Plicamycin (BioDeep_00000009284)

 

Secondary id: BioDeep_00000599953

human metabolite blood metabolite Chemicals and Drugs Antibiotics natural product


代谢物信息卡片


(2S,3S)-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-2-{[(2S,4R,5R,6R)-4-{[(2S,4R,5S,6R)-4-{[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-6-{[(2S,4R,5R,6R)-4-{[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-8,9-dihydroxy-7-methyl-1,2,3,4-tetrahydroanthracen-1-one

化学式: C52H76O24 (1084.4726)
中文名称: 普卡酶素
谱图信息: 最多检出来源 Homo sapiens(blood) 70.13%

分子结构信息

SMILES: CC1C(C(CC(O1)OC2CC(OC(C2O)C)OC3=CC4=CC5=C(C(=O)C(C(C5)C(C(=O)C(C(C)O)O)OC)OC6CC(C(C(O6)C)O)OC7CC(C(C(O7)C)O)OC8CC(C(C(O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O
InChI: InChI=1S/C52H76O24/c1-18-29(72-34-14-30(43(58)21(4)68-34)73-33-13-28(54)42(57)20(3)67-33)12-26-10-25-11-27(49(66-9)48(63)41(56)19(2)53)50(47(62)39(25)46(61)38(26)40(18)55)76-36-16-31(44(59)23(6)70-36)74-35-15-32(45(60)22(5)69-35)75-37-17-52(8,65)51(64)24(7)71-37/h10,12,19-24,27-28,30-37,41-45,49-51,53-61,64-65H,11,13-17H2,1-9H3

描述信息

Plicamycin is only found in individuals that have used or taken this drug. It is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Pagets disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. Plicamycin is presumed to inhibit cellular and enzymic RNA synthesis by forming a complex with DNA. Plicamycin may also lower calcium serum levels by inhibiting the effect of parathyroid hormone upon osteoclasts or by blocking the hypercalcemic action of pharmacologic doses of vitamin D.
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents
C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D004396 - Coloring Agents > D005456 - Fluorescent Dyes
D000077264 - Calcium-Regulating Hormones and Agents
D000970 - Antineoplastic Agents
Same as: D00468

同义名列表

14 个代谢物同义名

(2S,3S)-3-[(1S,3S,4R)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-2-{[(2S,4R,5R,6R)-4-{[(2S,4R,5S,6R)-4-{[(2S,4S,5R,6R)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-6-{[(2S,4R,5R,6R)-4-{[(2S,4R,5S,6R)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-8,9-dihydroxy-7-methyl-1,2,3,4-tetrahydroanthracen-1-one; 2-[4-[4-(4,5-dihydroxy-4,6-dimethyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-5-hydroxy-6-methyloxan-2-yl]oxy-3-(3,4-dihydroxy-1-methoxy-2-oxopentyl)-6-[4-(4,5-dihydroxy-6-methyloxan-2-yl)oxy-5-hydroxy-6-methyloxan-2-yl]oxy-8,9-dihydroxy-7-methyl-3,4-dihydro-2H-anthracen-1-one; Acid, aureolic; Aureolic acid; Mithramycinum; mithramycin a; Plicamycinum; Mithramycine; Mithramycin; Plicamycine; Plicamycin; Mitramycin; Aureolate; Mithracin



