Leukotriene D4 (BioDeep_00000003315)

 

Secondary id: BioDeep_00000629574

human metabolite Endogenous blood metabolite Volatile Flavor Compounds


代谢物信息卡片


(5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-amino-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid

化学式: C25H40N2O6S (496.26069400000006)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 0.37%

分子结构信息

SMILES: CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)N
InChI: InChI=1S/C25H40N2O6S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-22(21(28)15-14-17-23(29)30)34-19-20(26)25(33)27-18-24(31)32/h6-7,9-13,16,20-22,28H,2-5,8,14-15,17-19,26H2,1H3,(H,27,33)(H,29,30)(H,31,32)/b7-6-,10-9-,12-11+,16-13+/t20-,21-,22+/m0/s1

描述信息

Leukotriene D4 (LTD4) is a cysteinyl leukotriene. Cysteinyl leukotrienes (CysLTs) are a family of potent inflammatory mediators that appear to contribute to the pathophysiologic features of allergic rhinitis. LTD4 is a pro-inflammatory mediator known to mediate its effects through specific cell-surface receptors belonging to the G-protein-coupled receptor family, namely the high-affinity CysLT1 (cysteinyl leukotriene 1) receptor. LTD4 is present at high levels in many inflammatory conditions, and areas of chronic inflammation have an increased risk for subsequent cancer development. LTD4 is associated with the pathogenesis of several inflammatory disorders, such as asthma and inflammatory bowel disease. Exposure to LTD4 increases survival and proliferation in intestinal epithelial cells. CysLT1 regulator is up-regulated in colon cancer tissue and LTD4 signalling facilitates the survival of cancer cells. LTD4 could reduce apoptosis in non-transformed epithelial cells. LTD4 causes up-regulation of beta-catenin through the CysLT1 receptor, PI3K (phosphoinositide 3-kinase), and GSK-3β (glycogen synthase kinase 3β). LTD4 induces beta-catenin translocation to the nucleus and activation of TCF/LEF family of transcription factors. LTD4 causes accumulation of free beta-catenin in non-transformed intestinal epithelial cells through the CysLT1 receptor, and this accumulation is dependent upon the activation of PI3K as well as GSK-3β inactivation (PMID: 16042577, 12607939). Leukotrienes are eicosanoids. The eicosanoids consist of the prostaglandins (PGs), thromboxanes (TXs), leukotrienes (LTs), and lipoxins (LXs). The PGs and TXs are collectively identified as prostanoids. Prostaglandins were originally shown to be synthesized in the prostate gland, thromboxanes from platelets (thrombocytes), and leukotrienes from leukocytes, hence the derivation of their names. All mammalian cells except erythrocytes synthesize eicosanoids. These molecules are extremely potent and are able to cause profound physiological effects at very dilute concentrations. All eicosanoids function locally at the site of synthesis through receptor-mediated G-protein linked signaling pathways.
Leukotriene D4 (LTD4) is a cysteinyl leukotriene a family of potent inflammatory mediators. LTD4 is a pro-inflammatory mediator known to mediate its effects through specific cell-surface receptors belonging to the G-protein-coupled receptor family, namely the high-affinity CysLT1 (cysteinyl leukotriene 1) receptor. LTD4 is present at high levels in many inflammatory conditions, and areas of chronic inflammation have an increased risk for subsequent cancer development; LTD4 is associated with the pathogenesis of several inflammatory disorders, such as asthma and inflammatory bowel disease. Exposure to LTD4 increases survival and proliferation in intestinal epithelial cells. CysLT1 regulator is up-regulated in colon cancer tissue and LTD4 signalling facilitates the survival of cancer cells. LTD4 could reduce apoptosis in non-transformed epithelial cells. LTD4 causes up-regulation of b-catenin through the CysLT1 receptor, PI3K (phosphoinositide 3-kinase) and GSK-3b (glycogen synthase kinase 3b). LTD4 induces b-catenin translocation to the nucleus and activation of TCF/LEF family of transcription factors. LTD4 causes accumulation of free b-catenin in non-transformed intestinal epithelial cells through the CysLT1 receptor, and this accumulation is dependent upon the activation of PI3K as well as GSK-3b inactivation. (PMID: 16042577, 12607939)

