chloroquine (BioDeep_00000408835)

Main id: BioDeep_00000002973

 

natural product


代谢物信息卡片


chloroquine

化学式: C18H26ClN3 (319.1815)
中文名称: 氯喹
谱图信息: 最多检出来源 Mus musculus(natural_products) 17.97%

分子结构信息

SMILES: CC(CCCN(CC)CC)NC1=CC=NC2=CC(Cl)=CC=C12
InChI: InChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)

描述信息

P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01B - Antimalarials > P01BA - Aminoquinolines
COVID info from Guide to PHARMACOLOGY, DrugBank, clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D018501 - Antirheumatic Agents
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

3 个代谢物同义名

chloroquine; Chloroquine; Chloroquine



数据库引用编号

26 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

13 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ALB, ATG5, ATG7, DHFR, DHPS, EGFR, G6PD, GAPDH, HPGDS, MAPK8, NFKB1, PIK3C3, TLR9, TNK1
Peripheral membrane protein 5 ATG5, CTSB, CYP1B1, G6PD, TNK1
Endosome membrane 2 EGFR, TLR9
Endoplasmic reticulum membrane 4 CD4, CYP1B1, EGFR, TLR9
Cytoplasmic vesicle, autophagosome 1 PIK3C3
Nucleus 5 ALB, EGFR, GAPDH, MAPK8, NFKB1
autophagosome 2 ATG5, PIK3C3
cytosol 12 ALB, ATG5, ATG7, DHFR, DHPS, G6PD, GAPDH, HPGDS, MAPK8, NFKB1, PIK3C3, PRKCQ
phagocytic vesicle 1 TLR9
phosphatidylinositol 3-kinase complex, class III 1 PIK3C3
centrosome 1 ALB
nucleoplasm 3 HPGDS, MAPK8, NFKB1
Cell membrane 2 CD4, EGFR
ruffle membrane 1 EGFR
Early endosome membrane 2 EGFR, TLR9
Golgi apparatus membrane 1 TLR9
Synapse 1 MAPK8
cell junction 1 EGFR
cell surface 1 EGFR
glutamatergic synapse 3 ATG5, EGFR, PIK3C3
Golgi apparatus 1 ALB
Golgi membrane 3 EGFR, INS, TLR9
postsynapse 1 ATG5
Cytoplasm, cytosol 2 G6PD, GAPDH
Lysosome 2 CTSB, TLR9
endosome 3 EGFR, PIK3C3, TLR9
plasma membrane 6 CD4, EGFR, GAPDH, PRKCQ, TLR9, TNK1
Membrane 8 ATG5, CYP1B1, EGFR, G6PD, GAPDH, PIK3C3, TLR9, TNK1
apical plasma membrane 3 CTSB, EGFR, TLR9
axon 2 ATG5, MAPK8
basolateral plasma membrane 2 EGFR, TLR9
extracellular exosome 4 ALB, CTSB, G6PD, GAPDH
endoplasmic reticulum 2 ALB, TLR9
extracellular space 5 ALB, CTSB, CXCL8, EGFR, INS
perinuclear region of cytoplasm 3 CTSB, EGFR, GAPDH
Schaffer collateral - CA1 synapse 1 ATG5
mitochondrion 3 CYP1B1, DHFR, NFKB1
protein-containing complex 3 ALB, ATG5, EGFR
intracellular membrane-bounded organelle 4 CYP1B1, G6PD, GAPDH, HPGDS
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 3 CD4, EGFR, TLR9
Secreted 3 ALB, CXCL8, INS
extracellular region 7 ALB, ATG7, CTSB, CXCL8, INS, NFKB1, TLR9
cytoplasmic side of plasma membrane 1 G6PD
Extracellular side 1 CTSB
anchoring junction 1 ALB
transcription regulator complex 1 NFKB1
centriolar satellite 2 G6PD, PRKCQ
nuclear membrane 2 EGFR, GAPDH
external side of plasma membrane 2 CD4, CTSB
microtubule cytoskeleton 1 GAPDH
midbody 1 PIK3C3
Early endosome 1 CD4
vesicle 1 GAPDH
Apical cell membrane 1 CTSB
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 2 CD4, EGFR
Cytoplasm, cytoskeleton 1 GAPDH
focal adhesion 1 EGFR
GABA-ergic synapse 1 PIK3C3
Peroxisome 1 PIK3C3
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 CTSB
axoneme 3 ATG5, ATG7, PIK3C3
Late endosome 1 PIK3C3
receptor complex 1 EGFR
ciliary basal body 1 ALB
chromatin 1 NFKB1
phagocytic vesicle membrane 2 ATG5, PIK3C3
cytoskeleton 1 GAPDH
centriole 1 ALB
Secreted, extracellular space 1 CTSB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Lipid droplet 1 GAPDH
phagophore assembly site 2 ATG7, PIK3C3
phosphatidylinositol 3-kinase complex, class III, type I 1 PIK3C3
phosphatidylinositol 3-kinase complex, class III, type II 1 PIK3C3
Preautophagosomal structure membrane 1 ATG5
Atg12-Atg5-Atg16 complex 1 ATG5
mitochondria-associated endoplasmic reticulum membrane contact site 1 ATG5
phagophore assembly site membrane 1 ATG5
Melanosome 1 CTSB
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 2 ATG7, CTSB
secretory granule lumen 3 ATG7, INS, NFKB1
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, CD4, INS
platelet alpha granule lumen 1 ALB
specific granule lumen 1 NFKB1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
presynaptic endosome 1 PIK3C3
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 2 CD4, EGFR
ribonucleoprotein complex 1 GAPDH
endolysosome membrane 1 TLR9
basal dendrite 1 MAPK8
early phagosome 1 TLR9
Cytoplasmic vesicle, phagosome 1 TLR9
GAIT complex 1 GAPDH
Preautophagosomal structure 1 ATG7
transferase complex 1 ATG5
postsynaptic endosome 1 PIK3C3
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
peptidase inhibitor complex 1 CTSB
T cell receptor complex 1 CD4
Autolysosome 1 PIK3C3
endolysosome lumen 1 CTSB
endolysosome 1 TLR9
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
ciliary transition fiber 1 ALB
phagophore 1 ATG5


