(±)-Methamidophos (BioDeep_00000002851)
Secondary id: BioDeep_00000404221
human metabolite Endogenous
代谢物信息卡片
Methyl phosphoramidothioate ((meo)(mes)p(O)(NH2))
化学式: C2H8NO2PS (141.0013)
中文名称: 甲胺磷
谱图信息:
最多检出来源 not specific(not specific) 0%
分子结构信息
SMILES: COP(=O)(N)SC
InChI: InChI=1S/C2H8NO2PS/c1-5-6(3,4)7-2/h1-2H3,(H2,3,4)
描述信息
(±)-Methamidophos is an agricultural systemic insecticide and acaricide. It is a metabolite of acephate
C471 - Enzyme Inhibitor > C47792 - Acetylcholinesterase Inhibitor
D010575 - Pesticides > D007306 - Insecticides
D016573 - Agrochemicals
同义名列表
37 个代谢物同义名
Methyl phosphoramidothioate ((meo)(mes)p(O)(NH2)); Phosphoramidothioic acid, O,S-dimethyl ester; Thiophosphoramidic acid O,S-dimethyl ester; [methoxy(methylsulfanyl)phosphoryl]amine; Phosphoramidothioate, O,S-dimethyl ester; O,S-Dimethyl phosphoramidothiolic acid; Thiophosphoramidate O,S-dimethyl ester; O,S-Dimethyl amidothiophosphoric acid; O,S-Dimethyl phosphoroamidothioate; O,S-Dimethyl phosphoramidothiolate; O,S-Dimethyl phosphoramidothioate; O,S-Dimethylphosphoroamidothioate; Methyl phosphoramidothioic acid; O,S-Dimethyl amidothiophosphate; Methyl phosphoramidothioate; Monitor (insecticide); Metamidofos estrella; Chevron ortho 9006; (±)-Methamidophos; Ortho monitor; methamidophos; Chevron 9006; Metamidophos; Acephate-met; Pillaron; Tahmabon; Tamaron; Monitor; Filitox; Hamidop; Tamanox; Patrole; Sniper; Amidor; MTD; Methamidophos; Methamidophos
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:38721
- KEGG: C18667
- PubChem: 4096
- HMDB: HMDB0031803
- Metlin: METLIN44566
- DrugBank: DB14972
- ChEMBL: CHEMBL504888
- foodb: FDB008476
- chemspider: 3954
- CAS: 115182-35-9
- CAS: 10265-92-6
- PMhub: MS000006662
- PubChem: 124489341
- KNApSAcK: 38721
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Weiting Jiao, Ruyan Hou, Jianchao Li, Guoqin Ge, Pei Lv, Tiejun Ling, Taozhong Shi, Zhaoxian Zhang, Qing X Li, Rimao Hua. Enantiomer metabolism of acephate and its metabolite methamidophos in in vitro tea (Camellia sinensis L.) systems: Comparison between cell suspensions and excised tissues.
The Science of the total environment.
2022 Feb; 806(Pt 4):150863. doi:
10.1016/j.scitotenv.2021.150863. [PMID: 34626633] - Jia-Ruei Yu, Yi-Chou Hou, Jen-Fen Fu, I-Kuan Wang, Ming-Jen Chan, Chao-Yu Chen, Cheng-Hao Weng, Wen-Hung Huang, Huang-Yu Yang, Ching-Wei Hsu, Tzung-Hai Yen. Outcomes of elderly patients with organophosphate intoxication.
Scientific reports.
2021 06; 11(1):11615. doi:
10.1038/s41598-021-91230-2. [PMID: 34079035] - Toshiko Tanaka, Hiroaki Sato, Kosho Yoshida, Kentaro Kasai. The Role of Brain Methamidophos in Acephate Poisoning in Mice.
Journal of UOEH.
