Diosmin (BioDeep_00000000373)

 

Secondary id: BioDeep_00000270488

natural product human metabolite PANOMIX_OTCML-2023 Endogenous BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one

化学式: C28H32O15 (608.1741122)
中文名称: 地奥司明
谱图信息: 最多检出来源 Viridiplantae(plant) 5.09%

分子结构信息

SMILES: c(O)(c3)c(C(=O)2)c(cc3O[C@H](O4)[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H](O5)[C@H](O)[C@@H]([C@H]([C@@H]5C)O)O)4)OC(=C2)c(c1)ccc(c1O)OC
InChI: InChI=1/C28H32O15/c1-10-21(32)23(34)25(36)27(40-10)39-9-19-22(33)24(35)26(37)28(43-19)41-12-6-14(30)20-15(31)8-17(42-18(20)7-12)11-3-4-16(38-2)13(29)5-11/h3-8,10,19,21-30,32-37H,9H2,1-2H3/t10-,19+,21-,22+,23+,24-,25+,26+,27+,28+/m0/s1

描述信息

Isolated from parsley. Diosmetin 7-rutinoside is found in many foods, some of which are sweet orange, spearmint, rosemary, and peppermint.
C - Cardiovascular system > C05 - Vasoprotectives > C05C - Capillary stabilizing agents > C05CA - Bioflavonoids
Diosmin is found in green vegetables. Diosmin is isolated from parsle
C26170 - Protective Agent > C275 - Antioxidant > C306 - Bioflavonoid
Diosmin is a disaccharide derivative that consists of diosmetin substituted by a 6-O-(alpha-L-rhamnopyranosyl)-beta-D-glucopyranosyl moiety at position 7 via a glycosidic linkage. It has a role as an antioxidant and an anti-inflammatory agent. It is a glycosyloxyflavone, a rutinoside, a disaccharide derivative, a monomethoxyflavone and a dihydroxyflavanone. It is functionally related to a diosmetin.
Chronic venous insufficiency is a common condition the western population. Compression and pharmacotherapy are frequently used to manage chronic venous insufficiency, improving circulation and symptoms of venous disease. Diosmin is a bioflavonoid isolated from various plants or synthesized from [hesperidin]. It is used for the improvement of capillary fragility or venous insufficiency, including chronic venous insufficiency (CVI) and hemorrhoids. Diosmin is widely available over-the-counter and demonstrates a favourable a favorable safety profile.
Diosmin is a natural product found in Asyneuma argutum, Citrus hystrix, and other organisms with data available.
A bioflavonoid that strengthens vascular walls.
See also: Agathosma betulina leaf (part of).
[Raw Data] CBA89_Diosmin_neg_50eV.txt
[Raw Data] CBA89_Diosmin_pos_10eV.txt
[Raw Data] CBA89_Diosmin_neg_20eV.txt
[Raw Data] CBA89_Diosmin_pos_50eV.txt
[Raw Data] CBA89_Diosmin_neg_30eV.txt
[Raw Data] CBA89_Diosmin_neg_40eV.txt
[Raw Data] CBA89_Diosmin_pos_30eV.txt
[Raw Data] CBA89_Diosmin_neg_10eV.txt
[Raw Data] CBA89_Diosmin_pos_20eV.txt
[Raw Data] CBA89_Diosmin_pos_40eV.txt
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).
Diosmin is a flavonoid found in a variety of citrus fruits and also an agonist of the aryl hydrocarbon receptor (AhR).

同义名列表

89 个代谢物同义名

5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(3,4,5-trihydroxy-6-{[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy]methyl}oxan-2-yl)oxy]-4H-chromen-4-one; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-2-yl]oxychromen-4-one; 5,7,3-Trihydroxy-4-methoxyflavone 7-O-rutinoside; Luteolin 4-methyl ether 7-rutinoside; Diosmetinidin O-rutinoside; Diosmetin-7-O-rutinoside; Salinigricoflavonoloside; Diosmetin 7-O-rutinoside; Diosmetin 7-rutinoside; Diosmin, ban, inn; Ven-Detrex; Flebosten; Venosmine; Diosminum; Diosmine; Barosmin; Diovenor; Diosmin; Diosmil; Rioven; Daflon; Veno-V; Tovene; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(((2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)methyl)tetrahydro-2H-pyran-2-yloxy)-4H-chromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxy-phenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyl-tetrahydropyran-2-yl]oxymethyl]tetrahydropyran-2-yl]oxy-chromen-4-one; 5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-7-{[(2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-({[(2R,3R,4R,5R,6S)-3,4,5-TRIHYDROXY-6-METHYLOXAN-2-YL]OXY}METHYL)OXAN-2-YL]OXY}-4H-CHROMEN-4-ONE; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3S,4S,5S,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-.alpha.-L-mannopyranosyl)-.beta.-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 4H-1-Benzopyran-4-one, 7-((6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 7-((6-O-(6-DEOXY-GA-L-MANNOPYRANOSYL)-.BETA.