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

117 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ABCB1, BCL2, CALCA, CASP3, CASP7, CDKN1A, EGFR, GLI3, MCL1, MTOR, SOX2, SP1, TP53, VEGFA, XIAP
Peripheral membrane protein 1 MTOR
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 BCL2, EGFR, MTOR
Nucleus 15 BCL2, CASP3, CASP7, CDKN1A, EGFR, GLI3, MCL1, MTOR, SOX2, SP1, SP3, SP4, TP53, VEGFA, XIAP
cytosol 13 BCL2, CASP3, CASP7, CDKN1A, GLI3, HBB, MCL1, MTOR, SOX2, SP3, SP4, TP53, XIAP
dendrite 1 MTOR
nuclear body 1 CDKN1A
phagocytic vesicle 1 MTOR
centrosome 1 TP53
nucleoplasm 12 CASP3, CASP7, CDKN1A, GLI3, MCL1, MTOR, SOX2, SP1, SP3, SP4, TP53, XIAP
Cell membrane 3 ABCB1, EGFR, TNF
Cytoplasmic side 1 MTOR
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 ABCB1
Golgi apparatus membrane 1 MTOR
cell junction 1 EGFR
cell surface 4 ABCB1, EGFR, TNF, VEGFA
glutamatergic synapse 2 CASP3, EGFR
Golgi apparatus 1 VEGFA
Golgi membrane 2 EGFR, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 3 CALCA, CASP3, TNF
Cytoplasm, cytosol 1 CASP7
Lysosome 1 MTOR
endosome 1 EGFR
plasma membrane 4 ABCB1, EGFR, GCG, TNF
terminal bouton 1 CALCA
Membrane 8 ABCB1, BCL2, EGFR, HBB, MCL1, MTOR, TP53, VEGFA
apical plasma membrane 2 ABCB1, EGFR
basolateral plasma membrane 1 EGFR
extracellular exosome 2 ABCB1, HBB
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, TP53, VEGFA
extracellular space 8 CALCA, CASP7, EGFR, GCG, HBB, SP1, TNF, VEGFA
perinuclear region of cytoplasm 2 CDKN1A, EGFR
adherens junction 1 VEGFA
mitochondrion 3 BCL2, MCL1, TP53
protein-containing complex 4 BCL2, CDKN1A, EGFR, TP53
intracellular membrane-bounded organelle 1 GLI3
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 EGFR
Secreted 4 CALCA, GCG, SP1, VEGFA
extracellular region 6 CALCA, GCG, HBB, SP1, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 2 BCL2, MCL1
mitochondrial outer membrane 3 BCL2, MCL1, MTOR
hippocampal mossy fiber to CA3 synapse 1 CALCA
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 2 SOX2, TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 2 BCL2, MCL1
nuclear membrane 2 BCL2, EGFR
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
nucleolus 3 CDKN1A, GLI3, TP53
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Membrane raft 2 EGFR, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 EGFR
extracellular matrix 1 VEGFA
intracellular vesicle 1 EGFR
Nucleus, PML body 2 MTOR, TP53
PML body 3 MTOR, SP3, TP53
secretory granule 1 VEGFA
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 2 GLI3, SOX2
receptor complex 1 EGFR
ciliary base 1 GLI3
cilium 1 GLI3
chromatin 5 SOX2, SP1, SP3, SP4, TP53
phagocytic cup 1 TNF
Secreted, extracellular space 1 CASP7
blood microparticle 1 HBB
site of double-strand break 1 TP53
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
myosin complex 1 MCL1
Nucleus, nucleoplasm 1 MCL1
Nucleus speckle 1 SOX2
euchromatin 1 SP1
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 HBB
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 1 GCG
nuclear matrix 1 TP53
transcription repressor complex 4 GLI3, SP1, SP3, TP53
platelet alpha granule lumen 1 VEGFA
tertiary granule lumen 1 HBB
neuronal dense core vesicle 1 CALCA
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 TP53
protein-DNA complex 2 SP1, SP3
external side of apical plasma membrane 1 ABCB1
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
cyclin-dependent protein kinase holoenzyme complex 1 CDKN1A
hemoglobin complex 1 HBB
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 HBB
haptoglobin-hemoglobin complex 1 HBB
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
GLI-SUFU complex 1 GLI3
BAD-BCL-2 complex 1 BCL2
PCNA-p21 complex 1 CDKN1A
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • J R Rivas, Y Liu, S S Alhakeem, J M Eckenrode, F Marti, J P Collard, Y Zhang, K A Shaaban, N Muthusamy, G C Hildebrandt, R A Fleischman, L Chen, J S Thorson, M Leggas, S Bondada. Interleukin-10 suppression enhances T-cell antitumor immunity and responses to checkpoint blockade in chronic lymphocytic leukemia. Leukemia. 2021 11; 35(11):3188-3200. doi: 10.1038/s41375-021-01217-1. [PMID: 33731852]
