Quinacrine (BioDeep_00000003331)
Secondary id: BioDeep_00000397940, BioDeep_00001867737
human metabolite blood metabolite
代谢物信息卡片
化学式: C23H30ClN3O (399.20772800000003)
中文名称: 疟涤平
谱图信息:
最多检出来源 Homo sapiens(blood) 11.86%
分子结构信息
SMILES: CCN(CC)CCCC(C)N=c1c2ccc(Cl)cc2[nH]c2ccc(OC)cc12
InChI: InChI=1S/C23H30ClN3O/c1-5-27(6-2)13-7-8-16(3)25-23-19-11-9-17(24)14-22(19)26-21-12-10-18(28-4)15-20(21)23/h9-12,14-16H,5-8,13H2,1-4H3,(H,25,26)
描述信息
An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [PubChem]
P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
30 个代谢物同义名
N(4)-(6-Chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine; 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine; 6-chloro-N-[5-(diethylamino)pentan-2-yl]-2-methoxyacridin-9-amine; 3-Chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine; 2-Methoxy-6-chloro-9-diethylaminopentylaminoacridine; Quinacrine dihyrochloride, (R)-isomer; Quinacrine dihyrochloride, (S)-isomer; Quinacrine dihydrochloride, dihydrate; Quinacrine Dihydrochloride Dihydrate; Monohydrochloride, quinacrine; Quinacrine monohydrochloride; Dihydrochloride, quinacrine; Quinacrine dihydrochloride; Hydrochloride, quinacrine; Monomesylate, quinacrine; Quinacrine hydrochloride; Quinacrine, (+-)-isomer; Monoacetate, quinacrine; Quinacrine monomesylate; Quinacrine, (R)-isomer; Quinacrine monoacetate; Quinacrine, (S)-isomer; Dimesylate, quinacrine; Quinacrine dimesylate; quinacrine; Mepacrine; Quinacrin; Acrichine; Atabrine; Atebrin
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:8711
- KEGG: C07339
- KEGGdrug: D08179
- PubChem: 237
- HMDB: HMDB0015235
- Metlin: METLIN24079
- DrugBank: DB01103
- ChEMBL: CHEMBL7568
- Wikipedia: Quinacrine
- MeSH: Quinacrine
- MetaCyc: ATABRINE
- chemspider: 232
- CAS: 65960-39-6
- CAS: 83-89-6
- PMhub: MS000009369
- PubChem: 9546
- NIKKAJI: J3.877F
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Biswajit Das, Somya Ranjan Dash, Harun Patel, Saptarshi Sinha, Subhasmita Bhal, Subarno Paul, Chinmay Das, Rajalaxmi Pradhan, Iqrar Ahmed, Kunal Goutam, Chanakya Nath Kundu. Quinacrine inhibits HIF-1α/VEGF-A mediated angiogenesis by disrupting the interaction between cMET and ABCG2 in patient-derived breast cancer stem cells.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2023 Aug; 117(?):154914. doi:
10.1016/j.phymed.2023.154914
. [PMID: 37321076] - Xiangxiang Li, Jing Zhou, Zhuozhou Hu, Liang Han, Wenyang Zhao, Tongyu Wu, Chun Li, Jingjing Liu, Jia Kang, Xinping Chen. Quinacrine attenuates diet-induced obesity by inhibiting adipogenesis via activation of AMPK signaling.
European journal of pharmacology.
2023 Jan; 938(?):175432. doi:
10.1016/j.ejphar.2022.175432
. [PMID: 36460132] - Nirod Kumar Sarangi, Amrutha Prabhakaran, Tia E Keyes. Multimodal Investigation into the Interaction of Quinacrine with Microcavity-Supported Lipid Bilayers.
Langmuir : the ACS journal of surfaces and colloids.
2022 05; 38(20):6411-6424. doi:
10.1021/acs.langmuir.2c00524
. [PMID: 35561255] - Benjamin Pineda. Quinacrine, an Old Drug with Potentially usefull in the Treatment for COVID-19.
Archives of medical research.
2021 11; 52(8):858-859. doi:
10.1016/j.arcmed.2021.06.002
. [PMID: 34154830] - Nada F Abo El-Magd, Hasnaa Ali Ebrahim, Mohamed El-Sherbiny, Nada H Eisa. Quinacrine Ameliorates Cisplatin-Induced Renal Toxicity via Modulation of Sirtuin-1 Pathway.
International journal of molecular sciences.
2021 Oct; 22(19):. doi:
10.3390/ijms221910660
. [PMID: 34639002] - Lucy Martinez-Guerrero, Xiaohong Zhang, Kimberley M Zorn, Sean Ekins, Stephen H Wright. Cationic Compounds with SARS-CoV-2 Antiviral Activity and Their Interaction with Organic Cation Transporter/Multidrug and Toxin Extruder Secretory Transporters.
The Journal of pharmacology and experimental therapeutics.
