3-HPT (BioDeep_00000000953)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C16H16O4 (272.1049)
中文名称: 3’-羟基紫檀茋, 3-羟基紫檀芪, 3'-羟基紫檀茋
谱图信息:
最多检出来源 Astragalus membranaceus(otcml) 80%
分子结构信息
SMILES: COC1=CC(/C=C/C2=CC=C(O)C(O)=C2)=CC(OC)=C1
InChI: InChI=1S/C16H16O4/c1-19-13-7-12(8-14(10-13)20-2)4-3-11-5-6-15(17)16(18)9-11/h3-10,17-18H,1-2H3/b4-3+
描述信息
(E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol is a natural product found in Sphaerophysa salsula with data available.
3'-Hydroxypterostilbene is a Pterostilbene (HY-N0828) analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 μM, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer[1].
同义名列表
9 个代谢物同义名
trans-4-[2-(3,5-dimethoxyphenyl)ethenyl]-1,2-benzenediol; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol; 4-((e)-2-(3,5-dimethoxyphenyl)ethenyl)benzene-1,2-diol; 4-[(1E)-2-(3,5-Dimethoxyphenyl)vinyl]benzene-1,2-diol; (E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol; 3?-Hydroxypterostilbene; 3-Hydroxypterostilbene; 3-HPT; 3'-Hydroxypterostilbene
数据库引用编号
5 个数据库交叉引用编号
- KEGG: C15837
- PubChem: 10038868
- MeSH: 3-hydroxypterostilbene
- CAS: 475231-21-1
- medchemexpress: HY-N6002
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 33090 - Plants: -
- 47651 - Sphaerophysa salsula: 10.1016/S0367-326X(02)00074-6
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Hui-Yun Tsai, Yu-Yuan Shih, Yao-Tsung Yeh, Cheng-Hsieh Huang, Chorng-An Liao, Chun-Yi Hu, Kalyanam Nagabhushanam, Chi-Tang Ho, Yu-Kuo Chen. Pterostilbene and Its Derivative 3'-Hydroxypterostilbene Ameliorated Nonalcoholic Fatty Liver Disease Through Synergistic Modulation of the Gut Microbiota and SIRT1/AMPK Signaling Pathway.
Journal of agricultural and food chemistry.
2022 Apr; 70(16):4966-4980. doi:
10.1021/acs.jafc.2c00641
. [PMID: 35416649] - Muhammed Majeed, Sarang Bani, Sankaran Natarajan, Anjali Pandey, Naveed S. Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals.
PloS one.
2017; 12(3):e0172770. doi:
10.1371/journal.pone.0172770
. [PMID: 28257483] - Jody K Takemoto, Neal M Davies. A high-performance liquid chromatographic analysis and preliminary pharmacokinetic characterization of 3'-hydroxypterostilbene in rats.
Biomedical chromatography : BMC.
2009 Oct; 23(10):1086-91. doi:
10.1002/bmc.1228
. [PMID: 19385002]