同义名列表

12 个代谢物同义名

(5S,6R,7E,9E,11Z,14Z)-6-{[(2R)-2-amino-2-[(carboxymethyl)carbamoyl]ethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid; (R-(R*,s*-(e,e,Z,Z)))-N-(S-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-L-cysteinyl)glycine; 5S-hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoic acid; 5S-Hydroxy-6R-(S-cysteinylglycinyl)-7E,9E,11E,14Z-eicosatetraenoate; Leukotriene D 4; Leukotriene D-4; Leukotrienes D; Leukotriene D4; Leukotriene D; FT-0641731; LTD4; Leukotriene D4



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(8)

BioCyc(0)

PlantCyc(0)

代谢反应

200 个相关的代谢反应过程信息。

Reactome(149)

BioCyc(0)

WikiPathways(4)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jesper Säfholm, Willem Abma, Lora G Bankova, Joshua A Boyce, Mamdoh Al-Ameri, Ann-Charlotte Orre, Craig E Wheelock, Sven-Erik Dahlén, Mikael Adner. Cysteinyl-maresin 3 inhibits IL-13 induced airway hyperresponsiveness through alternative activation of the CysLT1 receptor. European journal of pharmacology. 2022 Nov; 934(?):175257. doi: 10.1016/j.ejphar.2022.175257. [PMID: 36116518]
  • Ko Fujimori, Saki Uno, Kyohei Kuroda, Chihiro Matsumoto, Toko Maehara. Leukotriene C4 synthase is a novel PPARγ target gene, and leukotriene C4 and D4 activate adipogenesis through cysteinyl LT1 receptors in adipocytes. Biochimica et biophysica acta. Molecular cell research. 2022 03; 1869(3):119203. doi: 10.1016/j.bbamcr.2021.119203. [PMID: 34968576]
  • Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi. Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption. PloS one. 2022; 17(11):e0277307. doi: 10.1371/journal.pone.0277307. [PMID: 36395281]
  • Niraj Nepal, Subha Arthur, Molly R Butts, Soudamani Singh, Balasubramanian Palaniappan, Uma Sundaram. Molecular Mechanism of Stimulation of Na-K-ATPase by Leukotriene D4 in Intestinal Epithelial Cells. International journal of molecular sciences. 2021 Jul; 22(14):. doi: 10.3390/ijms22147569. [PMID: 34299188]
  • Neeraj Dholia, Gurupreet S Sethi, Amarjit S Naura, Umesh C S Yadav. Cysteinyl leukotriene D4 (LTD4) promotes airway epithelial cell inflammation and remodelling. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2021 Jan; 70(1):109-126. doi: 10.1007/s00011-020-01416-z. [PMID: 33136175]
  • Nosayba Al-Azzam, Lina Elsalem. Leukotriene D4 role in allergic asthma pathogenesis from cellular and therapeutic perspectives. Life sciences. 2020 Nov; 260(?):118452. doi: 10.1016/j.lfs.2020.118452. [PMID: 32956660]
  • Michele Biagioli, Adriana Carino, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Martina Bordoni, Chiara Fiorucci, Valentina Sepe, Paolo Conflitti, Vittorio Limongelli, Eleonora Distrutti, Monia Baldoni, Angela Zampella, Stefano Fiorucci. Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1. Biochemical pharmacology. 2020 07; 177(?):113987. doi: 10.1016/j.bcp.2020.113987. [PMID: 32330496]
  • Gwenaëlle Conseil, May Arama-Chayoth, Yossi Tsfadia, Susan P C Cole. Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1). FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 10; 33(10):10692-10704. doi: 10.1096/fj.201900140r. [PMID: 31268744]
  • Eric E Figueroa, Meghan Kramer, Kevin Strange, Jerod S Denton. CysLT1 receptor antagonists pranlukast and zafirlukast inhibit LRRC8-mediated volume regulated anion channels independently of the receptor. American journal of physiology. Cell physiology. 2019 10; 317(4):C857-C866. doi: 10.1152/ajpcell.00281.2019. [PMID: 31390227]
