Aristolochic_acid (BioDeep_00001867467)

Main id: BioDeep_00000000132

 

PANOMIX_OTCML-2023 Toxin


代谢物信息卡片


8-methoxy-6-nitro-naphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid

化学式: C17H11NO7 (341.0535496)
中文名称: 马兜铃酸 A, 马兜铃酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=CC=CC2=C3C(=C(C=C21)[N+](=O)[O-])C(=CC4=C3OCO4)C(=O)O
InChI: InChI=1S/C17H11NO7/c1-23-12-4-2-3-8-9(12)5-11(18(21)22)14-10(17(19)20)6-13-16(15(8)14)25-7-24-13/h2-6H,7H2,1H3,(H,19,20)

描述信息

Aristolochic acid A is an aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic. It has a role as a nephrotoxin, a carcinogenic agent, a mutagen, a toxin and a metabolite. It is a monocarboxylic acid, a C-nitro compound, a cyclic acetal, an organic heterotetracyclic compound, an aromatic ether and a member of aristolochic acids.
Aristolochic acid is a natural product found in Thottea duchartrei, Aristolochia, and other organisms with data available.
Aristolochic acids are a family of carcinogenic, mutagenic, and nephrotoxic compounds commonly found in the Aristolochiaceae family of plants, including Aristolochia and Asarum (wild ginger), which are commonly used in Chinese herbal medicine. Aristolochic acid I is the most abundant of the aristolochic acids and is found in almost all Aristolochia species. Aristolochic acids are often accompanied by aristolactams.
See also: Aristolochia fangchi root (part of).
An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
D009676 - Noxae > D002273 - Carcinogens
D009676 - Noxae > D009153 - Mutagens
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].
Aristolochic acid A (Aristolochic acid I; TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum. Aristolochic acid A significantly reduces both activator protein 1 (AP-1) and NF-κB activities. Aristolochic acid A reduces BLCAP gene expression in human cell lines[1].

同义名列表

73 个代谢物同义名

8-methoxy-6-nitro-naphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid; Phenanthro[3,4-d]-1,3-dioxole-5-carbocylic acid, 8-methoxy-6-nitro-; Aristolochic acid I, European Pharmacopoeia (EP) Reference Standard; Phenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-; 8-Methoxy-3,4-methylenedioxy-10-nitrophenanthrene-1-carboxylic acid; Phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-; 3,4-Methylenedioxy-8-methoxy-10-nitro-1-phenanthrenecarboxylic acid; 8-methoxy-6-nitro-naphtho[1,2-e][1,3]benzodioxole-5-carboxylic acid; 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid #; 8-methoxy-6-nitronaphtho[2,1-g][1,3]benzodioxole-5-carboxylic acid; 8-Methoxy-6-nitrophenanthol (3,4-d) 1,3-dioxole-5-carboxylic acid; 8-Methoxy-6-nitro-phenanthro[3,4-d][1,3]dioxole-5-carboxylic acid; 8-methoxy-6-nitrophenanthro(3,4-d)(1,3)dioxole-5-carboxylic acid; 8-methoxy-6-nitrophenanthro(3,4-d)-1,3-dioxole-5-carboxylic acid; 8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid; 8-Methoxy-3,4-methylendioxxy-10-nitro-1-phenanthrencarbonsaeure; Aristolochia, European Pharmacopoeia (EP) Reference Standard; Phenanthro[3,3-dioxole-5-carboxylic acid, 8-methoxy-6-nitro-; ARISTOLOCHIC ACID, PLANTS CONTAINING [IARC]; ARISTOLOCHIC ACID, PLANTS CONTAINING (IARC); 2-Naphthyl Pyrovalerone-d8 Hydrochloride; Mixture of Aristolochic Acid A and B; aristolochic acid I, sodium salt; Aristolochic acid I, powder; BBFQZRXNYIEMAW-UHFFFAOYSA-N; ARISTOLOCHIC ACID [WHO-DD]; ARISTOLOCHIC ACID [IARC]; ARISTOLOCHIC ACID (IARC); Aristolochic acid A,(S); ARISTOLOCHIC ACID [MI]; sodium aristolochate; aristolochic acid A; aristolochic acid I; Aristolochic acid 1; Aristolochic acid-I; Aristolochic-acid-A; aris-tolochic acid; Aristolochiazaeure; AristolochicacidA; Aristolochic acid; Spectrum2_000822; Spectrum3_001114; Spectrum5_000729; Spectrum4_001952; ARISTOLOCHIA A; DivK1c_006544; ARISTOLOCHINE; KBio1_001488; KBio3_000320; KBio2_001636; KBio3_000319; KBio2_005296; Aristolochia; Aristolochic; KBio3_002068; NCI60_000460; KBio2_002728; KBio2_006772; KBio2_004204; Aristolochin; KBio2_000160; Bio2_000640; Bio1_000418; Bio1_001396; IDI1_033910; Bio2_000160; Bio1_000907; Birthwort; C17H11NO7; Tardolyt; GOQ; TR 1736; Aristolochic acid



