2,2,2-Trichloroethanol (BioDeep_00000006511)
Secondary id: BioDeep_00000870673
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
2,2,2-Trichloroethanol (acd/name 4.0)
化学式: C2H3Cl3O (147.9249)
中文名称: 2,2,2-三氯乙醇
谱图信息:
最多检出来源 Viridiplantae(plant) 11.35%
分子结构信息
SMILES: C(C(Cl)(Cl)Cl)O
InChI: InChI=1S/C2H3Cl3O/c3-2(4,5)1-6/h6H,1H2
描述信息
2,2,2-trichloroethanol belongs to the family of Primary Alcohols. These are compounds comprising the primary alcohol functional group, with the general strucuture RCOH (R=alkyl, aryl).
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
2,2,2-Trichloroethanol, the active form of Chloral hydrate, is an agonist for the nonclassical K2P channels TREK-1 (KCNK2) and TRAAK (KCNK4)[1].
同义名列表
17 个代谢物同义名
2,2,2-Trichloroethanol (acd/name 4.0); beta,beta,.beta-trichloroethanol; (Hydroxymethyl)trichloromethane; 2,2,2-Trichloroethyl alcohol; 2,2,2-trichloroethan-1-ol; 2,2,2-Trichloro-1-ethanol; 2, 2,2-Trichloroethanol; 2,2,2-Trichloro-ethanol; Trichloroethyl alcohol; 2,2,2-TRICHLOROETHANOL; beta-Trichloroethanol; Trichloroethanol; Trichlorethanol; CCL3ch2oh; Ethapon; Trichloroethanol; 2,2,2-Trichloroethanol
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:28094
- KEGG: C07490
- KEGGdrug: D70779
- PubChem: 8259
- HMDB: HMDB0041796
- Metlin: METLIN1643
- ChEMBL: CHEMBL1171
- Wikipedia: 2,2,2-Trichloroethanol
- MetaCyc: CPD-9673
- foodb: FDB111662
- chemspider: 7961
- CAS: 115-20-8
- PMhub: MS000019560
- PubChem: 9693
- PDB-CCD: 8FH
- NIKKAJI: J2.895I
- medchemexpress: HY-B1500
- KNApSAcK: 28094
- LOTUS: LTS0085100
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
4 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(3)
- trichloroethene degradation:
2,2,2-trichloroacetate + NADPH + O2 ⟶ H+ + NADP+ + chloride + oxalate - trichloroethene degradation:
O2 + trichloroethene ⟶ 2,2,2-trichloroacetate + H+ - trichloroethene degradation:
2,2,2-trichloroacetate + NADPH + O2 ⟶ H+ + NADP+ + chloride + oxalate
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Hirotaka Sato, Yuki Ito, Miho Inoue, Yuki Nakahira, Satoru Hashimoto, Tamie Nakajima, Michihiro Kamijima. Simple method to detect triclofos and its metabolites in plasma of children by combined use of liquid chromatography tandem-mass spectrometry and gas chromatography-mass spectrometry.
Scientific reports.
2019 06; 9(1):9294. doi:
10.1038/s41598-019-45790-z. [PMID: 31243319] - Jie Gao, Caixia Yang, Hui Ding, Yanli Zhang, Jinhua Xue, Yanning Cai. 2,2,2-Trichloroethanol lengthens the circadian period of Bmal1-driven circadian bioluminescence rhythms in U2OS cells.
Biochemical and biophysical research communications.
2015 Jul; 462(3):239-44. doi:
10.1016/j.bbrc.2015.04.123. [PMID: 25956065] - Hong Sik Yoo, Blair U Bradford, Oksana Kosyk, Takeki Uehara, Svitlana Shymonyak, Leonard B Collins, Wanda M Bodnar, Louise M Ball, Avram Gold, Ivan Rusyn. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects.
Journal of toxicology and environmental health. Part A.
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10.1080/15287394.2015.1020977. [PMID: 26039745] - Noreen Yaqoob, Andrew Evans, John R Foster, Edward A Lock. Trichloroethylene and trichloroethanol-induced formic aciduria and renal injury in male F-344 rats following 12 weeks exposure.
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PloS one.
2012; 7(4):e35214. doi:
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PloS one.
2012; 7(3):e32361. doi:
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PLoS pathogens.
2012; 8(5):e1002675. doi:
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PloS one.
2012; 7(5):e37703. doi:
10.1371/journal.pone.0037703. [PMID: 22629445] - Simon Ittig, Buko Lindner, Marco Stenta, Pablo Manfredi, Evelina Zdorovenko, Yuriy A Knirel, Matteo dal Peraro, Guy R Cornelis, Ulrich Zähringer. The lipopolysaccharide from Capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in MD-2 binding.
PLoS pathogens.
2012; 8(5):e1002667. doi:
10.1371/journal.ppat.1002667. [PMID: 22570611] - Frida Dangardt, Yun Chen, Eva Gronowitz, Jovanna Dahlgren, Peter Friberg, Birgitta Strandvik. High physiological omega-3 Fatty Acid supplementation affects muscle Fatty Acid composition and glucose and insulin homeostasis in obese adolescents.
Journal of nutrition and metabolism.
2012; 2012(?):395757. doi:
10.1155/2012/395757. [PMID: 22523671] - Chia-Chang Tsai, Hui-Hsing Hung, Chien-Pang Liu, Yit-Tsong Chen, Chien-Yuan Pan. Changes in plasma membrane surface potential of PC12 cells as measured by Kelvin probe force microscopy.
