Bergenin (BioDeep_00000000094)

   

natural product PANOMIX_OTCML-2023


代谢物信息卡片


NCGC00346587-02_C14H16O9_Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-

化学式: C14H16O9 (328.0794)
中文名称: 佛手配质, 虎耳草素, 矮茶素, 岩白菜素, 岩白菜宁
谱图信息: 最多检出来源 Viridiplantae(plant) 34.18%

分子结构信息

SMILES: COC1=C(C=C2C(=C1O)C3C(C(C(C(O3)CO)O)O)OC2=O)O
InChI: InChI=1S/C14H16O9/c1-21-11-5(16)2-4-7(9(11)18)12-13(23-14(4)20)10(19)8(17)6(3-15)22-12/h2,6,8,10,12-13,15-19H,3H2,1H3

描述信息

Bergenin is a trihydroxybenzoic acid. It has a role as a metabolite.
Bergenin is a natural product found in Ficus racemosa, Ardisia paniculata, and other organisms with data available.
A natural product found in Cenostigma gardnerianum.
C26170 - Protective Agent > C275 - Antioxidant
Annotation level-1
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].
Bergenin is a cytoprotective and antioxidative polyphenol found in many medicinal plants. Bergenin has a wide spectrum activities such as hepatoprotective, antiinflammatory, immunomodulatory, antitumor, antiviral, and antifungal properties[1][2].

同义名列表

51 个代谢物同义名

Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-; (2S,4R,5S,6S,7R)-5,6,12,14-tetrahydroxy-4-(hydroxymethyl)-13-methoxy-3,8-dioxatricyclo[8.4.0.0,2,7]tetradeca-1(10),11,13-trien-9-one; Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-; PYRANO(3,2-C)(2)BENZOPYRAN-6(2H)-ONE, 3,4,4A,10B-TETRAHYDRO-3,4,8,10-TETRAHYDROXY-2-(HYDROXYMETHYL)-9-METHOXY-(2R,3S,4S,4AR,10BS)-; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-2,3,4,4a-tetrahydropyrano[3,2-c]isochromen-6(10bH)-one; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one; 3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one hydrate; 3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano(3,2-c)(2)benzopyran-6(H)-one; 3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one; 4-Methoxy-2-(tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl)alpha-resorcylic acid gamma lactone; bergenin, (2alpha,3beta,4alpha,4aalpha,10bbeta)-isomer, sodium salt; Bergenin, >=95\\% (LC/MS-ELSD); Bergenin, analytical standard; YWJXCIXBAKGUKZ-HJJNZUOJSA-N; Bergenin (Cuscutin); Bergenin, Cuscutin; BERGENIN [WHO-DD]; bergenin hydrate; BERGENINUM [CHP]; BERGENIN [INCI]; UNII-L84RBE4IDC; Ardisic Acid B; Bergenin [JAN]; Ardisinic acid; Copylopsin,(S); Bergenin (JAN); BERGENIN [MI]; Peltophorin; Yanbaicaisu; Bergeninum; Bergenitol; L84RBE4IDC; Corylopsin; Cuscutin; Bergenin; Bengenin; vakerin; (2R,3S,4S,4aR,10bS)-3,4,8,10-tetrahydroxy-9-methoxy-2-methylol-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one; 477-90-7 (ANYDROUS); ZINC04046820; AIDS-031337; AIDS031337; BB_NC-1749; 477-90-7; C09919; D01040; NCGC00346587-02_C14H16O9_Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, (2R,3S,4S,4aR,10bS)-; 3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydro-2H-pyrano[3,2-c]isochromen-6-one; Bergenin; Bergenin