2021; 43(2):197-203. doi:
10.7888/juoeh.43.197. [PMID: 34092764] - Sonia Díaz-Criollo, Marien Palma, Andrés A Monroy-García, Alvaro J Idrovo, David Combariza, Marcela E Varona-Uribe. Chronic pesticide mixture exposure including paraquat and respiratory outcomes among Colombian farmers.
Industrial health.
2020 Feb; 58(1):15-21. doi:
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Forensic science international.
2019 Jul; 300(?):e38-e43. doi:
10.1016/j.forsciint.2019.02.015. [PMID: 31000354] - Juan Wang, Qinjin Li, Yuande Peng, Huilin Yang, Zhi Wang, Lin Luo, Qisheng Song, David Stanely. Methamidophos Influences Midgut Proteinase Activity and Subcellular Structures in the Wolf Spider Pardosa pseudoamulata (Araneae: Lycosidae).
Journal of economic entomology.
2019 02; 112(1):335-340. doi:
10.1093/jee/toy318. [PMID: 30321348] - Antonio Monroy-Noyola, Miguel Angel Sogorb, Eugenio Vilanova. Albumin, the responsible protein of the Cu2+-dependent hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) by chicken serum "antagonistic stereoselectivity".
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2018 Oct; 120(?):523-527. doi:
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Neurotoxicity research.
2017 Oct; 32(3):398-408. doi:
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2017 Jun; 10(2):105-112. doi:
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Environmental toxicology.
2017 Jan; 32(1):147-155. doi:
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Environmental toxicology.
2016 Jul; 31(7):842-54. doi:
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Toxicology letters.
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Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2015; 50(1):45-54. doi:
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Toxicology letters.
2014 Dec; 231(2):277-81. doi:
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Toxicology and applied pharmacology.
2014 Sep; 279(3):391-400. doi:
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Environmental toxicology.
2014 Aug; 29(8):942-9. doi:
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Clinical toxicology (Philadelphia, Pa.).
2013 Jun; 51(5):402-8. doi:
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The Science of the total environment.
2013 Apr; 450-451(?):334-47. doi:
10.1016/j.scitotenv.2012.10.066. [PMID: 23146311] - Thiago Henrique Lugokenski, Priscila Gubert, Diones Caeran Bueno, Pablo Andrei Nogara, Rogério de Aquino Saraiva, Rômulo Pillon Barcelos, Vanessa Santana Carratu, Leandro Bresolin, Nilda Berenice de Vargas Barbosa, Maria Ester Pereira, João Batista Teixeira da Rocha, Félix Alexandre Antunes Soares. Effect of different oximes on rat and human cholinesterases inhibited by methamidophos: a comparative in vitro and in silico study.
Basic & clinical pharmacology & toxicology.
2012 Dec; 111(6):362-70. doi:
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Ecotoxicology and environmental safety.
2012 Jun; 80(?):203-7. doi:
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2012 Jun; 78(3):122-8. doi:
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Pest management science.
2012 May; 68(5):811-7. doi:
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Journal of Zhejiang University. Science. B.
2012 Apr; 13(4):267-73. doi:
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2012 Apr; 120(4):487-93. doi:
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International journal of environmental research and public health.
2012 04; 9(4):1135-58. doi:
10.3390/ijerph9041135. [PMID: 22690187] - Guilherme L Emerick, Regina V Oliveira, Kátia Roberta A Belaz, Monique Gonçalves, Georgino H DeOliveira. Semipreparative enantioseparation of methamidophos by HPLC-UV and preliminary in vitro study of butyrylcholinesterase inhibition.
Environmental toxicology and chemistry.
2012 Feb; 31(2):239-45. doi:
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Occupational and environmental medicine.
2012 Feb; 69(2):119-25. doi:
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Neurotoxicology.
2011 Dec; 32(6):718-24. doi:
10.1016/j.neuro.2011.08.002. [PMID: 21871486] - Lucas O Maia, Walter Dias Júnior, Loraine S Carvalho, Luciana R Jesus, Greice D Paiva, Paula Araujo, Marcos F O Costa, Monica L Andersen, Sergio Tufik, Renata Mazaro-Costa. Association of methamidophos and sleep loss on reproductive toxicity of male mice.
