Silibinin (BioDeep_00000001706)

 

Secondary id: BioDeep_00000230327, BioDeep_00000270728, BioDeep_00000396889, BioDeep_00000396894

human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019 natural product


代谢物信息卡片


Silybin B, 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one

化学式: C25H22O10 (482.1213)
中文名称: 水飞蓟素, 水飞蓟宾, 水飞蓟提取物
谱图信息: 最多检出来源 Viridiplantae(not specific) 19.15%

分子结构信息

SMILES: COc(c(O)5)cc(cc5)C(O1)C(CO)Oc(c4)c(cc(c4)C(O2)C(O)C(=O)c(c(O)3)c(cc(O)c3)2)1
InChI: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

描述信息

A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
Silibinin is found in coffee and coffee products. Silibinin is isolated from Silybum marianum (milk thistle
D020011 - Protective Agents > D000975 - Antioxidants
[Raw Data] CBA85_Silybin-B_pos_30eV.txt
[Raw Data] CBA85_Silybin-B_neg_30eV.txt
[Raw Data] CBA85_Silybin-B_pos_50eV.txt
[Raw Data] CBA85_Silybin-B_pos_20eV.txt
[Raw Data] CBA85_Silybin-B_pos_40eV.txt
[Raw Data] CBA85_Silybin-B_pos_10eV.txt
[Raw Data] CBA85_Silybin-B_neg_40eV.txt
[Raw Data] CBA85_Silybin-B_neg_10eV.txt
[Raw Data] CBA85_Silybin-B_neg_50eV.txt
[Raw Data] CBA85_Silybin-B_neg_20eV.txt
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

同义名列表

49 个代谢物同义名

Silybin B, 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one; (2R,3R)-3,5,7-trihydroxy-2-[(2S,3S)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one; 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; Milk Thistle Extract; Silybum substance e6; 2,3 Dehydrosilybin; 2,3-dehydrosilybin; Flavobin Spofa; Silibinin, inn; Cefasilymarin; Silybin (7ci); Hepa Merz Sil; Hepa-Merz Sil; legalon forte; durasilymarin; Silymarine I; Alepa-forte; Alepa forte; Silymarin I; Silibinin A; Silibinin B; Silibininum; Hepar-Pasc; Hepa loges; Ardeyhepan; Hepar Pasc; Silibinina; Silibinine; hepa-loges; silybinin; SILYMARIN; HepaBesch; Silibinin; silybin B; Silimarin; silybin A; Silybine; Flavobin; Silliver; Heparsyx; Heplant; Legalon; silibin; silybin; Karsil; Carsil; Lagosa; Silymarin