  • Yunhui Zhang, Yinru Tang, Yuping Luo, Li Luo, Feihai Shen, Zhiying Huang. Triptolide impairs glycolysis by suppressing GATA4/Sp1/PFKP signaling axis in mouse Sertoli cells. Toxicology and applied pharmacology. 2021 08; 425(?):115606. doi: 10.1016/j.taap.2021.115606. [PMID: 34087332]
  • Yang Liu, Joseph M Eckenrode, Yinan Zhang, Jianjun Zhang, Reiya C Hayden, Annet Kyomuhangi, Larissa V Ponomareva, Zheng Cui, Jürgen Rohr, Oleg V Tsodikov, Steven G Van Lanen, Khaled A Shaaban, Markos Leggas, Jon S Thorson. Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy. Journal of medicinal chemistry. 2020 11; 63(22):14067-14086. doi: 10.1021/acs.jmedchem.0c01526. [PMID: 33191745]
  • Cristina García-Iriepa, Cécilia Hognon, Antonio Francés-Monerris, Isabel Iriepa, Tom Miclot, Giampaolo Barone, Antonio Monari, Marco Marazzi. Thermodynamics of the Interaction between the Spike Protein of Severe Acute Respiratory Syndrome Coronavirus-2 and the Receptor of Human Angiotensin-Converting Enzyme 2. Effects of Possible Ligands. The journal of physical chemistry letters. 2020 Nov; 11(21):9272-9281. doi: 10.1021/acs.jpclett.0c02203. [PMID: 33085491]
  • E R Vagapova, T D Lebedev, A D Tikhonova, B V Goikhman, K A Ivanenko, P V Spirin, V S Prassolov. [High Expression Level of SP1, CSF1R, and PAK1 Correlates with Sensitivity of Leukemia Cells to the Antibiotic Mithramycin]. Molekuliarnaia biologiia. 2020 May; 54(3):522-528. doi: 10.31857/s0026898420030192. [PMID: 32492016]
  • Joseph M Eckenrode, Prithiba Mitra, Jürgen Rohr, Markos Leggas. Bioanalytical method for quantitative determination of mithramycin analogs in mouse plasma by HPLC-QTOF. Biomedical chromatography : BMC. 2019 Aug; 33(8):e4544. doi: 10.1002/bmc.4544. [PMID: 30927450]
  • Tristan M Sissung, Phoebe A Huang, Ralph J Hauke, Edel M McCrea, Cody J Peer, Roberto H Barbier, Jonathan D Strope, Ariel M Ley, Mary Zhang, Julie A Hong, David Venzon, Jonathan P Jackson, Kenneth R Brouwer, Patrick Grohar, Jon Glod, Brigitte C Widemann, Theo Heller, David S Schrump, William D Figg. Severe Hepatotoxicity of Mithramycin Therapy Caused by Altered Expression of Hepatocellular Bile Transporters. Molecular pharmacology. 2019 08; 96(2):158-167. doi: 10.1124/mol.118.114827. [PMID: 31175181]
  • Peirong Huang, Junran Sun, Fenghua Wang, Xueting Luo, Hong Zhu, Qing Gu, Xiangjun Sun, Te Liu, Xiaodong Sun. DNMT1 and Sp1 competitively regulate the expression of BACE1 in A2E-mediated photo-oxidative damage in RPE cells. Neurochemistry international. 2018 12; 121(?):59-68. doi: 10.1016/j.neuint.2018.09.001. [PMID: 30273642]
  • Patrick J Grohar, John Glod, Cody J Peer, Tristan M Sissung, Fernanda I Arnaldez, Lauren Long, William D Figg, Patricia Whitcomb, Lee J Helman, Brigitte C Widemann. A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript. Cancer chemotherapy and pharmacology. 2017 Sep; 80(3):645-652. doi: 10.1007/s00280-017-3382-x. [PMID: 28735378]
  • Kwon-Ho Song, Choong-Hwan Kwak, Un-Ho Jin, Sun-Hyung Ha, Jun-Young Park, Fukushi Abekura, Young-Chae Chang, Seung-Hak Cho, Kichoon Lee, Tae-Wook Chung, Ki-Tae Ha, Young-Choon Lee, Cheorl-Ho Kim. Housekeeping promoter 5'pcmah-2 of pig CMP-N-acetylneuraminic acid hydroxylase gene for NeuGc expression. Glycoconjugate journal. 2016 10; 33(5):779-88. doi: 10.1007/s10719-016-9671-5. [PMID: 27188588]
  • Eyal Asor, Shiri Stempler, Avi Avital, Ehud Klein, Eytan Ruppin, Dorit Ben-Shachar. The role of branched chain amino acid and tryptophan metabolism in rat's behavioral diversity: Intertwined peripheral and brain effects. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2015 Oct; 25(10):1695-705. doi: 10.1016/j.euroneuro.2015.07.009. [PMID: 26271721]
  • Tony N Wang, Xing Chen, Renzhong Li, Bo Gao, Zahraa Mohammed-Ali, Chao Lu, Victoria Yum, Jeffrey G Dickhout, Joan C Krepinsky. SREBP-1 Mediates Angiotensin II-Induced TGF-β1 Upregulation and Glomerular Fibrosis. Journal of the American Society of Nephrology : JASN. 2015 Aug; 26(8):1839-54. doi: 10.1681/asn.2013121332. [PMID: 25398788]
  • Jeffrey Roth, Cody J Peer, Brigitte Widemann, Diane E Cole, Rachel Ershler, Lee Helman, David Schrump, William D Figg. Quantitative determination of mithramycin in human plasma by a novel, sensitive ultra-HPLC-MS/MS method for clinical pharmacokinetic application. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Nov; 970(?):95-101. doi: 10.1016/j.jchromb.2014.08.021. [PMID: 25247492]