-D-GLUCOPYRANOSYL)OXY)-5-HYDROXY-2-(3-HYDROXY-4-METHOXYPHENYL)-4H-1-BENZOPYRAN-4-ONE; 7-((6-O-(6-Deoxy-ga-L-mannopyranosyl)-beta-D-glucopyranosyl)oxy)-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-4H-1-benzopyran-7-yl 6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranoside; 4H-1-Benzopyran-4-one,7-[[6-O-(6-deoxy-a-L-mannopyranosyl)-b-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-; 5-Hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-((6-O-alpha-L-rhamnopyranosyl-beta-D-glycopyranosyl)oxy)-4-chromenon; 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-7-(O6-alpha-L-rhamnopyranosyl-beta-D-glucopyranosyloxy)chromen-4-one; 3,5,7-Trihydroxy-4-methoxyflavone-7-(6-O-(-deoxy-alpha-L-mannopyraonsyl)-beta-D-glucopyranoside; Diosmin for system suitability, European Pharmacopoeia (EP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid (IUPAC); Diosmin, United States Pharmacopeia (USP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid [IUPAC]; Diosmin, European Pharmacopoeia (EP) Reference Standard; 3,5-Dihydroxy-4-methoxy-4-oxo-4H-chromen-7-ylrutosid; 3,5,7-trihydroxy-4-methoxyflavone 7-rhamnoglucoside; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside;; 3,5,7-trihydroxy-4-methoxy flavone-7-rutinoside; 3,5,7-trihydroxy-4-methoxyflavone-7-rutinoside; 3,5,7-Trihydroxy-4-methoxyflavone 7-rutinoside; Diosmin, analytical standard; DIOSMIN [EP MONOGRAPH]; DIOSMIN (EP MONOGRAPH); Diosmine [INN-French]; Diosminum [INN-Latin]; Diosmin [INN-Spanish]; Diosmin [INN:BAN]; DIOSMIN (USP-RS); DIOSMIN [WHO-DD]; DIOSMIN [USP-RS]; DIOSMINE [INCI]; UNII-7QM776WJ5N; DIOSMIN [MART.]; DIOSMIN (MART.); Tox21_111392_1; Diosmin [INN]; Diosmin (INN); DIOSMIN [DSC]; Tox21_111392; DIOSMIN [MI]; Resin, Buchu; Diosmin (8); SMP1_000183; Daflon (TN); Buchu Resin; 7QM776WJ5N; Flebavena; flebosmil; Diosmina; Litosmil; Flebaven; Diosimin; Hemerven; Insuven; Varinon; Diosven; C05CA03; Dioven; Diosmin



数据库引用编号

48 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

119 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yinai Deng, Peng Yang, Qianle Zhang, Qingwen Wu, Lingfang Feng, Wenjing Shi, Qian Peng, Li Ding, Xukai Tan, Ruoting Zhan, Dongming Ma. Genomic insights into the evolution of flavonoid biosynthesis and O-methyltransferase and glucosyltransferase in Chrysanthemum indicum. Cell reports. 2024 Jan; 43(2):113725. doi: 10.1016/j.celrep.2024.113725. [PMID: 38300800]
  • Kaushal Vyas, Supraja Prabaker, Dhamodharan Prabhu, Meenakumari Sakthivelu, Sundararaj Rajamanikandan, Palaniyandi Velusamy, Chia-Hung Su, Subash C B Gopinath, Raman Pachaiappan. Study of an inhibitory effect of plant polyphenolic compounds against digestive enzymes using bench-working experimental evidence predicted by molecular docking and dynamics. International journal of biological macromolecules. 2024 Jan; 259(Pt 1):129222. doi: 10.1016/j.ijbiomac.2024.129222. [PMID: 38185307]
  • Jingwei Zhao, Mingming Zhang, Huamin Zhang, Ying Wang, Bingyu Chen, Jing Shao. Diosmin ameliorates LPS-induced depression-like behaviors in mice: Inhibition of inflammation and oxidative stress in the prefrontal cortex. Brain research bulletin. 2024 Jan; 206(?):110843. doi: 10.1016/j.brainresbull.2023.110843. [PMID: 38092305]
  • Clare Njoki Kimani, Helmuth Reuter, Sanet Henriët Kotzé, Pieter Venter, Pritika Ramharack, Christo John Frederick Muller. Pancreatic beta cell regenerative potential of Zanthoxylum chalybeum Engl. Aqueous stem bark extract. Journal of ethnopharmacology. 2023 Nov; ?(?):117374. doi: 10.1016/j.jep.2023.117374. [PMID: 37944876]
  • Mehdi Rahimmalek, Antoni Szumny, Shima Gharibi, Natalia Pachura, Mehran Miroliaei, Jacek Łyczko. Chemical Investigations in Kelussia odoratissima Mozaff. Leaves Based on Comprehensive Analytical Methods: LC-MS, SPME, and GC-MS Analyses. Molecules (Basel, Switzerland). 2023 Aug; 28(16):. doi: 10.3390/molecules28166140. [PMID: 37630391]
  • Marcin Feldo, Magdalena Wójciak, Sławomir Dresler, Paweł Sowa, Bartosz J Płachno, Dariusz Samborski, Ireneusz Sowa. Effect of Diosmin on Selected Parameters of Oxygen Homeostasis. International journal of molecular sciences. 2023 Aug; 24(16):. doi: 10.3390/ijms241612917. [PMID: 37629098]
  • K S Kiran, Vivek Hamse Kameshwar, Kiran Kumar Munakudu-Nagaraju, P Nagalambika, R Kavitha, Avathade Karthick, D Guru Kumar, S Nanjunda Swamy, K L Krishna, J R Kumar. Diosmin: A Daboia russelii venom PLA2s inhibitor- purified, and characterized from Oxalis corniculata L medicinal plant. Journal of ethnopharmacology. 2023 Aug; ?(?):116977. doi: 10.1016/j.jep.2023.116977. [PMID: 37544341]
  • Lukasz Gwozdzinski, Joanna Bernasinska-Slomczewska, Anna Wiktorowska-Owczarek, Edward Kowalczyk, Anna Pieniazek. Diosmin and Bromelain Stimulate Glutathione and Total Thiols Production in Red Blood Cells. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052291. [PMID: 36903535]