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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Plant Reactome(0)

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58 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xueli Liu, Yuan Luo, Yu Fan, Xiujun Cao, Jun Lu, Guoxin Song, Chunhui Deng. Magnetic quaternary ammonium polymer bearing porous agarose for selective extraction of Aristolochic acids in the plasma. Journal of chromatography. A. 2024 Jul; 1726(?):464965. doi: 10.1016/j.chroma.2024.464965. [PMID: 38733925]
  • Dong-Zhu Tu, Pei-Qi Liu, Guang-Hao Zhu, Hai-Rong Zeng, Yan-Yan Deng, Jian Huang, Xiao-Ting Niu, Yan-Fang Liu, Jing Hu, Xin-Miao Liang, Moshe Finel, Ping Wang, Guang-Bo Ge. Human UDP-glucuronosyltransferase 1As catalyze aristolochic acid D O-glucuronidation to form a lesser nephrotoxic glucuronide. Journal of ethnopharmacology. 2024 Jun; 328(?):118116. doi: 10.1016/j.jep.2024.118116. [PMID: 38548118]
  • Chuanting Xu, Qi Wang, Changlin Du, Lu Chen, Zhongnan Zhou, Zhenming Zhang, Na Cai, Jun Li, Cheng Huang, Taotao Ma. Histone deacetylase-mediated silencing of PSTPIP2 expression contributes to aristolochic acid nephropathy-induced PANoptosis. British journal of pharmacology. 2024 May; 181(9):1452-1473. doi: 10.1111/bph.16299. [PMID: 38073114]
  • Yun-Shu Hu, Jian-Qing Zhang, Wen-Long Wei, Huan-Ya Yang, Fei Sha, Xuan-Jing Shen, Shuai Yao, Jia-Yuan Li, Hua Qu, Ping Li, Xiang-Mei Chen, Dean Guo. Comprehensive HRMS Screening and Risk Assessments of Aristolochic Acid Analogues in Asari Radix et Rhizoma and Related Commercial Health Products. Journal of agricultural and food chemistry. 2024 Apr; 72(13):7438-7456. doi: 10.1021/acs.jafc.4c00751. [PMID: 38513720]
  • Changlin Du, Chuanting Xu, Pengcheng Jia, Na Cai, Zhenming Zhang, Wenna Meng, Lu Chen, Zhongnan Zhou, Qi Wang, Rui Feng, Jun Li, Xiaoming Meng, Cheng Huang, Taotao Ma. PSTPIP2 ameliorates aristolochic acid nephropathy by suppressing interleukin-19-mediated neutrophil extracellular trap formation. eLife. 2024 Feb; 13(?):. doi: 10.7554/elife.89740. [PMID: 38314821]
  • Tao Su, Zhi-E Fang, Yu-Ming Guo, Chun-Yu Wang, Jia-Bo Wang, Dong Ji, Zhao-Fang Bai, Li Yang, Xiao-He Xiao. No Incidence of Liver Cancer Was Observed in A Retrospective Study of Patients with Aristolochic Acid Nephropathy. Chinese journal of integrative medicine. 2023 Nov; ?(?):. doi: 10.1007/s11655-023-3560-0. [PMID: 37943487]
  • Chin-Chung Lin, Pei-Ying Lin, Zhenyuan Han, Chen-Yu Tsai, David E Beck, Shuchen Hsieh. Rapid identification and detection of aristolochic acids in the herbal extracts by Raman spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Nov; 300(?):122918. doi: 10.1016/j.saa.2023.122918. [PMID: 37269653]
  • Meilin Chen, Chongjun Zhao, Zhiqi Li, Qiqi Fan, Shan Lu, Xiaoyu Tao, Yifan Lin, Ruichao Lin, Jiarui Wu. Investigation of the applicability of the zebrafish model for the evaluation of aristolochic acid-related nephrotoxicity. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Sep; 121(?):155092. doi: 10.1016/j.phymed.2023.155092. [PMID: 37804820]