  • Hang-Eun Lee, Eun-Sun Choi, Ji-Ae Shin, Lee-Han Kim, Nam-Pyo Cho, Sung-Dae Cho. Apoptotic effect of methanol extract of Picrasma quassioides by regulating specificity protein 1 in human cervical cancer cells. Cell biochemistry and function. 2014 Apr; 32(3):229-35. doi: 10.1002/cbf.2996. [PMID: 24037733]
  • Weiliang Tang, Jinxiu Yang, Furong Zhang, Hangyuan Guo, Fang Peng, Xingxiang Wang. Activation of extracellular signal-regulated kinase 1/2 and Sp1 may contribute to the expression of tissue inhibitor of metalloproteinases-1 induced by transforming growth factor-β1 in human pulmonary arterial smooth muscle cells. Cytotherapy. 2014 Feb; 16(2):225-33. doi: 10.1016/j.jcyt.2013.08.009. [PMID: 24113427]
  • Bo Hyung Lee, Pan Dong Ryu, So Yeong Lee. Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells. International journal of molecular sciences. 2014 Jan; 15(1):977-93. doi: 10.3390/ijms15010977. [PMID: 24434641]
  • Eyal Asor, Hila Belhanes, Alexandra Kavushansky, Salman Zubedat, Ehud Klein, Avi Avital, Dorit Ben-Shachar. Early postnatal interference with the expression of multiple Sp1 regulated genes leads to disparate behavioral response to sub-chronic and chronic stress in rats. Psychoneuroendocrinology. 2013 Oct; 38(10):2173-83. doi: 10.1016/j.psyneuen.2013.04.005. [PMID: 23669323]
  • Donatella Vizza, Anna Perri, Danilo Lofaro, Giuseppina Toteda, Simona Lupinacci, Francesca Leone, Paolo Gigliotti, Teresa Papalia, Renzo Bonofiglio. Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. PloS one. 2013; 8(11):e80113. doi: 10.1371/journal.pone.0080113. [PMID: 24244623]
  • Marina Isshiki, Haruka Ohta, Hiroomi Tamura. Coffee reduces SULT1E1 expression in human colon carcinoma Caco-2 cells. Biological & pharmaceutical bulletin. 2013; 36(2):299-304. doi: 10.1248/bpb.b12-00902. [PMID: 23370358]
  • Yasuhito Ohsaka, Hoyoku Nishino. Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes. Cryobiology. 2012 Aug; 65(1):12-20. doi: 10.1016/j.cryobiol.2012.03.001. [PMID: 22465333]
  • Anastasia Malek, Luz-Elena Núñez, Marco Magistri, Lara Brambilla, Sandra Jovic, Giuseppina M Carbone, Francisco Morís, Carlo V Catapano. Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer. PloS one. 2012; 7(4):e35130. doi: 10.1371/journal.pone.0035130. [PMID: 22545098]
  • Sai-Wen Tang, Jung-Yaw Lin. Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma. Journal of oncology. 2012; 2012(?):680796. doi: 10.1155/2012/680796. [PMID: 22545051]
  • Ali Rahil, Fahmi Yousef Khan. Humoral hypercalcemic crisis in a pregnant woman with uterine leiomyoma. Journal of emergencies, trauma, and shock. 2012 Jan; 5(1):87-9. doi: 10.4103/0974-2700.93093. [PMID: 22416164]
  • Guilherme Guimarães, Luísa Cardoso, Helena Oliveira, Conceição Santos, Patrícia Duarte, Mariana Sottomayor. Cytogenetic characterization and genome size of the medicinal plant Catharanthus roseus (L.) G. Don. AoB PLANTS. 2012; 2012(?):pls002. doi: 10.1093/aobpla/pls002. [PMID: 22479673]
  • Bianca Fuhrman. Regulation of hepatic paraoxonase-1 expression. Journal of lipids. 2012; 2012(?):684010. doi: 10.1155/2012/684010. [PMID: 22548179]
  • B Chhunchha, N Fatma, B Bhargavan, E Kubo, A Kumar, D P Singh. Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress. Cell death & disease. 2011 Nov; 2(?):e234. doi: 10.1038/cddis.2011.121. [PMID: 22113199]
  • Xinmin Zhao, Xiaofeng Xu, Qunling Zhang, Zhen Jia, Si Sun, Jian Zhang, Biyun Wang, Zhonghua Wang, Xichun Hu. Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving 'metronomic' zoledronic acid. BMC cancer. 2011 Sep; 11(?):403. doi: 10.1186/1471-2407-11-403. [PMID: 21936956]
  • Anna Stachurska, Magdalena Kozakowska, Alicja Jozkowicz, Jozef Dulak, Agnieszka Loboda. Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors. Toxicology letters. 2011 Jul; 204(2-3):118-26. doi: 10.1016/j.toxlet.2011.04.022. [PMID: 21554934]
  • E Beaulieu, L Green, L Elsby, Z Alourfi, E F Morand, D W Ray, R Donn. Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin. Clinical and experimental immunology. 2011 Feb; 163(2):178-88. doi: 10.1111/j.1365-2249.2010.04289.x. [PMID: 21087445]
