Chlorprothixene (BioDeep_00000001934)

 

Secondary id: BioDeep_00000398967

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]dimethylamine

化学式: C18H18ClNS (315.0848)
中文名称: 氯普噻吨
谱图信息: 最多检出来源 Homo sapiens(blood) 26.79%

分子结构信息

SMILES: CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2
InChI: InChI=1S/C18H18ClNS/c1-20(2)11-5-7-14-15-6-3-4-8-17(15)21-18-10-9-13(19)12-16(14)18/h3-4,6-10,12H,5,11H2,1-2H3

描述信息

Chlorprothixene is only found in individuals that have used or taken this drug. It is a typical antipsychotic drug of the thioxanthene (tricyclic) class. Chlorprothixene exerts strong blocking effects by blocking the 5-HT2 D1, D2, D3, histamine H1, muscarinic and alpha1 adrenergic receptors. Chlorprothixene blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis.
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AF - Thioxanthene derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

同义名列表

16 个代谢物同义名

[3-(2-chloro-9H-thioxanthen-9-ylidene)propyl]dimethylamine; Alpha-Chlorprothixene; cis-Chlorprothixene; Α-chlorprothixene; a-Chlorprothixene; Chloroprothixene; Chlorprothixenum; Chlorprothixine; chlorprothixene; Chlorprotixene; Chlorprotixine; Chlorprothixen; Chlorprotixen; Clorprotixeno; Chlothixen; Chlorprothixene



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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亚细胞结构定位 关联基因列表
Cytoplasm 7 AXIN2, CA3, DBH, HTT, PML, RARA, TYR
Peripheral membrane protein 2 CYP1B1, PML
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 3 CYP1B1, DRD1, PML
Nucleus 7 ARID5B, AXIN2, DRD1, HTT, PML, RARA, RUNX1
autophagosome 1 HTT
cytosol 7 AXIN2, CA3, GPT, HTT, MB, PML, RARA
dendrite 3 DRD2, HTT, RARA
centrosome 1 AXIN2
nucleoplasm 6 ARID5B, ATP2B1, HTT, PML, RARA, RUNX1
RNA polymerase II transcription regulator complex 1 RARA
Cell membrane 5 ATP2B1, DRD1, DRD2, HTT, KCNH2
Cytoplasmic side 1 PML
Early endosome membrane 1 PML
Multi-pass membrane protein 6 ATP2B1, CACNA1I, DRD1, DRD2, HTT, KCNH2
Golgi apparatus membrane 1 DRD2
Synapse 4 ATP2B1, DBH, DRD2, HTT
cell surface 1 KCNH2
glutamatergic synapse 3 ATP2B1, DRD1, DRD2
Golgi apparatus 1 HTT
Golgi membrane 2 DRD2, INS
presynaptic membrane 4 ATP2B1, DRD1, DRD2, HTT
Lysosome 1 TYR
acrosomal vesicle 1 DRD2
plasma membrane 8 ATP2B1, AXIN2, CACNA1I, DRD1, DRD2, HTT, KCNH2, RARA
synaptic vesicle membrane 2 ATP2B1, DRD2
Membrane 5 ATP2B1, CACNA1I, CYP1B1, DBH, KCNH2
axon 2 DRD2, HTT
basolateral plasma membrane 1 ATP2B1
extracellular exosome 3 ATP2B1, GPT, MB
endoplasmic reticulum 2 DBH, HTT
extracellular space 3 DBH, GH1, INS
perinuclear region of cytoplasm 4 HTT, KCNH2, RARA, TYR
mitochondrion 1 CYP1B1
protein-containing complex 2 HTT, RARA
intracellular membrane-bounded organelle 5 ATP2B1, CYP1B1, DBH, RUNX1, TYR
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 TYR
Secreted 3 DBH, GH1, INS
extracellular region 4 DBH, DNAH9, GH1, INS
transcription regulator complex 1 RARA
centriolar satellite 1 DBH
ciliary membrane 2 DRD1, DRD2
motile cilium 1 DNAH9
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 PML
actin cytoskeleton 1 RARA
dendritic spine 2 DRD1, DRD2
perikaryon 1 DRD2
beta-catenin destruction complex 1 AXIN2
nucleolus 2 PML, RARA
Melanosome membrane 1 TYR
sarcoplasm 1 MB
Early endosome 1 HTT
Golgi-associated vesicle 1 TYR
Single-pass type II membrane protein 1 DBH
postsynaptic membrane 3 DRD1, DRD2, HTT
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
microtubule 1 DNAH9
GABA-ergic synapse 2 DRD1, DRD2
Cell projection, dendritic spine 1 DRD1
Nucleus, PML body 1 PML
PML body 1 PML
lateral plasma membrane 2 ATP2B1, DRD2
axoneme 1 DNAH9
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 1 HTT
cilium 2 DRD1, DRD2
chromatin 2 RARA, RUNX1
cell projection 1 ATP2B1
centriole 1 HTT
chromosome, telomeric region 1 PML
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH9
non-motile cilium 2 DRD1, DRD2
Basolateral cell membrane 1 ATP2B1
sperm flagellum 1 DRD2
Endomembrane system 1 HTT
endosome lumen 2 GH1, INS
monoatomic ion channel complex 1 KCNH2
Cytoplasmic vesicle membrane 1 HTT
Cell projection, dendrite 1 DRD1
Melanosome 1 TYR
Presynaptic cell membrane 1 ATP2B1
inward rectifier potassium channel complex 1 KCNH2
voltage-gated potassium channel complex 1 KCNH2
secretory granule lumen 2 DBH, INS
secretory granule membrane 1 DBH
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
nuclear matrix 1 PML
axon terminus 1 DRD2
voltage-gated calcium channel complex 1 CACNA1I
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
9+2 motile cilium 1 DNAH9
dynein complex 1 DNAH9
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
postsynaptic cytosol 1 HTT
Cell projection, cilium membrane 1 DRD1
presynaptic cytosol 1 HTT
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
growth hormone receptor complex 1 GH1
transport vesicle membrane 1 DBH
Cytoplasm, sarcoplasm 1 MB
inclusion body 1 HTT
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
photoreceptor ribbon synapse 1 ATP2B1
G protein-coupled receptor complex 2 DRD1, DRD2
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
core-binding factor complex 1 RUNX1
outer dynein arm 1 DNAH9
distal portion of axoneme 1 DNAH9


