pentamidine (BioDeep_00000016560)
Main id: BioDeep_00000002280
代谢物信息卡片
pentamidine
化学式: C19H24N4O2 (340.1899)
中文名称: 喷他脒
谱图信息:
最多检出来源 Homo sapiens(urine) 14.04%
分子结构信息
SMILES: C(CCOc1ccc(cc1)C(=N)N)CCOc1ccc(cc1)C(=N)N
InChI: InChI=1S/C19H24N4O2/c20-18(21)14-4-8-16(9-5-14)24-12-2-1-3-13-25-17-10-6-15(7-11-17)19(22)23/h4-11H,1-3,12-13H2,(H3,20,21)(H3,22,23)
描述信息
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
[Raw Data] CB201_Pentamidine_pos_50eV_isCID-10eV_rep000006.txt
[Raw Data] CB201_Pentamidine_pos_40eV_isCID-10eV_rep000006.txt
[Raw Data] CB201_Pentamidine_pos_30eV_isCID-10eV_rep000006.txt
[Raw Data] CB201_Pentamidine_pos_20eV_isCID-10eV_rep000006.txt
[Raw Data] CB201_Pentamidine_pos_10eV_isCID-10eV_rep000006.txt
KEIO_ID P209; [MS2] KO009179
KEIO_ID P209; [MS3] KO009180
KEIO_ID P209
同义名列表
2 个代谢物同义名
数据库引用编号
28 个数据库交叉引用编号
- ChEBI: CHEBI:45081
- KEGG: C07420
- KEGG: C08004
- KEGGdrug: D08333
- PubChem: 4735
- PubChem: 96025020
- DrugBank: DB00738
- ChEMBL: CHEMBL55
- MeSH: Pentamidine
- CAS: 100-33-4
- MoNA: FIO00454
- MoNA: FIO00453
- MoNA: FIO00452
- MoNA: FIO00451
- MoNA: FIO00450
- MoNA: KO003939
- MoNA: KO003940
- MoNA: KO003941
- MoNA: KO003938
- MoNA: KO009180
- MoNA: KO003937
- MoNA: KO009181
- MoNA: KO009179
- PubChem: 9624
- PDB-CCD: PNT
- NIKKAJI: J5.512C
- RefMet: Pentamidine
- KNApSAcK: 45081
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiang Li, Dongjing Deng, Gizem Cataltepe, Ángela Román, Christopher R Buckley, Carolina Cassano Monte-Bello, Aleksandra Skirycz, Camila Caldana, Michael J Haydon. A reactive oxygen species Ca2+ signalling pathway identified from a chemical screen for modifiers of sugar-activated circadian gene expression.
The New phytologist.
2022 Nov; 236(3):1027-1041. doi:
10.1111/nph.18380. [PMID: 35842791] - Hugo I MacDermott-Opeskin, Alessandra Panizza, Bart A Eijkelkamp, Megan L O'Mara. Dynamics of the Acinetobacter baumannii inner membrane under exogenous polyunsaturated fatty acid stress.
Biochimica et biophysica acta. Biomembranes.
2022 07; 1864(7):183908. doi:
10.1016/j.bbamem.2022.183908. [PMID: 35276227] - Yingxiao Yu, Huimin Zhao, Jiayin Lin, Zongshao Li, Guobao Tian, Yi Yan Yang, Peiyan Yuan, Xin Ding. Repurposing Non-Antibiotic Drugs Auranofin and Pentamidine in Combination to Combat Multidrug-Resistant Gram-Negative Bacteria.
International journal of antimicrobial agents.
2022 May; 59(5):106582. doi:
10.1016/j.ijantimicag.2022.106582. [PMID: 35378227] - Bo Zhang, Yushan Jin, Lei Zhang, Hongshuang Wang, Xiaohui Wang. Ninety Years of Pentamidine: The Development and Applications of Pentamidine and its Analogs.
Current medicinal chemistry.