  • Tarique Anwer, Saeed Alshahrani, Ahmad M H Somaili, Abdullah H Khubrani, Rayan A Ahmed, Abdulmajeed M Jali, Ayed Alshamrani, Hina Rashid, Yousra Nomeir, Mohammad Khalid, Mohammad Firoz Alam. Nephroprotective Effect of Diosmin against Cisplatin-Induced Kidney Damage by Modulating IL-1β, IL-6, TNFα and Renal Oxidative Damage. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031302. [PMID: 36770968]
  • Seyed Sajad Hossieni Geshnigani, Masoud Mahdavinia, Mojtaba Kalantar, Mehdi Goudarzi, Layasadat Khorsandi, Hadi Kalantar. Diosmin prophylaxis reduces gentamicin-induced kidney damage in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 01; 396(1):63-71. doi: 10.1007/s00210-022-02295-3. [PMID: 36121447]
  • Qing-Wen Wu, Min Wei, Ling-Fang Feng, Li Ding, Wu-Ke Wei, Jin-Fen Yang, Xiao-Jing Lin, Hui-Lin Liang, Ruo-Ting Zhan, Dong-Ming Ma. Rhamnosyltransferases involved in the biosynthesis of flavone rutinosides in Chrysanthemum species. Plant physiology. 2022 11; 190(4):2122-2136. doi: 10.1093/plphys/kiac371. [PMID: 35947689]
  • Magdalena Wójciak, Marcin Feldo, Grzegorz Borowski, Tomasz Kubrak, Bartosz J Płachno, Ireneusz Sowa. Antioxidant Potential of Diosmin and Diosmetin against Oxidative Stress in Endothelial Cells. Molecules (Basel, Switzerland). 2022 Nov; 27(23):. doi: 10.3390/molecules27238232. [PMID: 36500323]
  • Johirul Islam, Alpa Shree, Haider Ali Khan, Sarwat Sultana. Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice. Journal of biochemical and molecular toxicology. 2022 Nov; 36(11):e23187. doi: 10.1002/jbt.23187. [PMID: 35920545]
  • Piyush Kashyap, Mamta Thakur, Nidhi Singh, Deep Shikha, Shiv Kumar, Poonam Baniwal, Yogender Singh Yadav, Minaxi Sharma, Kandi Sridhar, Baskaran Stephen Inbaraj. In Silico Evaluation of Natural Flavonoids as a Potential Inhibitor of Coronavirus Disease. Molecules (Basel, Switzerland). 2022 Sep; 27(19):. doi: 10.3390/molecules27196374. [PMID: 36234910]
  • Rosa Martha Pérez Gutiérrez, Julio Téllez Gómez, Raúl Borja Urby, José G Contreras Soto, Héctor Romo Parra. Evaluation of Diabetes Effects of Selenium Nanoparticles Synthesized from a Mixture of Luteolin and Diosmin on Streptozotocin-Induced Type 2 Diabetes in Mice. Molecules (Basel, Switzerland). 2022 Sep; 27(17):. doi: 10.3390/molecules27175642. [PMID: 36080407]
  • Hasnaa Osama, Ehdaa O Hamed, Muhammed A Mahmoud, Mohamed E A Abdelrahim. The Effect of Hesperidin and Diosmin Individually or in Combination on Metabolic Profile and Neuropathy among Diabetic Patients with Metabolic Syndrome: A Randomized Controlled Trial. Journal of dietary supplements. 2022 Aug; ?(?):1-14. doi: 10.1080/19390211.2022.2107138. [PMID: 35946912]
  • Marcin Feldo, Magdalena Wójciak, Aleksandra Ziemlewska, Sławomir Dresler, Ireneusz Sowa. Modulatory Effect of Diosmin and Diosmetin on Metalloproteinase Activity and Inflammatory Mediators in Human Skin Fibroblasts Treated with Lipopolysaccharide. Molecules (Basel, Switzerland). 2022 Jul; 27(13):. doi: 10.3390/molecules27134264. [PMID: 35807509]
  • Jiuhong Deng, Chao Zheng, Zhou Hua, Haideng Ci, Guiying Wang, Lijing Chen. Diosmin mitigates high glucose-induced endoplasmic reticulum stress through PI3K/AKT pathway in HK-2 cells. BMC complementary medicine and therapies. 2022 Apr; 22(1):116. doi: 10.1186/s12906-022-03597-y. [PMID: 35477428]
  • Dinesh Kumar, M S Ladaniya, Manju Gurjar, Sunil Kumar. Impact of drying methods on natural antioxidants, phenols and flavanones of immature dropped Citrus sinensis L. Osbeck fruits. Scientific reports. 2022 04; 12(1):6684. doi: 10.1038/s41598-022-10661-7. [PMID: 35461355]
  • Shivani Sharma, Konica Porwal, Chirag Kulkarni, Subhashis Pal, Praveer Sihota, Saroj Kumar, Mahesh Chandra Tiwari, Roshan Katekar, Ashish Kumar, Priya Singh, Swati Rajput, Rajdeep Guha, Navin Kumar, Jiaur R Gayen, Naibedya Chattopadhyay. Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function. Food & function. 2022 Feb; 13(4):2184-2199. doi: 10.1039/d1fo03867b. [PMID: 35119062]
  • Samar H Gerges, Sara A Wahdan, Doaa A Elsherbiny, Ebtehal El-Demerdash. Pharmacology of Diosmin, a Citrus Flavone Glycoside: An Updated Review. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):1-18. doi: 10.1007/s13318-021-00731-y. [PMID: 34687440]
  • Nicolas Monjotin, Guillaume Tenca. Lymphotonic activity of Ruscus extract, hesperidin methyl chalcone and vitamin C in human lymphatic smooth muscle cells. Microvascular research. 2022 01; 139(?):104274. doi: 10.1016/j.mvr.2021.104274. [PMID: 34717967]
  • Sumit Kumar, Prem Prakash Sharma, Charu Upadhyay, Prakasha Kempaiah, Brijesh Rathi, Poonam. Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies. Methods (San Diego, Calif.). 2021 11; 195(?):44-56. doi: 10.1016/j.ymeth.2021.02.017. [PMID: 33639316]