  • Jun Miyata, Koichi Fukunaga, Yusuke Kawashima, Takashi Watanabe, Akina Saitoh, Tomomi Hirosaki, Yasutomo Araki, Toru Kikawada, Tomoko Betsuyaku, Osamu Ohara, Makoto Arita. Dysregulated fatty acid metabolism in nasal polyp-derived eosinophils from patients with chronic rhinosinusitis. Allergy. 2019 06; 74(6):1113-1124. doi: 10.1111/all.13726. [PMID: 30667533]
  • Fanny Lapointe, Sylvie Turcotte, Steeve Véronneau, Marek Rola-Pleszczynski, Jana Stankova. Role of Protein Tyrosine Phosphatase Epsilon (PTPε) in Leukotriene D4-Induced CXCL8 Expression. The Journal of pharmacology and experimental therapeutics. 2019 05; 369(2):270-281. doi: 10.1124/jpet.118.255422. [PMID: 30867226]
  • Nan Chiang, Ian R Riley, Jesmond Dalli, Ana R Rodriguez, Bernd W Spur, Charles N Serhan. New maresin conjugates in tissue regeneration pathway counters leukotriene D4-stimulated vascular responses. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2018 07; 32(7):4043-4052. doi: 10.1096/fj.201701493r. [PMID: 29490167]
  • Maged W Helmy, Mai M Helmy, Mahmoud M El-Mas. Enhanced lipoxygenase/LTD4 signaling accounts for the exaggerated hypertensive and nephrotoxic effects of cyclosporine plus indomethacin in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jun; 102(?):309-316. doi: 10.1016/j.biopha.2018.03.065. [PMID: 29571015]
  • Neeraj Dholia, Umesh C S Yadav. Lipid mediator Leukotriene D4-induces airway epithelial cells proliferation through EGFR/ERK1/2 pathway. Prostaglandins & other lipid mediators. 2018 05; 136(?):55-63. doi: 10.1016/j.prostaglandins.2018.05.003. [PMID: 29751150]
  • Mai M Helmy, Amel A Hashim, Samar M Mouneir. Zileuton alleviates acute cisplatin nephrotoxicity: Inhibition of lipoxygenase pathway favorably modulates the renal oxidative/inflammatory/caspase-3 axis. Prostaglandins & other lipid mediators. 2018 03; 135(?):1-10. doi: 10.1016/j.prostaglandins.2018.01.001. [PMID: 29355720]
  • Qian Zhang, Ying Xiong, Guo-Bing Li, Qin Tang, Min Cao, Jing-Bin Huang, Mao Xing, Chang-Peng Hu, Ya Gong, Qing-Hua Wang, Ning Gao, Rong Zhang. Xinqin exhibits the anti-allergic effect through the JAK2/STAT5 signaling pathway. Journal of ethnopharmacology. 2016 Dec; 193(?):466-473. doi: 10.1016/j.jep.2016.09.045. [PMID: 27666014]
  • Ana Lukic, Jie Ji, Helena Idborg, Bengt Samuelsson, Lena Palmberg, Susanne Gabrielsson, Olof Rådmark. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4. Journal of lipid research. 2016 09; 57(9):1659-69. doi: 10.1194/jlr.m066910. [PMID: 27436590]
  • Kishan Bellamkonda, Naveen Kumar Chandrashekar, Janina Osman, Benson Chellakkan Selvanesan, Sayeh Savari, Anita Sjölander. The eicosanoids leukotriene D4 and prostaglandin E2 promote the tumorigenicity of colon cancer-initiating cells in a xenograft mouse model. BMC cancer. 2016 07; 16(?):425. doi: 10.1186/s12885-016-2466-z. [PMID: 27388564]
  • X Y Zhang, C X Shen, Z Wen, G X Li, H G Wang, F Chen. [The relationship between the key nasal symptoms and the level of histamineand leukotriene D4 in serum and nasal secretions in allergic rhinitis]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2016 Jul; 30(13):1025-1028. doi: 10.13201/j.issn.1001-1781.2016.13.005. [PMID: 29798030]
  • Kishan Bellamkonda, Wondossen Sime, Anita Sjölander. The impact of inflammatory lipid mediators on colon cancer-initiating cells. Molecular carcinogenesis. 2015 Nov; 54(11):1315-27. doi: 10.1002/mc.22207. [PMID: 25154976]
  • Hongya Han, Yongtao Xue-Franzén, Xinyan Miao, Edit Nagy, Nailin Li, Dawei Xu, Jan Sjöberg, Magnus Björkholm, Hans-Erik Claesson. Early growth response gene (EGR)-1 regulates leukotriene D4-induced cytokine transcription in Hodgkin lymphoma cells. Prostaglandins & other lipid mediators. 2015 Sep; 121(Pt A):122-30. doi: 10.1016/j.prostaglandins.2015.06.004. [PMID: 26115646]