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 14 ABCB1, ANG, CASP8, CCND1, CDKN1A, EGFR, NFE2L2, NFKB1, NOS2, PIK3CA, SIRT1, STAT3, TGFB1, TLR4
Endosome membrane 2 EGFR, TLR4
Endoplasmic reticulum membrane 2 EGFR, HMOX1
Nucleus 14 ANG, CASP8, CCND1, CDKN1A, EGFR, HMOX1, NFE2L2, NFKB1, NOS2, PCNA, PPARA, SIRT1, STAT3, TGFB1
cytosol 11 ANG, CASP8, CCND1, CDKN1A, HMOX1, NFE2L2, NFKB1, NOS2, PIK3CA, SIRT1, STAT3
nuclear body 2 CDKN1A, PCNA
centrosome 3 CCND1, NFE2L2, PCNA
nucleoplasm 11 CASP8, CCND1, CDKN1A, HMOX1, NFE2L2, NFKB1, NOS2, PCNA, PPARA, SIRT1, STAT3
RNA polymerase II transcription regulator complex 2 NFE2L2, STAT3
Cell membrane 3 ABCB1, EGFR, TLR4
Cytoplasmic side 1 HMOX1
lamellipodium 2 CASP8, PIK3CA
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
cell junction 1 EGFR
cell surface 4 ABCB1, EGFR, TGFB1, TLR4
glutamatergic synapse 1 EGFR
Golgi apparatus 1 NFE2L2
Golgi membrane 2 EGFR, INS
growth cone 1 ANG
neuronal cell body 2 ANG, TGFB1
Cytoplasm, cytosol 2 NFE2L2, NOS2
endosome 1 EGFR
plasma membrane 9 ABCB1, EGFR, IFNLR1, NFE2L2, NOS2, PIK3CA, STAT3, TGFB1, TLR4
Membrane 5 ABCB1, EGFR, HMOX1, IFNLR1, TLR4
apical plasma membrane 2 ABCB1, EGFR
axon 1 TGFB1
basolateral plasma membrane 1 EGFR
extracellular exosome 2 ABCB1, PCNA
endoplasmic reticulum 1 HMOX1
extracellular space 6 ANG, CCL4, EGFR, HMOX1, INS, TGFB1
perinuclear region of cytoplasm 6 CDKN1A, EGFR, HMOX1, NOS2, PIK3CA, TLR4
bicellular tight junction 1 CCND1
intercalated disc 1 PIK3CA
mitochondrion 3 CASP8, NFKB1, SIRT1
protein-containing complex 3 CASP8, CDKN1A, EGFR
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 3 EGFR, IFNLR1, TLR4
Secreted 3 ANG, INS, TGFB1
extracellular region 5 ANG, CCL4, INS, NFKB1, TGFB1
mitochondrial outer membrane 2 CASP8, HMOX1
transcription regulator complex 2 NFKB1, STAT3
Nucleus membrane 1 CCND1
nuclear membrane 2 CCND1, EGFR
external side of plasma membrane 1 TLR4
Secreted, extracellular space, extracellular matrix 1 TGFB1
actin cytoskeleton 1 ANG
nucleolus 3 ANG, CDKN1A, SIRT1
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
Early endosome 1 TLR4
Apical cell membrane 1 ABCB1
Cell projection, lamellipodium 1 CASP8
Cytoplasm, perinuclear region 1 NOS2
heterochromatin 1 SIRT1
Membrane raft 1 EGFR
focal adhesion 1 EGFR
extracellular matrix 1 TGFB1
Peroxisome 1 NOS2
basement membrane 1 ANG
intracellular vesicle 1 EGFR
peroxisomal matrix 1 NOS2
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
collagen-containing extracellular matrix 1 TGFB1
secretory granule 1 TGFB1
nuclear inner membrane 1 SIRT1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 EGFR, TLR4
chromatin 6 NFE2L2, NFKB1, PCNA, PPARA, SIRT1, STAT3
mediator complex 1 NFE2L2
phagocytic cup 1 TLR4
Chromosome 1 ANG
cytoskeleton 1 CASP8
Nucleus, nucleolus 1 ANG
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
blood microparticle 1 TGFB1
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 1 SIRT1
cell body 1 CASP8
replication fork 1 PCNA
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
lipopolysaccharide receptor complex 1 TLR4
secretory granule lumen 2 INS, NFKB1
Golgi lumen 2 INS, TGFB1
endoplasmic reticulum lumen 1 INS
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
platelet alpha granule lumen 1 TGFB1
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 NFKB1
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Single-pass type IV membrane protein 1 HMOX1
nuclear lamina 1 PCNA
clathrin-coated endocytic vesicle membrane 1 EGFR
protein-DNA complex 1 NFE2L2
external side of apical plasma membrane 1 ABCB1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDKN1A, PCNA
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
[Latency-associated peptide]: Secreted, extracellular space, extracellular matrix 1 TGFB1
[Transforming growth factor beta-1]: Secreted 1 TGFB1