2021 10; 379(1):96-107. doi:
10.1124/jpet.121.000619
. [PMID: 34253645] - M F Ara-Montojo, J Bustamante, T Sainz, S Pérez, B Jiménez-Moreno, G Ruiz-Carrascoso, P Rodríguez-Molino, J Villota, M García-López-Hortenano, M J Mellado-Peña. Intestinal giardiasis in children: Five years' experience in a reference unit.
Travel medicine and infectious disease.
2021 Jul; 42(?):102082. doi:
10.1016/j.tmaid.2021.102082
. [PMID: 34020030] - Raphael J Eberle, Danilo S Olivier, Marcos S Amaral, Ian Gering, Dieter Willbold, Raghuvir K Arni, Monika A Coronado. The Repurposed Drugs Suramin and Quinacrine Cooperatively Inhibit SARS-CoV-2 3CLpro In Vitro.
Viruses.
2021 05; 13(5):. doi:
10.3390/v13050873
. [PMID: 34068686] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Tomohisa Kitagawa, Atsushi Matsumoto, Ichiro Terashima, Yukifumi Uesono. Antimalarial Quinacrine and Chloroquine Lose Their Activity by Decreasing Cationic Amphiphilic Structure with a Slight Decrease in pH.
Journal of medicinal chemistry.
2021 04; 64(7):3885-3896. doi:
10.1021/acs.jmedchem.0c02056
. [PMID: 33775096] - Mónica Salas Rojas, Raúl Silva Garcia, Estela Bini, Verónica Pérez de la Cruz, Juan Carlos León Contreras, Rogelio Hernández Pando, Fernando Bastida Gonzalez, Eduardo Davila-Gonzalez, Mario Orozco Morales, Armando Gamboa Domínguez, Julio Sotelo, Benjamín Pineda. Quinacrine, an Antimalarial Drug with Strong Activity Inhibiting SARS-CoV-2 Viral Replication In Vitro.
Viruses.
2021 Jan; 13(1):. doi:
10.3390/v13010121
. [PMID: 33477376] - B Pineda, V Pérez de la Cruz, R Hernández Pando, J Sotelo. Quinacrine as a potential treatment for COVID-19 virus infection.
European review for medical and pharmacological sciences.
2021 01; 25(1):556-566. doi:
10.26355/eurrev_202101_24428
. [PMID: 33506949] - R Cañete, A L Noda, M Rodríguez, K Brito, E Herrera, P-E Kofoed, J Ursing. 5-Nitroimidazole refractory giardiasis is common in Matanzas, Cuba and effectively treated by secnidazole plus high-dose mebendazole or quinacrine: a prospective observational cohort study.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2020 Aug; 26(8):1092.e1-1092.e6. doi:
10.1016/j.cmi.2019.12.017
. [PMID: 31901492] - Krushna Chandra Hembram, Somya Ranjan Dash, Biswajit Das, Chinmayee Sethy, Subhajit Chatterjee, Birendra Kumar Bindhani, Chanakya Nath Kundu. Quinacrine Based Gold Hybrid Nanoparticles Caused Apoptosis through Modulating Replication Fork in Oral Cancer Stem Cells.
Molecular pharmaceutics.
2020 07; 17(7):2463-2472. doi:
10.1021/acs.molpharmaceut.0c00197
. [PMID: 32407635] - Bhuvaneshwar Vaidya, Nishant S Kulkarni, Snehal K Shukla, Vineela Parvathaneni, Gautam Chauhan, Jenna K Damon, Apoorva Sarode, Jerome V Garcia, Nitesh Kunda, Samir Mitragotri, Vivek Gupta. Development of inhalable quinacrine loaded bovine serum albumin modified cationic nanoparticles: Repurposing quinacrine for lung cancer therapeutics.
International journal of pharmaceutics.
2020 Mar; 577(?):118995. doi:
10.1016/j.ijpharm.2019.118995
. [PMID: 31935471] - Silvia Biggi, Michael Pancher, Claudia Stincardini, Silvia Luotti, Tania Massignan, Andrea Dalle Vedove, Andrea Astolfi, Pamela Gatto, Graziano Lolli, Maria Letizia Barreca, Valentina Bonetto, Valentina Adami, Emiliano Biasini. Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface.
Journal of neurochemistry.
2020 01; 152(1):136-150. doi:
10.1111/jnc.14805
. [PMID: 31264722] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964
. [PMID: 31515284] - Sabrina Forveille, Juliette Humeau, Allan Sauvat, Lucillia Bezu, Guido Kroemer, Oliver Kepp. Quinacrine-mediated detection of intracellular ATP.
Methods in enzymology.
2019; 629(?):103-113. doi:
10.1016/bs.mie.2019.05.050
. [PMID: 31727236] - Mariachiara Buccarelli, Matteo Marconi, Simone Pacioni, Ivana De Pascalis, Quintino Giorgio D'Alessandris, Maurizio Martini, Barbara Ascione, Walter Malorni, Luigi Maria Larocca, Roberto Pallini, Lucia Ricci-Vitiani, Paola Matarrese. Inhibition of autophagy increases susceptibility of glioblastoma stem cells to temozolomide by igniting ferroptosis.
