590-019-02533-0. [PMID: 31471738]
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Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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Jayesh A Dhanani, Sara Diab, Jivesh Chaudhary, Jeremy Cohen, Suzanne L Parker, Steven C Wallis, Clément Boidin, Adrian Barnett, Michelle Chew, Jason A Roberts, John F Fraser. Lung Pharmacokinetics of Tobramycin by Intravenous and Nebulized Dosing in a Mechanically Ventilated Healthy Ovine Model. Anesthesiology. 2019 08; 131(2):344-355. doi: 10.1097/aln.0000000000002752. [PMID: 31107274]
Mengxiang Shang, Jinling Zhang, Hui Qi, Yao Gao, Jianyue Yan, Wenbo Song. All-electrodeposited amorphous MoSx@ZnO core-shell nanorod arrays for self-powered visible-light-activated photoelectrochemical tobramycin aptasensing. Biosensors & bioelectronics. 2019 Jul; 136(?):53-59. doi: 10.1016/j.bios.2019.04.019. [PMID: 31035027]
J E Möhlmann, M van Luin, E M Mascini, H J van Leeuwen, M R de Maat. Monitoring of tobramycin serum concentrations in selected critically ill patients receiving selective decontamination of the digestive tract: a retrospective evaluation. European journal of clinical pharmacology. 2019 Jun; 75(6):831-836. doi: 10.1007/s00228-019-02644-x. [PMID: 30778624]
Cornelis Smit, Roeland E Wasmann, Marinus J Wiezer, Hendricus P A van Dongen, Johan W Mouton, Roger J M Brüggemann, Catherijne A J Knibbe. Tobramycin Clearance Is Best Described by Renal Function Estimates in Obese and Non-obese Individuals: Results of a Prospective Rich Sampling Pharmacokinetic Study. Pharmaceutical research. 2019 May; 36(8):112. doi: 10.1007/s11095-019-2651-2. [PMID: 31147853]
Geetika Dhanda, Paramita Sarkar, Sandip Samaddar, Jayanta Haldar. Battle against Vancomycin-Resistant Bacteria: Recent Developments in Chemical Strategies. Journal of medicinal chemistry. 2019 04; 62(7):3184-3205. doi: 10.1021/acs.jmedchem.8b01093. [PMID: 30404451]
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Edyta Konecka, Joanna Mokracka, Sylwia Krzymińska, Adam Kaznowski. Evaluation of The Pathogenic Potential of Insecticidal Serratia marcescens Strains to Humans. Polish journal of microbiology. 2019; 68(2):185-191. doi: 10.21307/pjm-2019-018. [PMID: 31257791]
Ryan L Crass, Manjunath P Pai, Thomas P Lodise. Individualizing piperacillin/tazobactam dosing in adult patients with cystic fibrosis: can tobramycin measurements help?. The Journal of antimicrobial chemotherapy. 2019 01; 74(1):126-129. doi: 10.1093/jac/dky388. [PMID: 30252050]
Tiantian Ye, Siping Sun, Tiffanie Daisy Sugianto, Patricia Tang, Thaigarajan Parumasivam, Yoon Kyung Chang, Ariel Astudillo, Shujun Wang, Hak-Kim Chan. Novel combination proliposomes containing tobramycin and clarithromycin effective against Pseudomonas aeruginosa biofilms. International journal of pharmaceutics. 2018 Dec; 552(1-2):130-138. doi: 10.1016/j.ijpharm.2018.09.061. [PMID: 30267753]
Yazeed Toukan, Michal Gur, Fahed H Hakim, Yuval Geffen, Ronen Bar-Yoseph, Vered Nir, Lea Bentur. Intermittent inhaled tobramycin and systemic cytokines response in CF patients with Pseudomonas aeruginosa. Clinical and investigative medicine. Medecine clinique et experimentale. 2018 09; 41(3):E136-E143. doi: 10.25011/cim.v41i3.30792. [PMID: 30315749]
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Steven V Iasella, Amy Z Stetten, Timothy E Corcoran, Stephen Garoff, Todd M Przybycien, Robert D Tilton. Aerosolizing Lipid Dispersions Enables Antibiotic Transport Across Mimics of the Lung Airway Surface Even in the Presence of Pre-existing Lipid Monolayers. Journal of aerosol medicine and pulmonary drug delivery. 2018 08; 31(4):212-220. doi: 10.1089/jamp.2017.1412. [PMID: 29053080]
