Beta-Tyrosine (BioDeep_00000001229)

Main id: BioDeep_00000015942

 

human metabolite Endogenous


代谢物信息卡片


3-Amino-3-(4-hydroxyphenyl)propionic acid

化学式: C9H11NO3 (181.0739)
中文名称: (R)-3-氨基-3-(4-羟基苯基)-丙酸, 3-氨基-3-(4-羟基苯基)丙酸
谱图信息: 最多检出来源 Homo sapiens(plant) 9.5%

分子结构信息

SMILES: C1=CC(=CC=C1C(CC(=O)O)N)O
InChI: InChI=1S/C9H11NO3/c10-8(5-9(12)13)6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)

描述信息

The use of tyrosine kinase receptor inhibitors is increasingly becoming a valuable therapeutic alternative in tumors carrying activated tyrosine kinase receptors. GMR beta tyrosine residues are not necessary for activation of the JAK/STAT pathway, or for proliferation, viability, or adhesion signaling in Ba/F3 cells, although tyrosine residues significantly affect the magnitude of the response. (PMID:10372132).
The use of tyrosine kinase receptor inhibitors is increasingly becoming a valuable therapeutic alternative in tumors carrying activated tyrosine kinase receptors.
KEIO_ID A176

同义名列表

7 个代谢物同义名

3-Amino-3-(4-hydroxyphenyl)propionic acid; 3-amino-3-(4-hydroxyphenyl)propanoic acid; 3-Amino-3-(4-hydroxyphenyl)propanoate; 3-Amino-3-(4-hydroxyphenyl)propionate; Beta-Tyrosine; b-Tyrosine; Β-tyrosine