Environmental toxicology and pharmacology.
2011 Sep; 32(2):155-61. doi:
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Archives of environmental contamination and toxicology.
2011 Jul; 61(1):59-67. doi:
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Journal of emergencies, trauma, and shock.
2011 Jan; 4(1):132-4. doi:
10.4103/0974-2700.76825. [PMID: 21633583] - Shahid Afzal Gill, Farzana Rizvi, Muhammad Zargham Khan, Ahrar Khan. Toxic effects of cypermethrin and methamidophos on bovine corpus luteal cells and progesterone production.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.
2011 Jan; 63(1-2):131-5. doi:
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2011 Jan; 20(1):274-82. doi:
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Journal of insect science (Online).
2011; 11(?):61. doi:
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Environmental monitoring and assessment.
2010 Sep; 168(1-4):231-40. doi:
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International journal of molecular sciences.
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Environmental health perspectives.
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2010 Apr; 45(3):242-8. doi:
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Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2010 Apr; 45(3):222-8. doi:
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Aquatic toxicology (Amsterdam, Netherlands).
2009 Sep; 94(3):211-8. doi:
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2009 Jun; 5(2):68-72. doi:
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Pest management science.
2009 Feb; 65(2):189-96. doi:
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2008 Nov; 56(22):10638-45. doi:
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International journal of clinical and experimental medicine.
2008; 1(3):274-82. doi:
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2008; 20(5):619-25. doi:
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Environmental health perspectives.
2007 Aug; 115(8):1254-60. doi:
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Journal of exposure science & environmental epidemiology.
2007 Jul; 17(4):321-30. doi:
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Food additives and contaminants.
2007 Apr; 24(4):360-8. doi:
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Journal of occupational medicine and toxicology (London, England).
2006 Dec; 1(?):27. doi:
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Journal of agricultural and food chemistry.
2006 Nov; 54(24):9085-91. doi:
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Journal of exposure science & environmental epidemiology.
2006 Sep; 16(5):387-96. doi:
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2006 Jul; 114(7):999-1006. doi:
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2006 Jul; 50(5):505-15. doi:
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Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2006 Jul; 24(7):437-8. doi:
NULL. [PMID: 16889713] - Cristina S Bastos, Raul P de Almeida, Fábio A Suinaga. Selectivity of pesticides used on cotton (Gossypium hirsutum) to Trichogramma pretiosum reared on two laboratory-reared hosts.
Pest management science.
2006 Jan; 62(1):91-8. doi:
10.1002/ps.1140. [PMID: 16308868] - J Castillo-Cadena, L E Tenorio-Vieyra, A I Quintana-Carabia, M M García-Fabila, E Ramírez-San Juan, E Madrigal-Bujaidar. Determination of DNA damage in floriculturists exposed to mixtures of pesticides.
Journal of biomedicine & biotechnology.
2006; 2006(2):97896. doi:
10.1155/jbb/2006/97896. [PMID: 16883059] - Meng-Cheng Wang, Ming Gong, Hong-Bing Zang, Xiao-Mei Hua, Jian Yao, Yan-Jun Pang, Yong-Hua Yang. Effect of methamidophos and urea application on microbial communities in soils as determined by microbial biomass and community level physiological profiles.
Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes.
2006; 41(4):399-413. doi:
10.1080/03601230600616155. [PMID: 16753959] - Rogelio Recio, Guadalupe Ocampo-Gómez, Javier Morán-Martínez, Victor Borja-Aburto, Malaquías López-Cervante, Marisela Uribe, Luisa Torres-Sánchez, Mariano E Cebrián. Pesticide exposure alters follicle-stimulating hormone levels in Mexican agricultural workers.
Environmental health perspectives.