  • Jinxia Wei, Xin Shao, Jinbiao Guo, Yanxue Zheng, Yuanyuan Wang, Zhenjie Zhang, Yao Chen, Yubo Li. Rapid and selective removal of aristolochic acid i in natural products by vinylene-linked iCOF resins. Journal of hazardous materials. 2023 Jul; 461(?):132140. doi: 10.1016/j.jhazmat.2023.132140. [PMID: 37734311]
  • Jiwei Li, Meiqi Chen, Sisi Ke, Jiangwei Tian, Haixiang Yu, Xiufeng Liu, Bo-Yang Yu. Generation of a high-affinity DNA aptamer for on-site screening of toxic aristolochic acid I in herbal medicines and botanical products. Analytica chimica acta. 2023 Jul; 1264(?):341302. doi: 10.1016/j.aca.2023.341302. [PMID: 37230722]
  • Su-Yin Chiang, Ming-Tsai Wey, Yu-Syuan Luo, Wei-Chung Shih, Dalaijamts Chimeddulam, Po-Chi Hsu, Hui-Fen Huang, Tung-Hu Tsai, Kuen-Yuh Wu. Simultaneous toxicokinetic studies of aristolochic acid I and II and aristolactam I and II using a newly-developed microdialysis liquid chromatography-tandem mass spectrometry. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2023 May; ?(?):113856. doi: 10.1016/j.fct.2023.113856. [PMID: 37257633]
  • Jingzhuo Tian, Chenyue Liu, Lianmei Wang, Zhong Xian, Yong Zhao, Shasha Qin, Yan Yi, Chunying Li, Jiayin Han, Chen Pan, Yushi Zhang, Suyan Liu, Jing Meng, Xuan Tang, Fang Wang, Meiting Liu, Aihua Liang. Study on the difference and correlation between the contents and toxicity of aristolochic acid analogues in Aristolochia plants. Journal of ethnopharmacology. 2023 May; ?(?):116568. doi: 10.1016/j.jep.2023.116568. [PMID: 37217154]
  • Miyu Komatsu, Takeshi Funakoshi, Toshihiko Aki, Kana Unuma, Koichi Uemura. Aristolochic acid induces an inflammatory response with prostaglandin E2 production and apoptosis in NRK-52E proximal tubular cells. Toxicology letters. 2023 Feb; ?(?):. doi: 10.1016/j.toxlet.2023.02.009. [PMID: 36863539]
  • Shuang Wang, Zhihui Liu, Yao Wang, Bendong Shi, Yinzhu Jin, Yu Wang, Xiaowen Jiang, Mingxin Song, Wenhui Yu. Grape seed extract proanthocyanidin antagonizes aristolochic acid I-induced liver injury in rats by activating PI3K-AKT pathway. Toxicology mechanisms and methods. 2023 Feb; 33(2):131-140. doi: 10.1080/15376516.2022.2103479. [PMID: 35850572]
  • Meiting Liu, Lianmei Wang, Shasha Qin, Yong Zhao, Suyan Liu, Yan Yi, Chunying Li, Jingzhuo Tian, Chenyue Liu, Jing Meng, Yuan Wang, Yushi Zhang, Fang Wang, Chen Pan, Jiayin Han, Xuan Tang, Liping Wang, Aihua Liang. Long-term oral administration of Asarum heterotropoides f. mandshuricum (Maxim.) Kitag. decoction and its aristolochic acid analogs do not cause renal toxicity in mice. Journal of ethnopharmacology. 2023 Jan; 307(?):116202. doi: 10.1016/j.jep.2023.116202. [PMID: 36708883]
  • Xiao Meng, Mengping Zhang, Lingfei Liu, Jie Du, Nianlu Li, Wei Zou, Cuijuan Wang, Wenwen Chen, Haiyan Wei, Ranran Liu, Qiang Jia, Hua Shao, Yongchao Lai. Rapid and robust analysis of aristolochic acid I in Chinese medicinal herbal preparations by surface-enhanced Raman spectroscopy. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2023 Jan; 285(?):121880. doi: 10.1016/j.saa.2022.121880. [PMID: 36130467]