文献列表

  • Yujing Feng, Huaiqing Wei, Meng Lyu, Zhiyuan Yu, Jia Chen, Xinxing Lyu, Fengfeng Zhuang. Iron retardation in lysosomes protects senescent cells from ferroptosis. Aging. 2024 Apr; 16(9):7683-7703. doi: 10.18632/aging.205777. [PMID: 38683121]
  • Yuman Li, Ping Yu, Yingying Gao, Zitong Ma, Han Wang, Yuting Long, Zaina Ma, Renhui Liu. Effects of the combination of Epimedii Folium and Ligustri Lucidi Fructus on apoptosis and autophagy in SOP rats and osteoblasts via PI3K/AKT/mTOR pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Apr; 173(?):116346. doi: 10.1016/j.biopha.2024.116346. [PMID: 38428312]
  • Juan Long, Jiaxin Wang, Yuanyuan Dong, Jian Yang, Gang Xie, Ying Tong. Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling. Cellular signalling. 2024 Jan; 113(?):110940. doi: 10.1016/j.cellsig.2023.110940. [PMID: 38084839]
  • Laise Trindade Paes, Carolina Thomaz Dos Santos D'Almeida, Mariana Araújo Vieira do Carmo, Laura da Silva Cruz, Amanda Bubula de Souza, Leonara Martins Viana, Vinicius Gonçalves Maltarollo, Hércia Stampini Duarte Martino, Graziela Domingues de Almeida Lima, Mariana Simões Larraz Ferreira, Luciana Azevedo, Frederico Augusto Ribeiro de Barros. Phenolic-rich extracts from toasted white and tannin sorghum flours have distinct profiles influencing their antioxidant, antiproliferative, anti-adhesive, anti-invasive, and antimalarial activities. Food research international (Ottawa, Ont.). 2024 Jan; 176(?):113739. doi: 10.1016/j.foodres.2023.113739. [PMID: 38163694]
  • Jialu Zhang, Muhammad Shahbaz, Muhammad Ijaz, Huimin Zhang. Bibliometric analysis of antimalarial drug resistance. Frontiers in cellular and infection microbiology. 2024; 14(?):1270060. doi: 10.3389/fcimb.2024.1270060. [PMID: 38410722]
  • Tobiloba Christiana Elebiyo, Olarewaju Michael Oluba, Oluyomi Stephen Adeyemi. Anti-malarial and haematological evaluation of the ethanolic, ethyl acetate and aqueous fractions of Chromolaena odorata. BMC complementary medicine and therapies. 2023 Nov; 23(1):402. doi: 10.1186/s12906-023-04200-8. [PMID: 37946127]
  • Kun Wang, Jiatong Tang, Shengxian Fan, Haochen Su, Ranran Yu, Yixuan Zhang, Hao Wu, Ying Lv, Shu Zhang, Xiaoping Zou. ABBV-744 induces autophagy in gastric cancer cells by regulating PI3K/AKT/mTOR/p70S6k and MAPK signaling pathways. Neoplasia (New York, N.Y.). 2023 11; 45(?):100936. doi: 10.1016/j.neo.2023.100936. [PMID: 37769529]
  • Alessio Malfanti, Haider Sami, Anna Balasso, Giulia Marostica, Busra Arpac, Francesca Mastrotto, Giuseppe Mantovani, Elisa Cola, Martina Anton, Paolo Caliceti, Manfred Ogris, Stefano Salmaso. Control of cell penetration enhancer shielding and endosomal escape-kinetics crucial for efficient and biocompatible siRNA delivery. Journal of controlled release : official journal of the Controlled Release Society. 2023 11; 363(?):101-113. doi: 10.1016/j.jconrel.2023.09.022. [PMID: 37722420]
  • Gabrielle Ange Amang À Ngnoung, Yves Oscar Nganso Ditchou, Peron Bosco Leutcha, Darline Dize, Simplice Joël Ndendoung Tatsimo, Lauve Rachel Yamthe Tchokouaha, Theodora Kopa Kowa, Babalwa Tembeni, Hamadou Mamoudou, Madan Poka, Patrick Hulisani Demana, Xavier Siwe Noundou, Fabrice Fekam Boyom, Alain Meli Lannang. Antiplasmodial and Antileishmanial Activities of a New Limonoid and Other Constituents from the Stem Bark of Khaya senegalensis. Molecules (Basel, Switzerland). 2023 Oct; 28(20):. doi: 10.3390/molecules28207227. [PMID: 37894704]
  • Emmanuel Kofi Kumatia, Felix Kwame Zoiku, Alex Asase, Nguyen Huu Tung. In vitro and in silico anti-malarial activity and cytotoxicity of n-hexyl 1-O-rutinoside (a glycoside) isolated from Annickia polycarpa (DC.) Setten and Maas ex I.M. turner. (Annonaceae). Journal of ethnopharmacology. 2023 Oct; ?(?):117287. doi: 10.1016/j.jep.2023.117287. [PMID: 37827299]
  • Evelyn Assadian, Zhaleh Jamali, Ahmad Salimi, Jalal Pourahmad. Antioxidants and mitochondrial/lysosomal protective agents reverse toxicity induced by titanium dioxide nanoparticles on human lymphocytes. Toxicology and industrial health. 2023 Oct; 39(10):594-602. doi: 10.1177/07482337231196293. [PMID: 37593903]
  • Sayantan Pradhan, Samrat Hore, Stabak Roy, Simi Manna, Paulami Dam, Rittick Mondal, Amit Ghati, Trishanjan Biswas, Subhajit Shaw, Supriya Sharma, Waikhom Somraj Singh, Suman Kumar Maji, Sankarsan Roy, Aparajita Basu, Kailash C Pandey, Soumadri Samanta, Kapil Vashisht, Tuphan Kanti Dolai, Pratip Kumar Kundu, Saptarshi Mitra, Debasish Biswas, Abdul Sadat, Masuma Shokriyan, Amit Bikram Maity, Amit Kumar Mandal, İkbal Agah İnce. Geo-environmental factors and the effectiveness of mulberry leaf extract in managing malaria. Scientific reports. 2023 09; 13(1):14808. doi: 10.1038/s41598-023-41668-3. [PMID: 37684270]
  • Julee Verma, Ajit Kumar Rai, Neeraj Kumar Satija. Autophagy perturbation upon acute pyrethroid treatment impacts adipogenic commitment of mesenchymal stem cells. Pesticide biochemistry and physiology. 2023 Sep; 195(?):105566. doi: 10.1016/j.pestbp.2023.105566. [PMID: 37666621]