  • Xianqiong Zou, Yongguang Gao, Vivian R Ruvolo, Tawnya L Gardner, Peter P Ruvolo, Rhoderick E Brown. Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide. The Journal of biological chemistry. 2011 Jan; 286(2):1301-11. doi: 10.1074/jbc.m110.127837. [PMID: 20974858]
  • Shi-Hai Xing, Xin-Bo Guo, Quan Wang, Qi-Fang Pan, Yue-Sheng Tian, Pin Liu, Jing-Ya Zhao, Guo-Feng Wang, Xiao-Fen Sun, Ke-Xuan Tang. Induction and flow cytometry identification of tetraploids from seed-derived explants through colchicine treatments in Catharanthus roseus (L.) G. Don. Journal of biomedicine & biotechnology. 2011; 2011(?):793198. doi: 10.1155/2011/793198. [PMID: 21660143]
  • Daniel Scott, Jürgen Rohr, Younsoo Bae. Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity. International journal of nanomedicine. 2011; 6(?):2757-67. doi: 10.2147/ijn.s25427. [PMID: 22114504]
  • Xiaohong Lu, Wenbin Wei, Janine Fenton, Michael S Nahorski, Erzsebet Rabai, Anne Reiman, Laurence Seabra, Zsuzsanna Nagy, Farida Latif, Eamonn R Maher. Therapeutic targeting the loss of the birt-hogg-dube suppressor gene. Molecular cancer therapeutics. 2011 Jan; 10(1):80-9. doi: 10.1158/1535-7163.mct-10-0628. [PMID: 21220493]
  • Myriam Ravache, Chantal Weber, Karine Mérienne, Yvon Trottier. Transcriptional activation of REST by Sp1 in Huntington's disease models. PloS one. 2010 Dec; 5(12):e14311. doi: 10.1371/journal.pone.0014311. [PMID: 21179468]
  • Yasuhito Ohsaka, Hoyoku Nishino. MDM2-related responses in 3T3-L1 adipocytes exposed to cooling and subsequent rewarming. Cryobiology. 2010 Dec; 61(3):308-16. doi: 10.1016/j.cryobiol.2010.10.156. [PMID: 21034728]
  • Vera Vukić, Dragana Jovanović, Vesna Skodrić-Trifunović. [Lung carcinoma with paraneoplastic hyponatremia and hypercalcemia]. Medicinski pregled. 2010 Jul; 63(7-8):512-5. doi: 10.2298/mpns1008512v. [PMID: 21446140]
  • Jessy Deshane, Junghyun Kim, Subhashini Bolisetty, Thomas D Hock, Nathalie Hill-Kapturczak, Anupam Agarwal. Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells. The Journal of biological chemistry. 2010 May; 285(22):16476-86. doi: 10.1074/jbc.m109.058586. [PMID: 20351094]
  • Hiroko Hagiwara, Masaomi Iyo, Kenji Hashimoto. Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine. Brain research. 2009 Dec; 1301(?):189-96. doi: 10.1016/j.brainres.2009.09.010. [PMID: 19748494]
  • Akira Ikari, Kosuke Atomi, Ayumi Takiguchi, Yasuhiro Yamazaki, Masao Miwa, Junko Sugatani. Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells. Biochemical and biophysical research communications. 2009 Jul; 384(3):306-10. doi: 10.1016/j.bbrc.2009.04.120. [PMID: 19409881]
  • Nicoletta Bianchi, Cristina Zuccato, Ilaria Lampronti, Monica Borgatti, Roberto Gambari. Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia. Evidence-based complementary and alternative medicine : eCAM. 2009 Jun; 6(2):141-51. doi: 10.1093/ecam/nem139. [PMID: 18955291]
  • Franco Lumachi, Antonella Brunello, Anna Roma, Umberto Basso. Cancer-induced hypercalcemia. Anticancer research. 2009 May; 29(5):1551-5. doi: . [PMID: 19443365]
  • Xian Zhang, Ling Chen, Xun-Chang Fei, Yin-Sheng Ma, Hong-Wen Gao. Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals. BMC molecular biology. 2009 Feb; 10(?):16. doi: 10.1186/1471-2199-10-16. [PMID: 19239717]
  • Carmen D Zorrilla, Vivian Tamayo-Agrait. Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy. HIV/AIDS (Auckland, N.Z.). 2009; 1(?):41-53. doi: 10.2147/hiv.s6326. [PMID: 22096378]
  • Yukio Ikeda, Tadashi Suehiro, Kaoru Arii, Yoshitaka Kumon, Kozo Hashimoto. High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes. Metabolism: clinical and experimental. 2008 Dec; 57(12):1725-32. doi: 10.1016/j.metabol.2008.07.032. [PMID: 19013297]
  • M Rafiq Islam, Sanjeev Puri, Marianna Rodova, Brenda S Magenheimer, Robin L Maser, James P Calvet. Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter. American journal of physiology. Renal physiology. 2008 Dec; 295(6):F1845-54. doi: 10.1152/ajprenal.90355.2008. [PMID: 18922886]
  • Fang Cai, Bin Chen, Weihui Zhou, Odysseus Zis, Shengchun Liu, Robert A Holt, William G Honer, Weihong Song. SP1 regulates a human SNAP-25 gene expression. Journal of neurochemistry. 2008 Apr; 105(2):512-23. doi: 10.1111/j.1471-4159.2007.05167.x. [PMID: 18194215]
