Silibinin (BioDeep_00000230327)

Main id: BioDeep_00000001706

Secondary id: BioDeep_00000270728, BioDeep_00000396894

natural product PANOMIX_OTCML-2023 Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-3,5,7-trihydroxy-, (2R-(2-alpha,3-beta,6(2R*,3R*)))-

化学式: C25H22O10 (482.1213)
中文名称: 西利马灵, 水飞蓟宾 A, 水飞蓟素, 水飞蓟宾
谱图信息: 最多检出来源 Viridiplantae(plant) 46.44%

分子结构信息

SMILES: C1(O)C=C(O)C2C(=O)[C@H](O)[C@](C3=CC4O[C@H](C5=CC(OC)=C(O)C=C5)[C@@H](CO)OC=4C=C3)([H])OC=2C=1
InChI: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-16-5-3-12(7-18(16)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9,20,23-29,31H,10H2,1H3

描述信息

Silibinin is a flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities. It has a role as an antioxidant, an antineoplastic agent, a hepatoprotective agent and a plant metabolite. It is a flavonolignan, a polyphenol, an aromatic ether, a benzodioxine and a secondary alpha-hydroxy ketone.
Silibinin is the major active constituent of silymarin, a standardized extract of the milk thistle seeds, containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silicristin, silidianin and others. Silibinin is presented as a mixture of two diastereomers, silybin A and silybin B, which are found in an approximately equimolar ratio. Both in vitro and animal research suggest that silibinin has hepatoprotective (antihepatotoxic) properties that protect liver cells against toxins. Silibinin has also demonstrated in vitro anti-cancer effects against human prostate adenocarcinoma cells, estrogen-dependent and -independent human breast carcinoma cells, human ectocervical carcinoma cells, human colon cancer cells, and both small and nonsmall human lung carcinoma cells.
Silibinin is a natural product found in Aspergillus iizukae, Asteraceae, and other organisms with data available.
Silymarin is a mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. (NCI04)
The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.
A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic activities.
A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
D000970 - Antineoplastic Agents
D020011 - Protective Agents
(±)-Silybin is the racemate of Silybin (HY-N0779A). Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin is a flavonolignan isolated from milk thistle (Silybum marianum) seeds. Silybin induces apoptosis and exhibits hepatoprotective, antioxidant, anti-inflammatory, anti-cancer activity[1][2].
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.
Silybin A (Silibinin A), an effective anti-cancer and chemopreventive agent, has been shown to exert multiple effects on cancer cells, including inhibition of both cell proliferation and migration.

同义名列表

84 个代谢物同义名

4H-1-Benzopyran-4-one, 2,3-dihydro-2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-3,5,7-trihydroxy-, (2R-(2-alpha,3-beta,6(2R*,3R*)))-; 4H-1-Benzopyran-4-one, 2-(2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-, (2R-(2alpha,3beta,6(2R*,3R*)))-; 4H-1-Benzopyran-4-one, 2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; 4H-1-Benzopyran-4-one, 2-((2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; 4H-1-Benzopyran-4-one,2-[(2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-3,4-dihydro-2H-1-benzopyran-4-one; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydro-4H-chromen-4-one; 3,5,7-trihydroxy-2-[3-(4-hydroxy-3-methoxyphenyl)-2-hydroxymethyl-(2R,3R)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl]-(2R,3R)-3,4-dihydro-2H-4-chromenone; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-one; (2R,3R)-3,5,7-trihydroxy-2-((2R,3R)-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one; (2R,3R)-3,5,7-Trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl]-chroman-4-one; (2R,3R)-3,5,7-trihydroxy-2-[(2R,3R)-3-(4-hydroxy-3-methoxy-phenyl)-2-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]chroman-4-one; (2R,3R)-3,5,7-trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxin-6-yl)chroman-4-one; (2R,3R)-3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl]-chroman-4-one; 3,5,7-Trihydroxy-2-[3-(4-hydroxy-3-methoxy-phenyl)-2-hydroxymethyl-2,3-dihydro-benzo[1,4]dioxin-6-yl]-chroman-4-one; 3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)- 2-(hydroxymethyl)-1,4-benzodioxan-6-yl)-4-chromanone; 3,5,7-Trihydroxy-2-(3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxan-6-yl)-4-chromanone; SILYBIN A (CONSTITUENT OF MILK THISTLE) [DSC]; Silybin A (constituent of milk thistle); Methanone, cyclohexyl-1-pyrrolidinyl-; ( inverted exclamation markA)-SILYBIN; Silybin;Silibinin A;Silymarin I; SEBFKMXJBCUCAI-HKTJVKLFSA-N; Silibinina [INN-Spanish]; Silibininum [INN-Latin]; Silibinine [INN-French]; Silibinin (Silybin); 2,3 Dehydrosilybin; 2,3-dehydrosilybin; Spectrum5_001893; Spectrum4_001978; Spectrum2_001694; Spectrum3_001132; Silibinin (INN); UNII-33X338MNE4; Silibinin [INN]; Flavobin Spofa; SILYBIN A [MI]; Tox21_111070_1; Cefasilymarin; Hepa Merz Sil; Hepa-Merz Sil; legalon forte; durasilymarin; MEGxp0_001301; Legalon (TN); KBio3_002123; Silymarine I; Tox21_200755; Tox21_111070; Alepa-forte; Alepa forte; Silymarin I; Silibinin A; Silibinin B; SMP2_000323; Silibininum; Hepar-Pasc; Silymarine; Hepa loges; Ardeyhepan; Hepar Pasc; Silibinina; Silibinine; hepa-loges; 33X338MNE4; silybinin; SILYMARIN; HepaBesch; Silibinin; silybin B; silybin A; Silybine; Flavobin; Silliver; Heparsyx; Heplant; silibin; silybin; Lagosa; 7C3MT; Silibinin (mixture of Silybin A and Silybin B); (±)-Silybin; Silymarin