  • Anne Zebitz Eriksen, Fredrik Melander, Grace De Malona Eriksen, Paul Joseph Kempen, Andreas Kjaer, Thomas Lars Andresen, Andrew James Urquhart. Active Transport and Ocular Distribution of Intravitreally Injected Liposomes. Translational vision science & technology. 2023 Aug; 12(8):20. doi: 10.1167/tvst.12.8.20. [PMID: 37615641]
  • Ya-Yue Yang, Li-Xia Du, Jian-Yu Zhu, Ting Yi, Ya-Chen Yang, Zheng Qiao, Qi-Liang Maoying, Yu-Xia Chu, Yan-Qing Wang, Wen-Li Mi. Antipruritic effects of geraniol on acute and chronic itch via modulating spinal GABA/GRPR signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Jul; 119(?):154969. doi: 10.1016/j.phymed.2023.154969. [PMID: 37516088]
  • Lulu Niu, Wenwen Li, Xin Chen, Xiaosan Su, Jingjing Dong, Quanyang Liao, Xuhong Zhou, Shaoqing Shi, Ruifen Sun. 1-Monopalmitin promotes lung cancer cells apoptosis through PI3K/Akt pathway in vitro. Environmental toxicology. 2023 Jul; ?(?):. doi: 10.1002/tox.23897. [PMID: 37466199]
  • Zhao Deng, Dexin Shen, Mengxue Yu, Fenfang Zhou, Danni Shan, Yayun Fang, Wan Jin, Kaiyu Qian, Shenjuan Li, Gang Wang, Yi Zhang, Lingao Ju, Yu Xiao, Xinghuan Wang. Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways. Cell death discovery. 2023 Jul; 9(1):214. doi: 10.1038/s41420-023-01508-9. [PMID: 37393350]
  • Can Can Guo, Zhao Meng Xu, Yi Lyu, Xiao Hui Li, Zhao Fei Li, Hui He, Feng Jie Tian, Jin Ping Zheng. PM2.5 induces autophagy-dependent ferroptosis by endoplasmic reticulum stress in SH-SY5Y cells. Journal of applied toxicology : JAT. 2023 07; 43(7):1013-1025. doi: 10.1002/jat.4439. [PMID: 36700298]
  • Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects]. Medecine tropicale et sante internationale. 2023 06; 3(2):. doi: 10.48327/mtsi.v3i2.2023.378. [PMID: 37525671]
  • Ziying Ye, Chuna Li, Shuqiong Liu, Hongbin Liang, Jialiang Feng, Danyu Lin, Ying Chen, Sudan Peng, Lulu Bu, Enxiang Tao, Xiuna Jing, Yanran Liang. Dl-3-n-butylphthalide activates Nrf2, inhibits ferritinophagy, and protects MES23.5 dopaminergic neurons from ferroptosis. Chemico-biological interactions. 2023 Jun; ?(?):110604. doi: 10.1016/j.cbi.2023.110604. [PMID: 37315914]
  • Weifeng Tian, Dongmei He, Jingjing Liu, Feiyu Chen, Wenjie Zhang, Jinsheng Hu, Shu Wang. Topical borneol relieves nonhistaminergic pruritus via targeting TRPA1 and TRPM8 channels in peripheral nerve terminals of mice. European journal of pharmacology. 2023 Jun; 953(?):175833. doi: 10.1016/j.ejphar.2023.175833. [PMID: 37290679]
  • Christoph Beitzinger, Angelika Kronhardt, Roland Benz. Chloroquine-analogues block anthrax protective antigen channels in steady-state and kinetic studies. Toxicology. 2023 May; 492(?):153547. doi: 10.1016/j.tox.2023.153547. [PMID: 37201861]
  • Yenesew Wudu Ejigu, Bedilu Linger Endalifer. In vitro anti-plasmodial activity of three selected medicinal plants that are used in local traditional medicine in Amhara region of Ethiopia. BMC pharmacology & toxicology. 2023 05; 24(1):30. doi: 10.1186/s40360-023-00672-z. [PMID: 37170269]
  • Kyeong-Eon Park, Soo Hee Lee, Sung Il Bae, Yeran Hwang, Seong-Ho Ok, Dawon Kang, Seung Hyun Ahn, Gyujin Sim, Jin Kyeong Park, Ju-Tae Sohn. Chloroquine inhibits vasodilation induced by ATP-sensitive potassium channels in isolated rat aorta. General physiology and biophysics. 2023 May; 42(3):297-306. doi: 10.4149/gpb_2023008. [PMID: 37098743]
  • Ling Liu, Dan Shi, Zi-Yi Xia, Bo-Wen Wang, Xue-Li Wang, Xiao-Ting Wang, Guo-Li Wang, Min-Jing Li, Qiu-Sheng Zheng, Defang Li, Bo-Han Li. Gamabufotalin Induces Apoptosis and Cytoprotective Autophagy through the mTOR Signaling Pathway in Hepatocellular Carcinoma. Journal of natural products. 2023 Apr; 86(4):966-978. doi: 10.1021/acs.jnatprod.2c01155. [PMID: 37043698]
  • Pravin Phadatare, Jayanta Debnath. Lysosomal lipid peroxidation mediates immunogenic cell death. The Journal of clinical investigation. 2023 04; 133(8):. doi: 10.1172/jci169240. [PMID: 37066873]
  • Jun Li, Nasir Tajuddeen, Doris Feineis, Virima Mudogo, Marcel Kaiser, Ean-Jeong Seo, Thomas Efferth, Gerhard Bringmann. Jozibrevine D from Ancistrocladus ileboensis, the fifth alkaloid in a series of six possible atropo-diastereomeric naphthylisoquinoline dimers, showing antiparasitic and antileukemic activities. Bioorganic & medicinal chemistry letters. 2023 Apr; 86(?):129258. doi: 10.1016/j.bmcl.2023.129258. [PMID: 36972793]
  • Rifaldi, Arif Fadlan, Sri Fatmawati, Adi Setyo Purnomo, Taslim Ersam. Antiplasmodial and anticancer activities of xanthones isolated from Garcinia bancana Miq. Natural product research. 2023 Apr; ?(?):1-6. doi: 10.1080/14786419.2023.2199212. [PMID: 37029625]
  • Trinh Van Le, Hong-Thuy Phan-Thi, My-Xuan Huynh-Thi, Thanh Minh Dang, Ai Xuan Le Holterman, Gabriele Grassi, Thao-Uyen Nguyen-Luu, Nhung Hai Truong. Autophagy Inhibitor Chloroquine Downmodulates Hepatic Stellate Cell Activation and Liver Damage in Bile-Duct-Ligated Mice. Cells. 2023 03; 12(7):. doi: 10.3390/cells12071025. [PMID: 37048098]
  • Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis. Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations. Journal of natural products. 2023 03; 86(3):557-565. doi: 10.1021/acs.jnatprod.2c01041. [PMID: 36799121]
  • Gabrielle Ange Amang À Ngnoung, Lazare S Sidjui, Peron B Leutcha, Yves O Nganso Ditchou, Lauve R Y Tchokouaha, Gaëtan Herbette, Beatrice Baghdikian, Theodora K Kowa, Desire Soh, Raoul Kemzeu, Madan Poka, Patrick H Demana, Xavier Siwe Noundou, Alembert T Tchinda, Fabrice Fekam Boyom, Alain M Lannang, Barthélemy Nyassé. Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae). Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062730. [PMID: 36985700]
  • Brice Maxime Nkouayeb Nangmou, Hermine Laure Maza Djomkam, Georges Bellier Tabekoueng, Willifred Dongmo Tékapi Tsopgni, Gabin Thierry Mbahbou Bitchagno, Michel Arnaud Mbock, Raceline Gounoue Kamkumo, Marcel Frese, Bruno Ndjakou Lenta, Silvère Augustin Ngouela, Nobert Sewald, Anatole Guy Blaise Azebaze. Bioguided Fractionation and Isolation of an Antiplasmodial Saponin from the Roots of Nauclea xanthoxylon (A.Chev.) Aubrév. (Rubiaceae). Chemistry & biodiversity. 2023 Mar; ?(?):e202200271. doi: 10.1002/cbdv.202200271. [PMID: 36890112]
  • Lu Liu, Zongshan Zhang, Hui Liu, Shengnan Zhu, Taoxun Zhou, Chunqun Wang, Min Hu. Identification and characterisation of the haemozoin of Haemonchus contortus. Parasites & vectors. 2023 Mar; 16(1):88. doi: 10.1186/s13071-023-05714-3. [PMID: 36879311]
  • Gergő Tóth, Kata Horváti, Márta Kraszni, Tim Ausbüttel, Bernadett Pályi, Zoltán Kis, Zoltán Mucsi, Gábor M Kovács, Szilvia Bősze, Imre Boldizsár. Arylnaphthalene Lignans with Anti-SARS-CoV-2 and Antiproliferative Activities from the Underground Organs of Linum austriacum and Linum perenne. Journal of natural products. 2023 Mar; ?(?):. doi: 10.1021/acs.jnatprod.2c00580. [PMID: 36857518]
  • Sudarshana Rajasekaran, Anand Ramaian Santhaseela, Shamila Ragunathan, Sangita Venkataraman, Tamilselvan Jayavelu. Altered Lysosomal Function Manipulates Cellular Biosynthetic Capacity By Remodeling Intracellular Cholesterol Distribution. Cell biochemistry and biophysics. 2023 Mar; 81(1):29-38. doi: 10.1007/s12013-022-01123-y. [PMID: 36459362]
  • Genlin Sun, Dong Min Choi, Helong Xu, Sung Hyeon Baeck, Kyung Ho Row, Weiyang Tang. Lipase-based MIL-100(Fe) biocomposites as chiral stationary phase for high-efficiency capillary electrochromatographic enantioseparation. Mikrochimica acta. 2023 02; 190(3):84. doi: 10.1007/s00604-023-05647-9. [PMID: 36749401]
  • Vietxuan Phan, Denisa Hathazi, Corinna Preuße, Artur Czech, Erik Freier, Gerta Shema, René P Zahedi, Andreas Roos. Molecular mechanisms in chloroquine-exposed muscle cells elucidated by combined proteomic and microscopic studies. Neuropathology and applied neurobiology. 2023 02; 49(1):e12877. doi: 10.1111/nan.12877. [PMID: 36633103]
  • Chang Guo, Linyan Zheng, Shuyu Chen, Xuxuan Liang, Xue Song, Yue Wang, Baoyu Hua, Longxin Qiu. Thymol ameliorates ethanol-induced hepatotoxicity via regulating metabolism and autophagy. Chemico-biological interactions. 2023 Jan; 370(?):110308. doi: 10.1016/j.cbi.2022.110308. [PMID: 36535314]
  • Mingming Fang, Chen Zhong. Vitamin D Receptor Regulates Autophagy to Inhibit Apoptosis and Promote Proliferation in Hepatocyte Injury. Journal of Nippon Medical School = Nippon Ika Daigaku zasshi. 2023; 90(1):89-95. doi: 10.1272/jnms.jnms.2023_90-114. [PMID: 36908130]
  • Pugazhenthan Thangaraju, Gopinathan Narasimhan, Vijayakumar Arumugam Ramamurthy, Meenalochini Prakash Gurunthalingam, Sree Sudha Tanguturi Yella, Sajitha Venkatesan, Eswaran Thangaraju. Molecular Docking Analysis of Adhatoda vasica with Thromboxane A2 Receptor (TXA2R) (6IIU) and Antiviral Molecules for Possible Dengue Complications. Infectious disorders drug targets. 2023; 23(1):e180722206836. doi: 10.2174/1871526522666220718101544. [PMID: 35850647]
  • Pegah Shakib, Abdolrazagh Marzban, Omid Mardanshah, Shirzad Fallahi, Israr Ali Khan, Mohammad Azarhazin, Kourosh Cheraghipour. New Strategies in the Treatment of Plasmodium berghei Based on Nanoparticles: A Systematic Review. Current pharmaceutical biotechnology. 2023; 24(11):1376-1382. doi: 10.2174/1389201024666230103111833. [PMID: 36597608]
  • Hanjun Zhao, Lu Lu, Zheng Peng, Lin-Lei Chen, Xinjin Meng, Chuyuan Zhang, Jonathan Daniel Ip, Wan-Mui Chan, Allen Wing-Ho Chu, Kwok-Hung Chan, Dong-Yan Jin, Honglin Chen, Kwok-Yung Yuen, Kelvin Kai-Wang To. SARS-CoV-2 Omicron variant shows less efficient replication and fusion activity when compared with Delta variant in TMPRSS2-expressed cells. Emerging microbes & infections. 2022 Dec; 11(1):277-283. doi: 10.1080/22221751.2021.2023329. [PMID: 34951565]
  • H F Safar, A H Ali, N H Zakaria, N Kamal, N I Hassan, H K Agustar, N Talip, J Latip. Steroids from Diplazium esculentum: Antiplasmodial activity and molecular docking studies to investigate their binding modes. Tropical biomedicine. 2022 Dec; 39(4):552-558. doi: 10.47665/tb.39.4.011. [PMID: 36602215]
