Puerarin (BioDeep_00000002636)

 

Secondary id: BioDeep_00000270436, BioDeep_00000398478

natural product human metabolite PANOMIX_OTCML-2023 BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


InChI=1/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1

化学式: C21H20O9 (416.110727)
中文名称: 葛根素, 葛根黄酮
谱图信息: 最多检出来源 Viridiplantae(plant) 0.39%

分子结构信息

SMILES: C1(O)=C([C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C2OC=C(C3C=CC(O)=CC=3)C(=O)C=2C=C1
InChI: InChI=1S/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2

描述信息

Puerarin is a hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4 and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage. It has a role as a plant metabolite. It is a C-glycosyl compound and a hydroxyisoflavone. It is functionally related to an isoflavone.
Puerarin has been investigated for the treatment of Alcohol Abuse.
Puerarin is a natural product found in Neustanthus phaseoloides, Clematis hexapetala, and other organisms with data available.
Puerarin, also known as Kakonein, is a member of the class of compounds known as isoflavonoid C-glycosides. These compounds are C-glycosylated derivatives of isoflavonoids, which are natural products derived from 3-phenylchromen-4-one. Puerarin is considered a slightly soluble (in water), acidic compound. Puerarin can be synthesized into puerarin xyloside. Puerarin is found in a number of plants and herbs, such as the root of the kudzu plant.
A hydroxyisoflavone that is isoflavone substituted by hydroxy groups at positions 7 and 4 and a beta-D-glucopyranosyl residue at position 8 via a C-glycosidic linkage.
A polyphenol metabolite detected in biological fluids [PhenolExplorer]
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
Acquisition and generation of the data is financially supported in part by CREST/JST.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.
Puerarin, an isoflavone extracted from Radix puerariae, is a 5-HT2C receptor antagonist.

同义名列表

35 个代谢物同义名

InChI=1/C21H20O9/c22-7-14-17(26)18(27)19(28)21(30-14)15-13(24)6-5-11-16(25)12(8-29-20(11)15)9-1-3-10(23)4-2-9/h1-6,8,14,17-19,21-24,26-28H,7H2/t14-,17-,18+,19-,21+/m1/s1; 7-hydroxy-3-(4-hydroxyphenyl)-8-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-4H-chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydropyran-2-yl]chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-4H-chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; 7-hydroxy-3-(4-hydroxyphenyl)-8-[(3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; (1S)-1,5-anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-1-benzopyran-8-yl]-D-glucitol; (1S)-1,5-Anhydro-1-[7-hydroxy-3-(4-hydroxyphenyl)-4-oxo-4H-chromen-8-yl]-D-glucitol; 4H-1-BENZOPYRAN-4-ONE, 8-.BETA.-D-GLUCOPYRANOSYL-7-HYDROXY-3-(4-HYDROXYPHENYL)-; 4H-1-Benzopyran-4-one, 8-beta-D-glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-; 8-(beta-D-Glucopyranosyl-7-hydroxy-3- (4-hydroxyphenyl)-4H-1-benzopyran-4-one; 8-beta-D-Glucopyranosyl-7-hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; 7,4-dihydroxyisoflavone-8beta-glucopyranoside; 4-19-00-03200 (Beilstein Handbook Reference); 7,4-Dihydroxy-8-C-glucosylisoflavone; 4,7-DIHYDROXY-8-C-GLUCOSYLISOFLAVONE; Puerarin, analytical standard; HKEAFJYKMMKDOR-VPRICQMDSA-N; HKEAFJYKMMKDOR-VPRICQMDSA-; Puerarin, >=98.0\\% (HPLC); 8-Glucopyranosyldaidzein; Daidzein-8-C-glucoside; Daidzein 8-c-glucoside; 8-Glucosyldaidzein; PUERARIN [WHO-DD]; PUERARIN [INCI]; UNII-Z9W8997416; Puerarin 80 mm; 8-C-glucoside; Z9W8997416; kakonein; Puerarin; AC1NQZ4N; 7-Hydroxy-3-(4-hydroxyphenyl)-8-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]chromen-4-one; Puerarin