  • F Lumachi, A Brunello, A Roma, U Basso. Medical treatment of malignancy-associated hypercalcemia. Current medicinal chemistry. 2008; 15(4):415-21. doi: 10.2174/092986708783497346. [PMID: 18288996]
  • Efstathia Thymiakou, Vassilis I Zannis, Dimitris Kardassis. Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids. Biochemistry. 2007 Oct; 46(41):11473-83. doi: 10.1021/bi700994m. [PMID: 17887732]
  • Emanuela Corsini, Omar Zancanella, Laura Lucchi, Barbara Viviani, Marina Marinovich, Corrado L Galli. Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes. Gene regulation and systems biology. 2007 Oct; 1(?):207-15. doi: . [PMID: 19936089]
  • Amie Traylor, Thomas Hock, Nathalie Hill-Kapturczak. Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells. American journal of physiology. Renal physiology. 2007 Sep; 293(3):F885-94. doi: 10.1152/ajprenal.00519.2006. [PMID: 17567933]
  • Corrie L Messerer, Samuel P Bugis, Chris Baliski, Sam M Wiseman. Normocalcemic parathyroid carcinoma: an unusual clinical presentation. World journal of surgical oncology. 2006 Feb; 4(?):10. doi: 10.1186/1477-7819-4-10. [PMID: 16504029]
  • S M Guichard, R Else, E Reid, B Zeitlin, R Aird, M Muir, M Dodds, H Fiebig, P J Sadler, D I Jodrell. Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds. Biochemical pharmacology. 2006 Feb; 71(4):408-15. doi: 10.1016/j.bcp.2005.10.053. [PMID: 16360645]
  • Tuo Deng, Song Shan, Ping-Ping Li, Zhu-Fang Shen, Xian-Ping Lu, Jing Cheng, Zhi-Qiang Ning. Peroxisome proliferator-activated receptor-gamma transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1. Endocrinology. 2006 Feb; 147(2):875-84. doi: 10.1210/en.2005-0623. [PMID: 16269451]
  • S S Chung, H H Choi, K W Kim, Y M Cho, H K Lee, K S Park. Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site. Diabetologia. 2005 Jun; 48(6):1150-8. doi: 10.1007/s00125-005-1762-y. [PMID: 15864531]
  • T Lund, T Stokke, Ø E Olsen, Ø Fodstad. Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis. British journal of cancer. 2005 May; 92(9):1773-81. doi: 10.1038/sj.bjc.6602537. [PMID: 15827557]
  • Toshitaka Shin, Hideaki Sumiyoshi, Noritaka Matsuo, Fuminori Satoh, Yoshio Nomura, Hiromitsu Mimata, Hidekatsu Yoshioka. Sp1 and Sp3 transcription factors upregulate the proximal promoter of the human prostate-specific antigen gene in prostate cancer cells. Archives of biochemistry and biophysics. 2005 Mar; 435(2):291-302. doi: 10.1016/j.abb.2005.01.002. [PMID: 15708372]
  • Kikuko Ota, Tadashi Suehiro, Kaoru Arii, Yukio Ikeda, Yoshitaka Kumon, Fumiaki Osaki, Kozo Hashimoto. Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene. Metabolism: clinical and experimental. 2005 Feb; 54(2):142-50. doi: 10.1016/j.metabol.2004.06.018. [PMID: 15690306]
  • Artit Jinawath, Satoshi Miyake, Yuka Yanagisawa, Yoshimitsu Akiyama, Yasuhito Yuasa. Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins. The Biochemical journal. 2005 Jan; 385(Pt 2):557-64. doi: 10.1042/bj20040684. [PMID: 15362956]
  • Armin Meister. Calculation of binding length of base-specific DNA dyes by comparison of sequence and flow cytometric data. Application to Oryza sativa and Arabidopsis thaliana. Journal of theoretical biology. 2005 Jan; 232(1):93-7. doi: 10.1016/j.jtbi.2004.07.022. [PMID: 15498596]
  • Xianghong Zhang, Junwei Yang, Yingjian Li, Youhua Liu. Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells. American journal of physiology. Renal physiology. 2005 Jan; 288(1):F16-26. doi: 10.1152/ajprenal.00318.2003. [PMID: 15339794]
  • Fumiaki Osaki, Yukio Ikeda, Tadashi Suehiro, Kikuko Ota, Sachie Tsuzura, Kaoru Arii, Yoshitaka Kumon, Kozo Hashimoto. Roles of Sp1 and protein kinase C in regulation of human serum paraoxonase 1 (PON1) gene transcription in HepG2 cells. Atherosclerosis. 2004 Oct; 176(2):279-87. doi: 10.1016/j.atherosclerosis.2004.05.029. [PMID: 15380450]
  • Y Saunders, J R Ross, K E Broadley, P M Edmonds, S Patel. Systematic review of bisphosphonates for hypercalcaemia of malignancy. Palliative medicine. 2004 Jul; 18(5):418-31. doi: 10.1191/0269216304pm914ra. [PMID: 15332420]