  • Jia Xiao, Emily C Liong, Hai Huang, Wing On Tse, Kam Shing Lau, Jingfei Pan, Amin A Nanji, Man Lung Fung, Feiyue Xing, George L Tipoe. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2015 Feb; 143(2):430-40. doi: 10.1093/toxsci/kfu244. [PMID: 25432964]
  • Anna N Bukiya, Jacob McMillan, Jianxi Liu, Bangalore Shivakumar, Abby L Parrill, Alex M Dopico. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4. The Journal of biological chemistry. 2014 Dec; 289(51):35314-25. doi: 10.1074/jbc.m114.577825. [PMID: 25371198]
  • Tavga Salim, Janna Sand-Dejmek, Anita Sjölander. The inflammatory mediator leukotriene D₄ induces subcellular β-catenin translocation and migration of colon cancer cells. Experimental cell research. 2014 Feb; 321(2):255-66. doi: 10.1016/j.yexcr.2013.10.021. [PMID: 24211746]
  • Valérie Capra, G Enrico Rovati. Rosuvastatin inhibits human airway smooth muscle cells mitogenic response to eicosanoid contractile agents. Pulmonary pharmacology & therapeutics. 2014 Feb; 27(1):10-6. doi: 10.1016/j.pupt.2013.06.005. [PMID: 23806820]
  • Shu-ying Yu, Xia-yan Zhang, Xiao-rong Wang, Dong-min Xu, Lu Chen, Li-hui Zhang, San-hua Fang, Yun-bi Lu, Wei-ping Zhang, Er-qing Wei. Cysteinyl leukotriene receptor 1 mediates LTD4-induced activation of mouse microglial cells in vitro. Acta pharmacologica Sinica. 2014 Jan; 35(1):33-40. doi: 10.1038/aps.2013.130. [PMID: 24141567]
  • Hannah E Cummings, Tao Liu, Chunli Feng, Tanya M Laidlaw, Pamela B Conley, Yoshihide Kanaoka, Joshua A Boyce. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor. Journal of immunology (Baltimore, Md. : 1950). 2013 Dec; 191(12):5807-10. doi: 10.4049/jimmunol.1302187. [PMID: 24244016]
  • Leslie C Sharkey, M Judith Radin, Lois Heller, Lynette K Rogers, Anthony Tobias, Ilze Matise, Qi Wang, Fred S Apple, Sylvia A McCune. Differential cardiotoxicity in response to chronic doxorubicin treatment in male spontaneous hypertension-heart failure (SHHF), spontaneously hypertensive (SHR), and Wistar Kyoto (WKY) rats. Toxicology and applied pharmacology. 2013 Nov; 273(1):47-57. doi: 10.1016/j.taap.2013.08.012. [PMID: 23993975]
  • Kamila Syslová, Adéla Böhmová, Elvan Demirbağ, Kateřina Šimková, Marek Kuzma, Daniela Pelclová, Vratislav Sedlák, Petr Čáp, Pavel Martásek, Petr Kačer. Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes. Journal of pharmaceutical and biomedical analysis. 2013 Jul; 81-82(?):108-17. doi: 10.1016/j.jpba.2013.03.026. [PMID: 23644905]
  • Yoshihide Kanaoka, Akiko Maekawa, K Frank Austen. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand. The Journal of biological chemistry. 2013 Apr; 288(16):10967-72. doi: 10.1074/jbc.c113.453704. [PMID: 23504326]
  • Daihong Wan, Xuemei Liu, Guimei Li. The effects of montelukast on eosinophilic gastroenteritis in a mouse model. Immunopharmacology and immunotoxicology. 2013 Apr; 35(2):292-5. doi: 10.3109/08923973.2012.745871. [PMID: 23240855]
  • Xiao Yun Wang, Su Su Tang, Mei Hu, Yan Long, Yong Qi Li, Ming Xing Liao, Hui Ji, Hao Hong. Leukotriene D4 induces amyloid-β generation via CysLT(1)R-mediated NF-κB pathways in primary neurons. Neurochemistry international. 2013 Feb; 62(3):340-7. doi: 10.1016/j.neuint.2013.01.002. [PMID: 23318673]