Yuta Naro, Nicholas Ankenbruck, Meryl Thomas, Yaniv Tivon, Colleen M Connelly, Laura Gardner, Alexander Deiters. Small Molecule Inhibition of MicroRNA miR-21 Rescues Chemosensitivity of Renal-Cell Carcinoma to Topotecan. Journal of medicinal chemistry. 2018 Jul; 61(14):5900-5909. doi: 10.1021/acs.jmedchem.7b01891. [PMID: 29993250]
Paul Skorup, Lisa Maudsdotter, Eva Tano, Miklós Lipcsey, Markus Castegren, Anders Larsson, Jan Sjölin. Dynamics of Endotoxin, Inflammatory Variables, and Organ Dysfunction After Treatment With Antibiotics in an Escherichia coli Porcine Intensive Care Sepsis Model. Critical care medicine. 2018 07; 46(7):e634-e641. doi: 10.1097/ccm.0000000000003139. [PMID: 29595561]
Adam I Edelstein, Kamil T Okroj, Thea Rogers, Craig J Della Valle, Scott M Sporer. Nephrotoxicity After the Treatment of Periprosthetic Joint Infection With Antibiotic-Loaded Cement Spacers. The Journal of arthroplasty. 2018 07; 33(7):2225-2229. doi: 10.1016/j.arth.2018.02.012. [PMID: 29526331]
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Anthony D Kang, Kenneth P Smith, Anders H Berg, Katherine A Truelson, George M Eliopoulos, Christopher McCoy, James E Kirby. Efficacy of Apramycin against Multidrug-Resistant Acinetobacter baumannii in the Murine Neutropenic Thigh Model. Antimicrobial agents and chemotherapy. 2018 04; 62(4):. doi: 10.1128/aac.02585-17. [PMID: 29339396]
Stephen J McWilliam, Daniel J Antoine, Andrea L Jorgensen, Rosalind L Smyth, Munir Pirmohamed. Urinary Biomarkers of Aminoglycoside-Induced Nephrotoxicity in Cystic Fibrosis: Kidney Injury Molecule-1 and Neutrophil Gelatinase-Associated Lipocalin. Scientific reports. 2018 03; 8(1):5094. doi: 10.1038/s41598-018-23466-4. [PMID: 29572451]
Maria Loose, Kurt G Naber, Paul Shields, Harald Reinhart, Florian M E Wagenlehner. Urinary concentrations and antimicrobial activity of tobramycin in healthy volunteers receiving a single oral dose of a novel formulation for improved absorption. International journal of antimicrobial agents. 2018 Mar; 51(3):422-426. doi: 10.1016/j.ijantimicag.2017.11.004. [PMID: 29158143]
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Minghua Wang, Bin Hu, Chuang Yang, Zhihong Zhang, Linghao He, Shaoming Fang, Xiongwei Qu, Qingxin Zhang. Electrochemical biosensing based on protein-directed carbon nanospheres embedded with SnOx and TiO2 nanocrystals for sensitive detection of tobramycin. Biosensors & bioelectronics. 2018 Jan; 99(?):176-185. doi: 10.1016/j.bios.2017.07.059. [PMID: 28756323]
T Mulder, M F Q Kluytmans-van den Bergh, R M P H Crolla, A A M Ermens, J Romme, N E Van't Veer, J A J W Kluytmans. Oral Tobramycin Prophylaxis Prior to Colorectal Surgery Is Not Associated with Systemic Uptake. Antimicrobial agents and chemotherapy. 2018 01; 62(1):. doi: 10.1128/aac.01723-17. [PMID: 29061755]
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Bauke Albada, Nils Metzler-Nolte. Highly Potent Antibacterial Organometallic Peptide Conjugates. Accounts of chemical research. 2017 10; 50(10):2510-2518. doi: 10.1021/acs.accounts.7b00282. [PMID: 28953347]
Jeffrey A Geller, Gregory Cunn, Thomas Herschmiller, Taylor Murtaugh, Antonia Chen. Acute Kidney Injury After First-Stage Joint Revision for Infection: Risk Factors and the Impact of Antibiotic Dosing. The Journal of arthroplasty. 2017 10; 32(10):3120-3125. doi: 10.1016/j.arth.2017.04.054. [PMID: 28578840]
Lisa K LeCleir, Rebecca S Pettit. Piperacillin-tazobactam versus cefepime incidence of acute kidney injury in combination with vancomycin and tobramycin in pediatric cystic fibrosis patients. Pediatric pulmonology. 2017 08; 52(8):1000-1005. doi: 10.1002/ppul.23718. [PMID: 28440913]
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J Seth Eaton, Steven R Hollingsworth, Bradford J Holmberg, Michael H Brown, Patricia J Smith, David J Maggs. Effects of topically applied heterologous serum on reepithelialization rate of superficial chronic corneal epithelial defects in dogs. Journal of the American Veterinary Medical Association. 2017 May; 250(9):1014-1022. doi: 10.2460/javma.250.9.1014. [PMID: 28414606]
