Classification Term: 578

Acridines (ontology term: CHEMONTID:0000274)

Organic compounds containing the acridine moiety, a linear tricyclic heterocycle which consists of two benzene rings joined by a pyridine ring." []

found 38 associated metabolites at category metabolite taxonomy ontology rank level.

Ancestor: Benzoquinolines

Child Taxonomies: Quinacridines, Pyrroloacridines, Pyridoacridines, Acridones, Benzacridines

Acridine orange

N,N,N,n-tetramethyl-3,6-acridinediamine hydrochloride

C17H19N3 (265.1579)


D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents D004396 - Coloring Agents > D005456 - Fluorescent Dyes D009676 - Noxae > D009153 - Mutagens

   

Tacrine

Parke davis brand OF tacrine hydrochloride

C13H14N2 (198.1157)


Tacrine is only found in individuals that have used or taken this drug. It is a centerally active cholinesterase inhibitor that has been used to counter the effects of muscle relaxants, as a respiratory stimulant, and in the treatment of Alzheimers disease and other central nervous system disorders. [PubChem]The mechanism of tacrine is not fully known, but it is suggested that the drug is an anticholinesterase agent which reversibly binds with and inactivates cholinesterases. This inhibits the hydrolysis of acetylcholine released from functioning cholinergic neurons, thus leading to an accumulation of acetylcholine at cholinergic synapses. The result is a prolonged effect of acetylcholine. D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010277 - Parasympathomimetics D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors N - Nervous system > N06 - Psychoanaleptics > N06D - Anti-dementia drugs > N06DA - Anticholinesterases D002491 - Central Nervous System Agents > D018697 - Nootropic Agents C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D004791 - Enzyme Inhibitors KEIO_ID A123

   

Acridine

2,3,5,6-Dibenzopyridine

C13H9N (179.0735)


C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent CONFIDENCE standard compound; INTERNAL_ID 2517 CONFIDENCE standard compound; INTERNAL_ID 3

   

Quinacrine

N(4)-(6-Chloro-2-methoxy-9-acridinyl)-N(1),N(1)-diethyl-1,4-pentanediamine

C23H30ClN3O (399.2077)


An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years. It has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. [PubChem] P - Antiparasitic products, insecticides and repellents > P01 - Antiprotozoals > P01A - Agents against amoebiasis and other protozoal diseases D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000981 - Antiprotozoal Agents D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C277 - Antiprotozoal Agent D000970 - Antineoplastic Agents D004791 - Enzyme Inhibitors

   

Proflavine

Hemisulfate, proflavine

C13H11N3 (209.0953)


Proflavine is only found in individuals that have used or taken this drug. It is a topical antiseptic used mainly in wound dressings. [PubChem]Proflavine acts by interchelating DNA (intercalation), thereby disrupting DNA synthesis and leading to high levels of mutation in the copied DNA strands. This prevents bacterial reproduction. C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent D000890 - Anti-Infective Agents

   

Amsacrine

N-{4-[(acridin-9-yl)amino]-3-methoxyphenyl}methanesulfonamide

C21H19N3O3S (393.1147)


Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. [PubChem] C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D007364 - Intercalating Agents L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents D000970 - Antineoplastic Agents

   

Velnacrine

1,2,3,4-Tetrahydro-9-aminoacridin-1-ol maleate

C13H14N2O (214.1106)


Velnacrine belongs to the family of Acridines. These are organic compounds containing the acridine moiety, a linear tricyclic heterocyle which consists of two benzene rings joined by a pyridine ring. D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor D004791 - Enzyme Inhibitors

   

1-Aminoacridine

Hydrochloride, aminoacridine

C13H10N2 (194.0844)


D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents D004396 - Coloring Agents > D005456 - Fluorescent Dyes D009676 - Noxae > D009153 - Mutagens D000890 - Anti-Infective Agents

   

9-Amino-1,2,3,4-tetrahydroacridin-2-ol

9-amino-1,2,3,4-tetrahydroacridin-2-ol

C13H14N2O (214.1106)


   

Acridine, 3,6-bis(2-(1-piperidinyl)ethoxy)-

3,6-Bis(2-piperidinoethoxy)acridine trihydrochloride

C27H35N3O2 (433.2729)


   

4-Acridinecarboxamide

acridine-4-carboxamide

C14H10N2O (222.0793)


   

7-Methoxy-1,2,3,4-tetrahydroacridin-9-amine

9-Amino-7-methoxy-1,2,3,4-tetrahydroacridine

C14H16N2O (228.1263)


   

9-Amino-1,2,3,4-tetrahydroacridin-4-ol

9-amino-1,2,3,4-tetrahydroacridin-4-ol

C13H14N2O (214.1106)


   

9-Amino-N-[3-(Dimethylamino)Propyl]Acridine-4-Carboxamide

9-amino-N-[3-(dimethylamino)propyl]acridine-4-carboxamide

C19H22N4O (322.1794)


   

9-Aminoacridine

Beutlich brand OF aminacrine hydrochloride

C13H10N2 (194.0844)