  • Barbro Dahlén, Federico P Gómez, Alejandro Casas, Peter H Howarth, Sven-Erik Dahlén, Robert Rodriguez-Roisin. Salbutamol but not ipratropium abolishes leukotriene D4-induced gas exchange abnormalities in asthma. European journal of clinical pharmacology. 2012 Oct; 68(10):1375-83. doi: 10.1007/s00228-012-1256-z. [PMID: 22457014]
  • Pontus K A Forsell, Asa Brunnström, Malin Johannesson, Hans-Erik Claesson. Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and glutathione transferases. Lipids. 2012 Aug; 47(8):781-91. doi: 10.1007/s11745-012-3684-z. [PMID: 22684912]
  • Celine N Parmentier, Elisabeth Fuerst, Joanne McDonald, Holly Bowen, Tak H Lee, James E Pease, Grzegorz Woszczek, David J Cousins. Human T(H)2 cells respond to cysteinyl leukotrienes through selective expression of cysteinyl leukotriene receptor 1. The Journal of allergy and clinical immunology. 2012 Apr; 129(4):1136-42. doi: 10.1016/j.jaci.2012.01.057. [PMID: 22391114]
  • Nobuaki Mizutani, Takeshi Nabe, Masaji Shimazu, Shin Yoshino, Shigekatsu Kohno. Effect of Ganoderma lucidum on pollen-induced biphasic nasal blockage in a guinea pig model of allergic rhinitis. Phytotherapy research : PTR. 2012 Mar; 26(3):325-32. doi: 10.1002/ptr.3557. [PMID: 21698671]
  • Daniela Pelclová, Zdenka Fenclová, Stepánka Vlcková, Jindriška Lebedová, Kamila Syslová, Ondrej Pecha, Jaromír Belácek, Tomáš Navrátil, Marek Kuzma, Petr Kacer. Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis. Industrial health. 2012; 50(4):299-306. doi: 10.2486/indhealth.ms1274. [PMID: 22785421]
  • L Y Chen, M Eberlein, S Alsaaty, A Martinez-Anton, J Barb, P J Munson, R L Danner, Y Liu, C Logun, J H Shelhamer, G Woszczek. Cooperative and redundant signaling of leukotriene B4 and leukotriene D4 in human monocytes. Allergy. 2011 Oct; 66(10):1304-11. doi: 10.1111/j.1398-9995.2011.02647.x. [PMID: 21605126]
  • Hong Luo, Ye Yu, Ying Shen, Ligang Zeng, Nengbing Yan, Feng Ke, Xuanxiang Fu, Pengju Wang, Weijia Kong. [Changes of leukotriene D4 in nasal discharge and plasma of patients with persistent allergic rhinitis and the effects of antihistamine]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery. 2011 Apr; 25(8):342-6. doi: . [PMID: 21761705]
  • Ariane Brochu-Bourque, Steeve Véronneau, Marek Rola-Pleszczynski, Jana Stankova. Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor. The Journal of pharmacology and experimental therapeutics. 2011 Feb; 336(2):431-9. doi: 10.1124/jpet.110.172411. [PMID: 20966037]
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  • K Frank Austen, Akiko Maekawa, Yoshihide Kanaoka, Joshua A Boyce. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. The Journal of allergy and clinical immunology. 2009 Sep; 124(3):406-14; quiz 415. doi: 10.1016/j.jaci.2009.05.046. [PMID: 19647860]
  • Hans-Erik Claesson. On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma. Prostaglandins & other lipid mediators. 2009 Sep; 89(3-4):120-5. doi: 10.1016/j.prostaglandins.2008.12.003. [PMID: 19130894]
  • Akiko Maekawa, Barbara Balestrieri, K Frank Austen, Yoshihide Kanaoka. GPR17 is a negative regulator of the cysteinyl leukotriene 1 receptor response to leukotriene D4. Proceedings of the National Academy of Sciences of the United States of America. 2009 Jul; 106(28):11685-90. doi: 10.1073/pnas.0905364106. [PMID: 19561298]
  • Ewa Selg, Margareta Andersson, Lena Låstbom, Ake Ryrfeldt, Sven-Erik Dahlén. Two different mechanisms for modulation of bronchoconstriction in guinea-pigs by cyclooxygenase metabolites. Prostaglandins & other lipid mediators. 2009 Apr; 88(3-4):101-10. doi: 10.1016/j.prostaglandins.2008.11.003. [PMID: 19103301]
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