数据库引用编号

78 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

188 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, ANXA5, BCL2, CASP3, HPGDS, MAPK14, NFE2L2, PPARG, PTGS2, SIRT1, TLR4
Peripheral membrane protein 4 ANXA5, GORASP1, PTGS2, SORD
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Mitochondrion membrane 1 SORD
Nucleus 8 AKT1, BCL2, CASP3, MAPK14, MPO, NFE2L2, PPARG, SIRT1
cytosol 12 AKT1, ANXA5, BCL2, CASP3, GPT, GSR, HPGDS, MAPK14, NFE2L2, PPARG, SIRT1, SORD
mitochondrial membrane 1 SORD
centrosome 1 NFE2L2
nucleoplasm 8 AKT1, CASP3, HPGDS, MAPK14, MPO, NFE2L2, PPARG, SIRT1
RNA polymerase II transcription regulator complex 2 NFE2L2, PPARG
Cell membrane 3 AKT1, TLR4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 AKT1
Golgi apparatus membrane 1 GORASP1
cell cortex 1 AKT1
cell surface 2 TLR4, TNF
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 2 GORASP1, NFE2L2
Golgi membrane 1 GORASP1
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
sarcolemma 1 ANXA5
Cytoplasm, cytosol 1 NFE2L2
Lysosome 1 MPO
plasma membrane 4 AKT1, NFE2L2, TLR4, TNF
Membrane 5 AKT1, ANXA5, BCL2, SORD, TLR4
caveola 1 PTGS2
extracellular exosome 5 ANXA5, GPT, GSR, MPO, SORD
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 6 CCL2, IL4, IL6, MPO, SORD, TNF
perinuclear region of cytoplasm 2 PPARG, TLR4
mitochondrion 4 BCL2, GSR, MAPK14, SIRT1
protein-containing complex 3 AKT1, BCL2, PTGS2
intracellular membrane-bounded organelle 3 HPGDS, MPO, PPARG
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Single-pass type I membrane protein 1 TLR4
Secreted 3 CCL2, IL4, IL6
extracellular region 7 ANXA5, CCL2, IL4, IL6, MAPK14, MPO, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 GSR
motile cilium 1 SORD
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 ANXA5, GSR, TLR4, TNF
microtubule cytoskeleton 1 AKT1
nucleolus 1 SIRT1
Early endosome 1 TLR4
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 ANXA5
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 MPO
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 PPARG, TLR4
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 3 NFE2L2, PPARG, SIRT1
mediator complex 1 NFE2L2
phagocytic cup 2 TLR4, TNF
spindle pole 1 MAPK14
Cell projection, cilium, flagellum 1 SORD
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
euchromatin 1 SIRT1
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 2 IL6, PTGS2
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
vesicle membrane 1 ANXA5
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 NFE2L2
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • Li Zhang, Yingying Tong, Yan Fang, Jinjin Pei, Qilan Wang, Gang Li. Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment. Lipids in health and disease. 2023 Nov; 22(1):203. doi: 10.1186/s12944-023-01973-2. [PMID: 38001454]
  • Samyah T Alanazi, Gamaleldin I Harisa, Samir A Salama. Modulating SIRT1, Nrf2, and NF-κB signaling pathways by bergenin ameliorates the cadmium-induced nephrotoxicity in rats. Chemico-biological interactions. 2023 Nov; ?(?):110797. doi: 10.1016/j.cbi.2023.110797. [PMID: 37949422]
  • Sidra Faiz, Durdana Waseem, Ihsan-Ul Haq, Malik Mumtaz Taqi, Syeda Aroosa Mohsin, Nadeem Irshad, Abdul Rehman Phull, Humaira Fatima. Comparative appraisal of in vitro biological profile and in vivo wound healing attributes of bergenin and Bergenia ciliata (Haw.) Sternb. Journal of ethnopharmacology. 2023 Mar; 304(?):115993. doi: 10.1016/j.jep.2022.115993. [PMID: 36509257]