Cell death & disease.
2018 08; 9(8):841. doi:
10.1038/s41419-018-0864-7
. [PMID: 30082680] - Ana Requena-Méndez, Pilar Goñi, Encarnación Rubio, Diana Pou, Victoria Fumadó, Silvia Lóbez, Edelweiss Aldasoro, Juan Cabezos, Maria Eugenia Valls, Begoña Treviño, Antonio Federico Martínez Montseny, Antonio Clavel, Joaquim Gascon, José Muñoz. The Use of Quinacrine in Nitroimidazole-resistant Giardia Duodenalis: An Old Drug for an Emerging Problem.
The Journal of infectious diseases.
2017 03; 215(6):946-953. doi:
10.1093/infdis/jix066
. [PMID: 28453841] - Anna-Maria Kreidler, Roland Benz, Holger Barth. Chloroquine derivatives block the translocation pores and inhibit cellular entry of Clostridium botulinum C2 toxin and Bacillus anthracis lethal toxin.
Archives of toxicology.
2017 Mar; 91(3):1431-1445. doi:
10.1007/s00204-016-1716-9
. [PMID: 27106023] - Abdulrahman K Al Asmari, Khalid Tariq Al Sadoon, Ali Ahmed Obaid, Deivakadatcham Yesunayagam, Mohammad Tariq. Protective effect of quinacrine against glycerol-induced acute kidney injury in rats.
BMC nephrology.
2017 01; 18(1):41. doi:
10.1186/s12882-017-0450-8
. [PMID: 28129740] - Wenlin Huang, Zhongsheng Zhang, Ximena Barros-Álvarez, Cho Yeow Koh, Ranae M Ranade, J Robert Gillespie, Sharon A Creason, Sayaka Shibata, Christophe L M J Verlinde, Wim G J Hol, Frederick S Buckner, Erkang Fan. Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.
European journal of medicinal chemistry.
2016 Nov; 124(?):1081-1092. doi:
10.1016/j.ejmech.2016.10.024
. [PMID: 27788467] - Natalia S Voynova, Carole Roubaty, Hector M Vazquez, Shamroop K Mallela, Christer S Ejsing, Andreas Conzelmann. Saccharomyces cerevisiae Is Dependent on Vesicular Traffic between the Golgi Apparatus and the Vacuole When Inositolphosphorylceramide Synthase Aur1 Is Inactivated.
Eukaryotic cell.
2015 Dec; 14(12):1203-16. doi:
10.1128/ec.00117-15
. [PMID: 26432633] - Xue-Tao Li, Zhi-Yan Zhou, Ying Jiang, Mei-Li He, Lian-Qun Jia, Lin Zhao, Lan Cheng, Tian-Zhu Jia. PEGylated VRB plus quinacrine cationic liposomes for treating non-small cell lung cancer.
Journal of drug targeting.
2015 Apr; 23(3):232-43. doi:
10.3109/1061186x.2014.979829
. [PMID: 25417934] - Xue-Tao Li, Rui-Jun Ju, Xiu-Ying Li, Fan Zeng, Ji-Feng Shi, Lei Liu, Cheng-Xiang Zhang, Meng-Ge Sun, Jin-Ning Lou, Wan-Liang Lu. Multifunctional targeting daunorubicin plus quinacrine liposomes, modified by wheat germ agglutinin and tamoxifen, for treating brain glioma and glioma stem cells.
Oncotarget.
2014 Aug; 5(15):6497-511. doi:
10.18632/oncotarget.2267
. [PMID: 25153726] - Hari Babu Tatipaka, J Robert Gillespie, Arnab K Chatterjee, Neil R Norcross, Matthew A Hulverson, Ranae M Ranade, Pendem Nagendar, Sharon A Creason, Joshua McQueen, Nicole A Duster, Advait Nagle, Frantisek Supek, Valentina Molteni, Tanja Wenzler, Reto Brun, Richard Glynne, Frederick S Buckner, Michael H Gelb. Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.
Journal of medicinal chemistry.
2014 Feb; 57(3):828-35. doi:
10.1021/jm401178t
. [PMID: 24354316] - Muhammad Usman, Mohammad Siddiq. Probing the micellar properties of Quinacrine 2HCl and its binding with surfactants and human serum albumin.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2013 Sep; 113(?):182-90. doi:
10.1016/j.saa.2013.04.089
. [PMID: 23727671] - Caroline Roy, Valérie Gagné, Maria J G Fernandes, François Marceau. High affinity capture and concentration of quinacrine in polymorphonuclear neutrophils via vacuolar ATPase-mediated ion trapping: comparison with other peripheral blood leukocytes and implications for the distribution of cationic drugs.
Toxicology and applied pharmacology.
2013 Jul; 270(2):77-86. doi:
10.1016/j.taap.2013.04.004
. [PMID: 23603060] - Annaliese K Franz, Megan A Danielewicz, Diana M Wong, Lisa A Anderson, Jordan R Boothe. Phenotypic screening with oleaginous microalgae reveals modulators of lipid productivity.