数据库引用编号

47 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

108 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yingying Lai, Ningning Yang, Donghao Shi, Xianhui Ma, Yingying Huang, Jingzhou Lu, Xuzi Zhang, Hui Zhou, Weiyang Gao, Cong Mao, Long Wang. Puerarin enhances TFEB-mediated autophagy and attenuates ROS-induced pyroptosis after ischemic injury of random-pattern skin flaps. European journal of pharmacology. 2024 Jul; 974(?):176621. doi: 10.1016/j.ejphar.2024.176621. [PMID: 38679118]
  • Qing Tao, Yu Chen, Qiao Liang, Jianfeng Shi, Zhiguo Wang, Haiyan Min, Qian Gao, Xiaoming Yao, Lei Wang. Puerarin Alleviates Experimental Autoimmune Thyroiditis by Regulating Macrophages. Journal of immunology (Baltimore, Md. : 1950). 2024 Jun; 212(11):1670-1679. doi: 10.4049/jimmunol.2300779. [PMID: 38668725]
  • Tian-Ci Zhang, Yi-Can Lin, Ning-Ning Sun, Shan Liu, Wen-Zhu Hu, Yan Zhao, Xian-Hui Dong, Xiao-Ping He. Icariin, astragaloside a and puerarin mixture attenuates cognitive impairment in APP/PS1 mice via inhibition of ferroptosis-lipid peroxidation. Neurochemistry international. 2024 May; 175(?):105705. doi: 10.1016/j.neuint.2024.105705. [PMID: 38412923]
  • Huizhen Wei, Mengru Sun, Ruixuan Wang, Hairong Zeng, Bei Zhao, Shenyi Jin. Puerarin mitigated LPS-ATP or HG-primed endothelial cells damage and diabetes-associated cardiovascular disease via ROS-NLRP3 signalling. Journal of cellular and molecular medicine. 2024 May; 28(10):e18239. doi: 10.1111/jcmm.18239. [PMID: 38774996]
  • Yu Mu, Yalin Yang, Shuang Jiang, Chilu Liu, Yanxing Han, Jiandong Jiang, Yuhong Wang. Benefits of Puerarin on Metabolic Syndrome and Its Associated Cardiovascular Diseases in Rats Fed a High-Fat/High-Sucrose Diet. Nutrients. 2024 Apr; 16(9):. doi: 10.3390/nu16091273. [PMID: 38732519]
  • Shiyan Yue, Yunxiang Liu, Rongrong Zhou, Zhilai Zhan, Liping Kang, Luqi Huang, Yuan Yuan, Tiegui Nan. A Highly Sensitive and Rapid Colloidal Gold Immunoassay for Puerarin Detection. Journal of agricultural and food chemistry. 2024 Apr; 72(15):8817-8822. doi: 10.1021/acs.jafc.4c00644. [PMID: 38578981]
  • Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081169. [PMID: 38674860]
  • Xiaoxue Fang, Xintian Lan, Ming Zhu, Min He, Mengmeng Sun, Yiming Cao, Difu Zhu, Dean Guo, Haoming Luo. Puerarin Induces Macrophage M2 Polarization to Exert Antinonalcoholic Steatohepatitis Pharmacological Activity via the Activation of Autophagy. Journal of agricultural and food chemistry. 2024 Apr; 72(13):7187-7202. doi: 10.1021/acs.jafc.3c09601. [PMID: 38515289]
  • Yuhan Lin, Rui Liang, Kairong Xie, Tingting Ma, Jigui Zhang, Tao Xu, Aimei Wang, Shuangyue Liu. Puerarin inhibits cisplatin-induced ototoxicity in mice through regulation of TRPV1-dependent calcium overload. Biochemical pharmacology. 2024 Feb; 220(?):115962. doi: 10.1016/j.bcp.2023.115962. [PMID: 38043717]
  • L I Xi, Lin Xiangquan, Chen Dongdong, Liu Hui. B-cell lymphoma-2 phosphorylation at Ser70 site-related autophagy mediates puerarin-inhibited the apoptosis of MC3T3-E1 cells during osteoblastogenesis. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):27-34. doi: 10.19852/j.cnki.jtcm.20231024.002. [PMID: 38213236]