2022; 29(26):4602-4609. doi:
10.2174/0929867329666220314121446. [PMID: 35289252] - Eduardo J Cueto-Díaz, Godwin U Ebiloma, Ibrahim A Alfayez, Marzuq A Ungogo, Leandro Lemgruber, M Carmen González-García, Maria D Giron, Rafael Salto, Francisco José Fueyo-González, Tomoo Shiba, Juan A González-Vera, Maria José Ruedas Rama, Angel Orte, Harry P de Koning, Christophe Dardonville. Synthesis, biological, and photophysical studies of molecular rotor-based fluorescent inhibitors of the trypanosome alternative oxidase.
European journal of medicinal chemistry.
2021 Aug; 220(?):113470. doi:
10.1016/j.ejmech.2021.113470. [PMID: 33940464] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Bo Zhang, Yibo Wang, Cong Lin, Hongyuan Li, Xiaojie Wang, Yinghua Peng, Konstatin S Mineev, Andrew J Wilson, Hongshuang Wang, Xiaohui Wang. Targeting the transmembrane domain 5 of latent membrane protein 1 using small molecule modulators.
European journal of medicinal chemistry.
2021 Mar; 214(?):113210. doi:
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Revista da Sociedade Brasileira de Medicina Tropical.
2021; 54(?):e0633-2020. doi:
10.1590/0037-8682-0633-2020. [PMID: 33759923] - Whitney Fu, Maria Barahona, Taylor Harkness, Elizabeth Cohen, David Reardon, Peter S Yoo. Higher risk of urinary tract infections in renal transplant recipients receiving pentamidine versus trimethoprim-sulfamethoxazole (TMP-SMX) for Pneumocystis pneumonia prophylaxis.
Clinical transplantation.
2020 11; 34(11):e14067. doi:
10.1111/ctr.14067. [PMID: 32810885] - Gregorio Basile, Glauco Cristofaro, Luca Giovanni Locatello, Iacopo Vellere, Matteo Piccica, Silvia Bresci, Giandomenico Maggiore, Oreste Gallo, Andrea Novelli, Trentina Di Muccio, Marina Gramiccia, Luigi Gradoni, Giovanni Gaiera, Alessandro Bartoloni, Lorenzo Zammarchi. Refractory mucocutaneous leishmaniasis resolved with combination treatment based on intravenous pentamidine, oral azole, aerosolized liposomal amphotericin B, and intralesional meglumine antimoniate.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2020 Aug; 97(?):204-207. doi:
10.1016/j.ijid.2020.06.003. [PMID: 32505874] - Barbara Stella, Ilaria Andreana, Daniele Zonari, Silvia Arpicco. Pentamidine-Loaded Lipid and Polymer Nanocarriers as Tunable Anticancer Drug Delivery Systems.
Journal of pharmaceutical sciences.
2020 03; 109(3):1297-1302. doi:
10.1016/j.xphs.2019.11.011. [PMID: 31751563] - Yongchang Li, Mingming Liu, Mohamed Abdo Rizk, Paul Franck Adjou Moumouni, Seung-Hun Lee, Eloiza May Galon, Huanping Guo, Yang Gao, Jixu Li, Amani Magdy Beshbishy, Arifin Budiman Nugraha, Shengwei Ji, Maria Agnes Tumwebaze, Byamukama Benedicto, Naoaki Yokoyama, Ikuo Igarashi, Xuenan Xuan. Drug screening of food and drug administration-approved compounds against Babesia bovis in vitro.
Experimental parasitology.
2020 Mar; 210(?):107831. doi:
10.1016/j.exppara.2020.107831. [PMID: 31926147] - Masaya Takahashi, Katsuyuki Takahashi, Ryo Inose, Takashi Sugimoto, Hideo Koh, Masayuki Hino, Katsuya Nagayama. Safety profile of the concomitant use of foscarnet and aerosolized pentamidine in allogeneic hematopoietic stem cell transplantation recipients.