2005 Sep; 113(9):1160-3. doi:
10.1289/ehp.7374. [PMID: 16140621] - Ying Yu, Qixing Zhou. [Degradation-detoxification behavior of methamidophos in phaiozem and burozem rhizosphere].
Ying yong sheng tai xue bao = The journal of applied ecology.
2005 Sep; 16(9):1761-4. doi:
". [PMID: 16355797] - Toshiko Tanaka, Noriyuki Tanaka, Toshiro Kita, Kentaro Kasai, Hiroaki Sato. Acephate in biological fluids of two autopsy cases after ingestion of the chemical.
Journal of forensic sciences.
2005 Jul; 50(4):933-6. doi:
. [PMID: 16078501] - Salim Satar, Deniz Satar, Sinan Kirim, Hülya Leventerler. Effects of acute organophosphate poisoning on thyroid hormones in rats.
American journal of therapeutics.
2005 May; 12(3):238-42. doi:
. [PMID: 15891268] - Kaoru Kimura, Kazuhito Yokoyama, Hajime Sato, Rusli Bin Nordin, Lin Naing, Satoshi Kimura, Shingo Okabe, Takashi Maeno, Yasuki Kobayashi, Fumihiko Kitamura, Shunichi Araki. Effects of pesticides on the peripheral and central nervous system in tobacco farmers in Malaysia: studies on peripheral nerve conduction, brain-evoked potentials and computerized posturography.
Industrial health.
2005 Apr; 43(2):285-94. doi:
10.2486/indhealth.43.285. [PMID: 15895843] - Salim Satar, Deniz Satar, Ufuk Ozgu Mete, Jeffrey R Suchard, Metin Topal, Mehmet Kaya. Ultrastructural effects of acute organophosphate poisoning on rat kidney.
Renal failure.
2005; 27(5):623-7. doi:
10.1080/08860220500200536. [PMID: 16153004] - Xiao-Fei Wang, Qi-Xing Zhou. Joint toxicity of methamidophos and cadmium acting on Abelmoschus manihot.
Journal of environmental sciences (China).
2005; 17(3):379-83. doi:
". [PMID: 16083107] - Apostolos Vlyssides, Dimitris Arapoglou, Sofia Mai, Elli Maria Barampouti. Electrochemical detoxification of four phosphorothioate obsolete pesticides stocks.
Chemosphere.
2005 Jan; 58(4):439-47. doi:
10.1016/j.chemosphere.2004.09.037. [PMID: 15620735] - John D Meeker, Louise Ryan, Dana B Barr, Robert F Herrick, Deborah H Bennett, Roberto Bravo, Russ Hauser. The relationship of urinary metabolites of carbaryl/naphthalene and chlorpyrifos with human semen quality.
Environmental health perspectives.
2004 Dec; 112(17):1665-70. doi:
10.1289/ehp.7234. [PMID: 15579410] - Gang Wu, Shuren Jiang, Tadashi Miyata. Effects of synergists on toxicity of six insecticides in parasitoid Diaeretiella rapae (Hymenoptera: Aphidiidae).
Journal of economic entomology.
2004 Dec; 97(6):2057-66. doi:
10.1093/jee/97.6.2057. [PMID: 15666765] - Salim Satar, Deniz Satar, Ozgul Tap, Zikret Koseoglu, Mehmet Kaya. Ultrastructural changes in rat liver treated with pralidoxime following acute organophosphate poisoning.
The Mount Sinai journal of medicine, New York.
2004 Nov; 71(6):405-10. doi:
. [PMID: 15592660] - Gang Wu, Shuren Jiang, Tadashi Miyata. Seasonal changes of methamidophos susceptibility and biochemical properties in Plutella xylostella (Lepidoptera: Yponomeutidae) and its parasitoid Cotesia plutellae (Hymenoptera: Braconidae).
Journal of economic entomology.