  • Changxuan Li, Yu Liu. Puerarin reduces cell damage from cerebral ischemia-reperfusion by inhibiting ferroptosis. Biochemical and biophysical research communications. 2024 Jan; 693(?):149324. doi: 10.1016/j.bbrc.2023.149324. [PMID: 38101001]
  • Wenjing Ta, Jie Wang, Jihong Song, Xingyue Li, Jianxiang Wang, Wen Lu. Elucidation the mechanism of the active ingredient imperatorin promoting drug absorption in cell model. The Journal of pharmacy and pharmacology. 2024 Jan; ?(?):. doi: 10.1093/jpp/rgad127. [PMID: 38215001]
  • Xueling Li, Jue Wang, Jiayi Yan, John Cijiang He, Yi Li, Yifei Zhong. Additive renal protective effects between arctigenin and puerarin in diabetic kidney disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2024 Jan; 171(?):116107. doi: 10.1016/j.biopha.2023.116107. [PMID: 38215692]
  • Qiongtao Song, Wenyuan Jian, Yuanyuan Zhang, Qiang Li, Ying Zhao, Rong Liu, Yan Zeng, Fuwen Zhang, Junguo Duan. Puerarin Attenuates Iron Overload-Induced Ferroptosis in Retina through a Nrf2-Mediated Mechanism. Molecular nutrition & food research. 2024 Jan; ?(?):e2300123. doi: 10.1002/mnfr.202300123. [PMID: 38196088]
  • Seungmee Lee, Hyeonmi Shin, Jihyun Bae, Taek Lee, Minji Kim, Heung Bae Jeon, Kang Hyun Lee, Hah Young Yoo, Chulhwan Park. Enhanced Enzymatic Synthesis of Puerarin Palmitate with Different Acyl Donors for Lipid Solubility Improvement. International journal of molecular sciences. 2024 Jan; 25(2):. doi: 10.3390/ijms25020709. [PMID: 38255784]
  • Jing Yang, Baochao Li, Jiangming Wang, Wenxing Fan. Inhibition of Pyroptosis of Renal Tubular Epithelial Cells by Puerarin via Regulation of lncRNA NEAT1 Ameliorating Chronic Renal Failure. Iranian journal of kidney diseases. 2024 Jan; 1(1):18-26. doi: . [PMID: 38308547]
  • Jianpeng Li, Yanan Li, Xiangke Yuan, Dengfeng Yao, Zongyue Gao, Zhaoyang Niu, Zheng Wang, Yue Zhang. The effective constituent puerarin, from Pueraria lobata, inhibits the proliferation and inflammation of vascular smooth muscle in atherosclerosis through the miR-29b-3p/IGF1 pathway. Pharmaceutical biology. 2023 Dec; 61(1):1-11. doi: 10.1080/13880209.2022.2099430. [PMID: 36537316]
  • Yu Lu, Shihao Ge, Haili Zhang, Wen Lu, Xiangli Bao, Shiling Pan, Quanhai Pang. Metabolomic and microbiome analysis of the protective effects of Puerarin against Salmonella Enteritidis Infection in chicks. BMC veterinary research. 2023 Nov; 19(1):242. doi: 10.1186/s12917-023-03806-x. [PMID: 37990191]
  • Da-He Qi, Hua Ma, Yuan-Yuan Chen, Ke-Xin Wang, Meng-Meng Ding, Yun-Long Hao, Ye Guo, Ling-Bo Kong. [Research progress in mechanism of puerarin in treating vascular dementia]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Nov; 48(22):5993-6002. doi: 10.19540/j.cnki.cjcmm.20230718.401. [PMID: 38114205]
  • Biyu Hou, Peng Ma, Xinyu Yang, Xiaoyue Zhao, Li Zhang, Yuerong Zhao, Ping He, Li Zhang, Guanhua Du, Guifen Qiang. In silico prediction and experimental validation to reveal the protective mechanism of Puerarin against excessive extracellular matrix accumulation through inhibiting ferroptosis in diabetic nephropathy. Journal of ethnopharmacology. 2023 Oct; ?(?):117281. doi: 10.1016/j.jep.2023.117281. [PMID: 37797872]