ACS chemical biology.
2013 May; 8(5):1053-62. doi:
10.1021/cb300573r
. [PMID: 23521767] - Ceren Kencebay, Narin Derin, Ozlem Ozsoy, Dijle Kipmen-Korgun, Gamze Tanriover, Nihal Ozturk, Goksun Basaranlar, Piraye Yargicoglu-Akkiraz, Berna Sozen, Aysel Agar. Merit of quinacrine in the decrease of ingested sulfite-induced toxic action in rat brain.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2013 Feb; 52(?):129-36. doi:
10.1016/j.fct.2012.11.015
. [PMID: 23168241] - Ranjan Preet, Purusottam Mohapatra, Dipon Das, Shakti R Satapathy, Tathagata Choudhuri, Michael D Wyatt, Chanakya N Kundu. Lycopene synergistically enhances quinacrine action to inhibit Wnt-TCF signaling in breast cancer cells through APC.
Carcinogenesis.
2013 Feb; 34(2):277-86. doi:
10.1093/carcin/bgs351
. [PMID: 23129580] - Andrzej Woznica, Agnieszka Nowak, Przemyslaw Ziemski, Mirosław Kwasniewski, Tytus Bernas. Stimulatory effect of xenobiotics on oxidative electron transport of chemolithotrophic nitrifying bacteria used as biosensing element.
PloS one.
2013; 8(1):e53484. doi:
10.1371/journal.pone.0053484
. [PMID: 23326438] - Tyler Spata, Daniel Bobek, Bryan A Whitson, Sampath Parthasarathy, Peter J Mohler, Robert S D Higgins, Ahmet Kilic. A nonthoracotomy myocardial infarction model in an ovine using autologous platelets.
BioMed research international.
2013; 2013(?):938047. doi:
10.1155/2013/938047
. [PMID: 24367790] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068
. [PMID: 22961681] - Takahiro Shimizu, Kenjiro Tanaka, Kumiko Nakamura, Keisuke Taniuchi, Kunihiko Yokotani. Brain phospholipase C, diacylglycerol lipase and monoacylglycerol lipase are involved in (±)-epibatidine-induced activation of central adrenomedullary outflow in rats.
European journal of pharmacology.
2012 Sep; 691(1-3):93-102. doi:
10.1016/j.ejphar.2012.07.017
. [PMID: 22796670] - Chim W Chan, Rita Spathis, Dana M Reiff, Stacy E McGrath, Ralph M Garruto, J Koji Lum. Diversity of Plasmodium falciparum chloroquine resistance transporter (pfcrt) exon 2 haplotypes in the Pacific from 1959 to 1979.
PloS one.
2012; 7(1):e30213. doi:
10.1371/journal.pone.0030213
. [PMID: 22272308] - Hanna Appelqvist, Linnea Sandin, Karin Björnström, Paul Saftig, Brett Garner, Karin Ollinger, Katarina Kågedal. Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content.
PloS one.
2012; 7(11):e50262. doi:
10.1371/journal.pone.0050262
. [PMID: 23166840] - Thuy Nguyen, Yuji Sakasegawa, Katsumi Doh-Ura, Mei-Lin Go. Anti-prion activities and drug-like potential of functionalized quinacrine analogs with basic phenyl residues at the 9-amino position.
European journal of medicinal chemistry.
2011 Jul; 46(7):2917-29. doi:
10.1016/j.ejmech.2011.04.016
. [PMID: 21531054] - Rebecca D Sandlin, Melissa D Carter, Patricia J Lee, Jennifer M Auschwitz, Susan E Leed, Jacob D Johnson, David W Wright. Use of the NP-40 detergent-mediated assay in discovery of inhibitors of beta-hematin crystallization.
Antimicrobial agents and chemotherapy.
2011 Jul; 55(7):3363-9. doi:
10.1128/aac.00121-11
. [PMID: 21518844] - Hirofumi Nishikawa, Seiichi Kitani. Inhibitory effect of ganglioside on mastoparan-induced cytotoxicity and degranulation in lipid raft of connective tissue type mast cell.
Journal of biochemical and molecular toxicology.
2011 May; 25(3):158-68. doi:
10.1002/jbt.20372
. [PMID: 21671308] - Alenka Kuznik, Mojca Bencina, Urban Svajger, Matjaz Jeras, Blaz Rozman, Roman Jerala. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines.
Journal of immunology (Baltimore, Md. : 1950).
2011 Apr; 186(8):4794-804. doi:
10.4049/jimmunol.1000702
. [PMID: 21398612] - Yan Wu, Zhen-Tao Su, Hong-Mei Zhou, Fei Wang, Shu-Hong Liu, Xue-Feng Ding, Yong-Qi Zhao, Ming Fan. [Effect of quinacrine on inflammatory reaction of blood system induced by microwave irradiation].
Zhongguo shi yan xue ye xue za zhi.