文献列表

  • Bozhi Yuan, Mei Yuan. Changes of Mental State and Serum Prolactin Levels in Patients with Schizophrenia and Depression after Receiving the Combination Therapy of Amisulpride and Chloroprothixol Tablets. Computational and mathematical methods in medicine. 2022; 2022(?):6580030. doi: 10.1155/2022/6580030. [PMID: 35242209]
  • Xiao Yu, Xinlin Li, Sunzhao You, Yuhang Shi, Ruiqin Zhu, Ying Dong, Chuixiu Huang. Electromembrane extraction of chlorprothixene, haloperidol and risperidone from whole blood and urine. Journal of chromatography. A. 2020 Oct; 1629(?):461480. doi: 10.1016/j.chroma.2020.461480. [PMID: 32827905]
  • Jun-Ichi Kurita, Yuuka Hirao, Hirofumi Nakano, Yoshifumi Fukunishi, Yoshifumi Nishimura. Sertraline, chlorprothixene, and chlorpromazine characteristically interact with the REST-binding site of the corepressor mSin3, showing medulloblastoma cell growth inhibitory activities. Scientific reports. 2018 09; 8(1):13763. doi: 10.1038/s41598-018-31852-1. [PMID: 30213984]
  • Louise Skov, Sys Stybe Johansen, Kristian Linnet. Postmortem femoral blood reference concentrations of aripiprazole, chlorprothixene, and quetiapine. Journal of analytical toxicology. 2015 Jan; 39(1):41-4. doi: 10.1093/jat/bku121. [PMID: 25342720]
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