  • Si-Hui Li, Yan-Fei Li, Di Wu, Yu Xu, Hui-Jia Yan, Jiang-Ning Hu. Metal-polyphenol microgels for oral delivery of puerarin to alleviate the onset of diabetes. Drug delivery and translational research. 2023 Sep; ?(?):. doi: 10.1007/s13346-023-01428-2. [PMID: 37768531]
  • Jongkeun Choi, Yongho Kim, Bekir Engin Eser, Jaehong Han. Theoretical study on the glycosidic C-C bond cleavage of 3''-oxo-puerarin. Scientific reports. 2023 09; 13(1):16282. doi: 10.1038/s41598-023-43379-1. [PMID: 37770535]
  • Wenxiang Deng, Wenan Zhang, Qinghu He. Study on the mechanism of puerarin against osteoarthritis from ferroptosis based on network pharmacology and bioinformatics. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Aug; ?(?):. doi: 10.1007/s00210-023-02653-9. [PMID: 37548663]
  • Peiyan Jiang, Lianyu Zhou, Linyang Zhao, Xinghang Fei, Zhifei Wang, Tianyao Liu, Yexi Tang, Dabing Li, Hong Gong, Yi Luo, Song Li, Hui Yang, Huiling Liao, Xiaotang Fan. Puerarin attenuates valproate-induced features of ASD in male mice via regulating Slc7a11-dependent ferroptosis. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2023 Jul; ?(?):. doi: 10.1038/s41386-023-01659-4. [PMID: 37491673]
  • Chunjing Guo, Min Cao, Ningning Diao, Wenxin Wang, Hongxu Geng, Yanguo Su, Tianying Sun, Xinyue Lu, Ming Kong, Daquan Chen. Novel pH-responsive E-selectin targeting natural polysaccharides hybrid micelles for diabetic nephropathy. Nanomedicine : nanotechnology, biology, and medicine. 2023 Jul; 52(?):102696. doi: 10.1016/j.nano.2023.102696. [PMID: 37394108]
  • Guo Lian, Xi-Xi Huang, Yan Zeng. Puerarin Induces Ferroptosis in Colorectal Cancer Cells via Triggering NCOA4 Upregulation. Nutrition and cancer. 2023 Jun; ?(?):1-8. doi: 10.1080/01635581.2023.2216922. [PMID: 37260353]
  • Jingwen Xu, Zhenhua Tian, Zhe Li, Xiaoshi Du, Yansong Cui, Jiangrong Wang, Mei Gao, Yinglong Hou. Puerarin-Tanshinone IIA Suppresses atherosclerosis inflammatory plaque via targeting succinate/HIF-1α/IL-1β axis. Journal of ethnopharmacology. 2023 May; ?(?):116675. doi: 10.1016/j.jep.2023.116675. [PMID: 37257708]
  • Li Wang, Tao Wang, Shuangquan Wen, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan. Puerarin Prevents Cadmium-Induced Neuronal Injury by Alleviating Autophagic Dysfunction in Rat Cerebral Cortical Neurons. International journal of molecular sciences. 2023 May; 24(9):. doi: 10.3390/ijms24098328. [PMID: 37176033]
  • Tian Liu, Kai Su, Weiye Cai, Hui Ao, Mingxiu Li. Therapeutic potential of puerarin against cerebral diseases: From bench to bedside. European journal of pharmacology. 2023 Mar; ?(?):175695. doi: 10.1016/j.ejphar.2023.175695. [PMID: 36977450]
  • Zhengdan Wu, Wendan Zeng, Changfu Li, Jihua Wang, Xiaohong Shang, Liang Xiao, Sheng Cao, Yansheng Zhang, Shiqiang Xu, Huabing Yan. Genome-wide identification and expression pattern analysis of R2R3-MYB transcription factor gene family involved in puerarin biosynthesis and response to hormone in Pueraria lobata var. thomsonii. BMC plant biology. 2023 Feb; 23(1):107. doi: 10.1186/s12870-023-04115-z. [PMID: 36814206]
  • Huiting Xi, Yaru Zhu, Wenwen Sun, Nan Tang, Zhengqin Xu, Xiaohong Shang, Yansheng Zhang, Huabing Yan, Changfu Li. Comparative Transcriptome Analysis of Pueraria lobata Provides Candidate Genes Involved in Puerarin Biosynthesis and Its Regulation. Biomolecules. 2023 01; 13(1):. doi: 10.3390/biom13010170. [PMID: 36671554]