2011 Apr; 19(2):499-502. doi:
. [PMID: 21518517]
- Jie Wang, David A Richards. Spatial regulation of exocytic site and vesicle mobilization by the actin cytoskeleton.
PloS one.
2011; 6(12):e29162. doi:
10.1371/journal.pone.0029162
. [PMID: 22195014] - Suman Dwivedi, Dharmendra Pandey, Anna L Khandoga, Richard Brandl, Wolfgang Siess. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque.
Journal of translational medicine.
2010 Dec; 8(?):128. doi:
10.1186/1479-5876-8-128
. [PMID: 21134286] - David R Berk, Alicia Miller, Debra Scarlett, Franz J Wippold, Susan J Bayliss, Dongsi Lu. Osseous metaplasia late in the course of nephrogenic systemic fibrosis.
Dermatology online journal.
2010 Aug; 16(8):3. doi:
NULL
. [PMID: 20804680] - A R Butler, S Khan, E Ferguson. A brief history of malaria chemotherapy.
The journal of the Royal College of Physicians of Edinburgh.
2010 Jun; 40(2):172-7. doi:
10.4997/jrcpe.2010.216
. [PMID: 20695174] - D B Kiselevsky, Yu E Kuznetsova, L A Vasil'ev, N V Lobysheva, R A Zinovkin, A V Nesov, A A Shestak, V D Samuilov. Effect of Ca2+ on programmed death of guard and epidermal cells of pea leaves.
Biochemistry. Biokhimiia.
2010 May; 75(5):614-22. doi:
10.1134/s0006297910050111
. [PMID: 20632941] - Kirsti Ytrehus, Torkjel Tveita, Einar Bugge. Loss of heart phospholipid arachidonic acid without phospholipid peroxidation in anaesthetized rats rewarmed after prolonged deep hypothermia.
Cryobiology.
2009 Dec; 59(3):297-301. doi:
10.1016/j.cryobiol.2009.08.006
. [PMID: 19723518] - Zsuzsanna Sasvari, Stéphane Bach, Marc Blondel, Peter D Nagy. Inhibition of RNA recruitment and replication of an RNA virus by acridine derivatives with known anti-prion activities.
PloS one.
2009 Oct; 4(10):e7376. doi:
10.1371/journal.pone.0007376
. [PMID: 19823675] - Juliana B R Corrêa Soares, Diego Menezes, Marcos A Vannier-Santos, Antonio Ferreira-Pereira, Giulliana T Almeida, Thiago M Venancio, Sergio Verjovski-Almeida, Vincent K Zishiri, David Kuter, Roger Hunter, Timothy J Egan, Marcus F Oliveira. Interference with hemozoin formation represents an important mechanism of schistosomicidal action of antimalarial quinoline methanols.
PLoS neglected tropical diseases.
2009 Jul; 3(7):e477. doi:
10.1371/journal.pntd.0000477
. [PMID: 19597543] - Yoon-Yub Park. Ischemia/reperfusion Lung Injury Increases Serum Ferritin and Heme Oxygenase-1 in Rats.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2009 Jun; 13(3):181-7. doi:
10.4196/kjpp.2009.13.3.181
. [PMID: 19885035] - Hye-Jin Choi, Jung Han Lee, Shin-Young Park, Ju Hwan Cho, Joong-Soo Han. STAT3 is involved in phosphatidic acid-induced Bcl-2 expression in HeLa cells.
Experimental & molecular medicine.
2009 Feb; 41(2):94-101. doi:
10.3858/emm.2009.41.2.012
. [PMID: 19287190] - Helio Miranda Costa-Junior, Anderson Nogueira Mendes, Gustavo Henrique Nolasco Grimmer Davis, Cristiane Monteiro da Cruz, Ana Lúcia Marques Ventura, Carlos Henrique Serezani, Lucia Helena Faccioli, Auro Nomizo, Célio G Freire-de-Lima, Rodrigo da Cunha Bisaggio, Pedro Muanis Persechini. ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages.
Prostaglandins & other lipid mediators.
2009 Jan; 88(1-2):51-61. doi:
10.1016/j.prostaglandins.2008.09.004
. [PMID: 18984060] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479
. [PMID: 18426954] - Jung J Kang, Ildikó Toma, Arnold Sipos, Elliott J Meer, Sarah L Vargas, János Peti-Peterdi. The collecting duct is the major source of prorenin in diabetes.
Hypertension (Dallas, Tex. : 1979).
2008 Jun; 51(6):1597-604. doi:
10.1161/hypertensionaha.107.107268
. [PMID: 18413493] - K Mørch, K Hanevik, L J Robertson, E A Strand, N Langeland. Treatment-ladder and genetic characterisation of parasites in refractory giardiasis after an outbreak in Norway.
The Journal of infection.
2008 Apr; 56(4):268-73. doi:
10.1016/j.jinf.2008.01.013
. [PMID: 18328567] - Ferenc Zsila, Júlia Visy, György Mády, Ilona Fitos. Selective plasma protein binding of antimalarial drugs to alpha1-acid glycoprotein.
Bioorganic & medicinal chemistry.