  • Jinghe Zhang, Yinan Wang, Changhong Wang, Kan Li, Weifang Tang, Jing Sun, Xikui Wang. Uptake, Translocation, and Fate of Carcinogenic Aristolochic Acid in Typical Vegetables in Soil-Plant Systems. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238271. [PMID: 36500364]
  • Samrat Das, Shefali Thakur, Michael Korenjak, Viktoriya S Sidorenko, Felicia Fei-Lei Chung, Jiri Zavadil. Aristolochic acid-associated cancers: a public health risk in need of global action. Nature reviews. Cancer. 2022 10; 22(10):576-591. doi: 10.1038/s41568-022-00494-x. [PMID: 35854147]
  • Wenjuan Jiang, Chuanting Xu, Songbing Xu, Wan Su, Changlin Du, Jiahui Dong, Rui Feng, Cheng Huang, Jun Li, Taotao Ma. Macrophage-derived, LRG1-enriched extracellular vesicles exacerbate aristolochic acid nephropathy in a TGFβR1-dependent manner. Cell biology and toxicology. 2022 08; 38(4):629-648. doi: 10.1007/s10565-021-09666-1. [PMID: 34677723]
  • Kathleen G Dickman, Chung-Hsin Chen, Arthur P Grollman, Yeong-Shiau Pu. Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review. World journal of urology. 2022 Jul; ?(?):. doi: 10.1007/s00345-022-04100-5. [PMID: 35867141]
  • Yan Yang, Fei-Lin Ge, Xiao-Yan Zhan, Wen-Qing Mu, Zhi-Yong Li, Li Lin, Zi-Ying Wei, Zhao-Fang Bai, Qin Sun, Xiao-He Xiao. Schisandra chinensis Oil Attenuates Aristolochic Acid I-Induced Nephrotoxicity in vivo and in vitro. Chinese journal of integrative medicine. 2022 Jul; 28(7):603-611. doi: 10.1007/s11655-022-3574-z. [PMID: 35391592]
  • Jing-Zhuo Tian, Su-Yan Liu, Yue Gao, Bo-Li Zhang, Ai-Hua Liang. [Risk assessment, safe medication and scientific supervision of traditional Chinese medicine containing aristolochic acids--toxicity is different among aristolochic acids, and detection and control of aristolochic acid Ⅰ/Ⅱ is critical]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Jul; 47(14):3693-3700. doi: 10.19540/j.cnki.cjcmm.20220520.401. [PMID: 35850825]
  • Alexandra T Lukinich-Gruia, Joëlle Nortier, Nikola M Pavlović, Dragan Milovanović, Miloš Popović, Lavinia Paula Drăghia, Virgil Păunescu, Călin A Tatu. Aristolochic acid I as an emerging biogenic contaminant involved in chronic kidney diseases: A comprehensive review on exposure pathways, environmental health issues and future challenges. Chemosphere. 2022 Jun; 297(?):134111. doi: 10.1016/j.chemosphere.2022.134111. [PMID: 35231474]
  • Mislav Mokos, Nikolina Bašić-Jukić. IgA nephropathy following SARS-CoV-2 vaccination in a renal transplant recipient with a history of aristolochic acid nephropathy. Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2022 06; 26(3):667-668. doi: 10.1111/1744-9987.13765. [PMID: 34816609]
  • Yating Lu, Yue Guo, Xiao Liang, Huimin Huang, Xue Ling, Zhiheng Su, Yonghong Liang. The recognition of aristolochic acid I based on fluorescence quenching of bovine serum albumin-stabilized gold nanoclusters. Analytical methods : advancing methods and applications. 2022 05; 14(20):1963-1972. doi: 10.1039/d2ay00492e. [PMID: 35531633]
