Geranylgeranyl diphosphate (BioDeep_00000638552)

Main id: BioDeep_00000001649

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


3,7,11,15-tetramethyl-2Z,6Z,10Z,14-hexadecatetraen-1-ol diphosphate

化学式: C20H36O7P2 (450.1936)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC/C(=C/CC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)/C)C
InChI: InChI=1S/C20H36O7P2/c1-17(2)9-6-10-18(3)11-7-12-19(4)13-8-14-20(5)15-16-26-29(24,25)27-28(21,22)23/h9,11,13,15H,6-8,10,12,14,16H2,1-5H3,(H,24,25)(H2,21,22,23)/b18-11+,19-13+,20-15+

描述信息

同义名列表

3 个代谢物同义名

Geranylgeranyl diphosphate; 3,7,11,15-tetramethyl-2Z,6Z,10Z,14-hexadecatetraen-1-ol diphosphate; Geranylgeranyl diphosphate



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(2)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 AKT1, BCL2, CASP3, CDKN1A, FDPS, FNTA, GGPS1, IPP, MAPK14, MAPK8, MVK, PPARG, RHOA
Peripheral membrane protein 1 CYP1B1
Endoplasmic reticulum membrane 5 BCL2, CYP1B1, FDFT1, HMGCR, RHOA
Nucleus 8 AKT1, BCL2, CASP3, CDKN1A, MAPK14, MAPK8, PPARG, RHOA
cytosol 12 AKT1, BCL2, CASP3, CDKN1A, FDPS, FNTA, GGPS1, MAPK14, MAPK8, MVK, PPARG, RHOA
nuclear body 1 CDKN1A
nucleoplasm 8 AKT1, CASP3, CDKN1A, FDPS, GGPS1, MAPK14, MAPK8, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 AKT1, RHOA, TNF
Lipid-anchor 1 RHOA
Cytoplasmic side 1 RHOA
Cleavage furrow 1 RHOA
lamellipodium 2 AKT1, RHOA
ruffle membrane 1 RHOA
Multi-pass membrane protein 2 FDFT1, HMGCR
Synapse 1 MAPK8
cell cortex 2 AKT1, RHOA
cell junction 1 RHOA
cell surface 1 TNF
glutamatergic synapse 4 AKT1, CASP3, MAPK14, RHOA
Golgi membrane 1 INS
neuronal cell body 2 CASP3, TNF
postsynapse 2 AKT1, RHOA
endosome 1 RHOA
plasma membrane 4 AKT1, FNTA, RHOA, TNF
Membrane 6 AKT1, BCL2, CYP1B1, FDFT1, FDPS, HMGCR
axon 1 MAPK8
extracellular exosome 1 RHOA
endoplasmic reticulum 3 BCL2, FDFT1, HMGCR
extracellular space 3 IL6, INS, TNF
perinuclear region of cytoplasm 3 CDKN1A, GGPS1, PPARG
mitochondrion 3 BCL2, CYP1B1, MAPK14
protein-containing complex 3 AKT1, BCL2, CDKN1A
intracellular membrane-bounded organelle 3 CYP1B1, MVK, PPARG
Microsome membrane 1 CYP1B1
postsynaptic density 1 CASP3
Secreted 2 IL6, INS
extracellular region 4 IL6, INS, MAPK14, TNF
cytoplasmic side of plasma membrane 1 RHOA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 FDPS
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TNF
actin cytoskeleton 1 IPP
dendritic spine 1 RHOA
Z disc 1 GGPS1
microtubule cytoskeleton 1 AKT1
nucleolus 1 CDKN1A
midbody 1 RHOA
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, RHOA
Cell projection, lamellipodium 1 RHOA
Cytoplasm, perinuclear region 1 GGPS1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 RHOA
spindle 1 AKT1
Peroxisome 2 FDPS, MVK
peroxisomal membrane 1 HMGCR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
nuclear speck 1 MAPK14
receptor complex 1 PPARG
ciliary basal body 1 AKT1
chromatin 1 PPARG
microtubule associated complex 1 FNTA
phagocytic cup 1 TNF
cell periphery 1 RHOA
cytoskeleton 1 RHOA
spindle pole 1 MAPK14
Cytoplasm, cell cortex 1 RHOA
endosome lumen 1 INS