2008 Apr; 16(7):3759-72. doi:
10.1016/j.bmc.2008.01.053
. [PMID: 18289858] - Yuji Moriyasu, Yuko Inoue. Use of protease inhibitors for detecting autophagy in plants.
Methods in enzymology.
2008; 451(?):557-80. doi:
10.1016/s0076-6879(08)03232-1
. [PMID: 19185740] - Evgeny Pryazhnikov, Leonard Khiroug. Sub-micromolar increase in [Ca(2+)](i) triggers delayed exocytosis of ATP in cultured astrocytes.
Glia.
2008 Jan; 56(1):38-49. doi:
10.1002/glia.20590
. [PMID: 17910050] - Jessica N Mazerik, Thomas Hagele, Shariq Sherwani, Valorie Ciapala, Susan Butler, M Lakshmi Kuppusamy, Melissa Hunter, Periannan Kuppusamy, Clay B Marsh, Narasimham L Parinandi. Phospholipase A2 activation regulates cytotoxicity of methylmercury in vascular endothelial cells.
International journal of toxicology.
2007 Nov; 26(6):553-69. doi:
10.1080/10915810701707759
. [PMID: 18066971] - Takahiro Shimizu, Naoko Yamaguchi, Shoshiro Okada, Lianyi Lu, Tsuyoshi Sasaki, Kunihiko Yokotani. Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats.
European journal of pharmacology.
2007 Oct; 571(2-3):138-44. doi:
10.1016/j.ejphar.2007.05.061
. [PMID: 17628524] - E M Shapovalova, A J Rudzevich. Effect of inhibitors of arachidonic acid conversion in platelets on thrombin-fibrinogen interaction and thrombin tolerance.
Bulletin of experimental biology and medicine.
2007 Oct; 144(4):527-8. doi:
10.1007/s10517-007-0368-4
. [PMID: 18642704] - Tina Pangršič, Maja Potokar, Matjaž Stenovec, Marko Kreft, Elsa Fabbretti, Andrea Nistri, Evgeny Pryazhnikov, Leonard Khiroug, Rashid Giniatullin, Robert Zorec. Exocytotic release of ATP from cultured astrocytes.
The Journal of biological chemistry.
2007 Sep; 282(39):28749-28758. doi:
10.1074/jbc.m700290200
. [PMID: 17627942] - Virgilio L Lew, Nuala Daw, Zipora Etzion, Teresa Tiffert, Adaeze Muoma, Laura Vanagas, Robert M Bookchin. Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells.
Blood.
2007 Aug; 110(4):1334-42. doi:
10.1182/blood-2006-11-057232
. [PMID: 17456724] - Tomohisa Mori, Shinobu Ito, Mizuho Namiki, Tadashi Suzuki, Shizuko Kobayashi, Kenji Matsubayashi, Toshiko Sawaguchi. Involvement of free radicals followed by the activation of phospholipase A2 in the mechanism that underlies the combined effects of methamphetamine and morphine on subacute toxicity or lethality in mice: comparison of the therapeutic potential of fullerene, mepacrine, and cooling.
Toxicology.
2007 Jul; 236(3):149-57. doi:
10.1016/j.tox.2007.03.027
. [PMID: 17553606] - Vedam Rama Murthy, Donkena Venkata Raghuram, Pirala Narayana Murthy. Drug, dosage, activity, studies of antimalarials by physical methods--II.
Bioinformation.
2007 May; 2(1):12-6. doi:
10.6026/97320630002012
. [PMID: 18084644] - L A Vasil'ev, A A Vorobyov, E V Dzyubinskaya, A V Nesov, A A Shestak, V D Samuilov. Cyanide-induced death of cells in plant leaves.
Biochemistry. Biokhimiia.
2007 May; 72(5):572-82. doi:
10.1134/s000629790705015x
. [PMID: 17573713] - Ho Jae Han, Min Jin Lim, Yun Jung Lee, Jang Hern Lee, Il Suk Yang, Mary Taub. Uric acid inhibits renal proximal tubule cell proliferation via at least two signaling pathways involving PKC, MAPK, cPLA2, and NF-kappaB.
American journal of physiology. Renal physiology.
2007 Jan; 292(1):F373-81. doi:
10.1152/ajprenal.00104.2006
. [PMID: 16985215] - W Kozak, S Wrotek, K Walentynowicz. Hypoxia-induced sickness behaviour.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2006 Nov; 57 Suppl 8(?):35-50. doi:
NULL
. [PMID: 17242471] - Roberto Canete, Angel A Escobedo, Maria E Gonzalez, Pedro Almirall. Randomized clinical study of five days apostrophe therapy with mebendazole compared to quinacrine in the treatment of symptomatic giardiasis in children.
World journal of gastroenterology.
2006 Oct; 12(39):6366-70. doi:
10.3748/wjg.v12.i39.6366
. [PMID: 17072963] - Robert Loncar, Uwe Kalina, Volker Stoldt, Volker Thomas, Rüdiger E Scharf, Aleksandar Vodovnik. Antithrombin significantly influences platelet adhesion onto immobilized fibrinogen in an in-vitro system simulating low flow.