Transplant infectious disease : an official journal of the Transplantation Society.
2020 Feb; 22(1):e13239. doi:
10.1111/tid.13239. [PMID: 31883423] - Christopher Evernden, Michelle Dowhan, Rosy Dabas, Ahsan Chaudhry, Amit Kalra, Poonam Dharmani-Khan, Daniel Gregson, Andrew Johnson, Jennifer Jupp, Victor Jimenez-Zepeda, Kareem Jamani, Peter Duggan, Jason Tay, Faisal Khan, Andrew Daly, Jan Storek. High incidence of Pneumocystis jirovecii pneumonia in allogeneic hematopoietic cell transplant recipients in the modern era.
Cytotherapy.
2020 01; 22(1):27-34. doi:
10.1016/j.jcyt.2019.11.002. [PMID: 31889628] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Shahram Khademvatan, Kaveh Eskandari, Khosrow Hazrati-Tappeh, Fakher Rahim, Masoud Foroutan, Elham Yousefi, Negar Asadi. In silico and in vitro comparative activity of green tea components against Leishmania infantum.
Journal of global antimicrobial resistance.
2019 09; 18(?):187-194. doi:
10.1016/j.jgar.2019.02.008. [PMID: 30797085] - Rami A Al-Horani, Daytriona Clemons, Madhusoodanan Mottamal. The In Vitro Effects of Pentamidine Isethionate on Coagulation and Fibrinolysis.
Molecules (Basel, Switzerland).
2019 Jun; 24(11):. doi:
10.3390/molecules24112146. [PMID: 31174390] - Ana Carolina Ribeiro Gomes Maia, Gabriane Nascimento Porcino, Michelle Lima Detoni, Leonardo Ramos Quellis, Nayara Braga Emídio, Danielle Gomes Marconato, Wagner Faria Messias, Laura Lavorato Soldati, Priscila Faria-Pinto, Priscila Vanessa da Silva Zabala Capriles, Elaine Soares Coimbra, Marcos José Marques, Eveline Gomes Vasconcelos. Leishmania infantum amastigote nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1): Its inhibition as a new insight into mode of action of pentamidine.
Experimental parasitology.
2019 May; 200(?):1-6. doi:
10.1016/j.exppara.2019.03.003. [PMID: 30904692] - Justin Lee Loy, Abhilash Koratala, Yanel De Los Santos, Gajapathiraju Chamarthi, Alfonso H Santos, Kawther F Alquadan. Disseminated toxoplasmosis: a life-threatening complication of inadequate posttransplant prophylaxis.
Kidney international.
2019 05; 95(5):1274. doi:
10.1016/j.kint.2018.10.002. [PMID: 31010482] - Harini Bejjanki, Olanrewaju A Olaoye, Alfonso H Santos, Abhilash Koratala. Liver transplant, toxoplasmosis and kidney stones: connecting the dots.
BMJ case reports.
2019 Feb; 12(2):. doi:
10.1136/bcr-2019-229197. [PMID: 30772835] - Yumiko Asahi, Fumimasa Nomura, Yasuyuki Abe, Masafumi Doi, Tomoko Sakakura, Kiyoshi Takasuna, Kenji Yasuda. Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment.
European journal of pharmacology.
2019 Jan; 842(?):221-230. doi:
10.1016/j.ejphar.2018.10.046. [PMID: 30391349] - Carolina Rocio Santos, Felipe Francisco Tuon, Juliette Cieslinski, Regina Maia de Souza, Rui Imamura, Valdir Sabbaga Amato. Comparative study on liposomal amphotericin B and other therapies in the treatment of mucosal leishmaniasis: A 15-year retrospective cohort study.
PloS one.
2019; 14(6):e0218786. doi:
10.1371/journal.pone.0218786. [PMID: 31242231] - Petr Tůma, Petr Heneberg, Šimon Vaculín, Dušan Koval. Electrophoretic large volume sample stacking for sensitive determination of the anti-microbial agent pentamidine in rat plasma for pharmacological studies.