  • Khalequz Zaman, Lisa A Palmer, Allan Doctor, John F Hunt, Benjamin Gaston. Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1. The Biochemical journal. 2004 May; 380(Pt 1):67-74. doi: 10.1042/bj20031687. [PMID: 14766015]
  • J R Ross, Y Saunders, P M Edmonds, S Patel, D Wonderling, C Normand, K Broadley. A systematic review of the role of bisphosphonates in metastatic disease. Health technology assessment (Winchester, England). 2004; 8(4):1-176. doi: 10.3310/hta8040. [PMID: 14960258]
  • J L Elejalde. [Metabolic emergencies in the oncology patient]. Anales del sistema sanitario de Navarra. 2004; 27 Suppl 3(?):53-62. doi: . [PMID: 15723105]
  • Satoshi Akiba, Masahiro Chiba, Yuki Mukaida, Takashi Sato. Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL. Biochemical and biophysical research communications. 2003 Oct; 310(2):491-7. doi: 10.1016/j.bbrc.2003.09.042. [PMID: 14521937]
  • Jih-Jung Chen, Chang-Yih Duh, Hung-Yi Huang, Ih-Sheng Chen. Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia. Planta medica. 2003 Jun; 69(6):542-6. doi: 10.1055/s-2003-40637. [PMID: 12865974]
  • Songbai Zhang, Akihiro Mizutani, Chihiro Hisatsune, Takayasu Higo, Hiroko Bannai, Tomohiro Nakayama, Mitsuharu Hattori, Katsuhiko Mikoshiba. Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells. The Journal of biological chemistry. 2003 Feb; 278(6):4048-56. doi: 10.1074/jbc.m209960200. [PMID: 12444087]
  • Martin Pecherstorfer, Karin Brenner, Niklas Zojer. Current management strategies for hypercalcemia. Treatments in endocrinology. 2003; 2(4):273-92. doi: 10.2165/00024677-200302040-00005. [PMID: 15966562]
  • Xianghong Zhang, Yingjian Li, Chunsun Dai, Junwei Yang, Peter Mundel, Youhua Liu. Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney. American journal of physiology. Renal physiology. 2003 Jan; 284(1):F82-94. doi: 10.1152/ajprenal.00200.2002. [PMID: 12473536]
  • L K H Koh. The diagnosis and management of hypercalcaemia. Annals of the Academy of Medicine, Singapore. 2003 Jan; 32(1):129-39. doi: NULL. [PMID: 12625112]
  • Valérie Antonio, Arthur Brouillet, Brigitte Janvier, Claire Monne, Gilbert Bereziat, Marise Andreani, Michel Raymondjean. Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1beta in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-kappaB and Ets transcription factors. The Biochemical journal. 2002 Dec; 368(Pt 2):415-24. doi: 10.1042/bj20020658. [PMID: 12188923]
  • Inmaculada García-Ruiz, Paz de la Torre, Teresa Díaz, Elena Esteban, Inmaculada Fernández, Teresa Muñoz-Yagüe, José A Solís-Herruzo. Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells. The Journal of biological chemistry. 2002 Aug; 277(34):30551-8. doi: 10.1074/jbc.m203368200. [PMID: 12055194]
  • J Hurtado, P Esbrit. Treatment of malignant hypercalcaemia. Expert opinion on pharmacotherapy. 2002 May; 3(5):521-7. doi: 10.1517/14656566.3.5.521. [PMID: 11996631]
  • T G Davidson. Conventional treatment of hypercalcemia of malignancy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. 2001 Nov; 58 Suppl 3(?):S8-15. doi: 10.1093/ajhp/58.suppl_3.s8. [PMID: 11757206]
  • H Ihn, Y Ihn, M Trojanowska. Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression. The Journal of investigative dermatology. 2001 Aug; 117(2):301-8. doi: 10.1046/j.0022-202x.2001.01371.x. [PMID: 11511308]
  • N Zojer, A V Keck, M Pecherstorfer. Comparative tolerability of drug therapies for hypercalcaemia of malignancy. Drug safety. 1999 Nov; 21(5):389-406. doi: 10.2165/00002018-199921050-00004. [PMID: 10554053]
  • H Nakahama. [Nephrotoxicity of antineoplastic agents (antibiotics)]. Ryoikibetsu shokogun shirizu. 1997; ?(16 Pt 1):539-41. doi: NULL. [PMID: 9277810]
  • C Demicheli, A Garnier-Suillerot. Chirality of the interaction of mithramycin with phosphatidylcholine-bilayer membranes in the presence of Mg2+ or Zn2+. European journal of biochemistry. 1994 May; 221(3):1063-9. doi: 10.1111/j.1432-1033.1994.tb18825.x. [PMID: 8181463]
  • S H Ralston. Pathogenesis and management of cancer associated hypercalcaemia. Cancer surveys. 1994; 21(?):179-96. doi: NULL. [PMID: 8564993]
  • E A Masson, I A MacFarlane, C W Bodmer, E D Vaughan. Parathyroid carcinoma presenting with a brown tumour of the mandible in a young man. The British journal of oral & maxillofacial surgery. 1993 Apr; 31(2):117-9. doi: 10.1016/0266-4356(93)90174-u. [PMID: 8471574]