Thrombosis journal.
2006 Oct; 4(?):19. doi:
10.1186/1477-9560-4-19
. [PMID: 17040572] - Dan Zhu, Ming-Yi Jiang, Ming-Pu Tan. [The mechanism of ABA-induced apoplastic H2O2 accumulation in maize leaves].
Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology.
2006 Oct; 32(5):519-26. doi:
. [PMID: 17075174]
- Ralf Klingenstein, Stefan Löber, Pekka Kujala, Susan Godsave, S Rutger Leliveld, Peter Gmeiner, Peter J Peters, Carsten Korth. Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments.
Journal of neurochemistry.
2006 Aug; 98(3):748-59. doi:
10.1111/j.1471-4159.2006.03889.x
. [PMID: 16749906] - Yong Huang, Hideaki Okochi, Barnaby C H May, Giuseppe Legname, Stanley B Prusiner, Leslie Z Benet, B Joseph Guglielmo, Emil T Lin. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Jul; 34(7):1136-44. doi:
10.1124/dmd.105.008664
. [PMID: 16581945] - J E Comer, D M Noffsinger, D J McHenry, D M Weisbaum, B M Chatuev, A K Chopra, J W Peterson. Evaluation of the protective effects of quinacrine against Bacillus anthracis Ames.
Journal of toxicology and environmental health. Part A.
2006 Jun; 69(11):1083-95. doi:
10.1080/15287390500360281
. [PMID: 16840255] - L D Alexander, Y Ding, S Alagarsamy, X-L Cui, J G Douglas. Arachidonic acid induces ERK activation via Src SH2 domain association with the epidermal growth factor receptor.
Kidney international.
2006 May; 69(10):1823-32. doi:
10.1038/sj.ki.5000363
. [PMID: 16598196] - E Toubi, A Kessel, I Rosner, M Rozenbaum, D Paran, Y Shoenfeld. The reduction of serum B-lymphocyte activating factor levels following quinacrine add-on therapy in systemic lupus erythematosus.
Scandinavian journal of immunology.
2006 Apr; 63(4):299-303. doi:
10.1111/j.1365-3083.2006.01737.x
. [PMID: 16623930] - Tze-Wen Chung, Min-Chia Yang, Wei-Jean Tsai. A fibrin encapsulated liposomes-in-chitosan matrix (FLCM) for delivering water-soluble drugs. Influences of the surface properties of liposomes and the crosslinked fibrin network.
International journal of pharmaceutics.
2006 Mar; 311(1-2):122-9. doi:
10.1016/j.ijpharm.2005.12.038
. [PMID: 16446064] - Miguel A Sanjuan, Navin Rao, Kuei-Tai A Lai, Yin Gu, Siquan Sun, Anja Fuchs, Wai-Ping Fung-Leung, Marco Colonna, Lars Karlsson. CpG-induced tyrosine phosphorylation occurs via a TLR9-independent mechanism and is required for cytokine secretion.
The Journal of cell biology.
2006 Mar; 172(7):1057-68. doi:
10.1083/jcb.200508058
. [PMID: 16567503] - Warren Thomas, Natasha Coen, Sheila Faherty, Cathal O Flatharta, Brian J Harvey. Estrogen induces phospholipase A2 activation through ERK1/2 to mobilize intracellular calcium in MCF-7 cells.
Steroids.
2006 Mar; 71(3):256-65. doi:
10.1016/j.steroids.2005.10.010
. [PMID: 16375935] - Yu-Jen Chen. Phospholipase A(2) activity of beta-bungarotoxin is essential for induction of cytotoxicity on cerebellar granule neurons.
Journal of neurobiology.
2005 Aug; 64(2):213-23. doi:
10.1002/neu.20137
. [PMID: 15849737] - Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi, Junichi Arai, Hiroshi Wakiguchi, Kunihiko Yokotani. Brain phospholipase C/diacylglycerol lipase are involved in bombesin BB2 receptor-mediated activation of sympatho-adrenomedullary outflow in rats.
European journal of pharmacology.
2005 May; 514(2-3):151-8. doi:
10.1016/j.ejphar.2005.03.033
. [PMID: 15910801] - Frank Orlik, Bettina Schiffler, Roland Benz. Anthrax toxin protective antigen: inhibition of channel function by chloroquine and related compounds and study of binding kinetics using the current noise analysis.
Biophysical journal.
2005 Mar; 88(3):1715-24. doi:
10.1529/biophysj.104.050336
. [PMID: 15596516] - Kenji Yamada, Kentaro Fuji, Tomoo Shimada, Mikio Nishimura, Ikuko Hara-Nishimura. Endosomal proteases facilitate the fusion of endosomes with vacuoles at the final step of the endocytotic pathway.
The Plant journal : for cell and molecular biology.