cortical cytoskeleton 1 NOS2
angiogenin-PRI complex 1 ANG
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 2 CDKN1A, PCNA
replisome 1 PCNA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
cyclin D1-CDK6 complex 1 CCND1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
interleukin-28 receptor complex 1 IFNLR1
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Fatma M El-Demerdash, Manal M Ahmed, Raghda A El-Sayed, Tarek M Mohemed, Marian N Gerges. Nephroprotective effects of silymarin and its fabricated nanoparticles against aluminum-induced oxidative stress, hyperlipidemia, and genotoxicity. Environmental toxicology. 2024 Jun; 39(6):3746-3759. doi: 10.1002/tox.24223. [PMID: 38546352]
  • J Anupama Sekar, Shiny Velayudhan, M Senthilkumar, P R Anil Kumar. Silymarin enriched gelatin methacrylamide bioink imparts hepatoprotectivity to 3D bioprinted liver construct against carbon tetrachloride induced toxicity. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2024 May; 198(?):114272. doi: 10.1016/j.ejpb.2024.114272. [PMID: 38537909]
  • Peihai Li, Dexu Wang, Xueliang Yang, Changyu Liu, Xiaobin Li, Xuanming Zhang, Kechun Liu, Yun Zhang, Mengqi Zhang, Changyun Wang, Rongchun Wang. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081901. [PMID: 38675723]
  • Xin Wang, Yufeng Jin, Can Di, Yupeng Zeng, Yuqing Zhou, Yu Chen, Zhijun Pan, Zhongxia Li, Wenhua Ling. Supplementation of Silymarin Alone or in Combination with Salvianolic Acids B and Puerarin Regulates Gut Microbiota and Its Metabolism to Improve High-Fat Diet-Induced NAFLD in Mice. Nutrients. 2024 Apr; 16(8):. doi: 10.3390/nu16081169. [PMID: 38674860]
  • Zoe D. Draelos, Martina Kerscher, Stephen Lynch, Stacy White, Hina Choudhary. A Silymarin Antioxidant Serum Improves Facial Acne Alone and as Part of a Treatment Regimen. Journal of drugs in dermatology : JDD. 2024 04; 23(4):233-238. doi: 10.36849/jdd.8120. [PMID: 38564394]
  • Lucia-Maria Ciovicescu, Simona Valeria Clichici, Ramona-Ariana Simedrea, Felix Ciovicescu, Simona Corina Lupan, Lavinia Ioana Sabău, Alina Mihaela Toader, Teodora Mocan. Innovative prophylactic and therapeutic approaches in liver cirrhosis. Physiology international. 2024 Mar; 111(1):1-18. doi: 10.1556/2060.2024.00339. [PMID: 38421387]
  • Xiang Zhang, Zhenghao Jiang, Xiaoliang Jin, Qiujun Zhou. Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review. Medicine. 2024 Feb; 103(5):e37052. doi: 10.1097/md.0000000000037052. [PMID: 38306552]
  • Hebatallah Husseini Atteia. A combination of silymarin and garlic extract enhances thyroid hormone activation and body metabolism in orally intoxicated male rats with atrazine: Impact on hepatic iodothyronine deiodinase type 1. Pesticide biochemistry and physiology. 2024 Feb; 199(?):105801. doi: 10.1016/j.pestbp.2024.105801. [PMID: 38458692]
  • Rajeev K Singla, Digvijay Singh, Ravinder Verma, Deepak Kaushik, Javier Echeverría, Vandana Garg, Pankaj Gupta, Mohammad Akhlaquer Rahman, Ajay Sharma, Vineet Mittal, Bairong Shen. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155286. doi: 10.1016/j.phymed.2023.155286. [PMID: 38241906]
  • Xin Zhang, Yuhan Jiang, Na Guo, Yifan Ding, Jingting Feng, Chenyang Miao, Yanni Lv. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115816. doi: 10.1016/j.jpba.2023.115816. [PMID: 37976988]
  • Mohammad Reza Karimzadeh, Afsane Masoudi Chelegahi, Shahrzad Shahbazi, Somayeh Reiisi. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Molecular biology reports. 2024 Jan; 51(1):118. doi: 10.1007/s11033-023-09026-8. [PMID: 38227082]
  • Jyoti Rani, Sanju Bala Dhull, Pawan Kumar Rose, Mohd Kashif Kidwai. Drug-induced liver injury and anti-hepatotoxic effect of herbal compounds: a metabolic mechanism perspective. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155142. doi: 10.1016/j.phymed.2023.155142. [PMID: 37913641]