Electrophoresis.
2018 10; 39(20):2605-2611. doi:
10.1002/elps.201700440. [PMID: 29292827] - Florian Vogt, Bewketu Mengesha, Helen Asmamaw, Tigist Mekonnen, Helina Fikre, Yegnasew Takele, Emebet Adem, Rezika Mohammed, Koert Ritmeijer, Wim Adriaensen, Yayehirad Melsew, Johan van Griensven, Ermias Diro. Antigen Detection in Urine for Noninvasive Diagnosis and Treatment Monitoring of Visceral Leishmaniasis in Human Immunodeficiency Virus Coinfected Patients: An Exploratory Analysis from Ethiopia.
The American journal of tropical medicine and hygiene.
2018 10; 99(4):957-966. doi:
10.4269/ajtmh.18-0042. [PMID: 30084342] - Godwin U Ebiloma, Teresa Díaz Ayuga, Emmanuel O Balogun, Lucía Abad Gil, Anne Donachie, Marcel Kaiser, Tomás Herraiz, Daniel K Inaoka, Tomoo Shiba, Shigeharu Harada, Kiyoshi Kita, Harry P de Koning, Christophe Dardonville. Inhibition of trypanosome alternative oxidase without its N-terminal mitochondrial targeting signal (ΔMTS-TAO) by cationic and non-cationic 4-hydroxybenzoate and 4-alkoxybenzaldehyde derivatives active against T. brucei and T. congolense.
European journal of medicinal chemistry.
2018 Apr; 150(?):385-402. doi:
10.1016/j.ejmech.2018.02.075. [PMID: 29544150] - Nicolas Audag, Giuseppe Liistro, Dimitri Van der Linden, Françoise Smets, Teresinha Leal, Gregory Reychler. In Vitro and In Vivo Comparison of Two Nebulizers Used for Inhaled Pentamidine Delivery.
Archivos de bronconeumologia.
2017 Dec; 53(12):697-698. doi:
10.1016/j.arbres.2017.05.001. [PMID: 28583257] - Iván A Aréchiga-Figueroa, Leticia G Marmolejo-Murillo, Meng Cui, Mayra Delgado-Ramírez, Marcel A G van der Heyden, José A Sánchez-Chapula, Aldo A Rodríguez-Menchaca. High-potency block of Kir4.1 channels by pentamidine: Molecular basis.
European journal of pharmacology.
2017 Nov; 815(?):56-63. doi:
10.1016/j.ejphar.2017.10.009. [PMID: 28993158] - Enpeng Zhao, Ghulam Ilyas, Francesca Cingolani, Jae Ho Choi, François Ravenelle, Kathryn E Tanaka, Mark J Czaja. Pentamidine blocks hepatotoxic injury in mice.
Hepatology (Baltimore, Md.).
2017 09; 66(3):922-935. doi:
10.1002/hep.29244. [PMID: 28470665] - Yuan Ji, Rosanne Varkevisser, Dragan Opacic, Alexandre Bossu, Marion Kuiper, Jet D M Beekman, Sihyung Yang, Azinwi Phina Khan, Dobromir Dobrev, Niels Voigt, Michael Zhuo Wang, Sander Verheule, Marc A Vos, Marcel A G van der Heyden. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models.
British journal of pharmacology.
2017 08; 174(15):2576-2590. doi:
10.1111/bph.13869. [PMID: 28542844] - Yuan Ji, Marlieke G Veldhuis, Jantien Zandvoort, Fee L Romunde, Marien J C Houtman, Karen Duran, Gijs van Haaften, Eva-Maria Zangerl-Plessl, Hiroki Takanari, Anna Stary-Weinzinger, Marcel A G van der Heyden. PA-6 inhibits inward rectifier currents carried by V93I and D172N gain-of-function KIR2.1 channels, but increases channel protein expression.