N Patel, D Hatch, C M Wells, D Ahn, M Harris, J A Jennings, W Haggard, D G Armstrong. Characteristics and clinical assessment of antibiotic delivery by chitosan sponge in the high-risk diabetic foot: a case series. Journal of wound care. 2017 Apr; 26(sup4):S32-S38. doi: 10.12968/jowc.2017.26.sup4.s32. [PMID: 28379101]
Aurélie Crabbé, Yulong Liu, Nele Matthijs, Petra Rigole, César De La Fuente-Nùñez, Richard Davis, Maria A Ledesma, Shameema Sarker, Rob Van Houdt, Robert E W Hancock, Tom Coenye, Cheryl A Nickerson. Antimicrobial efficacy against Pseudomonas aeruginosa biofilm formation in a three-dimensional lung epithelial model and the influence of fetal bovine serum. Scientific reports. 2017 03; 7(?):43321. doi: 10.1038/srep43321. [PMID: 28256611]
Vaibhav Keskar, Mohan Biyani, Syed Obaid Amin, Greg Knoll. Successful Treatment of PD Peritonitis Due to Morganella morganii Resistant to Third-Generation Cephalosporins - A Case Report. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 2017 Mar; 37(2):241-242. doi: 10.3747/pdi.2016.00268. [PMID: 28360373]
P M Bernardi, F Barreto, T Dalla Costa. Application of a LC-MS/MS method for evaluating lung penetration of tobramycin in rats by microdialysis. Journal of pharmaceutical and biomedical analysis. 2017 Feb; 134(?):340-345. doi: 10.1016/j.jpba.2016.10.023. [PMID: 27823925]
Iman Tabatabaei, Stephanie Ruf, Ralph Bock. A bifunctional aminoglycoside acetyltransferase/phosphotransferase conferring tobramycin resistance provides an efficient selectable marker for plastid transformation. Plant molecular biology. 2017 Feb; 93(3):269-281. doi: 10.1007/s11103-016-0560-x. [PMID: 27858324]
Karen Robijns, Niels W Boone, Rob T P Jansen, Aldy W H M Kuypers, Cees Neef, Daan J Touw. Commutability of proficiency testing material containing tobramycin: a study within the framework of the Dutch Calibration 2.000 project. Clinical chemistry and laboratory medicine. 2017 Feb; 55(2):212-217. doi: 10.1515/cclm-2015-1254. [PMID: 27487495]
Florian Stehling, Rainer Büscher, Jörg Grosse-Onnebrink, Peter F Hoyer, Uwe Mellies. Glomerular and Tubular Renal Function after Repeated Once-Daily Tobramycin Courses in Cystic Fibrosis Patients. Pulmonary medicine. 2017; 2017(?):2602653. doi: 10.1155/2017/2602653. [PMID: 28133546]
Kevin J Downes, Min Dong, Tsuyoshi Fukuda, John P Clancy, Christopher Haffner, Michael R Bennett, Alexander A Vinks, Stuart L Goldstein. Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis. The Journal of antimicrobial chemotherapy. 2017 01; 72(1):254-260. doi: 10.1093/jac/dkw351. [PMID: 27585963]
Sharmily Khanam, Manita Guragain, Dirk L Lenaburg, Ryan Kubat, Marianna A Patrauchan. Calcium induces tobramycin resistance in Pseudomonas aeruginosa by regulating RND efflux pumps. Cell calcium. 2017 01; 61(?):32-43. doi: 10.1016/j.ceca.2016.11.004. [PMID: 28034459]
Patrizia Chetoni, Susi Burgalassi, Daniela Monti, Silvia Tampucci, Vivian Tullio, Anna Maria Cuffini, Elisabetta Muntoni, Rita Spagnolo, Gian Paolo Zara, Roberta Cavalli. Solid lipid nanoparticles as promising tool for intraocular tobramycin delivery: Pharmacokinetic studies on rabbits. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2016 Dec; 109(?):214-223. doi: 10.1016/j.ejpb.2016.10.006. [PMID: 27789355]
Gregory Vrabec, Willis Stevenson, Sameh Elguizaoui, Matthew Kirsch, John Pinkowski. What is the Intraarticular Concentration of Tobramycin Using Low-dose Tobramycin Bone Cement in TKA: An In Vivo Analysis?. Clinical orthopaedics and related research. 2016 Nov; 474(11):2441-2447. doi: 10.1007/s11999-016-5006-x. [PMID: 27488378]