2005 Mar; 41(6):888-98. doi:
10.1111/j.1365-313x.2005.02349.x
. [PMID: 15743452] - Gabriele Jedlitschky, Konstanze Tirschmann, Lena E Lubenow, Hendrik K Nieuwenhuis, Jan W N Akkerman, Andreas Greinacher, Heyo K Kroemer. The nucleotide transporter MRP4 (ABCC4) is highly expressed in human platelets and present in dense granules, indicating a role in mediator storage.
Blood.
2004 Dec; 104(12):3603-10. doi:
10.1182/blood-2003-12-4330
. [PMID: 15297306] - Lotus Yung, Yong Huang, Pierre Lessard, Giuseppe Legname, Emil T Lin, Michael Baldwin, Stanley B Prusiner, Chongsuk Ryou, B Joseph Guglielmo. Pharmacokinetics of quinacrine in the treatment of prion disease.
BMC infectious diseases.
2004 Nov; 4(?):53. doi:
10.1186/1471-2334-4-53
. [PMID: 15569390] - Park Yoon-yub, Brooks Hybertson, Richard Wright, Mehdi Fini, Nancy Elkins, John Repine. Serum ferritin elevation and acute lung injury in rats subjected to hemorrhage: reduction by mepacrine treatment.
Experimental lung research.
2004 Oct; 30(7):571-84. doi:
10.1080/01902140490489207
. [PMID: 15371093] - Ho Jae Han, Min Jin Lim, Yun Jung Lee. Oxalate inhibits renal proximal tubule cell proliferation via oxidative stress, p38 MAPK/JNK, and cPLA2 signaling pathways.
American journal of physiology. Cell physiology.
2004 Oct; 287(4):C1058-66. doi:
10.1152/ajpcell.00063.2004
. [PMID: 15229103] - Takahiro Shimizu, Shoshiro Okada, Naoko Yamaguchi-Shima, Kunihiko Yokotani. Brain phospholipase C-diacylglycerol lipase pathway is involved in vasopressin-induced release of noradrenaline and adrenaline from adrenal medulla in rats.
European journal of pharmacology.
2004 Sep; 499(1-2):99-105. doi:
10.1016/j.ejphar.2004.07.087
. [PMID: 15363956] - Su Hyung Park, Yun Jung Lee, Min Jin Lim, Eun Jung Kim, Jang Hern Lee, Ho Jae Han. High glucose inhibits fructose uptake in renal proximal tubule cells: involvement of cAMP, PLC/PKC, p44/42 MAPK, and cPLA2.
Journal of cellular physiology.
2004 Sep; 200(3):407-16. doi:
10.1002/jcp.20023
. [PMID: 15254969] - Parvaiz A Koul. Species identification after treatment for taeniasis.
Lancet (London, England).
2004 Jun; 363(9425):1999; author reply 1999. doi:
10.1016/s0140-6736(04)16420-9
. [PMID: 15194265] - Walter Oleschko Arruda, Kelly C Bordignon, Jerônimo B Milano, Ricardo Ramina. [Creutzfeldt-Jakob disease, Heidenhain variant: case report with MRI (DWI) findings].
Arquivos de neuro-psiquiatria.
2004 Jun; 62(2A):347-52. doi:
10.1590/s0004-282x2004000200029
. [PMID: 15235744] - Ho Jae Han, Soo Hyun Park, Yun Jung Lee. Signaling cascade of ANG II-induced inhibition of alpha-MG uptake in renal proximal tubule cells.
American journal of physiology. Renal physiology.
2004 Apr; 286(4):F634-42. doi:
10.1152/ajprenal.00217.2003
. [PMID: 14644748] - Gian Gaetano Aloisi, Arianna Barbafina, Marcella Canton, Francesco Dall'Acqua, Fausto Elisei, Laura Facciolo, Loredana Latterini, Giampietro Viola. Photophysical and photobiological behavior of antimalarial drugs in aqueous solutions.
Photochemistry and photobiology.
2004 Mar; 79(3):248-58. doi:
10.1562/sa-03-29.1
. [PMID: 15115297] - Changbin Chen, Martin B Dickman. Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signalling pathways.
Molecular microbiology.
2004 Mar; 51(5):1493-507. doi:
10.1111/j.1365-2958.2003.03932.x
. [PMID: 14982641] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h
. [PMID: 14971904] - Larry D Alexander, Suganthi Alagarsamy, Janice G Douglas. Cyclic stretch-induced cPLA2 mediates ERK 1/2 signaling in rabbit proximal tubule cells.
Kidney international.
2004 Feb; 65(2):551-63. doi:
10.1111/j.1523-1755.2004.00405.x
. [PMID: 14717925] - A G Lopes, A C Soares, D P A Santos, M S Fernandes, L R Leão-Ferreira, E Quintana-Gomes, C Caruso-Neves. PLA2/PGE2 are involved in the inhibitory effect of bradykinin on the angiotensin-(1-7)-stimulated Na(+)-ATPase activity of the proximal tubule.
Regulatory peptides.
2004 Jan; 117(1):37-41. doi:
10.1016/j.regpep.2003.10.001
. [PMID: 14687699]