Lumazine (BioDeep_00000003138)
Secondary id: BioDeep_00000405889
human metabolite PANOMIX_OTCML-2023 blood metabolite BioNovoGene_Lab2019 natural product
代谢物信息卡片
化学式: C6H4N4O2 (164.0334)
中文名称: 无水茶碱, 2,4-二羟基蝶啶
谱图信息:
最多检出来源 Homo sapiens(blood) 25.98%
分子结构信息
SMILES: C1=CN=C2C(=N1)C(=O)NC(=O)N2
InChI: InChI=1S/C6H4N4O2/c11-5-3-4(8-2-1-7-3)9-6(12)10-5/h1-2H,(H2,8,9,10,11,12)
描述信息
Lumazine, also known as pteridine-2,4-dione or 2,4(3h,8h)-pteridinedione, belongs to pteridines and derivatives class of compounds. Those are polycyclic aromatic compounds containing a pteridine moiety, which consists of a pyrimidine fused to a pyrazine ring to form pyrimido(4,5-b)pyrazine. Lumazine is slightly soluble (in water) and a very weakly acidic compound (based on its pKa). Lumazine can be found in soy bean, which makes lumazine a potential biomarker for the consumption of this food product.
KEIO_ID L024
Pteridine-2,4(1H,3H)-dione is an endogenous metabolite.
同义名列表
13 个代谢物同义名
2,3,4,8-tetrahydropteridine-2,4-dione; 1H,3H-Pteridine-2,4-dione; 2,4(3H,8H)-Pteridinedione; 2,4-Dihydroxypteridine; 1H-pteridine-2,4-dione; Pteridine-2,4-dione; 2,4-Pteridinedione; 2,4-Pteridinediol; Lumazine; 2,4-Dihydroxypteridine; Pteridine-2,4(1H,3H)-dione; 2,4-Dihydroxypteridine; Lumazine
数据库引用编号
27 个数据库交叉引用编号
- ChEBI: CHEBI:16489
- KEGG: C03212
- PubChem: 10250
- HMDB: HMDB0254198
- Metlin: METLIN44770
- ChEMBL: CHEMBL1234104
- MetaCyc: CPD-15309
- KNApSAcK: C00019640
- foodb: FDB005597
- chemspider: 9832
- CAS: 487-21-8
- CAS: 525-77-9
- MoNA: KO003302
- MoNA: KO003306
- MoNA: KO003305
- MoNA: KO003304
- MoNA: KO003303
- PMhub: MS000008238
- PubChem: 6086
- PDB-CCD: LUZ
- 3DMET: B00559
- NIKKAJI: J6.019D
- RefMet: Lumazine
- medchemexpress: HY-W037619
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-293
- KNApSAcK: 16489
- LOTUS: LTS0182033
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 6656 - Arthropoda: LTS0182033
- 2759 - Eukaryota: LTS0182033
- 72766 - Formica: LTS0182033
- 145467 - Formica polyctena: 10.1515/ZNB-1969-0914
- 145467 - Formica polyctena: LTS0182033
- 36668 - Formicidae: LTS0182033
- 9606 - Homo sapiens: -
- 50557 - Insecta: LTS0182033
- 33208 - Metazoa: LTS0182033
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Karthik Dhananjayan, Felix Irrgang, Ritesh Raju, David G Harman, Chris Moran, Velandai Srikanth, Gerald Münch. Determination of glyoxal and methylglyoxal in serum by UHPLC coupled with fluorescence detection.
Analytical biochemistry.
2019 05; 573(?):51-66. doi:
10.1016/j.ab.2019.02.014. [PMID: 30796906] - Boonyanoot Chaiyosang, Kwanjai Kanokmedhakul, Jaursup Boonmak, Sujittra Youngme, Veerapol Kukongviriyapan, Kasem Soytong, Somdej Kanokmedhakul. A new lumazine peptide penilumamide E from the fungus Aspergillus terreus.
Natural product research.
2016; 30(9):1017-24. doi:
10.1080/14786419.2015.1101107. [PMID: 26518160] - N Shaemningwar Moyon, Mullah Muhaiminul Islam, Smritakshi Phukan, Sivaprasad Mitra. Fluorescence modulation and associative behavior of lumazine in hydrophobic domain of micelles and bovine serum albumin.
Journal of photochemistry and photobiology. B, Biology.
2013 Apr; 121(?):37-45. doi:
10.1016/j.jphotobiol.2013.02.008. [PMID: 23501728] - Cosima D Calvano, Saverio Carulli, Francesco Palmisano. 1H-pteridine-2,4-dione (lumazine): a new MALDI matrix for complex (phospho)lipid mixtures analysis.
Analytical and bioanalytical chemistry.
2010 Sep; 398(1):499-507. doi:
10.1007/s00216-010-3927-x. [PMID: 20593166] - Anunciación Espinosa-Mansilla, Isabel Durán-Merás, Florentina Cañada Cañada, Maria Prado Márquez. High-performance liquid chromatographic determination of glyoxal and methylglyoxal in urine by prederivatization to lumazinic rings using in serial fast scan fluorimetric and diode array detectors.
Analytical biochemistry.
2007 Dec; 371(1):82-91. doi:
10.1016/j.ab.2007.07.028. [PMID: 17884007] - J W Lin, Y F Chao, S F Weng. Riboflavin synthesis genes ribE, ribB, ribH, ribA reside in the lux operon of Photobacterium leiognathi.
Biochemical and biophysical research communications.
2001 Jun; 284(3):587-95. doi:
10.1006/bbrc.2001.5013. [PMID: 11396941] - E Sato, S Koyama, S L Camhi, D K Nelson, R A Robbins. Reactive oxygen and nitrogen metabolites modulate fibronectin-induced fibroblast migration in vitro.
Free radical biology & medicine.
2001 Jan; 30(1):22-9. doi:
10.1016/s0891-5849(00)00436-6. [PMID: 11134892] - E Sato, K L Simpson, M B Grisham, S Koyama, R A Robbins. Effects of reactive oxygen and nitrogen metabolites on RANTES- and IL-5-induced eosinophil chemotactic activity in vitro.
The American journal of pathology.
1999 Aug; 155(2):591-8. doi:
10.1016/s0002-9440(10)65154-1. [PMID: 10433951] - T Sasaoka, N Kaneda, T Nagatsu. Highly sensitive assay for xanthine oxidase activity by high-performance liquid chromatography with fluorescence detection.
Journal of chromatography.
1988 Feb; 424(2):392-7. doi:
10.1016/s0378-4347(00)81118-4. [PMID: 3372632]
