Bergenin (BioDeep_00000000094)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


NCGC00346587-02_C14H16O9_Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-

化学式: C14H16O9 (328.0794286)
中文名称: 岩白菜素, 岩白菜宁, 佛手配质, 虎耳草素, 矮茶素, 岩白菜素
谱图信息: 最多检出来源 Viridiplantae(plant) 3.89%

分子结构信息

SMILES: COC1=C(C=C2C(=C1O)C3C(C(C(C(O3)CO)O)O)OC2=O)O
InChI: InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3

描述信息

Bergenin is a trihydroxybenzoic acid. It has a role as a metabolite.
Bergenin is a natural product found in Ficus racemosa, Ardisia paniculata, and other organisms with data available.
A natural product found in Cenostigma gardnerianum.
C26170 - Protective Agent > C275 - Antioxidant
Annotation level-1
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].

同义名列表

49 个代谢物同义名

Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-; (2S,4R,5S,6S,7R)-5,6,12,14-tetrahydroxy-4-(hydroxymethyl)-13-methoxy-3,8-dioxatricyclo[8.4.0.0,2,7]tetradeca-1(10),11,13-trien-9-one; Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-; PYRANO(3,2-C)(2)BENZOPYRAN-6(2H)-ONE, 3,4,4A,10B-TETRAHYDRO-3,4,8,10-TETRAHYDROXY-2-(HYDROXYMETHYL)-9-METHOXY-(2R,3S,4S,4AR,10BS)-; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-2,3,4,4a-tetrahydropyrano[3,2-c]isochromen-6(10bH)-one; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one; 3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one hydrate; 3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano(3,2-c)(2)benzopyran-6(H)-one; 3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one; 4-Methoxy-2-(tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl)alpha-resorcylic acid gamma lactone; bergenin, (2alpha,3beta,4alpha,4aalpha,10bbeta)-isomer, sodium salt; Bergenin, >=95\\% (LC/MS-ELSD); Bergenin, analytical standard; YWJXCIXBAKGUKZ-HJJNZUOJSA-N; Bergenin (Cuscutin); Bergenin, Cuscutin; BERGENIN [WHO-DD]; bergenin hydrate; BERGENINUM [CHP]; BERGENIN [INCI]; UNII-L84RBE4IDC; Ardisic Acid B; Bergenin [JAN]; Ardisinic acid; Copylopsin,(S); Bergenin (JAN); BERGENIN [MI]; Peltophorin; Yanbaicaisu; Bergeninum; Bergenitol; L84RBE4IDC; Corylopsin; Cuscutin; Bergenin; Bengenin; vakerin; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-9-methoxy-2-methylol-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one; 477-90-7 (ANYDROUS); ZINC04046820; AIDS-031337; AIDS031337; BB_NC-1749; 477-90-7; C09919; D01040; NCGC00346587-02_C14H16O9_Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-; 3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one