数据库引用编号

51 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

54 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Peihai Li, Dexu Wang, Xueliang Yang, Changyu Liu, Xiaobin Li, Xuanming Zhang, Kechun Liu, Yun Zhang, Mengqi Zhang, Changyun Wang, Rongchun Wang. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules (Basel, Switzerland). 2024 Apr; 29(8):. doi: 10.3390/molecules29081901. [PMID: 38675723]
  • Xiang Zhang, Zhenghao Jiang, Xiaoliang Jin, Qiujun Zhou. Efficacy of traditional Chinese medicine combined with Silibinin on nonalcoholic fatty liver disease: A meta-analysis and systematic review. Medicine. 2024 Feb; 103(5):e37052. doi: 10.1097/md.0000000000037052. [PMID: 38306552]
  • Rajeev K Singla, Digvijay Singh, Ravinder Verma, Deepak Kaushik, Javier Echeverría, Vandana Garg, Pankaj Gupta, Mohammad Akhlaquer Rahman, Ajay Sharma, Vineet Mittal, Bairong Shen. Fermented formulation of Silybum marianum seeds: Optimization, heavy metal analysis, and hepatoprotective assessment. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Feb; 124(?):155286. doi: 10.1016/j.phymed.2023.155286. [PMID: 38241906]
  • Xin Zhang, Yuhan Jiang, Na Guo, Yifan Ding, Jingting Feng, Chenyang Miao, Yanni Lv. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. Journal of pharmaceutical and biomedical analysis. 2024 Jan; 238(?):115816. doi: 10.1016/j.jpba.2023.115816. [PMID: 37976988]
  • Hao-Ran Shen, Zhi-Yu Wang, Zhen Shen, Tong-Tong Liu, Yun-Dan Guo, Tian-Le Gao, Hui-Hui Guo, Yan-Xing Han, Jian-Dong Jiang. Bacterial butyrate mediates the anti-atherosclerotic effect of silybin. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Dec; 169(?):115916. doi: 10.1016/j.biopha.2023.115916. [PMID: 38000354]
  • Jialuo Cai, Yilin Zhu, Xiaoping Li, Guiming Deng, Yuanshan Han, Feiyun Yuan, Gangqiang Yi, Xinhua Xia. Liposomal Silybin Improves Glucose and Lipid Metabolisms in Type 2 Diabetes Mellitus Complicated with Non-Alcoholic Fatty Liver Disease via AMPK/TGF-β1/Smad Signaling. The Tohoku journal of experimental medicine. 2023 Dec; 261(4):257-265. doi: 10.1620/tjem.2023.j050. [PMID: 37344419]
  • Ebrahim Salimi-Sabour, Ramazan-Ali Tahri, Amirhossein Asgari, Maryam Ghorbani. The novel hepatoprotective effects of silibinin-loaded nanostructured lipid carriers against diazinon-induced liver injuries in male mice. Pesticide biochemistry and physiology. 2023 Dec; 197(?):105643. doi: 10.1016/j.pestbp.2023.105643. [PMID: 38072518]
  • Xinyu Wu, Yue Xin, Yeyun Ma, Kaixin Ping, Qiulu Li, Ying Sun, Zunhan Hu, Jingquan Dong. Abamectin induced brain and liver toxicity in carp: The healing potential of silybin and potential molecular mechanisms. Fish & shellfish immunology. 2023 Oct; ?(?):109152. doi: 10.1016/j.fsi.2023.109152. [PMID: 37821005]
  • Xiaolei Ma, Xiaoyou Yu, Rui Li, Jinjin Cui, Haoyang Yu, Ling Ren, Jiandong Jiang, Wenxuan Zhang, Lulu Wang. Berberine-silybin salt achieves improved anti-nonalcoholic fatty liver disease effect through regulating lipid metabolism. Journal of ethnopharmacology. 2023 Sep; 319(Pt 2):117238. doi: 10.1016/j.jep.2023.117238. [PMID: 37774895]