  • Hao-Ran Shen, Zhi-Yu Wang, Zhen Shen, Tong-Tong Liu, Yun-Dan Guo, Tian-Le Gao, Hui-Hui Guo, Yan-Xing Han, Jian-Dong Jiang. Bacterial butyrate mediates the anti-atherosclerotic effect of silybin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115916. doi: 10.1016/j.biopha.2023.115916. [PMID: 38000354]
  • Zheyuan Ren, Yang Yu, Zhongyao Ji, Huitao Li, Xiaoheng Li, Han Lin, Renshan Ge, Qiqi Zhu. Structure-activity relationship and docking analysis of nature flavonoids as inhibitors of human and rat gonadal 3β-hydroxysteroid dehydrogenases for therapeutic purposes. The Journal of steroid biochemistry and molecular biology. 2023 Dec; 238(?):106450. doi: 10.1016/j.jsbmb.2023.106450. [PMID: 38143010]
  • Jialuo Cai, Yilin Zhu, Xiaoping Li, Guiming Deng, Yuanshan Han, Feiyun Yuan, Gangqiang Yi, Xinhua Xia. Liposomal Silybin Improves Glucose and Lipid Metabolisms in Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease via AMPK/TGF-β1/Smad Signaling. The Tohoku journal of experimental medicine. 2023 Dec; 261(4):257-265. doi: 10.1620/tjem.2023.j050. [PMID: 37344419]
  • Ebrahim Salimi-Sabour, Ramazan-Ali Tahri, Amirhossein Asgari, Maryam Ghorbani. The novel hepatoprotective effects of silibinin-loaded nanostructured lipid carriers against diazinon-induced liver injuries in male mice. Pesticide biochemistry and physiology. 2023 Dec; 197(?):105643. doi: 10.1016/j.pestbp.2023.105643. [PMID: 38072518]
  • Helena Pluháčková, Barbora Kudláčková, Lenka Svojanovská, Michal Roth, Marta Bradáčová, Marie Bjelková. Effect of Field Trial on Silymarin Complex Composition and Antioxidant Assessment of Milk Thistle (Silybum marianum L. Gaertner). Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; 78(4):691-697. doi: 10.1007/s11130-023-01101-6. [PMID: 37668769]
  • Zhenzhen Chen, Wenhao Gao, Xianquan Feng, Guizhi Zhou, Minxin Zhang, Lingjun Zeng, Xiaomu Hu, Zhihong Liu, Hongtao Song. A comparative study on the preparation and evaluation of solubilizing systems for silymarin. Drug delivery and translational research. 2023 Nov; ?(?):. doi: 10.1007/s13346-023-01476-8. [PMID: 37964172]
  • Rasool Haddadi, Shahla Eyvari-Brooshghalan, Sajjad Makhdoomi, Ahmad Fadaiie, Alireza Komaki, Afsoon Daneshvar. Neuroprotective effects of silymarin in 3-nitropropionic acid-induced neurotoxicity in male mice: improving behavioral deficits by attenuating oxidative stress and neuroinflammation. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Oct; ?(?):. doi: 10.1007/s00210-023-02776-z. [PMID: 37847410]
  • Salah A Sheweita, Ahmed Abd El Rafea, Sabah G Elbana. The deleterious effects of cadmium on oxidative stress markers, drug-metabolizing, and antioxidant enzyme activities: Role of Silymarin and Garlic as Antioxidants. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30197-1. [PMID: 37831250]
  • Hanaa S S Gazwi, Osama I A Soltan, Sanaa M Abdel-Hameed. Cakes fortified with papaya seeds effectively protects against CCl4-induced immunotoxicity. Environmental science and pollution research international. 2023 Oct; ?(?):. doi: 10.1007/s11356-023-30172-w. [PMID: 37815681]
  • Xinyu Wu, Yue Xin, Yeyun Ma, Kaixin Ping, Qiulu Li, Ying Sun, Zunhan Hu, Jingquan Dong. Abamectin induced brain and liver toxicity in carp: The healing potential of silybin and potential molecular mechanisms. Fish & shellfish immunology. 2023 Oct; ?(?):109152. doi: 10.1016/j.fsi.2023.109152. [PMID: 37821005]
  • Pei-Ling Yen, Ting-An Lin, Wei Lin Chuah, Chih-Yi Chang, Yen-Hsueh Tseng, Chia-Yin Huang, Jeng-Chuann Yang, Fu-Lan Hsu, Vivian Hsiu-Chuan Liao. Methanol Extracts from Cirsium japonicum DC. var. australe Kitam. and Their Active Components Reduce Intracellular Oxidative Stress in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2023 Oct; 28(19):. doi: 10.3390/molecules28196923. [PMID: 37836767]
