Deoxyadenosine triphosphate (BioDeep_00000001317)

 

Secondary id: BioDeep_00000416027

human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019 natural product


代谢物信息卡片


({[({[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

化学式: C10H16N5O12P3 (491.0008)
中文名称: 2'-脱氧腺苷5'-三磷酸, 2'-脱氧腺苷-5'-三磷酸二钠盐
谱图信息: 最多检出来源 Homo sapiens(otcml) 18.6%

分子结构信息

SMILES: C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O
InChI: InChI=1S/C10H16N5O12P3/c11-9-8-10(13-3-12-9)15(4-14-8)7-1-5(16)6(25-7)2-24-29(20,21)27-30(22,23)26-28(17,18)19/h3-7,16H,1-2H2,(H,20,21)(H,22,23)(H2,11,12,13)(H2,17,18,19)/t5-,6+,7+/m0/s1

描述信息

Deoxyadenosine triphosphate (dATP) is a purine nucleoside triphosphate used in cells for DNA synthesis. A nucleoside triphosphate is a molecule type that contains a nucleoside with three phosphates bound to it. dATP contains the sugar deoxyribose, a precursor to DNA synthesis whereby the two existing phosphate groups are cleaved with the remaining deoxyadenosine monophosphate being incorporated into DNA during replication. Due to its enzymatic incorporation into DNA, photoreactive dATP analogs such as N6-[4-azidobenzoyl–(2-aminoethyl)]-2′-deoxyadenosine-5′-triphosphate (AB-dATP) and N6-[4-[3-(trifluoromethyl)-diazirin-3-yl]benzoyl-(2-aminoethyl)]-2′-deoxyadenosine-5′-triphosphate (DB-dATP) have been used for DNA photoaffinity labeling. When present in sufficiently high levels, dATP can act as an immunotoxin and a metabotoxin. An immunotoxin disrupts, limits the function, or destroys immune cells. A metabotoxin is an endogenous metabolite that causes adverse health effects at chronically high levels. Chronically high levels of deoxyadenosine triphosphate are associated with adenosine deaminase (ADA) deficiency, an inborn error of metabolism. ADA deficiency damages the immune system and causes severe combined immunodeficiency (SCID). People with SCID lack virtually all immune protection from bacteria, viruses, and fungi. They are prone to repeated and persistent infections that can be very serious or life-threatening. These infections are often caused by "opportunistic" organisms that ordinarily do not cause illness in people with a normal immune system. The main symptoms of ADA deficiency are pneumonia, chronic diarrhea, and widespread skin rashes. The mechanism by which dATP functions as an immunotoxin is as follows: a buildup of dATP in cells inhibits ribonucleotide reductase and prevents DNA synthesis, so cells are unable to divide. Since developing T cells and B cells are some of the most mitotically active cells, they are unable to divide and propagate to respond to immune challenges.
Animals obtain their energy by oxidation of foods, plants do so by trapping the sunlight using chlorophyll. However, before the energy can be used, it is first transformed into a form which the organism can handle easily. This special carrier of energy is the molecule adenosine triphosphate, or ATP. The ATP molecule is composed of three components. At the centre is a sugar molecule, [[ribose] (the same sugar that forms the basis of DNA). Attached to one side of this is a base (a group consisting of linked rings of carbon and nitrogen atoms); in this case the base is adenine. The other side of the sugar is attached to a string of phosphate groups. These phosphates are the key to the activity of ATP. ATP consists of a base, in this case adenine (red), a ribose (magenta) and a phosphate chain (blue). ATP works by losing the endmost phosphate group when instructed to do so by an enzyme. This reaction releases a lot of energy, which the organism can then use to build proteins, contact muscles, etc. [HMDB]. dATP is found in many foods, some of which are pepper (c. chinense), squashberry, safflower, and brussel sprouts.
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同义名列表

21 个代谢物同义名

({[({[(2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid; 2-Deoxyadenosine 5-triphosphate disodium salt(dATP); 2-Deoxyadenosine triphosphate, monomagnesium salt; 2-Deoxyadenosine triphosphate, p-(32)p-labeled; 2-Deoxyadenosine triphosphate, trisodium salt; 2-Deoxyadenosine triphosphate, 14C-labeled; 2-Deoxyadenosine 5-triphosphoric acid; Deoxyadenosine 5-triphosphoric acid; Deoxyadenosine triphosphoric acid; 2-Deoxyadenosine 5-triphosphate; 2-Deoxyadenosine triphosphate; Deoxyadenosine 5-triphosphate; Deoxyadenosine-triphosphate; Deoxyadenosine triphosphate; 2-Deoxy-5-ATP; 2-Deoxy-ATP; Deoxy-ATP; dATP CPD; dATP; 2'-Deoxyadenosine 5'-triphosphate(dATP); dATP



数据库引用编号

24 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

132 个相关的代谢反应过程信息。

Reactome(76)