  • Merve Yuce, Erdem Cicek, Tugce Inan, Aslihan Basak Dag, Ozge Kurkcuoglu, Fethiye Aylin Sungur. Repurposing of FDA-approved drugs against active site and potential allosteric drug-binding sites of COVID-19 main protease. Proteins. 2021 11; 89(11):1425-1441. doi: 10.1002/prot.26164. [PMID: 34169568]
  • Supaporn Khamchun, Sunisa Yoodee, Visith Thongboonkerd. Dual modulatory effects of diosmin on calcium oxalate kidney stone formation processes: Crystallization, growth, aggregation, crystal-cell adhesion, internalization into renal tubular cells, and invasion through extracellular matrix. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Sep; 141(?):111903. doi: 10.1016/j.biopha.2021.111903. [PMID: 34328112]
  • Azza Fahmy, Gehan Labib Abuelenain, Nesma Rasheed, Amr Abdou. 'de Novo' repurposing of Daflon as anti-intestinal parasitic drug in experimental giardiasis. Experimental parasitology. 2021 Jul; 226-227(?):108124. doi: 10.1016/j.exppara.2021.108124. [PMID: 34139241]
  • Fares E M Ali, Ahmed M Sayed, Ali H El-Bahrawy, Zainab M M Omar, Emad H M Hassanein. Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity. Life sciences. 2021 Jun; 275(?):119349. doi: 10.1016/j.lfs.2021.119349. [PMID: 33744325]
  • Muhammet Yasin Tekeli, Gökhan Eraslan, Latife Çakır Bayram, Zeynep Soyer Sarıca. Effect of diosmin on lipid peoxidation and organ damage against subacute deltamethrin exposure in rats. Environmental science and pollution research international. 2021 Apr; 28(13):15890-15908. doi: 10.1007/s11356-020-11277-y. [PMID: 33242198]
  • Michèle Cazaubon, Jean-Patrick Benigni, Marcio Steinbruch, Violaine Jabbour, Christelle Gouhier-Kodas. Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence. Vascular health and risk management. 2021; 17(?):591-600. doi: 10.2147/vhrm.s324112. [PMID: 34556990]
  • Kushagra Dubey, Raghvendra Dubey, Revathi Gupta, Arun Gupta. Exploration of Diosmin to Control Diabetes and Its Complications-an In Vitro and In Silico Approach. Current computer-aided drug design. 2021; 17(2):307-313. doi: 10.2174/1573409916666200324135734. [PMID: 32208122]
  • Marco Bagnati, Chiara Puricelli, Giulia Bauce, Matteo Basile, Barbara Grigollo, Flavia Prodam, Umberto Dianzani, Giorgio Bellomo, Roberta Rolla. Short-Term Effects of Supplemental L-Arginine, Diosmin, Troxerutin, and Hesperidin in Diabetic Patients: A Pilot Study. BioMed research international. 2021; 2021(?):3508281. doi: 10.1155/2021/3508281. [PMID: 34901269]
  • Cristina García-Iriepa, Cécilia Hognon, Antonio Francés-Monerris, Isabel Iriepa, Tom Miclot, Giampaolo Barone, Antonio Monari, Marco Marazzi. Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands. The journal of physical chemistry letters. 2020 Nov; 11(21):9272-9281. doi: 10.1021/acs.jpclett.0c02203. [PMID: 33085491]
  • Maria José Martinez-Zapata, Robin Wm Vernooij, Daniel Simancas-Racines, Sonia Maria Uriona Tuma, Airton T Stein, Rosa Maria M Moreno Carriles, Emilio Vargas, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews. 2020 11; 11(?):CD003229. doi: 10.1002/14651858.cd003229.pub4. [PMID: 33141449]
  • Yusuf A Haggag, Nahla E El-Ashmawy, Kamal M Okasha. Is hesperidin essential for prophylaxis and treatment of COVID-19 Infection?. Medical hypotheses. 2020 Nov; 144(?):109957. doi: 10.1016/j.mehy.2020.109957. [PMID: 32531538]
  • Yizhou Zheng, Rui Zhang, Weimei Shi, Linfu Li, Hai Liu, Zhixi Chen, Longhuo Wu. Metabolism and pharmacological activities of the natural health-benefiting compound diosmin. Food & function. 2020 Oct; 11(10):8472-8492. doi: 10.1039/d0fo01598a. [PMID: 32966476]
  • Hendawy Om, Mehrez E El-Naggar, Mona El-Banna, Moustafa M G Fouda, Sarah I Othman, Ahmed A Allam, Osama M Morsy. Combating atherosclerosis with targeted Diosmin nanoparticles-treated experimental diabetes. Investigational new drugs. 2020 10; 38(5):1303-1315. doi: 10.1007/s10637-020-00905-6. [PMID: 32048108]
  • Samar H Gerges, Sara A Wahdan, Doaa A Elsherbiny, Ebtehal El-Demerdash. Diosmin ameliorates inflammation, insulin resistance, and fibrosis in an experimental model of non-alcoholic steatohepatitis in rats. Toxicology and applied pharmacology. 2020 08; 401(?):115101. doi: 10.1016/j.taap.2020.115101. [PMID: 32512072]
  • Johirul Islam, Alpa Shree, Shekh M Afzal, Abul Vafa, Sarwat Sultana. Protective effect of Diosmin against benzo(a)pyrene-induced lung injury in Swiss Albino Mice. Environmental toxicology. 2020 Jul; 35(7):747-757. doi: 10.1002/tox.22909. [PMID: 32061149]
  • Shahenda Mahgoub, Anas O Sallam, Hazem K A Sarhan, Amal A A Ammar, Sameh H Soror. Role of Diosmin in protection against the oxidative stress induced damage by gamma-radiation in Wistar albino rats. Regulatory toxicology and pharmacology : RTP. 2020 Jun; 113(?):104622. doi: 10.1016/j.yrtph.2020.104622. [PMID: 32087353]