数据库引用编号

76 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

57 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Li Zhang, Yingying Tong, Yan Fang, Jinjin Pei, Qilan Wang, Gang Li. Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment. Lipids in health and disease. 2023 Nov; 22(1):203. doi: 10.1186/s12944-023-01973-2. [PMID: 38001454]
  • Samyah T Alanazi, Gamaleldin I Harisa, Samir A Salama. Modulating SIRT1, Nrf2, and NF-κB signaling pathways by bergenin ameliorates the cadmium-induced nephrotoxicity in rats. Chemico-biological interactions. 2023 Nov; ?(?):110797. doi: 10.1016/j.cbi.2023.110797. [PMID: 37949422]
  • Sidra Faiz, Durdana Waseem, Ihsan-Ul Haq, Malik Mumtaz Taqi, Syeda Aroosa Mohsin, Nadeem Irshad, Abdul Rehman Phull, Humaira Fatima. Comparative appraisal of in vitro biological profile and in vivo wound healing attributes of bergenin and Bergenia ciliata (Haw.) Sternb. Journal of ethnopharmacology. 2023 Mar; 304(?):115993. doi: 10.1016/j.jep.2022.115993. [PMID: 36509257]
  • Zeca M Salimo, Michael N Yakubu, Emanuelle L da Silva, Anne C G de Almeida, Yury O Chaves, Emmanoel V Costa, Felipe M A da Silva, Josean F Tavares, Wuelton M Monteiro, Gisely C de Melo, Hector H F Koolen. Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule. Biomolecules. 2023 02; 13(3):. doi: 10.3390/biom13030403. [PMID: 36979338]
  • Samir A Salama, Mostafa M Elshafey. Cross-talk between PPARγ, NF-κB, and p38 MAPK signaling mediates the ameliorating effects of bergenin against the iron overload-induced hepatotoxicity. Chemico-biological interactions. 2022 Dec; 368(?):110207. doi: 10.1016/j.cbi.2022.110207. [PMID: 36207002]
  • Xuemei Zhang, Fang Zhang, Fenfen Yao, Peng Wang, Qun Xiong, Penghui Neng. Bergenin has neuroprotective effects in mice with ischemic stroke through antioxidative stress and anti-inflammation via regulating Sirt1/FOXO3a/NF-κB signaling. Neuroreport. 2022 09; 33(13):549-560. doi: 10.1097/wnr.0000000000001789. [PMID: 36049159]
  • Yu Yin, Ruyi Xu, Lei Ning, Zhimin Yu. Bergenin alleviates Diabetic Retinopathy in STZ-induced rats. Applied biochemistry and biotechnology. 2022 May; ?(?):. doi: 10.1007/s12010-022-03949-x. [PMID: 35622274]
  • Hui Lin, Pengfei Wang, Wanhong Zhang, Hongwang Yan, Hongxi Yu, Lingqiao Yan, Hui Chen, Mindan Xie, Liqun Shan. Novel Combined Preparation and Investigation of Bergenin-Loaded Albumin Nanoparticles for the Treatment of Acute Lung Injury: In Vitro and In Vivo Evaluations. Inflammation. 2022 Feb; 45(1):428-444. doi: 10.1007/s10753-021-01556-2. [PMID: 34599707]
  • Xiaohe Li, Yanhua Wang, Jingjing Liang, Zhun Bi, Hao Ruan, Yunyao Cui, Ling Ma, Yuli Wei, Bingchen Zhou, Liang Zhang, Honggang Zhou, Cheng Yang. Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway. Phytotherapy research : PTR. 2021 Oct; 35(10):5808-5822. doi: 10.1002/ptr.7239. [PMID: 34375009]
  • Kyung-Ran Park, Yoon-Ju Kwon, Myounglae Cho, Il Keun Kwon, Jin Tae Hong, Hyung-Mun Yun. 11-O-Galloyl Bergenin from Corylopsis coreanas Leaves Induces Autophagy and Apoptosis in Human Osteosarcoma. The American journal of Chinese medicine. 2021; 49(8):2017-2031. doi: 10.1142/s0192415x21500956. [PMID: 34961419]
  • Ejaz Ali, Najma Arshad, Nadeem Irfan Bukhari, Muhammad Nawaz Tahir, Shamail Zafar, Amjad Hussain, Sajida Parveen, Shaista Qamar, Naureen Shehzadi, Khalid Hussain. Linking traditional anti-ulcer use of rhizomes of Bergenia ciliata (Haw.) to its anti-Helicobacter pylori constituents. Natural product research. 2020 Feb; 34(4):541-544. doi: 10.1080/14786419.2018.1488711. [PMID: 30362366]
  • Mei-Fang Song, Li-Xia Zhang, Yue Zhang, Yan-Hong Guan, Hai-Tai Li, Zhong-Lian Zhang. Effects of genetic variation and environmental factors on bergenin in Rodgersia sambucifolia Hemsl. Journal of ethnopharmacology. 2020 Jan; 247(?):112201. doi: 10.1016/j.jep.2019.112201. [PMID: 31499140]