  • Jiayin Zhang, Kwan-Kit Jason Chan, Wan Chan. Synergistic Interaction of Polycyclic Aromatic Hydrocarbons, Phthalate Esters, or Phenol on DNA Adduct Formation by Aristolochic Acid I: Insights into the Etiology of Balkan Endemic Nephropathy. Chemical research in toxicology. 2022 05; 35(5):849-857. doi: 10.1021/acs.chemrestox.2c00026. [PMID: 35471859]
  • Wenjing Guo, Zhangsheng Shi, Ting Zeng, Yu He, Zongwei Cai, Jialing Zhang. Metabolic study of aristolochic acid I-exposed mice liver by atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry imaging and machine learning. Talanta. 2022 May; 241(?):123261. doi: 10.1016/j.talanta.2022.123261. [PMID: 35101835]
  • Xianrui Chen, Ting Huang, Zhibing Huang, Quanbin Han. Development of an immunochromatographic test strip for the rapid detection of aristolochic acid A in herbal medicinal materials. Phytochemical analysis : PCA. 2022 Apr; 33(3):441-451. doi: 10.1002/pca.3100. [PMID: 34802168]
  • Kensuke Sasaki, Andrew S Terker, Jiaqi Tang, Shirong Cao, Juan Pablo Arroyo, Aolei Niu, Suwan Wang, Xiaofeng Fan, Yahua Zhang, Stephanie R Bennett, Ming-Zhi Zhang, Raymond C Harris. Macrophage interferon regulatory factor 4 deletion ameliorates aristolochic acid nephropathy via reduced migration and increased apoptosis. JCI insight. 2022 02; 7(4):. doi: 10.1172/jci.insight.150723. [PMID: 35025763]
  • Sandra Karanović, Maude Ardin, Zuojian Tang, Karla Tomić, Stephanie Villar, Claire Renard, Elisa Venturini, Adam H Lorch, Daniel S Lee, Želimir Stipančić, Neda Slade, Ivana Vuković Brinar, Damir Dittrich, Krešimir Karlović, Fran Borovečki, Kathleen G Dickman, Magali Olivier, Arthur P Grollman, Bojan Jelaković, Jiri Zavadil. Molecular profiles and urinary biomarkers of upper tract urothelial carcinomas associated with aristolochic acid exposure. International journal of cancer. 2022 01; 150(2):374-386. doi: 10.1002/ijc.33827. [PMID: 34569060]
  • Qian Zhang, Piao Luo, Jiayun Chen, Chuanbin Yang, Fei Xia, Junzhe Zhang, Huan Tang, Dandan Liu, Liwei Gu, Qiaoli Shi, Xueling He, Tong Yang, Jigang Wang. Dissection of Targeting Molecular Mechanisms of Aristolochic Acid-induced Nephrotoxicity via a Combined Deconvolution Strategy of Chemoproteomics and Metabolomics. International journal of biological sciences. 2022; 18(5):2003-2017. doi: 10.7150/ijbs.69618. [PMID: 35342337]
  • Xiaoyan Wang, Ping Jia, Ting Ren, Zhouping Zou, Sujuan Xu, Yunlu Zhang, Yiqin Shi, Siyu Bao, Yingxiang Li, Yi Fang, Xiaoqiang Ding. MicroRNA-382 Promotes M2-Like Macrophage via the SIRP-α/STAT3 Signaling Pathway in Aristolochic Acid-Induced Renal Fibrosis. Frontiers in immunology. 2022; 13(?):864984. doi: 10.3389/fimmu.2022.864984. [PMID: 35585990]