  • Sara Mahmmoud El-Dakhly, Abeer Abdallah Ali Salama, Soha Osama Mahmoud Hassanin, Noha Nazeeh Yassen, Alaaeldin Ahmed Hamza, Amr Amin. Aescin and diosmin each alone or in low dose- combination ameliorate liver damage induced by carbon tetrachloride in rats. BMC research notes. 2020 May; 13(1):259. doi: 10.1186/s13104-020-05094-2. [PMID: 32460808]
  • Mehmet Bozdağ, Gökhan Eraslan. The effect of diosmin against lead exposure in rats‡. Naunyn-Schmiedeberg's archives of pharmacology. 2020 04; 393(4):639-649. doi: 10.1007/s00210-019-01758-4. [PMID: 31792554]
  • Mengxia Wei, Ru Zhao, Xiaojin Peng, Chunte Feng, Huiyan Gu, Lei Yang. Ultrasound-Assisted Extraction of Taxifolin, Diosmin, and Quercetin from Abies nephrolepis (Trautv.) Maxim: Kinetic and Thermodynamic Characteristics. Molecules (Basel, Switzerland). 2020 Mar; 25(6):. doi: 10.3390/molecules25061401. [PMID: 32204461]
  • Tarek Mohamed Ali, Osama M Abo-Salem, Basem Hassan El Esawy, Ahmed El Askary. The Potential Protective Effects of Diosmin on Streptozotocin-Induced Diabetic Cardiomyopathy in Rats. The American journal of the medical sciences. 2020 01; 359(1):32-41. doi: 10.1016/j.amjms.2019.10.005. [PMID: 31902439]
  • Imene Adouani, Anas Sarwar Qureshi, Tai-Jun Hang. Preparation, evaluation and pharmacokinetics of diosmin herbosome in beagle dogs. Pakistan journal of pharmaceutical sciences. 2020 Jan; 33(1):33-40. doi: NULL. [PMID: 32122828]
  • Abdelazim E Elhelaly, Gadah AlBasher, Saleh Alfarraj, Rafa Almeer, Eshak I Bahbah, Maged M A Fouda, Simona G Bungău, Lotfi Aleya, Mohamed M Abdel-Daim. Protective effects of hesperidin and diosmin against acrylamide-induced liver, kidney, and brain oxidative damage in rats. Environmental science and pollution research international. 2019 Dec; 26(34):35151-35162. doi: 10.1007/s11356-019-06660-3. [PMID: 31686333]
  • Sirus Mirzaee, Esrafil Mansouri, Maryam Shirani, Marzieh Zeinvand-Lorestani, Mohammad Javad Khodayar. Diosmin ameliorative effects on oxidative stress and fibrosis in paraquat-induced lung injury in mice. Environmental science and pollution research international. 2019 Dec; 26(36):36468-36477. doi: 10.1007/s11356-019-06572-2. [PMID: 31732951]
  • Rania El-Fawal, Hassan M El Fayoumi, Mona F Mahmoud. Effects of diosmin and crocin on metabolic syndrome-associated cardio-vascular complications in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2019 12; 392(12):1523-1536. doi: 10.1007/s00210-019-01700-8. [PMID: 31352499]
  • Marcin Feldo, Magdalena Wójciak-Kosior, Ireneusz Sowa, Janusz Kocki, Jacek Bogucki, Tomasz Zubilewicz, Jan Kęsik, Anna Bogucka-Kocka. Effect of Diosmin Administration in Patients with Chronic Venous Disorders on Selected Factors Affecting Angiogenesis. Molecules (Basel, Switzerland). 2019 Sep; 24(18):. doi: 10.3390/molecules24183316. [PMID: 31547271]
  • Xiangyang Chen, Lulu Xu, Shuzhen Guo, Zijian Wang, Lijuan Jiang, Fei Wang, Jiayu Zhang, Bin Liu. Profiling and comparison of the metabolites of diosmetin and diosmin in rat urine, plasma and feces using UHPLC-LTQ-Orbitrap MSn. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Aug; 1124(?):58-71. doi: 10.1016/j.jchromb.2019.05.030. [PMID: 31177049]
  • Eman Shawky, Dina A Selim. NIR spectroscopy-multivariate analysis for discrimination and bioactive compounds prediction of different Citrus species peels. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2019 Aug; 219(?):1-7. doi: 10.1016/j.saa.2019.04.026. [PMID: 31026739]
  • Ritu Kataria, Anurag Khatkar. In-silico Designing, ADMET Analysis, Synthesis and Biological Evaluation of Novel Derivatives of Diosmin Against Urease Protein and Helicobacter pylori Bacterium. Current topics in medicinal chemistry. 2019; 19(29):2658-2675. doi: 10.2174/1568026619666191114123452. [PMID: 31724503]
  • Srinivasan Perumal, Kulanthaivel Langeshwaran, Jayaraman Selvaraj, Rajagopal Ponnulakshmi, B Shyamaladevi, M P Balasubramanian. Effect of diosmin on apoptotic signaling molecules in N-nitrosodiethylamine-induced hepatocellular carcinoma in experimental rats. Molecular and cellular biochemistry. 2018 Dec; 449(1-2):27-37. doi: 10.1007/s11010-018-3339-3. [PMID: 29479636]
  • Mona A Abdelmoneem, Mazen Mahmoud, Amira Zaky, Maged W Helmy, Marwa Sallam, Jia-You Fang, Kadria A Elkhodairy, Ahmed O Elzoghby. Dual-targeted casein micelles as green nanomedicine for synergistic phytotherapy of hepatocellular carcinoma. Journal of controlled release : official journal of the Controlled Release Society. 2018 10; 287(?):78-93. doi: 10.1016/j.jconrel.2018.08.026. [PMID: 30138716]