  • DNA Replication: ATP + pre-replicative complex ⟶ ADP + Homologues of p-S,T-ORC1 + pre-replicative complex (Orc1-minus)
  • Synthesis of DNA: ATP + pre-replicative complex ⟶ ADP + Homologues of p-S,T-ORC1 + pre-replicative complex (Orc1-minus)
  • DNA replication initiation: RNA primer:origin duplex:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:origin duplex
  • Cell Cycle: 2OG + Oxygen + PHF8:Nucleosome with H3K4me2/3:H4K20me1 ⟶ CH2O + PHF8:Nucleosome with H3K4me2/3 + SUCCA + carbon dioxide
  • Cell Cycle, Mitotic: 2OG + Oxygen + PHF8:Nucleosome with H3K4me2/3:H4K20me1 ⟶ CH2O + PHF8:Nucleosome with H3K4me2/3 + SUCCA + carbon dioxide
  • S Phase: ATP + pre-replicative complex ⟶ ADP + Homologues of p-S,T-ORC1 + pre-replicative complex (Orc1-minus)
  • Chromosome Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Extension of Telomeres: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Extension By Telomerase: TTP + Telomerase RNP Bound and base-paired to the Telomeric Chromosome End + dATP + dCTP + dGTP ⟶ Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat
  • Telomere C-strand (Lagging Strand) Synthesis: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:G-strand extended telomere
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand (Lagging Strand) Synthesis: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • DNA Replication: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • Synthesis of DNA: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • DNA replication initiation: RNA primer:origin duplex:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:origin duplex
  • Cell Cycle: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • Cell Cycle, Mitotic: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • S Phase: ATP + Q5N897 ⟶ ADP + phospho-p-CDC6
  • Chromosome Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Extension of Telomeres: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand (Lagging Strand) Synthesis: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:G-strand extended telomere
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Chromosome Maintenance: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere Maintenance: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Extension of Telomeres: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand (Lagging Strand) Synthesis: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand (Lagging Strand) Synthesis: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:POLA:primase + TTP + dATP + dCTP + dGTP ⟶ RNA primer:DNA primer:G-strand extended telomere:POLA:primase
  • Cell Cycle: ATP + p21,p27 ⟶ ADP + p-T-CDKN1A/B
  • Cell Cycle, Mitotic: ATP + p21,p27 ⟶ ADP + p-T-CDKN1A/B
  • S Phase: ATP + p21,p27 ⟶ ADP + p-T-CDKN1A/B
  • Synthesis of DNA: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:origin duplex ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:origin duplex:PCNA homotrimer
  • DNA replication initiation: RNA primer:origin duplex:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:origin duplex
  • Chromosome Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Maintenance: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Extension of Telomeres: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere Extension By Telomerase: TTP + Telomerase RNP Bound and base-paired to the Telomeric Chromosome End + dATP + dCTP + dGTP ⟶ Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat
  • Telomere C-strand (Lagging Strand) Synthesis: ATP + PCNA homotrimer + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end ⟶ ADP + RFC Heteropentamer:RNA primer-DNA primer:G-strand extended telomere end duplex:PCNA homotrimer
  • Telomere C-strand synthesis initiation: RNA primer:G-strand extended telomere end:DNA polymerase alpha:primase complex + TTP + dATP + dCTP + dGTP ⟶ RNA primer-DNA primer:G-strand extended telomere
  • DNA Replication: ATP + MCM2-7 ⟶ ADP + p-MCM2-7
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Processive synthesis on the C-strand of the telomere: Processive complex loaded on telomere + TTP + dATP + dCTP + dGTP ⟶ Processive complex loaded on telomere:Okazaki fragment complex
  • Telomere Extension By Telomerase: TTP + Telomerase RNP Bound and base-paired to the Telomeric Chromosome End + dATP + dCTP + dGTP ⟶ Telomerase RNP:Telomeric Chromosome End with an Additional single Stranded Telomere repeat
  • Metabolism: 2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
  • Carbohydrate metabolism: D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN
  • Pentose phosphate pathway: ATP + R5P ⟶ AMP + PRPP
  • PRPP biosynthesis: ATP + R5P ⟶ AMP + PRPP
  • Metabolism: 2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
  • Carbohydrate metabolism: D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN
  • Pentose phosphate pathway: ATP + R5P ⟶ AMP + PRPP
  • PRPP biosynthesis: ATP + R5P ⟶ AMP + PRPP
  • Metabolism: 1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA
  • Carbohydrate metabolism: D-glucuronate + H+ + TPNH ⟶ L-gulonate + TPN
  • Pentose phosphate pathway: ATP + R5P ⟶ AMP + PRPP
  • PRPP biosynthesis: ATP + R5P ⟶ AMP + PRPP
  • DNA Repair: MUTYH:(OGUA:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA
  • DNA Damage Bypass: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA + POLH
  • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA + POLH
  • Translesion Synthesis by POLH: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA + POLH
  • DNA Repair: MUTYH:(OGUA:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA
  • DNA Damage Bypass: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + Homologues of POLH + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA
  • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + Homologues of POLH + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA
  • Translesion Synthesis by POLH: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + Homologues of POLH + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA
  • DNA Repair: MUTYH:(OGUA:Ade)-dsDNA ⟶ Ade + MUTYH:AP-dsDNA
  • DNA Damage Bypass: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA + POLH
  • Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA + POLH
  • Translesion Synthesis by POLH: ATP + NPLOC4:UFD1L:VCP:SPRTN:POLH:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-DNA Template ⟶ ADP + NPLOC4:UFD1L:VPC:SPRTN:MonoUb:K164-PCNA:RPA:RFC:(TT-CPD:AA-polydNMP)-Template DNA + POLH