  • Fengming Xu, Hans-Michael Tautenhahn, Olaf Dirsch, Uta Dahmen. Blocking autophagy with chloroquine aggravates lipid accumulation and reduces intracellular energy synthesis in hepatocellular carcinoma cells, both contributing to its anti-proliferative effect. Journal of cancer research and clinical oncology. 2022 Dec; 148(12):3243-3256. doi: 10.1007/s00432-022-04074-2. [PMID: 35695930]
  • Tiantian Cai, Jing Zhao, Yanping Yang, Yanfei Jiang, Jin-An Zhang. Hydroxychloroquine use reduces mortality risk in systemic lupus erythematosus: A systematic review and meta-analysis of cohort studies. Lupus. 2022 Dec; 31(14):1714-1725. doi: 10.1177/09612033221129774. [PMID: 36325952]
  • Md Fahad Zamil, Saiful Arefeen Sazed, Muhammad Riadul Haque Hossainey, Anik Biswas, Mohammad Shafiul Alam, Hamida Khanum, Priyanka Barua. Anti-malarial investigation of Acorus calamus, Dichapetalum gelonioides, and Leucas aspera on Plasmodium falciparum strains. Journal of infection in developing countries. 2022 11; 16(11):1768-1772. doi: 10.3855/jidc.16741. [PMID: 36449650]
  • Titilayo Omolara Johnson, Abayomi Emmanuel Adegboyega, Grace I Johnson, Ngozi L Umedum, Olasunkanmi D Bamidele, Ayodele O Elekan, Christopher T Tarkaa, Asma'u Mahe, Adamu Abdulrahman, Olugbenga E Adeyemi, Desmond Okafor, Amina J Yusuf, Odunayo C Atewolara-Odule, Abdulrazaq O Ogunmoye, Tanko Ishaya. Uncovering the inhibitory potentials of Phyllanthus nivosus leaf and its bioactive compounds against Plasmodium lactate dehydrogenase for malaria therapy. Journal of biomolecular structure & dynamics. 2022 Nov; ?(?):1-10. doi: 10.1080/07391102.2022.2146750. [PMID: 36411736]
  • Dancan M Wakoli, Bartholomew N Ondigo, Douglas O Ochora, Joseph G Amwoma, Winnie Okore, Edwin W Mwakio, Gladys Chemwor, Jackeline Juma, Raphael Okoth, Charles Okudo, Redemptah Yeda, Benjamin H Opot, Agnes C Cheruiyot, Dennis Juma, Amanda Roth, Benhards R Ogutu, Daniel Boudreaux, Ben Andagalu, Hoseah M Akala. Impact of parasite genomic dynamics on the sensitivity of Plasmodium falciparum isolates to piperaquine and other antimalarial drugs. BMC medicine. 2022 11; 20(1):448. doi: 10.1186/s12916-022-02652-2. [PMID: 36397090]
  • Soo Hee Lee, Seong-Ho Ok, Seung Hyun Ahn, Gyujin Sim, Hyun-Jin Kim, Mingu Kim, Sangcheol Yoon, Ju-Tae Sohn. Lipid emulsion inhibits the cardiac toxicity caused by chloroquine via inhibition of reactive oxygen species production. Korean journal of anesthesiology. 2022 Nov; ?(?):. doi: 10.4097/kja.22572. [PMID: 36377332]
  • Wenyuan He, Andy Tran, Chuck T Chen, Neruja Loganathan, Richard P Bazinet, Denise D Belsham. Oleate restores altered autophagic flux to rescue palmitate lipotoxicity in hypothalamic neurons. Molecular and cellular endocrinology. 2022 11; 557(?):111753. doi: 10.1016/j.mce.2022.111753. [PMID: 35981630]
  • Denise Maria Figueiredo Araújo, Iranildo José da Cruz Filho, Tiago Santos, Daniel Tarciso Martins Pereira, Diego Santa Clara Marques, Alice da Conceição Alves de Lima, Thiago Mendonça de Aquino, George Jackson de Moraes Rocha, Maria do Carmo Alves de Lima, Fátima Nogueira. Biological activities and physicochemical characterization of alkaline lignins obtained from branches and leaves of Buchenavia viridiflora with potential pharmaceutical and biomedical applications. International journal of biological macromolecules. 2022 Oct; 219(?):224-245. doi: 10.1016/j.ijbiomac.2022.07.225. [PMID: 35926677]
  • Zhaoqi He, Peng Shen, Lianjun Feng, Haoyang Hao, Yuhong He, Guyue Fan, Zhuoyu Liu, Kun Zhu, Yiqi Wang, Naisheng Zhang, Xiaoyu Hu, Yunhe Fu, Jiacheng Wu. Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis. Ecotoxicology and environmental safety. 2022 Oct; 245(?):114123. doi: 10.1016/j.ecoenv.2022.114123. [PMID: 36183427]
  • Samuel Toluwani Akinyele, Christianah Abimbola Elusiyan, Nusrat Omotayo Omisore, Clement Oladapo Adewunmi. ANTIMALARIAL activities and alkaloids from Crinum jagus (Thomps) DANDY. Journal of ethnopharmacology. 2022 Oct; 296(?):115359. doi: 10.1016/j.jep.2022.115359. [PMID: 35605920]
  • Blaise Cedric Kamdoum, Ingrid Simo, Steven Collins Njonte Wouamba, Brice Mariscal Tchatat Tali, Bathelemy Ngameni, Ghislain Wabo Fotso, Pantaléon Ambassa, Fekam Boyom Fabrice, Bruno Ndjakou Lenta, Norbert Sewald, Bonaventure Tchaleu Ngadjui. Chemical constituents of two Cameroonian medicinal plants: Sida rhombifolia L. and Sida acuta Burm. f. (Malvaceae) and their antiplasmodial activity. Natural product research. 2022 Oct; 36(20):5311-5318. doi: 10.1080/14786419.2021.1937156. [PMID: 34121522]
  • Haresh S Kalasariya, Nikunj B Patel, Amel Gacem, Taghreed Alsufyani, Lisa M Reece, Virendra Kumar Yadav, Nasser S Awwad, Hala A Ibrahium, Yongtae Ahn, Krishna Kumar Yadav, Byong-Hun Jeon. Marine Alga Ulva fasciata-Derived Molecules for the Potential Treatment of SARS-CoV-2: An In Silico Approach. Marine drugs. 2022 Sep; 20(9):. doi: 10.3390/md20090586. [PMID: 36135775]
  • Neha Bajwa, Shipra Mahal, Srishti Naryal, Preet Amol Singh, Ashish Baldi. Development of Novel Solid Nanostructured Lipid Carriers for Bioavailability Enhancement Using a Quality by Design Approach. AAPS PharmSciTech. 2022 Sep; 23(7):253. doi: 10.1208/s12249-022-02386-7. [PMID: 36109467]