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANG, EGFR, JAK2, NFKB1, PDGFB, PDGFRA, PDGFRB, PLCG1, RAF1, TNK1, VEGFA
Peripheral membrane protein 2 JAK2, TNK1
Endosome membrane 2 EGFR, INSR
Endoplasmic reticulum membrane 2 EGFR, PDGFRA
Nucleus 10 ANG, EGFR, JAK2, KDR, MET, NFKB1, PDGFRA, PDGFRB, RAF1, VEGFA
cytosol 5 ANG, JAK2, NFKB1, PLCG1, RAF1
nuclear body 1 MET
nucleoplasm 5 ATP2B1, JAK2, MET, NFKB1, PDGFRA
Cell membrane 8 ATP2B1, EGFR, FLT1, INSR, KDR, KIT, PDGFRA, RAF1
lamellipodium 1 PLCG1
ruffle membrane 2 EGFR, PLCG1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ATP2B1
Synapse 1 ATP2B1
cell junction 3 EGFR, KDR, PDGFRA
cell surface 4 EGFR, MET, PDGFB, VEGFA
glutamatergic synapse 4 ATP2B1, EGFR, JAK2, PLCG1
Golgi apparatus 5 KDR, PDGFRA, PDGFRB, RAF1, VEGFA
Golgi membrane 3 EGFR, INS, PDGFB
growth cone 1 ANG
neuronal cell body 1 ANG
postsynapse 2 JAK2, MET
presynaptic membrane 1 ATP2B1
Lysosome 1 INSR
acrosomal vesicle 1 KIT
endosome 3 EGFR, FLT1, KDR
plasma membrane 15 ATP2B1, EDNRA, EGFR, FLT1, IFNLR1, INSR, JAK2, KDR, KIT, MET, PDGFRA, PDGFRB, PLCG1, RAF1, TNK1
synaptic vesicle membrane 1 ATP2B1
Membrane 13 ATP2B1, EGFR, FLT1, IFNLR1, INSR, JAK2, KIT, MET, PDGFB, PDGFRA, PDGFRB, TNK1, VEGFA
apical plasma membrane 2 EGFR, PDGFRB
axon 1 INSR
basolateral plasma membrane 3 ATP2B1, EGFR, PDGFB
caveola 2 INSR, JAK2
extracellular exosome 2 ATP2B1, INSR
endoplasmic reticulum 2 KDR, VEGFA
extracellular space 7 ANG, EGFR, FLT1, INS, KIT, PDGFB, VEGFA
lysosomal lumen 1 PDGFRB
perinuclear region of cytoplasm 1 EGFR
Schaffer collateral - CA1 synapse 1 PLCG1
adherens junction 1 VEGFA
mitochondrion 2 NFKB1, RAF1
protein-containing complex 2 EGFR, PDGFRA
intracellular membrane-bounded organelle 2 ATP2B1, PDGFRB
Single-pass type I membrane protein 6 EGFR, FLT1, IFNLR1, INSR, KIT, PDGFRA
Secreted 4 ANG, INS, PDGFB, VEGFA
extracellular region 7 ANG, INS, KDR, MET, NFKB1, PDGFB, VEGFA
cytoplasmic side of plasma membrane 2 JAK2, KIT
Single-pass membrane protein 1 MET
mitochondrial outer membrane 1 RAF1
neuronal cell body membrane 1 INSR
[Isoform 2]: Secreted 2 FLT1, KDR
anchoring junction 1 KDR
transcription regulator complex 1 NFKB1
Cell projection, cilium 1 PDGFRA
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 1 EGFR
external side of plasma membrane 4 INSR, KDR, KIT, PDGFRA
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 ANG, FLT1
cytoplasmic vesicle 1 PDGFRB
nucleolus 1 ANG
Early endosome 1 KDR
cell-cell junction 2 KIT, PLCG1
Cell projection, lamellipodium 1 PLCG1
Membrane raft 3 EGFR, JAK2, KDR
focal adhesion 4 EGFR, FLT1, JAK2, PDGFRB
extracellular matrix 1 VEGFA
basement membrane 1 ANG
intracellular vesicle 1 EGFR
collagen-containing extracellular matrix 1 PDGFB
secretory granule 1 VEGFA
lateral plasma membrane 1 ATP2B1
Cell projection, ruffle 1 PLCG1
Late endosome 1 INSR
ruffle 1 PLCG1
receptor complex 8 EGFR, FLT1, INSR, KDR, KIT, MET, PDGFRA, PDGFRB
cilium 1 PDGFRA
chromatin 1 NFKB1
cell projection 2 ATP2B1, PLCG1
Chromosome 1 ANG
cytoskeleton 1 JAK2
COP9 signalosome 1 PLCG1
[Isoform 5]: Cytoplasm 1 FLT1
Nucleus, nucleolus 1 ANG
Basolateral cell membrane 1 ATP2B1
fibrillar center 1 KIT
Endomembrane system 1 JAK2
endosome lumen 2 INS, JAK2
sorting endosome 1 KDR
microvillus 1 PDGFRA
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
euchromatin 1 JAK2
Presynaptic cell membrane 1 ATP2B1
pseudopodium 1 RAF1
basal plasma membrane 2 EGFR, MET
[Isoform 3]: Cytoplasm 1 KIT
synaptic membrane 1 EGFR
secretory granule lumen 2 INS, NFKB1
Golgi lumen 2 INS, PDGFB
endoplasmic reticulum lumen 2 INS, PDGFB
platelet alpha granule lumen 2 PDGFB, VEGFA
specific granule lumen 1 NFKB1
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 EGFR
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
dendrite membrane 1 INSR
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
[Isoform 7]: Cytoplasm 1 FLT1
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
platelet-derived growth factor complex 1 PDGFB
angiogenin-PRI complex 1 ANG
insulin receptor complex 1 INSR
[Isoform 6]: Cytoplasm 1 FLT1
photoreceptor ribbon synapse 1 ATP2B1
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Nuclear factor NF-kappa-B p105 subunit]: Cytoplasm 1 NFKB1
[Nuclear factor NF-kappa-B p50 subunit]: Nucleus 1 NFKB1
I-kappaB/NF-kappaB complex 1 NFKB1
NF-kappaB p50/p65 complex 1 NFKB1
interleukin-28 receptor complex 1 IFNLR1


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