  • Rosario Russo, Divya Chandradhara, Nunziatina De Tommasi. Comparative Bioavailability of Two Diosmin Formulations after Oral Administration to Healthy Volunteers. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092174. [PMID: 30158431]
  • Asmaa A Hassan, Noura M Thabet, Mohamed Kh Abdel-Rafei. Hyaluronan as a mediator for the hepatoprotective effect of Diosmin/Hesperidin complex. Pakistan journal of pharmaceutical sciences. 2018 Jul; 31(4):1191-1201. doi: . [PMID: 30033401]
  • Carolina Ferreira Vasco, Mirian Watanabe, Cassiane Dezoti da Fonseca, Maria de Fátima Fernandes Vattimo. Sepsis-induced acute kidney injury: kidney protection effects by antioxidants. Revista brasileira de enfermagem. 2018 Jul; 71(4):1921-1927. doi: 10.1590/0034-7167-2017-0469. [PMID: 30156678]
  • Rania El-Fawal, Hassan M El Fayoumi, Mona F Mahmoud. Diosmin and crocin alleviate nephropathy in metabolic syndrome rat model: Effect on oxidative stress and low grade inflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2018 Jun; 102(?):930-937. doi: 10.1016/j.biopha.2018.03.162. [PMID: 29710548]
  • S Sharmila Queenthy, P Stanely Mainzen Prince, Babu John. Diosmin Prevents Isoproterenol-Induced Heart Mitochondrial Oxidative Stress in Rats. Cardiovascular toxicology. 2018 04; 18(2):120-130. doi: 10.1007/s12012-017-9422-2. [PMID: 28819818]
  • Luis Fernando Sousa Filho, Paula P Menezes, Dayanne Valéria Soares Santana, Bruno S Lima, Shanmugan Saravanan, Grace Kelly M Almeida, José Evaldo R Menezes Filho, Marta M B Santos, Adriano Antunes S Araújo, Evaleide Diniz de Oliveira. Effect of Pulsed Therapeutic Ultrasound and Diosmin on Skeletal Muscle Oxidative Parameters. Ultrasound in medicine & biology. 2018 02; 44(2):359-367. doi: 10.1016/j.ultrasmedbio.2017.09.009. [PMID: 29126754]
  • Satish Kumar Bedada, Prasad Neerati. Modulation of CYP3A enzyme activity by diosmin and its consequence on carbamazepine pharmacokinetics in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2018 Feb; 391(2):115-121. doi: 10.1007/s00210-017-1439-3. [PMID: 29134244]
  • Marcin Feldo, Michał Woźniak, Magdalena Wójciak-Kosior, Ireneusz Sowa, Agata Kot-Waśik, Justyna Aszyk, Jacek Bogucki, Tomasz Zubilewicz, Anna Bogucka-Kocka. Influence of Diosmin Treatment on the Level of Oxidative Stress Markers in Patients with Chronic Venous Insufficiency. Oxidative medicine and cellular longevity. 2018; 2018(?):2561705. doi: 10.1155/2018/2561705. [PMID: 30228853]
  • R E Kalinin, I A Suchkov, A A Kamaev, V I Zvyagina, A A Krylov. [Endotheliotropic effects of venotonic drugs in treatment of patients with varicose veins]. Angiologiia i sosudistaia khirurgiia = Angiology and vascular surgery. 2018 ; 24(4):72-74. doi: ". [PMID: 30531772]
  • Wayne Young Liu, Shorong-Shii Liou, Tang-Yao Hong, I-Min Liu. The Benefits of the Citrus Flavonoid Diosmin on Human Retinal Pigment Epithelial Cells under High-Glucose Conditions. Molecules (Basel, Switzerland). 2017 Dec; 22(12):. doi: 10.3390/molecules22122251. [PMID: 29258224]
  • Gökhan Eraslan, Zeynep Soyer Sarıca, Latife Çakır Bayram, Muhammet Yasin Tekeli, Murat Kanbur, Mürsel Karabacak. The effects of diosmin on aflatoxin-induced liver and kidney damage. Environmental science and pollution research international. 2017 Dec; 24(36):27931-27941. doi: 10.1007/s11356-017-0232-7. [PMID: 28988357]
  • Cuilin Cheng, Hong Zhang, Yongzhi Li, Yingyu Zhou, Weihong Lu, Lei Yao. The effect of Diosmin on the blood proteome in a rat model of venous thrombosis. International journal of biological macromolecules. 2017 Nov; 104(Pt A):778-787. doi: 10.1016/j.ijbiomac.2017.06.045. [PMID: 28606843]
  • Satish Kumar Bedada, Praveen Kumar Boga. Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Oct; 47(10):879-884. doi: 10.1080/00498254.2016.1244368. [PMID: 27690733]
  • Weronika Wojnar, Ilona Kaczmarczyk-Sedlak, Maria Zych. Diosmin ameliorates the effects of oxidative stress in lenses of streptozotocin-induced type 1 diabetic rats. Pharmacological reports : PR. 2017 Oct; 69(5):995-1000. doi: 10.1016/j.pharep.2017.04.005. [PMID: 28846859]
  • Chia-Chen Hsu, Mang Hung Lin, Juei-Tang Cheng, Ming Chang Wu. Diosmin, a Citrus Nutrient, Activates Imidazoline Receptors to Alleviate Blood Glucose and Lipids in Type 1-Like Diabetic Rats. Nutrients. 2017 Jun; 9(7):. doi: 10.3390/nu9070684. [PMID: 28665324]
  • Chia-Chen Hsu, Mang Hung Lin, Juei Tang Cheng, Ming Chang Wu. Antihyperglycaemic action of diosmin, a citrus flavonoid, is induced through endogenous β-endorphin in type I-like diabetic rats. Clinical and experimental pharmacology & physiology. 2017 May; 44(5):549-555. doi: 10.1111/1440-1681.12739. [PMID: 28218955]