  • Jean W Liew, Elizabeth R Graef, Jeffrey A Sparks, Alfred Hyoungju Kim. Response to: 'Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?' by Santos-Moreno et al. Annals of the rheumatic diseases. 2022 Aug; 81(8):e155. doi: 10.1136/annrheumdis-2020-218432. [PMID: 32647030]
  • Ghada A Gamea, Dalia A Elmehy, Amina M Salama, Nema A Soliman, Omayma K Afifi, Heba H Elkaliny, Rehab E Abo El Gheit, Ahmad A El-Ebiary, Dina M Tahoon, Reem A Elkholy, Sarah M Shoeib, Mohamed A Eleryan, Salwa S Younis. Direct and indirect antiparasitic effects of chloroquine against the virulent RH strain of Toxoplasma gondii: An experimental study. Acta tropica. 2022 Aug; 232(?):106508. doi: 10.1016/j.actatropica.2022.106508. [PMID: 35568067]
  • Ali Tugrul Akin, Emin Kaymak, Tayfun Ceylan, Emel Ozturk, Kemal Erdem Basaran, Derya Karabulut, Saim Ozdamar, Birkan Yakan. Chloroquine attenuates chronic hypoxia-induced testicular damage via suppressing endoplasmic reticulum stress and apoptosis in experimental rat model. Clinical and experimental pharmacology & physiology. 2022 08; 49(8):813-823. doi: 10.1111/1440-1681.13669. [PMID: 35579513]
  • Pedro Santos-Moreno, Diana Buitrago-Garcia, Laura Villarreal, Anggie Aza, Michael Cabrera, Wilberto Rivero, Adriana Rojas-Villarraga. Emergency arising from patients' fear of taking antimalarials during these COVID-19 times: are antimalarials as unsafe for cardiovascular health as recent reports suggest?. Annals of the rheumatic diseases. 2022 Aug; 81(8):e154. doi: 10.1136/annrheumdis-2020-218259. [PMID: 32647029]
  • Li Wang, Yueying Pan, Fan Yang, Xiaowang Guo, Junjun Peng, Xiaoyu Wang, Yukun Fang, Jing Chen, Xin Yi, Huabin Cao, Guoliang Hu. New sight into interaction between endoplasmic reticulum stress and autophagy induced by vanadium in duck renal tubule epithelial cells. Chemico-biological interactions. 2022 Aug; 362(?):109981. doi: 10.1016/j.cbi.2022.109981. [PMID: 35588787]
  • Bhagteshwar Singh, Hannah Ryan, Tamara Kredo, Marty Chaplin, Tom Fletcher. Chloroquine or hydroxychloroquine for prevention and treatment of COVID-19. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2022 Aug; 34(4):305-307. doi: NULL. [PMID: 35833770]
  • Hua-Di Yang, Qun-Fei Zhu, Hui Li, Xue-Lu Jiang, Xu-Qun Xu, Yong Guo. Effect of Neiyi Prescription of QIU on autophagy and angiogenic ability of endometriosis via the PPARγ/NF-κB signaling pathway. Archives of gynecology and obstetrics. 2022 08; 306(2):533-545. doi: 10.1007/s00404-022-06537-w. [PMID: 35366690]
  • Hae Soo Yun, Sylvatrie-Danne Dinzouna-Boutamba, Sanghyun Lee, Zin Moon, Dongmi Kwak, Dong-Il Chung, Yeonchul Hong, Man Hee Rhee, Youn-Kyoung Goo. Petasites japonicus extract exerts anti-malarial effects by inhibiting platelet activation. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154167. doi: 10.1016/j.phymed.2022.154167. [PMID: 35598522]
  • Lucia Račková, Erika Csekes. Redox aspects of cytotoxicity and anti-neuroinflammatory profile of chloroquine and hydroxychloroquine in serum-starved BV-2 microglia. Toxicology and applied pharmacology. 2022 07; 447(?):116084. doi: 10.1016/j.taap.2022.116084. [PMID: 35618033]
  • Ahmed I Ashmawy, Hanan S El-Abhar, Dalaal M Abdallah, Mennatallah A Ali. Chloroquine modulates the sulforaphane anti-obesity mechanisms in a high-fat diet model: Role of JAK-2/ STAT-3/ SOCS-3 pathway. European journal of pharmacology. 2022 Jul; 927(?):175066. doi: 10.1016/j.ejphar.2022.175066. [PMID: 35643302]
  • Xiuge Gao, Xian Jing, Junqi Wang, Yuling Zheng, Yawei Qiu, Hui Ji, Lin Peng, Shanxiang Jiang, Wenda Wu, Dawei Guo. Safety considerations of chloroquine in the treatment of patients with diabetes and COVID-19. Chemico-biological interactions. 2022 Jul; 361(?):109954. doi: 10.1016/j.cbi.2022.109954. [PMID: 35469826]
  • Peng Gao, Yan-Qing Liu, Wei Xiao, Fei Xia, Jia-Yun Chen, Li-Wei Gu, Fan Yang, Liu-Hai Zheng, Jun-Zhe Zhang, Qian Zhang, Zhi-Jie Li, Yu-Qing Meng, Yong-Ping Zhu, Huan Tang, Qiao-Li Shi, Qiu-Yan Guo, Ying Zhang, Cheng-Chao Xu, Ling-Yun Dai, Ji-Gang Wang. Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA. Military Medical Research. 2022 06; 9(1):30. doi: 10.1186/s40779-022-00390-3. [PMID: 35698214]
  • Clifford TeBay, Jeffrey R McArthur, Melissa Mangala, Nicholas Kerr, Stewart Heitmann, Matthew D Perry, Monique J Windley, Jamie I Vandenberg, Adam P Hill. Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation. British journal of pharmacology. 2022 06; 179(11):2631-2646. doi: 10.1111/bph.15757. [PMID: 34837219]
  • Wen Zhang, Chenman Qin, Yunyun Fei, Min Shen, Yangzhong Zhou, Yan Zhang, Xiaofeng Zeng, Shuyang Zhang. Anti-inflammatory and immune therapy in severe coronavirus disease 2019 (COVID-19) patients: An update. Clinical immunology (Orlando, Fla.). 2022 Jun; 239(?):109022. doi: 10.1016/j.clim.2022.109022. [PMID: 35477027]
  • Thorsten R Doeppner, Cristin Coman, Daiana Burdusel, Diana-Larisa Ancuta, Ulf Brockmeier, Daniel Nicolae Pirici, Kuang Yaoyun, Dirk M Hermann, Aurel Popa-Wagner. Long-term treatment with chloroquine increases lifespan in middle-aged male mice possibly via autophagy modulation, proteasome inhibition and glycogen metabolism. Aging. 2022 05; 14(10):4195-4210. doi: 10.18632/aging.204069. [PMID: 35609021]