PloS one.
2012; 7(4):e33849. doi:
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International journal of molecular sciences.
2012; 13(1):994-1005. doi:
10.3390/ijms13010994. [PMID: 22312299] - Deqing Wang, Yuan Zhuang, Yaping Tian, Graham Neil Thomas, Mingzhong Ying, Brian Tomlinson. Study of the effects of total flavonoids of Astragalus on atherosclerosis formation and potential mechanisms.
Oxidative medicine and cellular longevity.
2012; 2012(?):282383. doi:
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International journal of molecular sciences.
2012; 13(3):3022-3037. doi:
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International journal of nanomedicine.
2012; 7(?):123-31. doi:
10.2147/ijn.s25468. [PMID: 22275828] - Daniel Lienhard, Meret Lauterburg, Geneviève Escher, Felix J Frey, Brigitte M Frey. High salt intake down-regulates colonic mineralocorticoid receptors, epithelial sodium channels and 11β-hydroxysteroid dehydrogenase type 2.
PloS one.
2012; 7(5):e37898. doi:
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International journal of hepatology.
2012; 2012(?):978136. doi:
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PloS one.
2012; 7(5):e37794. doi:
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Frontiers in plant science.
2012; 3(?):53. doi:
10.3389/fpls.2012.00053. [PMID: 22639651] - Katarzyna A Podyma-Inoue, Miki Hara-Yokoyama, Tamayuki Shinomura, Tomoko Kimura, Masaki Yanagishita. Syndecans reside in sphingomyelin-enriched low-density fractions of the plasma membrane isolated from a parathyroid cell line.
PloS one.
2012; 7(3):e32351. doi:
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PloS one.
2012; 7(2):e31317. doi:
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Experimental diabetes research.
2012; 2012(?):789730. doi:
10.1155/2012/789730. [PMID: 22110479] - Areum Cha, Youngshim Choi, Yoojeong Jin, Mi-Kyung Sung, Yun-Chang Koo, Kwang-Won Lee, Taesun Park. Antilipogenic and anti-inflammatory activities of Codonopsis lanceolata in mice hepatic tissues after chronic ethanol feeding.
Journal of biomedicine & biotechnology.
2012; 2012(?):141395. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):781812. doi:
10.1155/2012/781812. [PMID: 22649478] - Si Young Cho, Hyun Woo Jeong, Jong Hee Sohn, Dae-Bang Seo, Wan Gi Kim, Sang-Jun Lee. An ethanol extract of Artemisia iwayomogi activates PPARδ leading to activation of fatty acid oxidation in skeletal muscle.
PloS one.
2012; 7(3):e33815. doi:
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PloS one.
2012; 7(2):e30100. doi:
10.1371/journal.pone.0030100. [PMID: 22319559] - Thing-Fong Tzeng, Hung-Jen Lu, Shorong-Shii Liou, Chia Ju Chang, I-Min Liu. Vinegar-Baked Radix Bupleuri Regulates Lipid Disorders via a Pathway Dependent on Peroxisome-Proliferator-Activated Receptor-α in High-Fat-Diet-Induced Obese Rats.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):827278. doi:
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Plant methods.
2011 Dec; 7(?):48. doi:
10.1186/1746-4811-7-48. [PMID: 22192489] - Alicia Didsbury, Carol Wang, Daniel Verdon, Mary A Sewell, Julie D McIntosh, John A Taylor. Rotavirus NSP4 is secreted from infected cells as an oligomeric lipoprotein and binds to glycosaminoglycans on the surface of non-infected cells.
Virology journal.
2011 Dec; 8(?):551. doi:
10.1186/1743-422x-8-551. [PMID: 22185400] - Peter Meister, Sonia Schott, Cécile Bedet, Yu Xiao, Sabine Rohner, Selena Bodennec, Bruno Hudry, Laurent Molin, Florence Solari, Susan M Gasser, Francesca Palladino. Caenorhabditis elegans Heterochromatin protein 1 (HPL-2) links developmental plasticity, longevity and lipid metabolism.
Genome biology.
2011 Dec; 12(12):R123. doi:
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BMC biochemistry.
2011 Dec; 12(?):64. doi:
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Retrovirology.
2011 Dec; 8(?):99. doi:
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Biochimica et biophysica acta.
2011 Dec; 1811(12):1011-20. doi:
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PLoS pathogens.
2011 Dec; 7(12):e1002454. doi:
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Nutrition research and practice.
2011 Dec; 5(6):520-6. doi:
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PLoS pathogens.
2011 Dec; 7(12):e1002410. doi:
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Biochimica et biophysica acta.
2011 Dec; 1811(12):1030-7. doi:
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Oncotarget.
2011 Dec; 2(12):1176-90. doi:
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Journal of proteomics.
2011 Nov; 74(12):2866-80. doi:
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Molecular neurodegeneration.
2011 Nov; 6(?):76. doi:
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Molecular psychiatry.
2011 Nov; 16(11):1139-46. doi:
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International journal of environmental research and public health.
2011 11; 8(11):4238-72. doi:
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Analytical and bioanalytical chemistry.
2011 Nov; 401(8):2609-16. doi:
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Biology of the cell.
2011 Nov; 103(11):499-517. doi:
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