  • Panwen Liu, Wenhui Chen, Yu Kang, Chenkang Wang, Xiaoling Wang, Weiwei Liu, Toshihiko Hayashi, Zhiyue Qiu, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima. Silibinin ameliorates STING-mediated neuroinflammation via downregulation of ferroptotic damage in a sporadic Alzheimer's disease model. Archives of biochemistry and biophysics. 2023 08; 744(?):109691. doi: 10.1016/j.abb.2023.109691. [PMID: 37473980]
  • Ricardo J Ramírez-Carreto, Víctor J Zaldívar-Machorro, Dafne J Pérez-Ramírez, Blanca E Rodríguez-López, Claudia Meza, Esperanza García, Abel Santamaría, Anahí Chavarría. Oral Administration of Silybin Protects Against MPTP-Induced Neurotoxicity by Reducing Pro-inflammatory Cytokines and Preserving BDNF Levels in Mice. Molecular neurobiology. 2023 Jul; ?(?):. doi: 10.1007/s12035-023-03485-7. [PMID: 37480498]
  • Fatemeh Gheybi, Alireza Khooei, Azam Hoseinian, Maham Doagooyan, Kebria Houshangi, Mahmoud Reza Jaafari, Arash Papi, Zahra Khoddamipour, Amirhossein Sahebkar, Seyedeh Hoda Alavizadeh. Alleviation of acetaminophen-induced liver failure using silibinin nanoliposomes: An in vivo study. Biochemical and biophysical research communications. 2023 Jul; 676(?):103-108. doi: 10.1016/j.bbrc.2023.07.045. [PMID: 37506470]
  • Asimah Khalid, Imrana Naseem. Increased therapeutic effect of nanotized silibinin against glycation and diabetes: An in vitro and in silico-based approach. Biochimica et biophysica acta. General subjects. 2023 07; 1867(7):130364. doi: 10.1016/j.bbagen.2023.130364. [PMID: 37088248]
  • Chunqiu Fang, Jingzhou Zhang, Jiajun Han, Yuting Lei, Zhanhong Cao, Jianheng Pan, Zhi Pan, Zhong Zhang, Ning Qu, Haoming Luo, Yan Ma, Dong Han. Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats. Journal of ethnopharmacology. 2023 Jun; 317(?):116838. doi: 10.1016/j.jep.2023.116838. [PMID: 37355081]
  • Huan Gu, Xing Liu, Ping Chen, Mingyi Shi, Liping Chen, Xiaofang Li. Topical treatment of tea saponin stabilized silybin nanocrystal gel reduced oxidative stress in UV-induced skin damage. Biochemical and biophysical research communications. 2023 06; 660(?):82-87. doi: 10.1016/j.bbrc.2023.04.016. [PMID: 37075642]
  • Qingqing Du, Xiaoyun Wu, Kai Ma, Weiwei Liu, Panwen Liu, Toshihiko Hayashi, Kazunori Mizuno, Shunji Hattori, Hitomi Fujisaki, Takashi Ikejima. Silibinin alleviates ferroptosis of rat islet β cell INS-1 induced by the treatment with palmitic acid and high glucose through enhancing PINK1/parkin-mediated mitophagy. Archives of biochemistry and biophysics. 2023 May; ?(?):109644. doi: 10.1016/j.abb.2023.109644. [PMID: 37245586]
  • Jiang-Pei Shi, Rong-Guang Zhang, Xiao-Yan Gu, Ying-Wei Sun, Nian-Ping Feng, Ying Liu. [Effects of Platycodonis Radix-Curcumae Rhizoma on oral nanoparticle uptake and in vitro inhibition against breast cancer metastasis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 May; 48(9):2419-2425. doi: 10.19540/j.cnki.cjcmm.20230301.301. [PMID: 37282871]
  • Ekaterina-Michaela Tomou, Paraskevi Papakyriakopoulou, Helen Skaltsa, Georgia Valsami, Nikolaos P E Kadoglou. Bio-Actives from Natural Products with Potential Cardioprotective Properties: Isolation, Identification, and Pharmacological Actions of Apigenin, Quercetin, and Silibinin. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052387. [PMID: 36903630]