  • W Yamreudeewong, N E Henann, A Fazio, U Rangaraj. Possible severe thrombocytopenia associated with a single dose of plicamycin. The Annals of pharmacotherapy. 1992 Nov; 26(11):1369-73. doi: 10.1177/106002809202601105. [PMID: 1477439]
  • B Thürlimann, R Waldburger, H J Senn, D Thiébaud. Plicamycin and pamidronate in symptomatic tumor-related hypercalcemia: a prospective randomized crossover trial. Annals of oncology : official journal of the European Society for Medical Oncology. 1992 Sep; 3(8):619-23. doi: 10.1093/oxfordjournals.annonc.a058287. [PMID: 1450043]
  • K Fang, C A Koller, N Brown, W Covington, J R Lin, D H Ho. Determination of plicamycin in plasma by radioimmunoassay. Therapeutic drug monitoring. 1992 Jun; 14(3):255-60. doi: 10.1097/00007691-199206000-00013. [PMID: 1412612]
  • T J Rosol, D J Chew, C G Couto, R D Ayl, L A Nagode, C C Capen. Effects of mithramycin on calcium metabolism and bone in dogs. Veterinary pathology. 1992 May; 29(3):223-9. doi: 10.1177/030098589202900306. [PMID: 1535747]
  • J M Lehman, J Laffin, T D Friedrich. Flow cytometry of DNA increase after simian virus 40 infection of CV-1 cells. In vitro cellular & developmental biology : journal of the Tissue Culture Association. 1992 May; 28A(5):306-8. doi: NULL. [PMID: 1317836]
  • B Ostenstad, O K Andersen. Disodium pamidronate versus mithramycin in the management of tumour-associated hypercalcemia. Acta oncologica (Stockholm, Sweden). 1992; 31(8):861-4. doi: 10.3109/02841869209089719. [PMID: 1290634]
  • M A da Silva, J W Edmondson, C Eby, P J Loehrer. Humoral hypercalcemia in seminomas. Medical and pediatric oncology. 1992; 20(1):38-41. doi: 10.1002/mpo.2950200108. [PMID: 1370070]
  • N J Vogelzang. Nephrotoxicity from chemotherapy: prevention and management. Oncology (Williston Park, N.Y.). 1991 Oct; 5(10):97-102, 105; disc. 105, 109. doi: NULL. [PMID: 1838278]
  • J H Campbell, S Ralston, I T Boyle, S W Banham. Symptomatic hypercalcaemia in lung cancer. Respiratory medicine. 1991 May; 85(3):223-7. doi: 10.1016/s0954-6111(06)80084-3. [PMID: 1831917]
  • B Zerr, C Durand, A Ceccoli, J Fogliani. [Severe hypercalcemia after rhabdomyolysis and acute renal failure]. Annales francaises d'anesthesie et de reanimation. 1991; 10(5):482-5. doi: 10.1016/s0750-7658(05)80855-x. [PMID: 1836715]
  • S H Ralston, S J Gallacher, U Patel, J Campbell, I T Boyle. Cancer-associated hypercalcemia: morbidity and mortality. Clinical experience in 126 treated patients. Annals of internal medicine. 1990 Apr; 112(7):499-504. doi: 10.7326/0003-4819-112-7-499. [PMID: 2138442]
  • D W Galbraith. Flow cytometric analysis of plant genomes. Methods in cell biology. 1990; 33(?):549-62. doi: 10.1016/s0091-679x(08)60553-1. [PMID: 2150685]
  • Y Watanabe, Y Ogino, E Ubukata, Y Sakamoto, O Matsuzaki, N Shimizu. A case of a gallbladder cancer with marked hypercalcemia and leukocytosis. Japanese journal of medicine. 1989 Nov; 28(6):722-6. doi: 10.2169/internalmedicine1962.28.722. [PMID: 2534486]
  • G F Pieters, M J Mol, A M Boerbooms, H H de Boer, A G Smals, P W Kloppenborg. Pseudogout attacks after successful treatment of hyperparathyroidism. The Netherlands journal of medicine. 1989 Jun; 34(5-6):258-63. doi: NULL. [PMID: 2528078]
  • R A Tobey, N Oishi, H A Crissman. Synchronized human diploid fibroblasts: progression capabilities of a subpopulation that fails to keep pace with the predominant, rapidly dividing cohort of cells. Journal of cellular physiology. 1989 May; 139(2):432-40. doi: 10.1002/jcp.1041390228. [PMID: 2523893]
  • S A Chasan, L R Pothel, R P Huben. Management and prognostic significance of hypercalcemia in renal cell carcinoma. Urology. 1989 Mar; 33(3):167-70. doi: 10.1016/0090-4295(89)90383-x. [PMID: 2521966]
  • R A Schaiff, T G Hall, R S Bar. Medical treatment of hypercalcemia. Clinical pharmacy. 1989 Feb; 8(2):108-21. doi: . [PMID: 2521820]
  • C H Evans, P D Baker. Tumor-inhibitory antibiotic uptake facilitated by leukoregulin: a new approach to drug delivery. Journal of the National Cancer Institute. 1988 Aug; 80(11):861-4. doi: 10.1093/jnci/80.11.861. [PMID: 2969053]