2004 Oct; 97(5):1689-98. doi:
10.1603/0022-0493-97.5.1689. [PMID: 15568361] - Calogero Saieva, Cristina Aprea, Rosario Tumino, Giovanna Masala, Simonetta Salvini, Graziella Frasca, Maria Concetta Giurdanella, Ines Zanna, Adriano Decarli, Gianfranco Sciarra, Domenico Palli. Twenty-four-hour urinary excretion of ten pesticide metabolites in healthy adults in two different areas of Italy (Florence and Ragusa).
The Science of the total environment.
2004 Oct; 332(1-3):71-80. doi:
10.1016/j.scitotenv.2004.02.026. [PMID: 15336892] - S Padilla, H-J Sung, V C Moser. Further assessment of an in vitro screen that may help identify organophosphorus pesticides that are more acutely toxic to the young.
Journal of toxicology and environmental health. Part A.
2004 Sep; 67(18):1477-89. doi:
10.1080/15287390490483836. [PMID: 15371233] - Fei Li, Zhaojun Han. Mutations in acetylcholinesterase associated with insecticide resistance in the cotton aphid, Aphis gossypii Glover.
Insect biochemistry and molecular biology.
2004 Apr; 34(4):397-405. doi:
10.1016/j.ibmb.2004.02.001. [PMID: 15041023] - Su-qing Zhao, Yan-fei Cai, Hong-tao Lei, Yuan-ming Sun, Xiao-yu Huang, Hou-rui Zhang, Zhen-yu Zhu. [Study on spectral identification of methamidophos artificial antigen].
Guang pu xue yu guang pu fen xi = Guang pu.
2004 Feb; 24(2):207-9. doi:
NULL. [PMID: 15769019] - Elizabeth Tomaszewska, Vincent R Hebert. Analysis of O,S-dimethyl hydrogen phosphorothioate in urine, a specific biomarker for methamidophos.
Journal of agricultural and food chemistry.
2003 Oct; 51(21):6103-9. doi:
10.1021/jf030405d. [PMID: 14518930] - Anders O Olsson, Johnny V Nguyen, Melissa A Sadowski, Dana B Barr. A liquid chromatography/electrospray ionization-tandem mass spectrometry method for quantification of specific organophosphorus pesticide biomarkers in human urine.
Analytical and bioanalytical chemistry.
2003 Jul; 376(6):808-15. doi:
10.1007/s00216-003-1978-y. [PMID: 12811448] - Jae Koo Lee, Ki Chang Ahn, Donald W Stoutamire, Shirley J Gee, Bruce D Hammock. Development of an enzyme-linked immunosorbent assay for the detection of the organophosphorus insecticide acephate.
Journal of agricultural and food chemistry.
2003 Jun; 51(13):3695-703. doi:
10.1021/jf021020i. [PMID: 12797729] - Moreno Agostini, Andrea Bianchin. Acute renal failure from organophospate poisoning: a case of success with haemofiltration.
Human & experimental toxicology.
2003 Mar; 22(3):165-7. doi:
10.1191/0960327103ht343cr. [PMID: 12723899] - Neng Wu, Yin-an Hu, Yi Tan. [Study on the degradation of residual insecticides on and in the vegetables and washing off method].
Wei sheng yan jiu = Journal of hygiene research.
2003 Jan; 32(1):32-6. doi:
". [PMID: 12731283] - R P Santos, M J Cavaliere, F R Puga, E S Narciso, J R Pelegrino, E E Calore. Protective effect of early and late administration of pralidoxime against organophosphate muscle necrosis.
Ecotoxicology and environmental safety.
2002 Sep; 53(1):48-51. doi:
10.1006/eesa.2001.2138. [PMID: 12481856] - Fei Li, Zhaojun Han. Purification and characterization of acetylcholinesterase from cotton aphid (Aphis gossypii Glover).
Archives of insect biochemistry and physiology.
2002 Sep; 51(1):37-45. doi:
10.1002/arch.10048. [PMID: 12210959] - Z L Zhang, H S Hong, J L Zhou, G Yu. Occurrence and behaviour of organophosphorus insecticides in the River Wuchuan, southeast China.