  • Satish Kumar Bedada, Praveen Kumar Boga, Harish Kaushik Kotakonda. The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers. Xenobiotica; the fate of foreign compounds in biological systems. 2017 Mar; 47(3):230-235. doi: 10.1080/00498254.2016.1180564. [PMID: 27151911]
  • Anna Lewinska, Jagoda Adamczyk-Grochala, Ewa Kwasniewicz, Anna Deregowska, Maciej Wnuk. Diosmin-induced senescence, apoptosis and autophagy in breast cancer cells of different p53 status and ERK activity. Toxicology letters. 2017 Jan; 265(?):117-130. doi: 10.1016/j.toxlet.2016.11.018. [PMID: 27890807]
  • Renato Riera Toledo, Maria Elisabeth Rennó de Castro Santos, Taylor Brandão Schnaider. Effect of Pycnogenol on the Healing of Venous Ulcers. Annals of vascular surgery. 2017 Jan; 38(?):212-219. doi: 10.1016/j.avsg.2016.04.014. [PMID: 27521821]
  • Mohamed M Abdel-Daim, Hesham A Khalifa, Abdelrahman Ibrahim Abushouk, Mohamed A Dkhil, Saleh A Al-Quraishy. Diosmin Attenuates Methotrexate-Induced Hepatic, Renal, and Cardiac Injury: A Biochemical and Histopathological Study in Mice. Oxidative medicine and cellular longevity. 2017; 2017(?):3281670. doi: 10.1155/2017/3281670. [PMID: 28819543]
  • Sahabuddin Ahmed, Nitin Mundhe, Manash Borgohain, Liakat Chowdhury, Mohit Kwatra, Nityanand Bolshette, Anwaruddin Ahmed, Mangala Lahkar. Diosmin Modulates the NF-kB Signal Transduction Pathways and Downregulation of Various Oxidative Stress Markers in Alloxan-Induced Diabetic Nephropathy. Inflammation. 2016 Oct; 39(5):1783-97. doi: 10.1007/s10753-016-0413-4. [PMID: 27492452]
  • Luciana Naso, Valeria R Martínez, Luis Lezama, Clarisa Salado, María Valcarcel, Evelina G Ferrer, Patricia A M Williams. Antioxidant, anticancer activities and mechanistic studies of the flavone glycoside diosmin and its oxidovanadium(IV) complex. Interactions with bovine serum albumin. Bioorganic & medicinal chemistry. 2016 09; 24(18):4108-4119. doi: 10.1016/j.bmc.2016.06.053. [PMID: 27374881]
  • V Vinoth Prabhu, D Sathyamurthy, Anand Ramasamy, Saibal Das, Medepalli Anuradha, Sudhakar Pachiappan. Evaluation of protective effects of diosmin (a citrus flavonoid) in chemical-induced urolithiasis in experimental rats. Pharmaceutical biology. 2016 Sep; 54(9):1513-21. doi: 10.3109/13880209.2015.1107105. [PMID: 26799954]
  • Maria José Martinez-Zapata, Robin W M Vernooij, Sonia Maria Uriona Tuma, Airton T Stein, Rosa M Moreno, Emilio Vargas, Dolors Capellà, Xavier Bonfill Cosp. Phlebotonics for venous insufficiency. The Cochrane database of systematic reviews. 2016 Apr; 4(?):CD003229. doi: 10.1002/14651858.cd003229.pub3. [PMID: 27048768]
  • ". [Recommendations of the Polish Gynecological Society expert panel on the use of Detramax in pregnancy]. Ginekologia polska. 2015 Dec; 86(12):962-5. doi: ". [PMID: 26995949]
  • Rosario Russo, Angelo Mancinelli, Michele Ciccone, Fabio Terruzzi, Claudio Pisano, Lorella Severino. Pharmacokinetic Profile of µSMIN Plus™, a new Micronized Diosmin Formulation, after Oral Administration in Rats. Natural product communications. 2015 Sep; 10(9):1569-72. doi: NULL. [PMID: 26594761]
  • Yearam Jung, Soon Young Shin, Yeonjoong Yong, Hyeryoung Jung, Seunghyun Ahn, Young Han Lee, Yoongho Lim. Plant-derived flavones as inhibitors of aurora B kinase and their quantitative structure-activity relationships. Chemical biology & drug design. 2015 May; 85(5):574-85. doi: 10.1111/cbdd.12445. [PMID: 25298094]
  • Prasad Neerati, Satish Kumar Bedada. Effect of diosmin on the intestinal absorption and pharmacokinetics of fexofenadine in rats. Pharmacological reports : PR. 2015 Apr; 67(2):339-44. doi: 10.1016/j.pharep.2014.09.010. [PMID: 25712660]
  • Anna Lewinska, Justyna Siwak, Iwona Rzeszutek, Maciej Wnuk. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line. Toxicology in vitro : an international journal published in association with BIBRA. 2015 Apr; 29(3):417-25. doi: 10.1016/j.tiv.2014.12.005. [PMID: 25499067]
  • Hany H Arab, Samir A Salama, Hany A Omar, El-Shaimaa A Arafa, Ibrahim A Maghrabi. Diosmin protects against ethanol-induced gastric injury in rats: novel anti-ulcer actions. PloS one. 2015; 10(3):e0122417. doi: 10.1371/journal.pone.0122417. [PMID: 25821971]
  • Petr Vrbata, Pavel Berka, Denisa Stránská, Pavel Doležal, Milan Lázníček. Electrospinning of diosmin from aqueous solutions for improved dissolution and oral absorption. International journal of pharmaceutics. 2014 Oct; 473(1-2):407-13. doi: 10.1016/j.ijpharm.2014.07.017. [PMID: 25066074]
  • P Urios, I Kassab, A M Grigorova-Borsos, R Guillot, P Jacolot, F Tessier, J Peyroux, M Sternberg. A flavonoid fraction purified from Rutaceae aurantiae (Daflon(R)) inhibiting AGE formation, reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats. Diabetes research and clinical practice. 2014 Sep; 105(3):373-81. doi: 10.1016/j.diabres.2014.04.029. [PMID: 24956965]
