Pristimerin (BioDeep_00000406502)

Main id: BioDeep_00000000415

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-11-keto-2,4a,6a,6a,9,14a-hexamethyl-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid methyl ester

化学式: C30H40O4 (464.29264400000005)
中文名称: 扁塑藤素, 扁塑藤素
谱图信息: 最多检出来源 Viridiplantae(plant) 50%

分子结构信息

SMILES: CC1=C(C(=O)C=C2C1=CC=C1[C@@]2(C)CC[C@@]2(C)[C@@H]3C[C@@](C)(CC[C@]3(C)CC[C@]12C)C(=O)OC)O
InChI: InChI=1S/C30H40O4/c1-18-19-8-9-22-28(4,20(19)16-21(31)24(18)32)13-15-30(6)23-17-27(3,25(33)34-7)11-10-26(23,2)12-14-29(22,30)5/h8-9,16,23,32H,10-15,17H2,1-7H3/t23-,26-,27-,28+,29-,30+/m1/s1

描述信息

Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM.
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM.
Pristimerin is a potent and reversible monoacylglycerol lipase (MGL) inhibitor with an IC50 of 93 nM.

同义名列表

29 个代谢物同义名

(2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-11-keto-2,4a,6a,6a,9,14a-hexamethyl-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid methyl ester; (2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid methyl ester; methyl (2R,4aS,6aS,6aR,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylate; D:A-Friedo-24-noroleana-1(10),3,5,7-tetraen-29-oic acid, 3-hydroxy-2-oxo-, methyl ester, (20alpha)- (9CI); Celastrol-methylether; SDCCGMLS-0066814.P001; Spectrum4_001681; Spectrum5_000322; Spectrum3_001651; Spectrum2_000546; SPECTRUM1504181; Spectrum_001558; SpecPlus_000649; MEGxp0_000269; BSPBio_003401; DivK1c_006745; KBioSS_002038; KBioGR_001942; ACon0_000836; KBio2_007174; KBio3_002621; KBio2_004606; SPBio_000591; KBio2_002038; KBio1_001689; Pristimerin; 1258-84-0; C08633; Celastrol methyl ester



数据库引用编号

29 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

36 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Tao, Xiangyu Xia, Shujing Kong, Tingye Wang, Fangtian Fan, Weimin Wang. Natural pentacyclic triterpenoid from Pristimerin sensitizes p53-deficient tumor to PARP inhibitor by ubiquitination of Chk1. Pharmacological research. 2024 Feb; ?(?):107091. doi: 10.1016/j.phrs.2024.107091. [PMID: 38316371]
  • Jian Sun, Zhaochun Tian, Jing Wu, Jiafei Li, Qixia Wang, Shuhong Huang, Meng Wang. Pristimerin Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review. Drug design, development and therapy. 2024; 18(?):1673-1694. doi: 10.2147/dddt.s460093. [PMID: 38779590]
  • Fan Yang, Xiao-Lan Jiang, Akash Tariq, Sehrish Sadia, Zeeshan Ahmed, Jordi Sardans, Muhammad Aleem, Riaz Ullah, Rainer W Bussmann. Potential medicinal plants involved in inhibiting 3CLpro activity: A practical alternate approach to combating COVID-19. Journal of integrative medicine. 2022 11; 20(6):488-496. doi: 10.1016/j.joim.2022.08.001. [PMID: 35985974]
  • YingZheng Wang, WeiKe Feng, XueZhen Wang, Xiao Li, Yue Mou, XiaoYan Wang, YaNan Zhang. The multifaceted mechanisms of pristimerin in the treatment of tumors state-of-the-art. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Oct; 154(?):113575. doi: 10.1016/j.biopha.2022.113575. [PMID: 35988422]
  • Kajal Nagpal, Madhukar Garg, Deepshi Arora, Abhilasha Dubey, Ajmer Singh Grewal. An extensive review on phytochemistry and pharmacological activities of Indian medicinal plant Celastrus paniculatus Willd. Phytotherapy research : PTR. 2022 May; 36(5):1930-1951. doi: 10.1002/ptr.7424. [PMID: 35199395]
  • Anders Rehfeld, Christian Marcus Pedersen. Lupeol and pristimerin do not inhibit activation of the human sperm CatSper Ca(2+)-channel. F1000Research. 2022; 11(?):222. doi: 10.12688/f1000research.109279.2. [PMID: 36016990]
  • Xiao-Long Hu, Qi-Wei He, Huan Long, Li-Xin Zhang, Rong Wang, Bao-Lin Wang, Jia-Hao Feng, Quan Wang, Ji-Qin Hou, Xiao-Qi Zhang, Wen-Cai Ye, Hao Wang. Synthesis and Biological Evaluation of Celastrol Derivatives with Improved Cytotoxic Selectivity and Antitumor Activities. Journal of natural products. 2021 07; 84(7):1954-1966. doi: 10.1021/acs.jnatprod.1c00262. [PMID: 34170694]
  • Qun Zhao, Yun Bi, Jian Guo, Ying-Xiang Liu, Jing Zhong, Long-Rui Pan, Yan Tan, Xian-Jun Yu. Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation. Acta pharmacologica Sinica. 2021 Jun; 42(6):975-986. doi: 10.1038/s41401-020-00527-x. [PMID: 32989235]
  • Qi-Wei He, Jia-Hao Feng, Xiao-Long Hu, Huan Long, Xue-Feng Huang, Zhen-Zhou Jiang, Xiao-Qi Zhang, Wen-Cai Ye, Hao Wang. Synthesis and Biological Evaluation of Celastrol Derivatives as Potential Immunosuppressive Agents. Journal of natural products. 2020 09; 83(9):2578-2586. doi: 10.1021/acs.jnatprod.0c00067. [PMID: 32822186]
  • Dina S El-Agamy, Ahmed A Shaaban, Hamdi H Almaramhy, Sarah Elkablawy, Mohamed A Elkablawy. Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis. Frontiers in pharmacology. 2018; 9(?):292. doi: 10.3389/fphar.2018.00292. [PMID: 29643811]
  • Sandra M Oramas-Royo, Haydee Chávez, Patricia Martín-Rodíguez, Leandro Fernández-Pérez, Angel G Ravelo, Ana Estévez-Braun. Cytotoxic triterpenoids from Maytenus retusa. Journal of natural products. 2010 Dec; 73(12):2029-34. doi: 10.1021/np100517u. [PMID: 21090801]
  • Young Bae Ryu, Su-Jin Park, Young Min Kim, Ju-Yeon Lee, Woo Duck Seo, Jong Sun Chang, Ki Hun Park, Mun-Chual Rho, Woo Song Lee. SARS-CoV 3CLpro inhibitory effects of quinone-methide triterpenes from Tripterygium regelii. Bioorganic & medicinal chemistry letters. 2010 Mar; 20(6):1873-6. doi: 10.1016/j.bmcl.2010.01.152. [PMID: 20167482]
  • Gonzalo J Mena-Rejón, Aida R Pérez-Espadas, Rosa E Moo-Puc, Roberto Cedillo-Rivera, I L Bazzocchi, I A Jiménez-Diaz, Leovigildo Quijano. Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa. Journal of natural products. 2007 May; 70(5):863-5. doi: 10.1021/np060559y. [PMID: 17385912]
  • O Shirota, H Morita, K Takeya, H Itokawa. Cytotoxic aromatic triterpenes from Maytenus ilicifolia and Maytenus chuchuhuasca. Journal of natural products. 1994 Dec; 57(12):1675-81. doi: 10.1021/np50114a009. [PMID: 7714534]