5-Keto-D-gluconate (BioDeep_00000003264)
Secondary id: BioDeep_00001869571
human metabolite Endogenous
代谢物信息卡片
化学式: C6H10O7 (194.0427)
中文名称: 5-酮-D-葡糖酸
谱图信息:
最多检出来源 Homo sapiens(plant) 16.76%
分子结构信息
SMILES: C(C(=O)C(C(C(C(=O)O)O)O)O)O
InChI: InChI=1S/C6H10O7/c7-1-2(8)3(9)4(10)5(11)6(12)13/h3-5,7,9-11H,1H2,(H,12,13)
描述信息
5-Keto-D-gluconate is metabolized from glucose in certain bacterial species. It is an intermediate in L-idonate degradation and ketogluconate metabolism. 5-Keto-D-gluconate 5-reductase catalyzes the reversible reduction of 5-ketogluconate to D-gluconate. This is the second reaction of the L-idonate catabolic pathway after uptake of L-idonate into the cell. The enzyme specifically reduces 5-ketogluconate using either NADH or NADPH. The enzyme is also specific for D-gluconate oxidation using NADP as the coenzyme, NAD does not serve as a coenzyme. 5-Keto-D-gluconate has also been found to be a metabolite of Gluconobacter (https://www.sciencedirect.com/science/article/pii/S138111779800112X).
5-Keto-D-gluconate is metabolized from glucose in certain bacterial species. It is an intermediate in L-idonate degradation and ketogluconate metabolism. 5-Keto-D-gluconate 5-reductase catalyzes the reversible reduction of 5-ketogluconate to D-gluconate. This is the second reaction of the L-idonate catabolic pathway after uptake of L-idonate into the cell. The enzyme specifically reduces 5-ketogluconate using either NADH or NADPH. The enzyme is also specific for D-gluconate oxidation using NADP as the coenzyme, NAD does not serve as a coenzyme. [HMDB]
同义名列表
16 个代谢物同义名
2,3,4,6-tetrahydroxy-5-oxohexanoic acid; D-xylo-5-hexulosonic acid; D-Lyxo-5-hexulosonic acid; 5-Dehydrogluconic acid; 5-Keto-D-gluconic acid; 5-dehydro-D-Gluconate; hex-5-ulosonic acid; D-tagaturonic acid; 5-Dehydrogluconate; 5-Keto-D-gluconate; 5-Ketogluconate; D-Tagaturonate; 5-K-Gluconate; Tagaturonate; 5K-Gluconate; 5-Keto-D-gluconic acid
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:180368
- ChEBI: CHEBI:17426
- KEGG: C01062
- PubChem: 5460352
- PubChem: 157
- HMDB: HMDB0011731
- ChEMBL: CHEMBL3307203
- ChEMBL: CHEMBL2008942
- MetaCyc: 5-DEHYDROGLUCONATE
- MetaCyc: CPD-645
- foodb: FDB028411
- chemspider: 152
- CAS: 5287-64-9
- CAS: 3470-36-8
- CAS: 815-89-4
- PMhub: MS000008657
- PubChem: 4301
- NIKKAJI: J92.813E
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
3 个相关的代谢反应过程信息。
Reactome(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Ketogluconate Metabolism:
5-Keto-D-gluconate + Hydrogen Ion + NADPH ⟶ Gluconic acid + NADP - Ketogluconate Metabolism:
2-Keto-L-gluconate + Hydrogen Ion + NADPH ⟶ Gluconic acid + NADP
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- V S Saravanan, P Kalaiarasan, M Madhaiyan, M Thangaraju. Solubilization of insoluble zinc compounds by Gluconacetobacter diazotrophicus and the detrimental action of zinc ion (Zn2+) and zinc chelates on root knot nematode Meloidogyne incognita.
Letters in applied microbiology.
2007 Mar; 44(3):235-41. doi:
10.1111/j.1472-765x.2006.02079.x. [PMID: 17309498] - V S Saravanan, M Madhaiyan, M Thangaraju. Solubilization of zinc compounds by the diazotrophic, plant growth promoting bacterium Gluconacetobacter diazotrophicus.
Chemosphere.
2007 Jan; 66(9):1794-8. doi:
10.1016/j.chemosphere.2006.07.067. [PMID: 16956644] - M K Samson, R L Stephens, S Rivkin, M Opipari, T Maloney, C W Groppe, R Fisher. Vinblastine, bleomycin, and cis-dichlorodiammineplatinum(II) in disseminated testicular cancer: preliminary report of a Southwest Oncology Group Study.
Cancer treatment reports.
1979 Sep; 63(9-10):1663-7. doi:
. [PMID: 91435]