  • Xue-Mei Wan, Chuan Zheng, Xue-Lei Zhou. Puerarin prevents cadmium-induced mitochondrial fission in AML-12 cells via Sirt1-dependent pathway. Ecotoxicology and environmental safety. 2022 Dec; 248(?):114302. doi: 10.1016/j.ecoenv.2022.114302. [PMID: 36399995]
  • Fan Meng, Bin Guo, Yi-Qing Ma, Kun-Wei Li, Feng-Ju Niu. Puerarin: A review of its mechanisms of action and clinical studies in ophthalmology. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Dec; 107(?):154465. doi: 10.1016/j.phymed.2022.154465. [PMID: 36166943]
  • Wenhua Zhang, Mingchang Xu, Shuangquan Wen, Li Wang, Kanglei Zhang, Chaofan Zhang, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan. Puerarin alleviates cadmium-induced rat neurocyte injury by alleviating Nrf2-mediated oxidative stress and inhibiting mitochondrial unfolded protein response. Ecotoxicology and environmental safety. 2022 Dec; 247(?):114239. doi: 10.1016/j.ecoenv.2022.114239. [PMID: 36326556]
  • Hua Cheng, Xiaohua Huang, Shuai Wu, Shiyan Wang, Shen Rao, Li Li, Shuiyuan Cheng, Linling Li. Chromosome-Level Genome Assembly and Multi-Omics Dataset Provide Insights into Isoflavone and Puerarin Biosynthesis in Pueraria lobata (Wild.) Ohwi. Biomolecules. 2022 11; 12(12):. doi: 10.3390/biom12121731. [PMID: 36551157]
  • Qiuting Mo, Shuping Li, Shiquan You, Dongdong Wang, Jiachan Zhang, Meng Li, Changtao Wang. Puerarin Reduces Oxidative Damage and Photoaging Caused by UVA Radiation in Human Fibroblasts by Regulating Nrf2 and MAPK Signaling Pathways. Nutrients. 2022 Nov; 14(22):. doi: 10.3390/nu14224724. [PMID: 36432411]
  • Xia-Xia Zhang, Yan-Fei Lang, Xin Li, Zheng Li, You-Qing Xu, Hong-Qian Chu. The protective effect of puerarin-loaded mesoporous silicon nanoparticles on alcoholic hepatitis through mTOR-mediated autophagy pathway. Biomedical microdevices. 2022 10; 24(4):37. doi: 10.1007/s10544-022-00622-2. [PMID: 36308627]
  • Zhen Li, Shengguang Wang, Xinyu Wang, Peng Gao, Shiming Zhang, Yingning Mo, Dongsheng Zhao, Long Dai. Pharmacodynamic Interactions between Puerarin and Metformin in Type-2 Diabetic Rats. Molecules (Basel, Switzerland). 2022 Oct; 27(21):. doi: 10.3390/molecules27217197. [PMID: 36364022]
  • Xiao Chang, Yanhong He, Ling Wang, Chuanjin Luo, Yuntao Liu, Rong Li. Puerarin Alleviates LPS-Induced H9C2 Cell Injury by Inducing Mitochondrial Autophagy. Journal of cardiovascular pharmacology. 2022 10; 80(4):600-608. doi: 10.1097/fjc.0000000000001315. [PMID: 35881898]
  • Xiaoying Wang, Kai He, Linlin Ma, Lan Wu, Yan Yang, Yanfei Li. Puerarin attenuates isoproterenol‑induced myocardial hypertrophy via inhibition of the Wnt/β‑catenin signaling pathway. Molecular medicine reports. 2022 10; 26(4):. doi: 10.3892/mmr.2022.12822. [PMID: 35946454]
  • Zhenzhen Xu, Zakir Hussain Talpur, Wuye Yang, Yinran Xiong, Ting Wu, Yuqi Zhang, Xinyi Shen, Yiping Du. Dual-spectrum online monitoring of puerarin and total flavonoids contents during the extraction process of Pueraria lobata. Talanta. 2022 Oct; 248(?):123608. doi: 10.1016/j.talanta.2022.123608. [PMID: 35661845]