  • Simiao Qiao, Rui Liu, Changjun Lv, Yumeng Miao, Mengfan Yue, Yu Tao, Zhifeng Wei, Yufeng Xia, Yue Dai. Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway. Free radical biology & medicine. 2019 12; 145(?):118-135. doi: 10.1016/j.freeradbiomed.2019.09.003. [PMID: 31494242]
  • Yanping Ren, Changchen Wan, Man Liao, Xia Zhang, Xiaoye Cheng, Lin Yuan, Lantong Zhang. Pharmacokinetics and excretion study of bergenin and its phase II metabolite in rats by liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2019 Jul; 33(7):e4513. doi: 10.1002/bmc.4513. [PMID: 30793338]
  • Herbenya Peixoto, Mariana Roxo, Emerson Silva, Karla Valente, Markus Braun, Xiaojuan Wang, Michael Wink. Bark Extract of the Amazonian Tree Endopleura uchi (Humiriaceae) Extends Lifespan and Enhances Stress Resistance in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2019 Mar; 24(5):. doi: 10.3390/molecules24050915. [PMID: 30845642]
  • Sanasam Sanjeev, Meesala Krishna Murthy, Maibam Sunita Devi, Maurya Khushboo, Zothanmawii Renthlei, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian. Isolation, characterization, and therapeutic activity of bergenin from marlberry (Ardisia colorata Roxb.) leaf on diabetic testicular complications in Wistar albino rats. Environmental science and pollution research international. 2019 Mar; 26(7):7082-7101. doi: 10.1007/s11356-019-04139-9. [PMID: 30648235]
  • Caijuan Zhang, Baosheng Zhao, Chi Zhang, Minyi Qiu, Shuangshuang Ma, Xiaoyan Jin, Yuanyang Shao, Min Wang, Xueyong Wang. Mechanisms of bergenin treatment on chronic bronchitis analyzed by liquid chromatography-tandem mass spectrometry based on metabolomics. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):2270-2277. doi: 10.1016/j.biopha.2018.11.119. [PMID: 30551484]
  • Qiuchen Qi, Zhonghua Dong, Yueyue Sun, Siying Li, Zhongxi Zhao. Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102668. [PMID: 30336565]
  • Haoshi Gao, Yue Wei, Long Xi, Yuanyuan Sun, Tianhong Zhang. Evaluation of Intestinal Absorption and Bioavailability of a Bergenin-Phospholipid Complex Solid Dispersion in Rats. AAPS PharmSciTech. 2018 May; 19(4):1720-1729. doi: 10.1208/s12249-018-0984-5. [PMID: 29556829]
  • Bao Liu, Min Wang, Xiaonan Wang. Phytochemical analysis and antibacterial activity of methanolic extract of Bergenia purpurascens against common respiratory infection causing bacterial species in vitro and in neonatal rats. Microbial pathogenesis. 2018 Apr; 117(?):315-319. doi: 10.1016/j.micpath.2018.01.032. [PMID: 29366865]
  • Kengo Hori, Mikiyo Wada, Shoji Yahara, Takashi Watanabe, Hari Prasad Devkota. Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis. Natural product research. 2018 Feb; 32(4):453-456. doi: 10.1080/14786419.2017.1309536. [PMID: 28361551]
  • Yuan Wang, Qing Li, Yue Dai, Ronghua Pan, Yufeng Xia. Development of a LC-MS/MS method to investigate the interference of pharmacokinetics of the main constituents in Saxifraga stolonifera: Involvement of drug metabolism enzymes. Journal of pharmaceutical and biomedical analysis. 2018 Jan; 148(?):128-135. doi: 10.1016/j.jpba.2017.08.019. [PMID: 29017109]
  • Rohit Singh, Vikas Kumar, Sonali S Bharate, Ram A Vishwakarma. Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis. Bioorganic & medicinal chemistry. 2017 10; 25(20):5513-5521. doi: 10.1016/j.bmc.2017.08.011. [PMID: 28843845]
  • Shiv Vardan Singh, Ashan Manhas, Yogesh Kumar, Sonali Mishra, Karuna Shanker, Feroz Khan, Kumkum Srivastava, Anirban Pal. Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89(?):761-771. doi: 10.1016/j.biopha.2017.02.056. [PMID: 28273638]