  • Zeca M Salimo, Michael N Yakubu, Emanuelle L da Silva, Anne C G de Almeida, Yury O Chaves, Emmanoel V Costa, Felipe M A da Silva, Josean F Tavares, Wuelton M Monteiro, Gisely C de Melo, Hector H F Koolen. Chemistry and Pharmacology of Bergenin or Its Derivatives: A Promising Molecule. Biomolecules. 2023 02; 13(3):. doi: 10.3390/biom13030403. [PMID: 36979338]
  • Samir A Salama, Mostafa M Elshafey. Cross-talk between PPARγ, NF-κB, and p38 MAPK signaling mediates the ameliorating effects of bergenin against the iron overload-induced hepatotoxicity. Chemico-biological interactions. 2022 Dec; 368(?):110207. doi: 10.1016/j.cbi.2022.110207. [PMID: 36207002]
  • Xuemei Zhang, Fang Zhang, Fenfen Yao, Peng Wang, Qun Xiong, Penghui Neng. Bergenin has neuroprotective effects in mice with ischemic stroke through antioxidative stress and anti-inflammation via regulating Sirt1/FOXO3a/NF-κB signaling. Neuroreport. 2022 09; 33(13):549-560. doi: 10.1097/wnr.0000000000001789. [PMID: 36049159]
  • Yu Yin, Ruyi Xu, Lei Ning, Zhimin Yu. Bergenin alleviates Diabetic Retinopathy in STZ-induced rats. Applied biochemistry and biotechnology. 2022 May; ?(?):. doi: 10.1007/s12010-022-03949-x. [PMID: 35622274]
  • Hui Lin, Pengfei Wang, Wanhong Zhang, Hongwang Yan, Hongxi Yu, Lingqiao Yan, Hui Chen, Mindan Xie, Liqun Shan. Novel Combined Preparation and Investigation of Bergenin-Loaded Albumin Nanoparticles for the Treatment of Acute Lung Injury: In Vitro and In Vivo Evaluations. Inflammation. 2022 Feb; 45(1):428-444. doi: 10.1007/s10753-021-01556-2. [PMID: 34599707]
  • Xiaohe Li, Yanhua Wang, Jingjing Liang, Zhun Bi, Hao Ruan, Yunyao Cui, Ling Ma, Yuli Wei, Bingchen Zhou, Liang Zhang, Honggang Zhou, Cheng Yang. Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway. Phytotherapy research : PTR. 2021 Oct; 35(10):5808-5822. doi: 10.1002/ptr.7239. [PMID: 34375009]
  • Kyung-Ran Park, Yoon-Ju Kwon, Myounglae Cho, Il Keun Kwon, Jin Tae Hong, Hyung-Mun Yun. 11-O-Galloyl Bergenin from Corylopsis coreanas Leaves Induces Autophagy and Apoptosis in Human Osteosarcoma. The American journal of Chinese medicine. 2021; 49(8):2017-2031. doi: 10.1142/s0192415x21500956. [PMID: 34961419]
  • Ejaz Ali, Najma Arshad, Nadeem Irfan Bukhari, Muhammad Nawaz Tahir, Shamail Zafar, Amjad Hussain, Sajida Parveen, Shaista Qamar, Naureen Shehzadi, Khalid Hussain. Linking traditional anti-ulcer use of rhizomes of Bergenia ciliata (Haw.) to its anti-Helicobacter pylori constituents. Natural product research. 2020 Feb; 34(4):541-544. doi: 10.1080/14786419.2018.1488711. [PMID: 30362366]
  • Mei-Fang Song, Li-Xia Zhang, Yue Zhang, Yan-Hong Guan, Hai-Tai Li, Zhong-Lian Zhang. Effects of genetic variation and environmental factors on bergenin in Rodgersia sambucifolia Hemsl. Journal of ethnopharmacology. 2020 Jan; 247(?):112201. doi: 10.1016/j.jep.2019.112201. [PMID: 31499140]
  • Simiao Qiao, Rui Liu, Changjun Lv, Yumeng Miao, Mengfan Yue, Yu Tao, Zhifeng Wei, Yufeng Xia, Yue Dai. Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway. Free radical biology & medicine. 2019 12; 145(?):118-135. doi: 10.1016/j.freeradbiomed.2019.09.003. [PMID: 31494242]
  • Yanping Ren, Changchen Wan, Man Liao, Xia Zhang, Xiaoye Cheng, Lin Yuan, Lantong Zhang. Pharmacokinetics and excretion study of bergenin and its phase II metabolite in rats by liquid chromatography tandem mass spectrometry. Biomedical chromatography : BMC. 2019 Jul; 33(7):e4513. doi: 10.1002/bmc.4513. [PMID: 30793338]