  • Verónica Martín, Miguel Sanz-Novo, Iker León, Pilar Redondo, Antonio Largo, Carmen Barrientos. Computational study on the affinity of potential drugs to SARS-CoV-2 main protease. Journal of physics. Condensed matter : an Institute of Physics journal. 2022 05; 34(29):. doi: 10.1088/1361-648x/ac6c6c. [PMID: 35504274]
  • Zainab Jan, Muhammad Aqeel, Ammara Munir, Aamir Saeed, Haleema Sadia, Saeeda Kalsoom, Tariq Nadeem, Zainab Bashir, Larayb Awan, Sami Ud Din, Ghulam Muhammad Ali. In silico-prediction of chloroquine as a multi-targeted drug against CDKN2A signaling network associated with cutaneous malignant melanoma. Pakistan journal of pharmaceutical sciences. 2022 May; 35(3):731-739. doi: . [PMID: 35791470]
  • J O Adebayo, I P Ceravolo, G A Gyebi, O E Olorundare, A S Babatunde, J P Penna-Coutinho, M Koketsu, A U Krettli. Iloneoside, an antimalarial pregnane glycoside isolated from Gongronema latifolium leaf, potentiates the activity of chloroquine against multidrug resistant Plasmodium falciparum. Molecular and biochemical parasitology. 2022 05; 249(?):111474. doi: 10.1016/j.molbiopara.2022.111474. [PMID: 35307401]
  • Sandeep Kumar S, Shalini N Swamy, Varadahally Rangaiah Devaraj, Chennagiri S Premalatha, V R Pallavi, Bk Chandrashekar Sagar, Dhananjay D Shinde, Ramesh Gawari. Metabolic Reprogramming and Lipophagy Mediates Survival of Ascites Derived Metastatic Ovarian Cancer Cells. Asian Pacific journal of cancer prevention : APJCP. 2022 05; 23(5):1699-1709. doi: 10.31557/apjcp.2022.23.5.1699. [PMID: 35633555]
  • Toussaint Rouamba, Esperance Ouédraogo, Houreratou Barry, Nobila Valentin Yaméogo, Apoline Sondo, Rainatou Boly, Jacques Zoungrana, Abdoul Risgou Ouédraogo, Marc Christian Tahita, Armel Poda, Arnaud Eric Diendéré, Abdoul-Salam Ouedraogo, Innocent Valea, Isidore Traoré, Zekiba Tarnagda, Maxime K Drabo, Halidou Tinto. Assessment of Recovery Time, Worsening, and Death among Inpatients and Outpatients with COVID-19, Treated with Hydroxychloroquine or Chloroquine plus Azithromycin Combination in Burkina Faso. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2022 May; 118(?):224-229. doi: 10.1016/j.ijid.2022.02.034. [PMID: 35227869]
  • Mei Nee Chiu, Maitry Bhardwaj, Sangeeta Pilkhwal Sah. Safety profile of COVID-19 drugs in a real clinical setting. European journal of clinical pharmacology. 2022 May; 78(5):733-753. doi: 10.1007/s00228-021-03270-2. [PMID: 35088108]
  • Anmol, Surekha Kumari, Rakesh Kumar, Raman Singh, Gaurav Aggarwal, Prakhar Agrawal, Dinkar Sahal, Upendra Sharma. Antiplasmodial diterpenoid alkaloid from Aconitum heterophyllum Wall. ex Royle: Isolation, characterization, and UHPLC-DAD based quantification. Journal of ethnopharmacology. 2022 Apr; 287(?):114931. doi: 10.1016/j.jep.2021.114931. [PMID: 34942322]
  • Dhaval Patel, Mohd Athar, P C Jha. Computational investigation of binding of chloroquinone and hydroxychloroquinone against PLPro of SARS-CoV-2. Journal of biomolecular structure & dynamics. 2022 04; 40(7):3071-3081. doi: 10.1080/07391102.2020.1844804. [PMID: 33200683]
  • Yuhao Wang, Yonglun Wang, Fang Li, Jie Zou, Xiaoqian Li, Mengxia Xu, Daojiang Yu, Yijia Ma, Wei Huang, Xiaodong Sun, Yuanyuan Zhang. Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells. Cells. 2022 03; 11(7):. doi: 10.3390/cells11071067. [PMID: 35406631]
  • Kadarkarai Murugan, Chellasamy Panneerselvam, Jayapal Subramaniam, Manickam Paulpandi, Rajapandian Rajaganesh, Murugan Vasanthakumaran, Jagannathan Madhavan, S Syed Shafi, Mathath Roni, Johan S Portilla-Pulido, Stelia C Mendez, Jonny E Duque, Lan Wang, Al Thabiani Aziz, Balamurugan Chandramohan, Devakumar Dinesh, Shanmughavel Piramanayagam, Jiang-Shiou Hwang. Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases. Scientific reports. 2022 03; 12(1):4765. doi: 10.1038/s41598-022-08397-5. [PMID: 35306526]
  • David A Forero-Peña, Matthew M Hernandez, Iriana Paola Mozo Herrera, Iván Bolívar Collado Espinal, Joselyn Páez Paz, Carlos Ferro, David M Flora-Noda, Andrea L Maricuto, Viledy L Velásquez, Natasha A Camejo-Avila, Emilia M Sordillo, Lourdes A Delgado-Noguera, Luis A Perez-Garcia, Carlos G Morantes Rodríguez, María Eugenia Landaeta, Alberto E Paniz-Mondolfi. Remitting neuropsychiatric symptoms in COVID-19 patients: Viral cause or drug effect?. Journal of medical virology. 2022 03; 94(3):1154-1161. doi: 10.1002/jmv.27443. [PMID: 34755347]
  • Yanan Zhao, Ankang Mao, Ranran Zhang, Shuang Guan, Jing Lu. SIRT1/mTOR pathway-mediated autophagy dysregulation promotes Pb-induced hepatic lipid accumulation in HepG2 cells. Environmental toxicology. 2022 Mar; 37(3):549-563. doi: 10.1002/tox.23420. [PMID: 34842334]
  • Konstantin P Katin, Alexey I Kochaev, Savas Kaya, Fadoua El-Hajjaji, Mikhail M Maslov. Ab Initio Insight into the Interaction of Metal-Decorated Fluorinated Carbon Fullerenes with Anti-COVID Drugs. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042345. [PMID: 35216462]