Journal of biomedical science.
2017 Jul; 24(1):44. doi:
10.1186/s12929-017-0352-x. [PMID: 28711067] - Jonathan M Stokes, Craig R MacNair, Bushra Ilyas, Shawn French, Jean-Philippe Côté, Catrien Bouwman, Maya A Farha, Arthur O Sieron, Chris Whitfield, Brian K Coombes, Eric D Brown. Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance.
Nature microbiology.
2017 Mar; 2(?):17028. doi:
10.1038/nmicrobiol.2017.28. [PMID: 28263303] - Andriy Buchynskyy, J Robert Gillespie, Matthew A Hulverson, Joshua McQueen, Sharon A Creason, Ranae M Ranade, Nicole A Duster, Michael H Gelb, Frederick S Buckner. Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.
Bioorganic & medicinal chemistry.
2017 03; 25(5):1571-1584. doi:
10.1016/j.bmc.2016.11.019. [PMID: 28187957] - Wenlin Huang, Zhongsheng Zhang, Ximena Barros-Álvarez, Cho Yeow Koh, Ranae M Ranade, J Robert Gillespie, Sharon A Creason, Sayaka Shibata, Christophe L M J Verlinde, Wim G J Hol, Frederick S Buckner, Erkang Fan. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
European journal of medicinal chemistry.
2016 Nov; 124(?):1081-1092. doi:
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Bioorganic & medicinal chemistry letters.
2016 11; 26(21):5247-5253. doi:
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Antimicrobial agents and chemotherapy.
2016 Apr; 60(4):2502-4. doi:
10.1128/aac.02290-15. [PMID: 26824946] - Gabriele Pohlig, Sonja C Bernhard, Johannes Blum, Christian Burri, Alain Mpanya, Jean-Pierre Fina Lubaki, Alfred Mpoo Mpoto, Blaise Fungula Munungu, Patrick Mangoni N'tombe, Gratias Kambau Manesa Deo, Pierre Nsele Mutantu, Florent Mbo Kuikumbi, Alain Fukinsia Mintwo, Augustin Kayeye Munungi, Amadeu Dala, Stephen Macharia, Constantin Miaka Mia Bilenge, Victor Kande Betu Ku Mesu, Jose Ramon Franco, Ndinga Dieyi Dituvanga, Richard R Tidwell, Carol A Olson. Efficacy and Safety of Pafuramidine versus Pentamidine Maleate for Treatment of First Stage Sleeping Sickness in a Randomized, Comparator-Controlled, International Phase 3 Clinical Trial.
PLoS neglected tropical diseases.
2016 Feb; 10(2):e0004363. doi:
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International journal of pharmaceutics.
2015 Jul; 488(1-2):154-64. doi:
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European journal of medicinal chemistry.
2015 Mar; 93(?):93-100. doi:
10.1016/j.ejmech.2015.01.012. [PMID: 25659770] - Andreas Kronbichler, David R W Jayne, Gert Mayer. Frequency, risk factors and prophylaxis of infection in ANCA-associated vasculitis.
European journal of clinical investigation.
2015 Mar; 45(3):346-68. doi:
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PLoS neglected tropical diseases.
2015 Feb; 9(2):e0003409. doi:
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Biological & pharmaceutical bulletin.
2015; 38(7):1070-5. doi:
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Bioorganic & medicinal chemistry letters.
2014 Aug; 24(15):3247-50. doi:
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Journal of pharmaceutical and biomedical analysis.
2014 Jul; 95(?):54-60. doi:
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Antimicrobial agents and chemotherapy.
2014 Jul; 58(7):4064-74. doi:
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Molecular cancer therapeutics.
2014 Jul; 13(7):1929-1941. doi:
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BMC infectious diseases.
2014 Feb; 14(?):111. doi:
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Journal of medicinal chemistry.
2014 Feb; 57(3):828-35. doi:
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