  • Herbenya Peixoto, Mariana Roxo, Emerson Silva, Karla Valente, Markus Braun, Xiaojuan Wang, Michael Wink. Bark Extract of the Amazonian Tree Endopleura uchi (Humiriaceae) Extends Lifespan and Enhances Stress Resistance in Caenorhabditis elegans. Molecules (Basel, Switzerland). 2019 Mar; 24(5):. doi: 10.3390/molecules24050915. [PMID: 30845642]
  • Sanasam Sanjeev, Meesala Krishna Murthy, Maibam Sunita Devi, Maurya Khushboo, Zothanmawii Renthlei, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian. Isolation, characterization, and therapeutic activity of bergenin from marlberry (Ardisia colorata Roxb.) leaf on diabetic testicular complications in Wistar albino rats. Environmental science and pollution research international. 2019 Mar; 26(7):7082-7101. doi: 10.1007/s11356-019-04139-9. [PMID: 30648235]
  • Caijuan Zhang, Baosheng Zhao, Chi Zhang, Minyi Qiu, Shuangshuang Ma, Xiaoyan Jin, Yuanyang Shao, Min Wang, Xueyong Wang. Mechanisms of bergenin treatment on chronic bronchitis analyzed by liquid chromatography-tandem mass spectrometry based on metabolomics. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2019 Jan; 109(?):2270-2277. doi: 10.1016/j.biopha.2018.11.119. [PMID: 30551484]
  • Qiuchen Qi, Zhonghua Dong, Yueyue Sun, Siying Li, Zhongxi Zhao. Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice. Molecules (Basel, Switzerland). 2018 Oct; 23(10):. doi: 10.3390/molecules23102668. [PMID: 30336565]
  • Haoshi Gao, Yue Wei, Long Xi, Yuanyuan Sun, Tianhong Zhang. Evaluation of Intestinal Absorption and Bioavailability of a Bergenin-Phospholipid Complex Solid Dispersion in Rats. AAPS PharmSciTech. 2018 May; 19(4):1720-1729. doi: 10.1208/s12249-018-0984-5. [PMID: 29556829]
  • Bao Liu, Min Wang, Xiaonan Wang. Phytochemical analysis and antibacterial activity of methanolic extract of Bergenia purpurascens against common respiratory infection causing bacterial species in vitro and in neonatal rats. Microbial pathogenesis. 2018 Apr; 117(?):315-319. doi: 10.1016/j.micpath.2018.01.032. [PMID: 29366865]
  • Kengo Hori, Mikiyo Wada, Shoji Yahara, Takashi Watanabe, Hari Prasad Devkota. Antioxidant phenolic compounds from the rhizomes of Astilbe rivularis. Natural product research. 2018 Feb; 32(4):453-456. doi: 10.1080/14786419.2017.1309536. [PMID: 28361551]
  • Yuan Wang, Qing Li, Yue Dai, Ronghua Pan, Yufeng Xia. Development of a LC-MS/MS method to investigate the interference of pharmacokinetics of the main constituents in Saxifraga stolonifera: Involvement of drug metabolism enzymes. Journal of pharmaceutical and biomedical analysis. 2018 Jan; 148(?):128-135. doi: 10.1016/j.jpba.2017.08.019. [PMID: 29017109]
  • Rohit Singh, Vikas Kumar, Sonali S Bharate, Ram A Vishwakarma. Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis. Bioorganic & medicinal chemistry. 2017 10; 25(20):5513-5521. doi: 10.1016/j.bmc.2017.08.011. [PMID: 28843845]
  • Shiv Vardan Singh, Ashan Manhas, Yogesh Kumar, Sonali Mishra, Karuna Shanker, Feroz Khan, Kumkum Srivastava, Anirban Pal. Antimalarial activity and safety assessment of Flueggea virosa leaves and its major constituent with special emphasis on their mode of action. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 May; 89(?):761-771. doi: 10.1016/j.biopha.2017.02.056. [PMID: 28273638]
  • Shengqian Yang, Ziru Yu, Lin Wang, Tianyi Yuan, Xue Wang, Xue Zhang, Jinhua Wang, Yang Lv, Guanhua Du. The natural product bergenin ameliorates lipopolysaccharide-induced acute lung injury by inhibiting NF-kappaB activition. Journal of ethnopharmacology. 2017 Mar; 200(?):147-155. doi: 10.1016/j.jep.2017.02.013. [PMID: 28192201]