  • Carolina Q Sacramento, Natalia Fintelman-Rodrigues, Suelen S G Dias, Jairo R Temerozo, Aline de Paula D Da Silva, Carine S da Silva, Camilla Blanco, André C Ferreira, Mayara Mattos, Vinicius C Soares, Filipe Pereira-Dutra, Milene Dias Miranda, Debora F Barreto-Vieira, Marcos Alexandre N da Silva, Suzana S Santos, Mateo Torres, Otávio Augusto Chaves, Rajith K R Rajoli, Alberto Paccanaro, Andrew Owen, Dumith Chequer Bou-Habib, Patrícia T Bozza, Thiago Moreno L Souza. Unlike Chloroquine, Mefloquine Inhibits SARS-CoV-2 Infection in Physiologically Relevant Cells. Viruses. 2022 02; 14(2):. doi: 10.3390/v14020374. [PMID: 35215969]
  • Aditya R Kolli, Tanja Zivkovic Semren, David Bovard, Shoaib Majeed, Marco van der Toorn, Sophie Scheuner, Philippe A Guy, Arkadiusz Kuczaj, Anatoly Mazurov, Stefan Frentzel, Florian Calvino-Martin, Nikolai V Ivanov, John O'Mullane, Manuel C Peitsch, Julia Hoeng. Pulmonary Delivery of Aerosolized Chloroquine and Hydroxychloroquine to Treat COVID-19: In Vitro Experimentation to Human Dosing Predictions. The AAPS journal. 2022 02; 24(1):33. doi: 10.1208/s12248-021-00666-x. [PMID: 35132508]
  • Jing Zhang, Jing-Jing Zhu, Si-Qi He, Jian-Xun Wang. Efficacy of glucocorticoids, chloroquine and vitamin A on cytokine release syndrome: a network pharmacology study. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2022 02; 42(1):116-121. doi: . [PMID: 35294131]
  • Theo Rein. Harnessing autophagy to fight SARS-CoV-2: An update in view of recent drug development efforts. Journal of cellular biochemistry. 2022 02; 123(2):155-160. doi: 10.1002/jcb.30166. [PMID: 34668225]
  • John O Olanlokun, Wisdom Oshireku Abiodun, Oluwakemi Ebenezer, Neil A Koorbanally, Olufunso Olabode Olorunsogo. Curcumin modulates multiple cell death, matrix metalloproteinase activation and cardiac protein release in susceptible and resistant Plasmodium berghei-infected mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112454. doi: 10.1016/j.biopha.2021.112454. [PMID: 34894518]
  • Emmanuel O Adeyoju, Clement O Ajayi, Awodayo O Adepiti, Anthony A Elujoba. Comparative in vivo antimalarial activities of aqueous and methanol extracts of MAMA powder - A herbal antimalarial preparation. Journal of ethnopharmacology. 2022 Jan; 283(?):114686. doi: 10.1016/j.jep.2021.114686. [PMID: 34571079]
  • André Daher, Douglas Pereira Pinto, Laís Bastos da Fonseca, Heliana Martins Pereira, Diego Medeiros Dias da Silva, Letícia de Sá Fernandes Vallim da Silva, Alessandra Lanzillotta Esteves, Juliana J Soares Medeiros, Jorge Souza Mendonça. Pharmacokinetics of chloroquine and primaquine in healthy volunteers. Malaria journal. 2022 Jan; 21(1):16. doi: 10.1186/s12936-021-04035-z. [PMID: 34998391]
  • Martina P Liebl, Sarah C Meister, Lisa Frey, Kristina Hendrich, Anja Klemmer, Bettina Wohlfart, Christopher Untucht, Judith Nuber, Christian Pohl, Viktor Lakics. Robust LC3B lipidation analysis by precisely adjusting autophagic flux. Scientific reports. 2022 01; 12(1):79. doi: 10.1038/s41598-021-03875-8. [PMID: 34996966]
  • Xiao Lyu, Xuhui Zhang, Libin Sun, Jingqi Wang, Dongwen Wang. Inhibitory Effect of Ursolic Acid on Proliferation and Migration of Renal Carcinoma Cells and Its Mechanism. Computational intelligence and neuroscience. 2022; 2022(?):1529132. doi: 10.1155/2022/1529132. [PMID: 35571705]
  • Orsolya Kapuy, Tamás Korcsmáros. Chloroquine and COVID-19-A systems biology model uncovers the drug's detrimental effect on autophagy and explains its failure. PloS one. 2022; 17(4):e0266337. doi: 10.1371/journal.pone.0266337. [PMID: 35390060]
  • Cafer Saka. Analytical Methods on Determination in Pharmaceuticals and Biological Materials of Chloroquine as Available for the Treatment of COVID-19. Critical reviews in analytical chemistry. 2022; 52(1):19-34. doi: 10.1080/10408347.2020.1781592. [PMID: 32628049]
  • Canan Demir, Ahmet Ugur Demir. Letter to the editor: The effect of hydroxychloroquine on COVID-19. Journal of infection and public health. 2022 01; 15(1):68. doi: 10.1016/j.jiph.2021.12.006. [PMID: 34922225]
  • Shuang Liu, Xiangfu Gao, Zhenliang Fan, Qiao Wang. SIRT2 Affects Cell Proliferation and Apoptosis by Suppressing the Level of Autophagy in Renal Podocytes. Disease markers. 2022; 2022(?):4586198. doi: 10.1155/2022/4586198. [PMID: 35493297]
  • Aditya R Kolli, Florian Calvino-Martin, Julia Hoeng. Translational Modeling of Chloroquine and Hydroxychloroquine Dosimetry in Human Airways for Treating Viral Respiratory Infections. Pharmaceutical research. 2022 Jan; 39(1):57-73. doi: 10.1007/s11095-021-03152-3. [PMID: 35000036]
  • Stefanie Wüstner, Sara Hogger, Daniela Gartner-Freyer, Andrea Lebioda, Katharina Schley, Friedhelm Leverkus. Clinical Evidence Informing Treatment Guidelines on Repurposed Drugs for Hospitalized Patients During the Early COVID-19 Pandemic: Corticosteroids, Anticoagulants, (Hydroxy)chloroquine. Frontiers in public health. 2022; 10(?):804404. doi: 10.3389/fpubh.2022.804404. [PMID: 35252090]