  • Shinya Taguchi, Kengo Azushima, Takahiro Yamaji, Shingo Urate, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shunichiro Tsukamoto, Daisuke Kamimura, Sho Kinguchi, Akio Yamashita, Hiromichi Wakui, Kouichi Tamura. Effects of tumor necrosis factor-α inhibition on kidney fibrosis and inflammation in a mouse model of aristolochic acid nephropathy. Scientific reports. 2021 12; 11(1):23587. doi: 10.1038/s41598-021-02864-1. [PMID: 34880315]
  • Wenjing Guo, Zhangsheng Shi, Jing Zhang, Ting Zeng, Yu He, Zongwei Cai. Analysis of aristolochic acid I in mouse serum and tissues by using magnetic solid-phase extraction and UHPLC-MS/MS. Talanta. 2021 Dec; 235(?):122774. doi: 10.1016/j.talanta.2021.122774. [PMID: 34517632]
  • Yong-Zhen Liu, Heng-Lei Lu, Xin-Ming Qi, Guo-Zhen Xing, Xin Wang, Pan Yu, Lu Liu, Fang-Fang Yang, Xiao-Lan Ding, Ze-An Zhang, Zhong-Ping Deng, Li-Kun Gong, Jin Ren. Aristolochic acid I promoted clonal expansion but did not induce hepatocellular carcinoma in adult rats. Acta pharmacologica Sinica. 2021 Dec; 42(12):2094-2105. doi: 10.1038/s41401-021-00622-7. [PMID: 33686245]
  • Shingo Urate, Hiromichi Wakui, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Sho Kinguchi, Kazushi Uneda, Tomohiko Kanaoka, Yoshitoshi Atobe, Kengo Funakoshi, Akio Yamashita, Kouichi Tamura. Aristolochic Acid Induces Renal Fibrosis and Senescence in Mice. International journal of molecular sciences. 2021 Nov; 22(22):. doi: 10.3390/ijms222212432. [PMID: 34830314]
  • Yi Wang, Zhigang Wang, Zhengping Wu, Menglin Chen, Dong Dong, Pei Yu, Danyi Lu, Baojian Wu. Involvement of REV-ERBα dysregulation and ferroptosis in aristolochic acid I-induced renal injury. Biochemical pharmacology. 2021 11; 193(?):114807. doi: 10.1016/j.bcp.2021.114807. [PMID: 34673015]
  • Yueh-An Lu, Chia-Te Liao, Rachel Raybould, Bnar Talabani, Irina Grigorieva, Barbara Szomolay, Timothy Bowen, Robert Andrews, Philip R Taylor, Donald Fraser. Single-Nucleus RNA Sequencing Identifies New Classes of Proximal Tubular Epithelial Cells in Kidney Fibrosis. Journal of the American Society of Nephrology : JASN. 2021 10; 32(10):2501-2516. doi: 10.1681/asn.2020081143. [PMID: 34155061]
  • Zhong Xian, Jingzhuo Tian, Yushi Zhang, Jing Meng, Yong Zhao, Chunying Li, Yan Yi, Jiayin Han, Suyan Liu, Lianmei Wang, Chen Pan, Dunfang Wang, Fang Wang, Aihua Liang. Study on the potential nephrotoxicity and mutagenicity of aristolochic acid IVa and its mechanism. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112081. doi: 10.1016/j.biopha.2021.112081. [PMID: 34463271]
  • Khai Gene Leong, Elyce Ozols, John Kanellis, Frank Y Ma, David J Nikolic-Paterson. Cyclophilin D Promotes Acute, but Not Chronic, Kidney Injury in a Mouse Model of Aristolochic Acid Toxicity. Toxins. 2021 10; 13(10):. doi: 10.3390/toxins13100700. [PMID: 34678993]
  • Yao Wang, Xianglin Ma, Chong Zhou, Yongzhen Jia, Si Liu, Zongliang Xiong, Xu Guo, Xue Fei, Xiaowen Jiang, Wenhui Yu. Aristolochic acid induces mitochondrial apoptosis through oxidative stress in rats, leading to liver damage. Toxicology mechanisms and methods. 2021 Oct; 31(8):609-618. doi: 10.1080/15376516.2021.1946229. [PMID: 34167444]
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