  • Shiqin Luo, Yuping Yang, Ting Zhao, Rongping Zhang, Changlong Fang, Yan Li, Zhirong Zhang, Tao Gong. Albumin-Based Silibinin Nanocrystals Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy. ACS applied materials & interfaces. 2023 Feb; 15(6):7747-7758. doi: 10.1021/acsami.2c19269. [PMID: 36719351]
  • Ian Geddes Berlin, Charity Conlin Jennings, Spencer Shin, Jason Kenealey. Utilizing mixture design response surface methodology to determine effective combinations of plant derived compounds as prostate cancer treatments. Cancer reports (Hoboken, N.J.). 2023 Feb; ?(?):e1790. doi: 10.1002/cnr2.1790. [PMID: 36772872]
  • Peng Zhou, Yao-Yao Ma, Xiao-Ni Zhao, Fang Hua. Phytochemicals as potential target on thioredoxin-interacting protein (TXNIP) for the treatment of cardiovascular diseases. Inflammopharmacology. 2023 Feb; 31(1):207-220. doi: 10.1007/s10787-022-01130-8. [PMID: 36609715]
  • Vijay Kumar Shankar, Anitha Police, Srinivas Ajjarapu, S Narasimha Murthy. Development of silymarin topical formulation: In vitro and ex vivo dermal kinetics of silymarin. International journal of pharmaceutics. 2023 Jan; 630(?):122431. doi: 10.1016/j.ijpharm.2022.122431. [PMID: 36436747]
  • Qin Yang, Tiantian Tan, Qin He, Chenqi Guo, Dan Chen, Yulu Tan, Jiaxing Feng, Xu Song, Tao Gong, Jia Li. Combined Amphiphilic Silybin Meglumine Nanosuspension Effective Against Hepatic Fibrosis in Mice Model. International journal of nanomedicine. 2023; 18(?):5197-5211. doi: 10.2147/ijn.s407762. [PMID: 37720597]
  • Xumin Li, Runqi Zhou, Yue Han, Jun Zeng, Lixi Shi, Yixin Mao, Xiaoyu Sun, Yinghui Ji, Xiaorong Zhang, Yang Chen, Richard T Jaspers, Gang Wu, Shengbin Huang, Tim Forouzanfar. Silibinin Attenuates Experimental Periodontitis by Downregulation of Inflammation and Oxidative Stress. Oxidative medicine and cellular longevity. 2023; 2023(?):5617800. doi: 10.1155/2023/5617800. [PMID: 36846719]
  • Cong Xu, Yuan Yuan, Ping Pang, Huanhuan Yang, Qiang Zhang, Dan Yuan, Wen Qi. Urinary excretion of silibinin diastereoisomers and their conjugated metabolites in rat and human at different dosages. Biomedical chromatography : BMC. 2022 Dec; 36(12):e5480. doi: 10.1002/bmc.5480. [PMID: 35962523]
  • Wei Li, Yin-Nan Chen, Yue-Yue Chen, Zhe Wang, Zhen Wang, Li-Li Jiang, Hong-Can Shi, Yong Liu. Inhibition of UGT1A1*1 and UGT1A1*6 catalyzed glucuronidation of SN-38 by silybins. Chemico-biological interactions. 2022 Dec; 368(?):110248. doi: 10.1016/j.cbi.2022.110248. [PMID: 36343684]
  • Sevda Jafari, Atabak Bakhshaei, Morteza Eskandani, Ommoleila Molavi. Silibinin-Loaded Nanostructured Lipid Carriers for Growth Inhibition of Cisplatin-Resistant Ovarian Cancer Cells. Assay and drug development technologies. 2022 12; 20(8):339-348. doi: 10.1089/adt.2022.060. [PMID: 36383148]
  • Chang Chen, Jiahui Qian, Xinyu Zhao, Xuyang Han, Xu Tang, Junfeng Gao, Yan Liu, Jinzhu Jiang, Binyu Wen. Metabolic profiling of emodin drug-induced liver injury and silybin treatment in rats using ultra-performance liquid chromatography-quadrupole-time-of-flight-mass spectrometry: A metabolomic and mechanistic approach. Biomedical chromatography : BMC. 2022 Nov; 36(11):e5469. doi: 10.1002/bmc.5469. [PMID: 35904380]