BioCyc(4)

WikiPathways(3)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(46)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADA, AHCY, APAF1, BCL2, CASP3, CASP9, DCK, DHFR, MYLK, NUDT1, PNP, POLB
Peripheral membrane protein 1 ADA
Endoplasmic reticulum membrane 2 BCL2, CD4
Nucleus 12 ADK, AHCY, APAF1, BCL2, CASP3, CASP9, DCK, NUDT1, PCNA, POLB, POLH, SAMHD1
cytosol 13 ADA, ADK, AHCY, APAF1, BCL2, CASP3, CASP9, DCK, DHFR, MYLK, NUDT1, PNP, POLH
dendrite 1 P2RY1
nuclear body 1 PCNA
centrosome 1 PCNA
nucleoplasm 8 ADK, ATP2B1, CASP3, DCK, PCNA, POLB, POLH, SAMHD1
Cell membrane 5 ADA, ATP2B1, CD4, CD8A, P2RY1
Cleavage furrow 1 MYLK
lamellipodium 1 MYLK
Multi-pass membrane protein 2 ATP2B1, P2RY1
Synapse 2 ATP2B1, MYLK
cell junction 1 ADA
cell surface 2 ADA, P2RY1
glutamatergic synapse 3 ATP2B1, CASP3, P2RY1
Golgi apparatus 1 POLH
neuronal cell body 1 CASP3
presynaptic membrane 1 ATP2B1
Lysosome 1 ADA
acrosomal vesicle 1 NUDT1
plasma membrane 8 ADA, ADK, ATP2B1, CD4, CD8A, MYLK, P2RY1, SAMHD1
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ADA, APAF1, ATP2B1, BCL2
apical plasma membrane 1 P2RY1
basolateral plasma membrane 2 ATP2B1, P2RY1
extracellular exosome 5 AHCY, APAF1, ATP2B1, PCNA, PNP
endoplasmic reticulum 2 AHCY, BCL2
extracellular space 2 NUDT1, PNP
mitochondrion 5 BCL2, CASP9, DCK, DHFR, NUDT1
protein-containing complex 4 APAF1, BCL2, CASP9, POLB
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 2 CASP3, P2RY1
Single-pass type I membrane protein 2 CD4, CD8A
Secreted 1 PNP
extracellular region 3 APAF1, CD8A, PNP
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 CD8A
Mitochondrion matrix 1 NUDT1
mitochondrial matrix 1 NUDT1
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, NUDT1
external side of plasma membrane 3 ADA, CD4, CD8A
actin cytoskeleton 1 MYLK
Early endosome 1 CD4
postsynaptic membrane 1 P2RY1
presynaptic active zone membrane 1 P2RY1
Cell projection, lamellipodium 1 MYLK
Membrane raft 1 CD4
pore complex 1 BCL2
microtubule 1 POLB
mitochondrial nucleoid 1 POLH
lateral plasma membrane 1 ATP2B1
receptor complex 1 CD8A
cilium 1 P2RY1
chromatin 1 PCNA
cell projection 1 ATP2B1
Chromosome 2 POLH, SAMHD1
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
Basolateral cell membrane 1 ATP2B1
site of double-strand break 2 POLH, SAMHD1
Melanosome 1 AHCY
Presynaptic cell membrane 1 ATP2B1
cell body 1 P2RY1
replication fork 2 PCNA, POLH
myelin sheath 1 BCL2
stress fiber 1 MYLK
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 2 APAF1, PNP
secretory granule lumen 2 APAF1, PNP
endoplasmic reticulum lumen 1 CD4
male germ cell nucleus 1 PCNA
immunological synapse 1 ATP2B1
tetraspanin-enriched microdomain 1 SAMHD1
apoptosome 2 APAF1, CASP9
[Isoform 2]: Cytoplasm 1 ADK
nuclear lamina 1 PCNA
clathrin-coated endocytic vesicle membrane 1 CD4
Cytoplasm, cytoskeleton, stress fiber 1 MYLK
[Isoform 1]: Nucleus 1 ADK
spindle microtubule 1 POLB
death-inducing signaling complex 1 CASP3
[Isoform 1]: Cell membrane 1 CD8A
site of DNA damage 1 POLH
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
T cell receptor complex 2 CD4, CD8A
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
[Isoform p18]: Cytoplasm, cytosol 1 NUDT1
[Isoform p26]: Mitochondrion matrix 1 NUDT1
caspase complex 1 CASP9


文献列表

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