D - Dermatologicals > D08 - Antiseptics and disinfectants > D08A - Antiseptics and disinfectants > D08AA - Acridine derivatives D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent D004396 - Coloring Agents > D005456 - Fluorescent Dyes D009676 - Noxae > D009153 - Mutagens D000890 - Anti-Infective Agents

   

9-Anilinoacridine

N-phenylacridin-9-amine

C19H14N2 (270.1157)


   

9-Hydrazinoacridine

acridine, 9-hydrazino-

C13H11N3 (209.0953)


   

9-Hydroxymethyl-10-carbamoylacridan

9-(hydroxymethyl)-9,10-dihydroacridine-10-carboxamide

C15H14N2O2 (254.1055)


   

9,10-Dihydroacridine

910-Dihydro-acridine

C13H11N (181.0891)


   

1-[(6-Chloro-2-methoxyacridin-9-yl)amino]-3-(diethylamino)propan-2-ol

1-[(6-chloro-2-methoxy-9,10-dihydroacridin-9-ylidene)amino]-3-(diethylamino)propan-2-ol

C21H26ClN3O2 (387.1713)


   

Amustaline

(N,N-Bis(2-chloroethyl))-2-aminoethyl-3-((acridin-9-yl)amino)propionate

C22H25Cl2N3O2 (433.1324)


D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent

   

Asulacrine

N-5-Dimethyl-9-((2-methoxy-4-methylsulfonylamino)phenylamino)-4-acridinecarboxamide

C24H24N4O4S (464.1518)


C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D004791 - Enzyme Inhibitors

   

N,N'-Di-1,2,3,4-Tetrahydroacridin-9-Ylheptane-1,7-Diamine

N1,N7-bis(2,3,4,10-tetrahydro-1H-acridin-9-ylidene)heptane-1,7-diamine

C33H40N4 (492.3253)


   

9-((3-Dimethylaminopropyl)amino)acridine

N-[3-(dimethylamino)propyl]acridin-9-amine

C18H21N3 (279.1735)


   

Aminoacylase

7-[(1,3-dichloro-6,7,8,10-tetrahydro-5H-acridin-9-ylidene)amino]-N-[2-(1H-indol-3-yl)ethyl]heptanimidic acid

C30H34Cl2N4O (536.211)


   

Acridine carboxamide

N-[2-(Dimethylamino)ethyl]acridine-4-carboximidate

C18H19N3O (293.1528)


C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor > C1748 - Topoisomerase Inhibitor C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D004791 - Enzyme Inhibitors

   

Dimetacrine

[3-(9,9-dimethyl-9,10-dihydroacridin-10-yl)propyl]dimethylamine

C20H26N2 (294.2096)


N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants > N06AA - Non-selective monoamine reuptake inhibitors C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent

   

Ethacridine

7-ethoxy-9-imino-9,10-dihydroacridin-3-amine

C15H15N3O (253.1215)


D000890 - Anti-Infective Agents C254 - Anti-Infective Agent

   

N-(4-(4-Methyl-1-piperazinyl)phenyl)-9-acridinamine

Acridin-9-yl-(4-(4-methylpiperazin-1-yl)-phenyl)amine

C24H24N4 (368.2001)


   

2-[(Acridin-9-ylamino)methyl]-4-[bis(2-chloroethyl)amino]butanoic acid

4-[Bis(2-chloroethyl)amino]-2-{[(9,10-dihydroacridin-9-ylidene)amino]methyl}butanoate

C22H25Cl2N3O2 (433.1324)


   

Nitracrine

N-[3-(dimethylamino)propyl]-1-nitroacridin-9-amine

C18H20N4O2 (324.1586)


C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D000970 - Antineoplastic Agents

   

Nonyl acridine

1-nonylacridine

C22H27N (305.2143)


   

Pyrazoloacridine

(3-{4-methoxy-10-nitro-8,14,15-triazatetracyclo[7.6.1.0^{2,7}.0^{13,16}]hexadeca-1(15),2,4,6,9(16),10,12-heptaen-14-yl}propyl)dimethylamine

C19H21N5O3 (367.1644)


C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D007364 - Intercalating Agents D000970 - Antineoplastic Agents

   

pyrazoloacridone

8H,9H,10H-indazolo[5,4-b]quinolin-9-one

C14H9N3O (235.0746)


   

10-(2-(Diethylamino)ethyl)-9(10H)-acridinone (4,5-dihydro-2-thiazolyl)hydrazone

(2-{9-[2-(4,5-dihydro-1,3-thiazol-2-yl)hydrazin-1-ylidene]-9,10-dihydroacridin-10-yl}ethyl)diethylamine

C22H27N5S (393.1987)


   

10-Methyl-9-(10-methyl-1H-acridin-9-yl)-1H-acridine

10,10'-dimethyl-1H,1'H,10H,10'H-9,9'-biacridine

C28H24N2 (388.1939)


   

C1=CC=CC2=CC3=C(O)C(N)=CC=C3N=C21

2-aminoacridin-1-ol

C13H10N2O (210.0793)


   

4'-(9-Acridinylamino)methanesulfonanilide

N-{4-[(9,10-dihydroacridin-9-ylidene)amino]phenyl}methanesulphonamide

C20H17N3O2S (363.1041)