  • B Z Horowitz. Silibinin: a toxicologist's herbal medicine?. Clinical toxicology (Philadelphia, Pa.). 2022 11; 60(11):1194-1197. doi: 10.1080/15563650.2022.2128815. [PMID: 36222816]
  • Wei Dong, Tian-Ze Li, Xiao-Yan Huang, Xiao-Feng He, Chang-An Geng, Xue-Mei Zhang, Ji-Jun Chen. Artemzhongdianolides A1-A21, antihepatic fibrosis guaiane-type sesquiterpenoid dimers from Artemisia zhongdianensis. Bioorganic chemistry. 2022 11; 128(?):106056. doi: 10.1016/j.bioorg.2022.106056. [PMID: 35908354]
  • Costas Tsioptsias, Christina Spartali, Sotirios I Marras, Xanthi Ntampou, Ioannis Tsivintzelis, Costas Panayiotou. Thermochemical Transition in Low Molecular Weight Substances: The Example of the Silybin Flavonoid. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196345. [PMID: 36234879]
  • Sara Verdura, José Antonio Encinar, Salvador Fernández-Arroyo, Jorge Joven, Elisabet Cuyàs, Joaquim Bosch-Barrera, Javier A Menendez. Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells. International journal of molecular sciences. 2022 Sep; 23(17):. doi: 10.3390/ijms23179986. [PMID: 36077379]
  • Hui Wang, Zhongju Xu, Qi Wang, Shi Shu. Danshao Shugan Granule therapy for non-alcoholic fatty liver disease. Lipids in health and disease. 2022 Aug; 21(1):76. doi: 10.1186/s12944-022-01689-9. [PMID: 35999630]
  • Wenbiao Li, Xinni Qu, Xiangping Kang, Haiyin Zhang, Xueli Zhang, Haiyan Hu, Lingai Yao, Lina Zhang, Jing Zheng, Yuejuan Zheng, Jianghong Zhang, Yanwu Xu. Silibinin eliminates mitochondrial ROS and restores autophagy through IL6ST/JAK2/STAT3 signaling pathway to protect cardiomyocytes from doxorubicin-induced injury. European journal of pharmacology. 2022 Aug; 929(?):175153. doi: 10.1016/j.ejphar.2022.175153. [PMID: 35839932]
  • Ling Ren, Xiao-Lei Ma, Hong-Liang Wang, Rui Li, Jin-Jin Cui, Peng-Ju Yan, Ya-Nan Wang, Xiao-You Yu, Peng Du, Hao-Yang Yu, Hui-Hui Guo, Rou Tang, Yong-Sheng Che, Wen-Sheng Zheng, Jian-Dong Jiang, Lu-Lu Wang. Prebiotic-like cyclodextrin assisted silybin on NAFLD through restoring liver and gut homeostasis. Journal of controlled release : official journal of the Controlled Release Society. 2022 08; 348(?):825-840. doi: 10.1016/j.jconrel.2022.06.031. [PMID: 35752255]
  • Sajjad Makhdoomi, Mohammad Mehdi Mahboobian, Rasool Haddadi, Alireza Komaki, Mojdeh Mohammadi. Silibinin-loaded nanostructured lipid carriers (NLCs) ameliorated cognitive deficits and oxidative damages in aluminum chloride-induced neurotoxicity in male mice. Toxicology. 2022 07; 477(?):153260. doi: 10.1016/j.tox.2022.153260. [PMID: 35850386]
  • Rania Hamdy, Ahmed Mostafa, Noura M Abo Shama, Sameh S M Soliman, Bahgat Fayed. Comparative evaluation of flavonoids reveals the superiority and promising inhibition activity of silibinin against SARS-CoV-2. Phytotherapy research : PTR. 2022 Jul; 36(7):2921-2939. doi: 10.1002/ptr.7486. [PMID: 35596627]
  • Yuan Ding, Sitong Zhang, Zhongquan Sun, Zongrui Tong, Yao Ge, Liuzhi Zhou, Qianhui Xu, Huiping Zhou, Weilin Wang. Preclinical validation of silibinin/albumin nanoparticles as an applicable system against acute liver injury. Acta biomaterialia. 2022 Jul; 146(?):385-395. doi: 10.1016/j.actbio.2022.04.021. [PMID: 35460909]
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