  • Shengqian Yang, Ziru Yu, Lin Wang, Tianyi Yuan, Xue Wang, Xue Zhang, Jinhua Wang, Yang Lv, Guanhua Du. The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition. Journal of ethnopharmacology. 2017 Mar; 200(?):147-155. doi: 10.1016/j.jep.2017.02.013. [PMID: 28192201]
  • Jitender Singh, Ashwani Kumar, Anupam Sharma. Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots. Journal of ethnopharmacology. 2017 Jan; 195(?):182-187. doi: 10.1016/j.jep.2016.11.016. [PMID: 27845264]
  • Guilherme A L de Oliveira, George L da Silva Oliveira, Lucas A D Nicolau, Ana C Mafud, Larissa F Batista, Yvonne P Mascarenhas, Luan K M de Sousa, Jorge M David, Larissa S Pinto, Clayton Q Alves, Jand V R Medeiros. Bergenin from Peltophorum dubium: Isolation, Characterization, and Antioxidant Activities in Non-Biological Systems and Erythrocytes. Medicinal chemistry (Shariqah (United Arab Emirates)). 2017; 13(6):592-603. doi: 10.2174/1573406413666170306120152. [PMID: 28266277]
  • Ved P Dwivedi, Debapriya Bhattacharya, Vinod Yadav, Dhiraj K Singh, Santosh Kumar, Mona Singh, Durbadal Ojha, Anand Ranganathan, Luc Van Kaer, Debprasad Chattopadhyay, Gobardhan Das. The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages. Frontiers in cellular and infection microbiology. 2017; 7(?):149. doi: 10.3389/fcimb.2017.00149. [PMID: 28507951]
  • Deepika Aggarwal, Diksha Gautam, Minu Sharma, S K Singla. Bergenin attenuates renal injury by reversing mitochondrial dysfunction in ethylene glycol induced hyperoxaluric rat model. European journal of pharmacology. 2016 Nov; 791(?):611-621. doi: 10.1016/j.ejphar.2016.10.002. [PMID: 27717728]
  • Rong-Hua Pan, Hong-Mei He, Yue Dai, Yu-Feng Xia. Comparative pharmacokinetics of bergenin, a main active constituent of Saxifraga stolonifera Curt., in normal and hepatic injury rats after oral administration. Chinese journal of natural medicines. 2016 Oct; 14(10):776-782. doi: 10.1016/s1875-5364(16)30092-9. [PMID: 28236407]
  • Yi-Jie Li, Cheng-Ting Xu, Dan-Dan Lin, Jiang-Ke Qin, Gao-Jie Ye, Qing-Hua Deng. Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. Bioorganic & medicinal chemistry letters. 2016 08; 26(15):3425-8. doi: 10.1016/j.bmcl.2016.06.054. [PMID: 27374242]
  • Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdelbary M A Elhissi, Waqas Nawaz, Farid Ahmad, Abdul Sadiq, Imdad Ali. Glycoside-based niosomal nanocarrier for enhanced in-vivo performance of Cefixime. International journal of pharmaceutics. 2016 May; 505(1-2):122-32. doi: 10.1016/j.ijpharm.2016.03.042. [PMID: 27050867]
  • Xiaolei Ren, Shuangshuang Ma, Juan Wang, Simin Tian, Xiaorui Fu, Xinfeng Liu, Zhongfeng Li, Baosheng Zhao, Xueyong Wang. Comparative effects of dexamethasone and bergenin on chronic bronchitis and their anti-inflammatory mechanisms based on NMR metabolomics. Molecular bioSystems. 2016 05; 12(6):1938-47. doi: 10.1039/c6mb00041j. [PMID: 27098339]
  • Ji-Hye Seo, Jung-Eun Kim, Jung-Hyun Shim, Goo Yoon, Mi-Ae Bang, Chun-Sik Bae, Kyung-Jin Lee, Dae-Hun Park, Seung-Sik Cho. HPLC Analysis, Optimization of Extraction Conditions and Biological Evaluation of Corylopsis coreana Uyeki Flos. Molecules (Basel, Switzerland). 2016 Jan; 21(1):94. doi: 10.3390/molecules21010094. [PMID: 26784157]
  • Jing Yang, Ming Kan, Gui Yong Wu. Bergenin ameliorates diabetic nephropathy in rats via suppressing renal inflammation and TGF-β1-Smads pathway. Immunopharmacology and immunotoxicology. 2016; 38(2):145-52. doi: 10.3109/08923973.2016.1142560. [PMID: 26954391]
  • Hamayun Khan, Hazrat Amin, Asad Ullah, Sumbal Saba, Jamal Rafique, Khalid Khan, Nasir Ahmad, Syed Lal Badshah. Antioxidant and Antiplasmodial Activities of Bergenin and 11-O-Galloylbergenin Isolated from Mallotus philippensis. Oxidative medicine and cellular longevity. 2016; 2016(?):1051925. doi: 10.1155/2016/1051925. [PMID: 26998192]
