3-HPT (BioDeep_00000000953)

   

PANOMIX_OTCML-2023


代谢物信息卡片


trans-4-[2-(3,5-dimethoxyphenyl)ethenyl]-1,2-benzenediol

化学式: C16H16O4 (272.1049)
中文名称: 3’-羟基紫檀茋, 3-羟基紫檀芪, 3'-羟基紫檀茋
谱图信息: 最多检出来源 Astragalus membranaceus(otcml) 80%

分子结构信息

SMILES: COC1=CC(/C=C/C2=CC=C(O)C(O)=C2)=CC(OC)=C1
InChI: InChI=1S/C16H16O4/c1-19-13-7-12(8-14(10-13)20-2)4-3-11-5-6-15(17)16(18)9-11/h3-10,17-18H,1-2H3/b4-3+

描述信息

(E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol is a natural product found in Sphaerophysa salsula with data available.
3'-Hydroxypterostilbene is a Pterostilbene (HY-N0828) analogue. 3'-Hydroxypterostilbene inhibits the growth of COLO 205, HCT-116 and HT-29 cells with IC50s of 9.0, 40.2 and 70.9 μM, respectively. 3'-Hydroxypterostilbene significantly down-regulates PI3K/Akt and MAPKs signaling pathways and effectively inhibits the growth of human colon cancer cells by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene can be used for the research of cancer[1].

同义名列表

9 个代谢物同义名

trans-4-[2-(3,5-dimethoxyphenyl)ethenyl]-1,2-benzenediol; 4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]benzene-1,2-diol; 4-((e)-2-(3,5-dimethoxyphenyl)ethenyl)benzene-1,2-diol; 4-[(1E)-2-(3,5-Dimethoxyphenyl)vinyl]benzene-1,2-diol; (E)-4-(3,5-Dimethoxystyryl)benzene-1,2-diol; 3?-Hydroxypterostilbene; 3-Hydroxypterostilbene; 3-HPT; 3'-Hydroxypterostilbene



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADIG, BCL2, CASP3, CCNB1, CCND1, CDK1, CYP1A1, JAK2, NLRP3, PRKAA2, PTGS2, SIRT1, STAT3
Peripheral membrane protein 3 CYP1A1, JAK2, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CDK1, CYP1A1, PTGS2
Nucleus 12 ADIG, BCL2, CASP3, CCNB1, CCND1, CDK1, JAK2, NLRP3, PCNA, PRKAA2, SIRT1, STAT3
cytosol 11 BCL2, CASP3, CCNB1, CCND1, CDK1, JAK2, NLRP3, PRKAA2, SIRT1, SOCS3, STAT3
dendrite 1 PRKAA2
nuclear body 1 PCNA
centrosome 4 CCNB1, CCND1, CDK1, PCNA
nucleoplasm 9 CASP3, CCNB1, CCND1, CDK1, JAK2, PCNA, PRKAA2, SIRT1, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 2 PLVAP, TNF
Golgi apparatus membrane 1 NLRP3
cell surface 2 PLVAP, TNF
glutamatergic synapse 2 CASP3, JAK2
Golgi apparatus 1 PRKAA2
Golgi membrane 2 INS, NLRP3
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 3 CASP3, PRKAA2, TNF
postsynapse 1 JAK2
Cytoplasm, cytosol 1 NLRP3
plasma membrane 3 JAK2, STAT3, TNF
Membrane 8 ADIG, BCL2, CCNB1, CDK1, JAK2, NLRP3, PLVAP, PRKAA2
axon 1 PRKAA2
caveola 3 JAK2, PLVAP, PTGS2
extracellular exosome 3 CDK1, PCNA, PLVAP
endoplasmic reticulum 3 BCL2, NLRP3, PTGS2
extracellular space 4 CCL2, IL6, INS, TNF
perinuclear region of cytoplasm 1 PLVAP
bicellular tight junction 1 CCND1
mitochondrion 5 BCL2, CDK1, CYP1A1, NLRP3, SIRT1
protein-containing complex 2 BCL2, PTGS2
intracellular membrane-bounded organelle 1 CYP1A1
Microsome membrane 2 CYP1A1, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Secreted 5 ADIG, CCL2, IL6, INS, NLRP3
extracellular region 6 ADIG, CCL2, IL6, INS, NLRP3, TNF
cytoplasmic side of plasma membrane 2 JAK2, SOCS3
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 2 ADIG, BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 2 CCNB1, CDK1
transcription regulator complex 1 STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
nucleolus 1 SIRT1
midbody 1 CDK1
recycling endosome 1 TNF
Single-pass type II membrane protein 2 PLVAP, TNF
Cytoplasm, perinuclear region 1 PLVAP
Mitochondrion inner membrane 1 CYP1A1
heterochromatin 1 SIRT1
Membrane raft 2 JAK2, TNF
pore complex 1 BCL2
focal adhesion 1 JAK2
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
nuclear speck 1 PRKAA2
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
chromatin 3 PCNA, SIRT1, STAT3
phagocytic cup 1 TNF
mitotic spindle 1 CDK1
cytoskeleton 1 JAK2
spindle pole 1 CCNB1
nuclear replication fork 1 PCNA
chromosome, telomeric region 2 CDK1, PCNA
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
Endomembrane system 2 JAK2, NLRP3
endosome lumen 2 INS, JAK2
Lipid droplet 1 ADIG
Membrane, caveola 1 PLVAP
microtubule organizing center 1 NLRP3
cytoplasmic stress granule 1 PRKAA2
euchromatin 2 JAK2, SIRT1
replication fork 1 PCNA
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
phosphatidylinositol 3-kinase complex 1 SOCS3
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
outer kinetochore 1 CCNB1
nuclear lamina 1 PCNA
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
spindle microtubule 1 CDK1
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
nucleotide-activated protein kinase complex 1 PRKAA2
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
cyclin-dependent protein kinase holoenzyme complex 3 CCND1, CDK1, PCNA
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
cyclin A1-CDK1 complex 1 CDK1
cyclin A2-CDK1 complex 1 CDK1
cyclin B1-CDK1 complex 2 CCNB1, CDK1
BAD-BCL-2 complex 1 BCL2
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
cyclin D1-CDK6 complex 1 CCND1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Hui-Yun Tsai, Yu-Yuan Shih, Yao-Tsung Yeh, Cheng-Hsieh Huang, Chorng-An Liao, Chun-Yi Hu, Kalyanam Nagabhushanam, Chi-Tang Ho, Yu-Kuo Chen. Pterostilbene and Its Derivative 3'-Hydroxypterostilbene Ameliorated Nonalcoholic Fatty Liver Disease Through Synergistic Modulation of the Gut Microbiota and SIRT1/AMPK Signaling Pathway. Journal of agricultural and food chemistry. 2022 Apr; 70(16):4966-4980. doi: 10.1021/acs.jafc.2c00641. [PMID: 35416649]
  • Muhammed Majeed, Sarang Bani, Sankaran Natarajan, Anjali Pandey, Naveed S. Evaluation of 90 day repeated dose oral toxicity and reproductive/developmental toxicity of 3'-hydroxypterostilbene in experimental animals. PloS one. 2017; 12(3):e0172770. doi: 10.1371/journal.pone.0172770. [PMID: 28257483]
  • Jody K Takemoto, Neal M Davies. A high-performance liquid chromatographic analysis and preliminary pharmacokinetic characterization of 3'-hydroxypterostilbene in rats. Biomedical chromatography : BMC. 2009 Oct; 23(10):1086-91. doi: 10.1002/bmc.1228. [PMID: 19385002]