  • Jitender Singh, Ashwani Kumar, Anupam Sharma. Antianxiety activity guided isolation and characterization of bergenin from Caesalpinia digyna Rottler roots. Journal of ethnopharmacology. 2017 Jan; 195(?):182-187. doi: 10.1016/j.jep.2016.11.016. [PMID: 27845264]
  • Guilherme A L de Oliveira, George L da Silva Oliveira, Lucas A D Nicolau, Ana C Mafud, Larissa F Batista, Yvonne P Mascarenhas, Luan K M de Sousa, Jorge M David, Larissa S Pinto, Clayton Q Alves, Jand V R Medeiros. Bergenin from Peltophorum dubium: Isolation, Characterization, and Antioxidant Activities in Non-Biological Systems and Erythrocytes. Medicinal chemistry (Shariqah (United Arab Emirates)). 2017; 13(6):592-603. doi: 10.2174/1573406413666170306120152. [PMID: 28266277]
  • Ved P Dwivedi, Debapriya Bhattacharya, Vinod Yadav, Dhiraj K Singh, Santosh Kumar, Mona Singh, Durbadal Ojha, Anand Ranganathan, Luc Van Kaer, Debprasad Chattopadhyay, Gobardhan Das. The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages. Frontiers in cellular and infection microbiology. 2017; 7(?):149. doi: 10.3389/fcimb.2017.00149. [PMID: 28507951]
  • Deepika Aggarwal, Diksha Gautam, Minu Sharma, S K Singla. Bergenin attenuates renal injury by reversing mitochondrial dysfunction in ethylene glycol induced hyperoxaluric rat model. European journal of pharmacology. 2016 Nov; 791(?):611-621. doi: 10.1016/j.ejphar.2016.10.002. [PMID: 27717728]
  • Rong-Hua Pan, Hong-Mei He, Yue Dai, Yu-Feng Xia. Comparative pharmacokinetics of bergenin, a main active constituent of Saxifraga stolonifera Curt., in normal and hepatic injury rats after oral administration. Chinese journal of natural medicines. 2016 Oct; 14(10):776-782. doi: 10.1016/s1875-5364(16)30092-9. [PMID: 28236407]
  • Yi-Jie Li, Cheng-Ting Xu, Dan-Dan Lin, Jiang-Ke Qin, Gao-Jie Ye, Qing-Hua Deng. Anti-inflammatory polyphenol constituents derived from Cissus pteroclada Hayata. Bioorganic & medicinal chemistry letters. 2016 08; 26(15):3425-8. doi: 10.1016/j.bmcl.2016.06.054. [PMID: 27374242]
  • Muhammad Imran, Muhammad Raza Shah, Farhat Ullah, Shafi Ullah, Abdelbary M A Elhissi, Waqas Nawaz, Farid Ahmad, Abdul Sadiq, Imdad Ali. Glycoside-based niosomal nanocarrier for enhanced in-vivo performance of Cefixime. International journal of pharmaceutics. 2016 May; 505(1-2):122-32. doi: 10.1016/j.ijpharm.2016.03.042. [PMID: 27050867]
  • Xiaolei Ren, Shuangshuang Ma, Juan Wang, Simin Tian, Xiaorui Fu, Xinfeng Liu, Zhongfeng Li, Baosheng Zhao, Xueyong Wang. Comparative effects of dexamethasone and bergenin on chronic bronchitis and their anti-inflammatory mechanisms based on NMR metabolomics. Molecular bioSystems. 2016 05; 12(6):1938-47. doi: 10.1039/c6mb00041j. [PMID: 27098339]
  • Ji-Hye Seo, Jung-Eun Kim, Jung-Hyun Shim, Goo Yoon, Mi-Ae Bang, Chun-Sik Bae, Kyung-Jin Lee, Dae-Hun Park, Seung-Sik Cho. HPLC Analysis, Optimization of Extraction Conditions and Biological Evaluation of Corylopsis coreana Uyeki Flos. Molecules (Basel, Switzerland). 2016 Jan; 21(1):94. doi: 10.3390/molecules21010094. [PMID: 26784157]
  • Jing Yang, Ming Kan, Gui Yong Wu. Bergenin ameliorates diabetic nephropathy in rats via suppressing renal inflammation and TGF-β1-Smads pathway. Immunopharmacology and immunotoxicology. 2016; 38(2):145-52. doi: 10.3109/08923973.2016.1142560. [PMID: 26954391]
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