  • Ahmed H Sherif, Adel E Toulan, Naglaa El-Kalamwi, Enas A H Farag, Abeer E Mahmoud. Silymarin enhances the response to oxytetracycline treatment in Oreochromis niloticus experimentally infected with Aeromonas hydrophila. Scientific reports. 2023 Sep; 13(1):16235. doi: 10.1038/s41598-023-43270-z. [PMID: 37758826]
  • Xiaolei Ma, Xiaoyou Yu, Rui Li, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang, Lulu Wang. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117238. doi: 10.1016/j.jep.2023.117238. [PMID: 37774895]
  • Sajida Sumaiya, Aisha Siddiqui, Shahid Shah Chaudhary, Mohd Aslam, Sayeed Ahmad, Mairaj Ahmed Ansari. Isolation and characterization of bioactive components from hydroalcoholic extract of Cymbopogon jwarancusa (Jones) Schult. To evaluate its hepatoprotective activity. Journal of ethnopharmacology. 2023 Sep; ?(?):117185. doi: 10.1016/j.jep.2023.117185. [PMID: 37714225]
  • Fatemeh Gheybi, Fatemeh Rajabian, Zahra Tayarani-Najaran, Amir Reza Adibi, Seyedeh Hoda Alavizadeh, Prashant Kesharwani, Amirhossein Sahebkar. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS). 2023 Aug; 80(?):127291. doi: 10.1016/j.jtemb.2023.127291. [PMID: 37672872]
  • Hossein Abbasinia, Masoumeh Heshmati, Mohammad Yousefi, Nabaa Najjar, Hanieh Sadeghi. Silymarin-Loaded Tin(IV) Nanoparticles Exhibit Enhanced Bioavailability and Antiproliferative Effects on Colorectal Cancer Cells. ACS applied bio materials. 2023 Aug; ?(?):. doi: 10.1021/acsabm.3c00434. [PMID: 37608575]
  • Iman H Hasan, Amirah Badr, Haneen Almalki, Alanoud Alhindi, Hesham S Mostafa. Podocin, mTOR, and CHOP dysregulation contributes to nephrotoxicity induced of lipopolysaccharide/diclofenac combination in rats: Curcumin and silymarin could afford protective effect. Life sciences. 2023 Aug; 330(?):121996. doi: 10.1016/j.lfs.2023.121996. [PMID: 37536613]
  • Panwen Liu, Wenhui Chen, Yu Kang, Chenkang Wang, Xiaoling Wang, Weiwei Liu, Toshihiko Hayashi, Zhiyue Qiu, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. Archives of biochemistry and biophysics. 2023 08; 744(?):109691. doi: 10.1016/j.abb.2023.109691. [PMID: 37473980]
  • Hamed Baharara, Sara Rahsepar, Seyyed Ahmad Emami, Sepideh Elyasi, Amir Hooshang Mohammadpour, Vahid Ghavami, Rajkumar Rajendram, Amirhossein Sahebkar, Omid Arasteh. The efficacy of medicinal plant preparations in the alleviation of radiodermatitis in patients with breast cancer: A systematic review of clinical trials. Phytotherapy research : PTR. 2023 Aug; 37(8):3275-3295. doi: 10.1002/ptr.7894. [PMID: 37211432]
  • Ricardo J Ramírez-Carreto, Víctor J Zaldívar-Machorro, Dafne J Pérez-Ramírez, Blanca E Rodríguez-López, Claudia Meza, Esperanza García, Abel Santamaría, Anahí Chavarría. Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice. Molecular neurobiology. 2023 Jul; ?(?):. doi: 10.1007/s12035-023-03485-7. [PMID: 37480498]
  • Fatemeh Gheybi, Alireza Khooei, Azam Hoseinian, Maham Doagooyan, Kebria Houshangi, Mahmoud Reza Jaafari, Arash Papi, Zahra Khoddamipour, Amirhossein Sahebkar, Seyedeh Hoda Alavizadeh. Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. Biochemical and biophysical research communications. 2023 Jul; 676(?):103-108. doi: 10.1016/j.bbrc.2023.07.045. [PMID: 37506470]
  • A Jabbari, B Alani, A Arjmand, T Mazoochi, N Kheiripour, A Ardjmand. Silymarin pretreatment protects against ethanol-induced memory impairment: Biochemical and histopathological evidence. Journal of chemical neuroanatomy. 2023 Jul; 132(?):102310. doi: 10.1016/j.jchemneu.2023.102310. [PMID: 37429530]
  • Asimah Khalid, Imrana Naseem. Increased therapeutic effect of nanotized silibinin against glycation and diabetes: An in vitro and in silico-based approach. Biochimica et biophysica acta. General subjects. 2023 07; 1867(7):130364. doi: 10.1016/j.bbagen.2023.130364. [PMID: 37088248]
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