  • Luyan Zhang, Wei Zhang, Gang Chen. Determination of arbutin and bergenin in Bergeniae Rhizoma by capillary electrophoresis with a carbon nanotube-epoxy composite electrode. Journal of pharmaceutical and biomedical analysis. 2015 Nov; 115(?):323-9. doi: 10.1016/j.jpba.2015.07.044. [PMID: 26263060]
  • Helena Hendrychová, Jan Martin, Lenka Tůmová, Nina Kočevar-Glavač. Bergenin Content and Free Radical Scavenging Activity of Bergenia Extracts. . Natural product communications. 2015 Jul; 10(7):1273-5. doi: ". [PMID: 26411028]
  • Nasir A Siddiqui, Perwez Alam, Adnan J Al-Rehaily, Mai M Al-Oqail, Mohammad Khalid Parvez. Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method. Journal of chromatographic science. 2015 May; 53(5):824-9. doi: 10.1093/chromsci/bmu231. [PMID: 25662964]
  • Gan B Bajracharya. Diversity, pharmacology and synthesis of bergenin and its derivatives: potential materials for therapeutic usages. Fitoterapia. 2015 Mar; 101(?):133-52. doi: 10.1016/j.fitote.2015.01.001. [PMID: 25596093]
  • Anwar Sadat, Ghias Uddin, M Alam, Ashfaq Ahmad, Bina Shaheen Siddiqui. Structure activity relationship of bergenin, p-hydroxybenzoyl bergenin, 11-O-galloylbergenin as potent antioxidant and urease inhibitor isolated from Bergenia ligulata. Natural product research. 2015; 29(24):2291-4. doi: 10.1080/14786419.2015.1004173. [PMID: 25674661]
  • Xue-jiao Gao, Meng-yao Guo, Ze-cai Zhang, Tian-cheng Wang, Yong-guo Cao, Nai-sheng Zhang. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015; 38(3):1142-50. doi: 10.1007/s10753-014-0079-8. [PMID: 25487780]
  • Liang Zhao, Xian Qian, Wuhong Li, Lei Lv, Hai Zhang, Yifeng Chai, Guoqing Zhang. An LC-MS/MS method for the simultaneous determination and pharmacokinetic studies of bergenin, chlorogenic acid and four flavonoids in rat plasma after oral administration of a QingGanSanJie decotion extract. Biomedical chromatography : BMC. 2014 Dec; 28(12):1670-8. doi: 10.1002/bmc.3200. [PMID: 24828095]
  • De-Biao Yan, Dong-Ping Zhang, Ming Li, Wen-Yuan Liu, Feng Feng, Bin DI, Qing-Long Guo, Ning Xie. Synthesis and cytotoxic activity of 3, 4, 11-trihydroxyl modified derivatives of bergenin. Chinese journal of natural medicines. 2014 Dec; 12(12):929-36. doi: 10.1016/s1875-5364(14)60136-9. [PMID: 25556064]
  • G Uddin, A Sadat, B S Siddiqui. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Tropical biomedicine. 2014 Mar; 31(1):143-8. doi: . [PMID: 24862054]
  • Waranya Lakornwong, Kwanjai Kanokmedhakul, Somdej Kanokmedhakul. Chemical constituents from the roots of Leea thorelii Gagnep. Natural product research. 2014; 28(13):1015-7. doi: 10.1080/14786419.2014.891117. [PMID: 24784484]
  • Haojing Song, Jin Wang, Rui Zhang, Xiaoyan Liu, Guiyan Yuan, Chunmin Wei, Wenjing Zhao, Rong Li, Benjie Wang, Ruichen Guo. In vivo metabolism study of bergenin in rats by HPLC-QTOF mass spectrometry. Biomedical chromatography : BMC. 2013 Nov; 27(11):1398-405. doi: 10.1002/bmc.2934. [PMID: 23696420]
  • Jie Zhang, Yuki Nishimoto, Harukuni Tokuda, Nobutaka Suzuki, Ken Yasukawa, Worapong Kitdamrongtham, Hiroyuki Akazawa, Aranya Manosroi, Jiradej Manosroi, Toshihiro Akihisa. Cancer chemopreventive effect of bergenin from Peltophorum pterocarpum wood. Chemistry & biodiversity. 2013 Oct; 10(10):1866-75. doi: 10.1002/cbdv.201300182. [PMID: 24130029]
  • Xiao-Hua Wei, Sheng-Jie Yang, Na Liang, De-Yu Hu, Lin-Hong Jin, Wei Xue, Song Yang. Chemical constituents of Caesalpinia decapetala (Roth) Alston. Molecules (Basel, Switzerland). 2013 Jan; 18(1):1325-36. doi: 10.3390/molecules18011325. [PMID: 23340256]
  • Li-Hua Mu, Ju-Qiang Feng, Ping Liu. A new bergenin derivative from the rhizome of Ardisia gigantifolia. Natural product research. 2013; 27(14):1242-5. doi: 10.1080/14786419.2012.724415. [PMID: 22991954]
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