Cell projection, dendrite 1 RHOA
myelin sheath 1 BCL2
Peroxisome membrane 1 HMGCR
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
secretory granule membrane 1 RHOA
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ficolin-1-rich granule membrane 1 RHOA
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
apical junction complex 1 RHOA
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
CAAX-protein geranylgeranyltransferase complex 2 FNTA, PGGT1B
protein farnesyltransferase complex 1 FNTA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Xuan Song, Yao-Guo Qin, Yi-Han Zhang, Yu-Bei Zhou, Zheng-Xi Li. Farnesyl/geranylgeranyl diphosphate synthases regulate the biosynthesis of alarm pheromone in a unique manner in the vetch aphid Megoura viciae. Insect molecular biology. 2022 Dec; ?(?):. doi: 10.1111/imb.12826. [PMID: 36533988]
  • Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu. Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes PCSK9-Dependent Adipose Insulin Resistance. Nutrients. 2022 Dec; 14(24):. doi: 10.3390/nu14245314. [PMID: 36558473]
  • Xin Shu, Jiaqi Wu, Tao Zhang, Xiaoyu Ma, Zuoqin Du, Jin Xu, Jingcan You, Liqun Wang, Ni Chen, Mao Luo, Jianbo Wu. Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes Ferroptosis-Related Senescence in Adipose Tissue. Nutrients. 2022 Oct; 14(20):. doi: 10.3390/nu14204365. [PMID: 36297049]
  • Feifei Xu, Zining Wang, Hongxia Zhang, Jiemin Chen, Xiaojuan Wang, Lei Cui, Chunyuan Xie, Mengyun Li, Fang Wang, Penghui Zhou, Jinyun Liu, Peng Huang, Xiaodong Xia, Xiaojun Xia. Mevalonate Blockade in Cancer Cells Triggers CLEC9A+ Dendritic Cell-Mediated Antitumor Immunity. Cancer research. 2021 09; 81(17):4514-4528. doi: 10.1158/0008-5472.can-20-3977. [PMID: 34266895]
  • Lai Wang, Zu-Guo Zheng, Lingchang Meng, Lijun Zhu, Ping Li, Jun Chen, Hua Yang. Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue. Cell biology and toxicology. 2021 06; 37(3):441-460. doi: 10.1007/s10565-020-09558-w. [PMID: 33034787]
  • Liping Zhu, Fangbo Liu, Qiang Hao, Tian Feng, Zeshuai Chen, Shengquan Luo, Rui Xiao, Mengxiang Sun, Ting Zhang, Xiaohang Fan, Xianqin Zeng, Jianguo He, Ping Yuan, Jinming Liu, Matthieu Ruiz, Jocelyn Dupuis, Qinghua Hu. Dietary Geranylgeranyl Pyrophosphate Counteracts the Benefits of Statin Therapy in Experimental Pulmonary Hypertension. Circulation. 2021 05; 143(18):1775-1792. doi: 10.1161/circulationaha.120.046542. [PMID: 33660517]
  • Sarah Ötzkan, Walter E Muller, W Gibson Wood, Gunter P Eckert. Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice. Neuromolecular medicine. 2021 03; 23(1):130-139. doi: 10.1007/s12017-020-08640-0. [PMID: 33377988]
  • Joseph Longo, Petr Smirnov, Zhihua Li, Emily Branchard, Jenna E van Leeuwen, Jonathan D Licht, Benjamin Haibe-Kains, David W Andrews, Jonathan J Keats, Trevor J Pugh, Suzanne Trudel, Linda Z Penn. The mevalonate pathway is an actionable vulnerability of t(4;14)-positive multiple myeloma. Leukemia. 2021 03; 35(3):796-808. doi: 10.1038/s41375-020-0962-2. [PMID: 32665698]
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