Journal of environmental monitoring : JEM.
2002 Aug; 4(4):498-504. doi:
10.1039/b203852h. [PMID: 12195990] - T M Mowry. Green peach aphid (Homoptera: Aphididae) action thresholds for controlling the spread of potato leafroll virus in Idaho.
Journal of economic entomology.
2001 Dec; 94(6):1332-9. doi:
10.1603/0022-0493-94.6.1332. [PMID: 11777033] - M L Wu, J F Deng, W J Tsai, J Ger, S S Wong, H P Li. Food poisoning due to methamidophos-contaminated vegetables.
Journal of toxicology. Clinical toxicology.
2001; 39(4):333-6. doi:
10.1081/clt-100105150. [PMID: 11527224] - C Padungtod, D A Savitz, J W Overstreet, D C Christiani, L M Ryan, X Xu. Occupational pesticide exposure and semen quality among Chinese workers.
Journal of occupational and environmental medicine.
2000 Oct; 42(10):982-92. doi:
10.1097/00043764-200010000-00004. [PMID: 11039162] - P Cabras, A Angioni, V L Garau, F M Pirisi, F Cabitza, M Pala. Acephate and buprofezin residues in olives and olive oil.
Food additives and contaminants.
2000 Oct; 17(10):855-8. doi:
10.1080/026520300420420. [PMID: 11103269] - V R Burruel, O G Raabe, J W Overstreet, B W Wilson, L M Wiley. Paternal effects from methamidophos administration in mice.
Toxicology and applied pharmacology.
2000 Jun; 165(2):148-57. doi:
10.1006/taap.2000.8933. [PMID: 10828210] - D Spassova, T White, A K Singh. Acute effects of acephate and methamidophos on acetylcholinesterase activity, endocrine system and amino acid concentrations in rats.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2000 May; 126(1):79-89. doi:
10.1016/s0742-8413(00)00097-9. [PMID: 11048668] - M Güven, F Bayram, K Unlühizarci, F Keleştimur. Endocrine changes in patients with acute organophosphate poisoning.
Human & experimental toxicology.
1999 Oct; 18(10):598-601. doi:
10.1191/096032799678839419. [PMID: 10557009] - R McConnell, E Delgado-Téllez, R Cuadra, E Tórres, M Keifer, J Almendárez, J Miranda, H A El-Fawal, M Wolff, D Simpson, I Lundberg. Organophosphate neuropathy due to methamidophos: biochemical and neurophysiological markers.
Archives of toxicology.
1999 Aug; 73(6):296-300. doi:
10.1007/s002040050621. [PMID: 10447555] - C Padungtod, T J Hassold, E Millie, L M Ryan, D A Savitz, D C Christiani, X Xu. Sperm aneuploidy among Chinese pesticide factory workers: scoring by the FISH method.
American journal of industrial medicine.
1999 Aug; 36(2):230-8. doi:
10.1002/(sici)1097-0274(199908)36:2<230::aid-ajim2>3.0.co;2-6. [PMID: 10398931] - S Malato, J Blanco, C Richter, B Milow, M I Maldonado. Solar photocatalytic mineralization of commercial pesticides: methamidophos.
Chemosphere.
1999 Feb; 38(5):1145-56. doi:
10.1016/s0045-6535(98)00364-6. [PMID: 10028663] - S E Sparks, G B Quistad, J E Casida. Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice.
Journal of biochemical and molecular toxicology.
1999; 13(2):113-8. doi:
10.1002/(sici)1099-0461(1999)13:2<113::aid-jbt7>3.0.co;2-8. [PMID: 9890196] - C Padungtod, B L Lasley, D C Christiani, L M Ryan, X Xu. Reproductive hormone profile among pesticide factory workers.
Journal of occupational and environmental medicine.
1998 Dec; 40(12):1038-47. doi:
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