  • Jiayang Xu, Xiaoyue Zhang, Lili Yan, Zhichao Zhang, Jing Wei, Luqi Li, Qiang Zhang. Insight into Lotusine and Puerarin in Repairing Alcohol-Induced Metabolic Disorder Based on UPLC-MS/MS. International journal of molecular sciences. 2022 Sep; 23(18):. doi: 10.3390/ijms231810385. [PMID: 36142292]
  • Thi Hoa Pham, Gi Ho Lee, Sun Woo Jin, Seung Yeon Lee, Eun Hee Han, Nam Doo Kim, Hye Gwang Jeong. Puerarin attenuates hepatic steatosis via G-protein-coupled estrogen receptor-mediated calcium and SIRT1 signaling pathways. Phytotherapy research : PTR. 2022 Sep; 36(9):3601-3618. doi: 10.1002/ptr.7526. [PMID: 35871535]
  • Man Ki Kwok, Gabriel Matthew Leung, Lin Xu, Hung Fat Tse, Tai Hing Lam, C Mary Schooling. Effect of puerarin supplementation on cardiovascular disease risk factors: A randomized, double-blind, placebo-controlled, 2-way crossover trial. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Sep; 153(?):113472. doi: 10.1016/j.biopha.2022.113472. [PMID: 36076498]
  • Yumin Liu, Ziqi Hu, Jing Wang, Yanjun Liao, Luan Shu. Puerarin alleviates depressive-like behaviors in high-fat diet-induced diabetic mice via modulating hippocampal GLP-1R/BDNF/TrkB signaling. Nutritional neuroscience. 2022 Aug; ?(?):1-14. doi: 10.1080/1028415x.2022.2112439. [PMID: 36039913]
  • Lijun Du, Li Zhang, Fei Sun. Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis. Cancer biotherapy & radiopharmaceuticals. 2022 Aug; 37(6):435-450. doi: 10.1089/cbr.2019.3382. [PMID: 33016781]
  • Bo Li, Yu Wang, Shiqiang Gong, Weifan Yao, Hua Gao, Mingyan Liu, Minjie Wei. Puerarin improves OVX-induced osteoporosis by regulating phospholipid metabolism and biosynthesis of unsaturated fatty acids based on serum metabolomics. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Jul; 102(?):154198. doi: 10.1016/j.phymed.2022.154198. [PMID: 35636175]
  • Zeliha Keskin Alkaç, Fatih Ahmet Korkak, Gürdal Dağoğlu, Canan Akdeniz İncili, Betül Dağoğlu Hark, Sadettin Tanyıldızı. Puerarin mitigates oxidative injuries, opening of mitochondrial permeability transition pores and pathological damage associated with liver and kidney in Xanthium strumarium-intoxicated rats. Toxicon : official journal of the International Society on Toxinology. 2022 Jul; 213(?):13-22. doi: 10.1016/j.toxicon.2022.04.004. [PMID: 35427636]
  • Qingqing Zhu, Shumin Yang, Chengguo Wei, Geming Lu, Kyung Lee, John Cijiang He, Ruijie Liu, Yifei Zhong. Puerarin attenuates diabetic kidney injury through interaction with Guanidine nucleotide-binding protein Gi subunit alpha-1 (Gnai1) subunit. Journal of cellular and molecular medicine. 2022 07; 26(14):3816-3827. doi: 10.1111/jcmm.17414. [PMID: 35678269]
  • Zhiheng Lin, Xiaohui Sui, Wenjian Jiao, Ying Wang, Junde Zhao. Exploring the mechanism and experimental verification of puerarin in the treatment of endometrial carcinoma based on network pharmacology and bioinformatics analysis. BMC complementary medicine and therapies. 2022 Jun; 22(1):150. doi: 10.1186/s12906-022-03623-z. [PMID: 35672846]
  • Zi-Tan Peng, Hui Liu. Puerarin attenuates LPS-induced inflammatory injury in gastric epithelial cells by repressing NLRP3 inflammasome-mediated apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. 2022 Jun; 81(?):105350. doi: 10.1016/j.tiv.2022.105350. [PMID: 35331853]
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