  • Oomaidurai Senthamizhselvan, Jeganathan Manivannan, Thangarasu Silambarasan, Boobalan Raja. Diosmin pretreatment improves cardiac function and suppresses oxidative stress in rat heart after ischemia/reperfusion. European journal of pharmacology. 2014 Aug; 736(?):131-7. doi: 10.1016/j.ejphar.2014.04.026. [PMID: 24769512]
  • Giulia Milano, Silvia Leone, Carmen Fucile, Maria Laura Zuccoli, Andrea Stimamiglio, Antonietta Martelli, Francesca Mattioli. Uncommon serum creatine phosphokinase and lactic dehydrogenase increase during diosmin therapy: two case reports. Journal of medical case reports. 2014 Jun; 8(?):194. doi: 10.1186/1752-1947-8-194. [PMID: 24934505]
  • F Dogan, A Armagan, T Oksay, T Akman, F Aylak, E Bas. Impact of micronised purified flavonoid fraction on increased malondialdehyde and decreased metalloproteinase-2 and metalloproteinase-9 levels in varicocele: outcome of an experimentally induced varicocele. Andrologia. 2014 May; 46(4):380-5. doi: 10.1111/and.12091. [PMID: 23550531]
  • Patricia I Kobo, Joseph O Ayo, Tagang Aluwong, Abdulkadir U Zezi, Victor Maikai, Suleiman F Ambali. Flavonoid mixture ameliorates increase in erythrocyte osmotic fragility and malondialdehyde concentration induced by Trypanosoma brucei brucei-infection in Wistar rats. Research in veterinary science. 2014 Feb; 96(1):139-42. doi: 10.1016/j.rvsc.2013.10.005. [PMID: 24332272]
  • Dilpesh Jain, Manish Kumar Bansal, Rahul Dalvi, Aman Upganlawar, Rahul Somani. Protective effect of diosmin against diabetic neuropathy in experimental rats. Journal of integrative medicine. 2014 Jan; 12(1):35-41. doi: 10.1016/s2095-4964(14)60001-7. [PMID: 24461593]
  • Yusuf Tanrikulu, Mefaret Sahin, Kemal Kismet, Sibel Serin Kilicoglu, Erdinc Devrim, Ceren Sen Tanrikulu, Esra Erdemli, Serap Erel, Kenan Bayraktar, Mehmet Ali Akkus. The protective effect of diosmin on hepatic ischemia reperfusion injury: an experimental study. Bosnian journal of basic medical sciences. 2013 Nov; 13(4):218-24. doi: 10.17305/bjbms.2013.2305. [PMID: 24289756]
  • Davide Barreca, Giuseppina Laganà, Giuseppe Bruno, Salvatore Magazù, Ersilia Bellocco. Diosmin binding to human serum albumin and its preventive action against degradation due to oxidative injuries. Biochimie. 2013 Nov; 95(11):2042-9. doi: 10.1016/j.biochi.2013.07.014. [PMID: 23886889]
  • S Sharmila Queenthy, Babu John. Diosmin exhibits anti-hyperlipidemic effects in isoproterenol induced myocardial infarcted rats. European journal of pharmacology. 2013 Oct; 718(1-3):213-8. doi: 10.1016/j.ejphar.2013.08.031. [PMID: 24036254]
  • Raimondo Forte, Gilda Cennamo, Paola Bonavolontà, Arduino Pascotto, Giuseppe de Crecchio, Giovanni Cennamo. Long-term follow-up of oral administration of flavonoids, Centella asiatica and Melilotus, for diabetic cystoid macular edema without macular thickening. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2013 Oct; 29(8):733-7. doi: 10.1089/jop.2013.0010. [PMID: 23844756]
  • Muneeb U Rehman, Mir Tahir, Abdul Quaiyoom Khan, Rehan Khan, Abdul Lateef, Oday O Hamiza, Farrah Ali, Sarwat Sultana. Diosmin protects against trichloroethylene-induced renal injury in Wistar rats: plausible role of p53, Bax and caspases. The British journal of nutrition. 2013 Aug; 110(4):699-710. doi: 10.1017/s0007114512005752. [PMID: 23402272]
  • Mir Tahir, Muneeb U Rehman, Abdul Lateef, Abdul Quaiyoom Khan, Rehan Khan, Wajhul Qamar, Oday O'Hamiza, Farrah Ali, Syed Kazim Hasan, Sarwat Sultana. Diosmin abrogates chemically induced hepatocarcinogenesis via alleviation of oxidative stress, hyperproliferative and inflammatory markers in murine model. Toxicology letters. 2013 Jul; 220(3):205-18. doi: 10.1016/j.toxlet.2013.04.004. [PMID: 23665045]
  • Anna Bogucka-Kocka, Michał Woźniak, Marcin Feldo, Janusz Kockic, Katarzyna Szewczyk. Diosmin--isolation techniques, determination in plant material and pharmaceutical formulations, and clinical use. Natural product communications. 2013 Apr; 8(4):545-50. doi: ". [PMID: 23738475]
  • Mir Tahir, Muneeb U Rehman, Abdul Lateef, Rehan Khan, Abdul Quaiyoom Khan, Wajhul Qamar, Farrah Ali, Oday O'Hamiza, Sarwat Sultana. Diosmin protects against ethanol-induced hepatic injury via alleviation of inflammation and regulation of TNF-α and NF-κB activation. Alcohol (Fayetteville, N.Y.). 2013 Mar; 47(2):131-9. doi: 10.1016/j.alcohol.2012.12.010. [PMID: 23419394]
  • Jun Zhao, Fang Xu, Jin-Hua He, Wei Tan, Zheng-Yi Gu, Long Ma. [Study on chemical constituents of Hyssopus cuspidatus]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Jan; 36(1):54-7. doi: . [PMID: 23750409]