NCBI Taxonomy: 66869
Streptomyces atroolivaceus (ncbi_taxid: 66869)
found 99 associated metabolites at species taxonomy rank level.
Ancestor: Streptomyces atroolivaceus subgroup
Child Taxonomies: none taxonomy data.
Tryptophol
Tryptophol, also known as indole-3-ethanol, is an indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2. It has a role as a Saccharomyces cerevisiae metabolite, an auxin and a plant metabolite. Tryptophol is a catabolite of tryptophan converted by the gut microbiota. After absorption through the intestinal epithelium, tryptophan catabolites enter the bloodstream and are later excreted in the urine (PMID:30120222). Tryptophol production was negatively associated with interferon-gamma production (IFNγ) which suggests that tryptophol has anti-inflammatory properties (PMID:27814509). Tryptophol has also been identified as the hypnotic agent in trypanosomal sleeping sickness, and because it is formed in vivo after ethanol or disulfiram treatment, it is also associated with the study of alcoholism (PMID:7241135). Indole-3-ethanol is a dietary indole present in cruciferous vegetables that has been shown to influence estradiol metabolism in humans and may provide a new chemopreventive approach to estrogen-dependent diseases. (PMID 2342128) Tryptophol. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=526-55-6 (retrieved 2024-06-29) (CAS RN: 526-55-6). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0). Tryptophol (Indole-3-ethanol) is an endogenous metabolite. Tryptophol (Indole-3-ethanol) is an endogenous metabolite.
Plicamycin
Plicamycin is only found in individuals that have used or taken this drug. It is an antineoplastic antibiotic produced by Streptomyces plicatus. It has been used in the treatment of testicular cancer, Pagets disease of bone, and, rarely, the management of hypercalcemia. The manufacturer discontinued plicamycin in 2000. Plicamycin is presumed to inhibit cellular and enzymic RNA synthesis by forming a complex with DNA. Plicamycin may also lower calcium serum levels by inhibiting the effect of parathyroid hormone upon osteoclasts or by blocking the hypercalcemic action of pharmacologic doses of vitamin D. L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors D004396 - Coloring Agents > D005456 - Fluorescent Dyes D000077264 - Calcium-Regulating Hormones and Agents D000970 - Antineoplastic Agents Same as: D00468
Leinamycin
C22H26N2O6S3 (510.09529360000005)
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
Tryptophol
An indolyl alcohol that is ethanol substituted by a 1H-indol-3-yl group at position 2. Tryptophol (Indole-3-ethanol) is an endogenous metabolite. Tryptophol (Indole-3-ethanol) is an endogenous metabolite.
Plicamycin
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D049408 - Luminescent Agents C78281 - Agent Affecting Musculoskeletal System > C67439 - Bone Resorption Inhibitor D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors D004396 - Coloring Agents > D005456 - Fluorescent Dyes D000077264 - Calcium-Regulating Hormones and Agents D000970 - Antineoplastic Agents Same as: D00468
4-({18-[(2-{[2-({2-[(2-{[2-({2-[(1,2-dihydroxy-2-methyl-4-oxopentylidene)amino]-3-methyl-1-sulfanylbutylidene}amino)-4-(methylsulfanyl)-1-sulfanylbutylidene]amino}-1-sulfanylpropylidene)amino]-1-sulfanylpropylidene}amino)-1-sulfanylpropylidene]amino}-1-hydroxypropylidene)amino]-5,8,11,14,17-pentahydroxy-12-methyl-9-(2-methylpropyl)-15-(sec-butyl)-1-thia-4,7,10,13,16-pentaazacyclononadeca-2,4,7,10,13,16-hexaen-6-yl}(hydroxy)methyl)-1,3-dimethylimidazol-1-ium
[C56H93N14O10S7]+ (1345.5243778)
(9z,13z,15z)-3',4,11-trihydroxy-2,3',9-trimethyl-4',12-dioxo-19-thia-3,20-diazaspiro[bicyclo[15.2.1]icosane-6,2'-[1,5]dithiolane]-1(20),3,9,13,15,17-hexaen-1'-ium-1'-olate
C22H26N2O6S3 (510.09529360000005)
n-[(1r)-1-{4-[(1z,3e)-6-[(1r,2s)-2-hydroxy-2-methyl-5-oxocyclohexyl]-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl]ethanimidic acid
C20H26N2O4S (390.16131960000007)
n-[(1r)-1-{4-[(1z,3e)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl]ethanimidic acid
(2s)-3-[(1s,3s,4r)-3,4-dihydroxy-1-methoxy-2-oxopentyl]-2-{[(2s,4r,5r,6r)-4-{[(2s,4r,5s,6r)-4-{[(2s,4s,5r,6r)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-6-{[(2s,4r,5r,6r)-4-{[(2s,4r,5s,6r)-4,5-dihydroxy-6-methyloxan-2-yl]oxy}-5-hydroxy-6-methyloxan-2-yl]oxy}-8,9-dihydroxy-7-methyl-3,4-dihydro-2h-anthracen-1-one
n-(1-{4-[6-(2,5-dihydroxy-2-methylcyclohexyl)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl)ethanimidic acid
C20H28N2O4S (392.17696880000005)
n-(1-{4-[(3e)-6-(2-hydroxy-2-methyl-5-oxocyclohexyl)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl)ethanimidic acid
C20H26N2O4S (390.16131960000007)
n-[(1r)-1-{4-[(1e,3e)-6-[(1r,2s,5s)-2,5-dihydroxy-2-methylcyclohexyl]-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl]ethanimidic acid
C20H28N2O4S (392.17696880000005)
n-(1-{4-[6-(2-hydroxy-2-methyl-5-oxocyclohexyl)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl)ethanimidic acid
C20H26N2O4S (390.16131960000007)
4-{[(2z)-18-[(2-{[2-({2-[(2-{[2-({2-[(1,2-dihydroxy-2-methyl-4-oxopentylidene)amino]-3-methyl-1-sulfanylbutylidene}amino)-4-(methylsulfanyl)-1-sulfanylbutylidene]amino}-1-sulfanylpropylidene)amino]-1-sulfanylpropylidene}amino)-1-sulfanylpropylidene]amino}-1-hydroxypropylidene)amino]-5,8,11,14,17-pentahydroxy-12-methyl-9-(2-methylpropyl)-15-(sec-butyl)-1-thia-4,7,10,13,16-pentaazacyclononadeca-2,4,7,10,13,16-hexaen-6-yl](hydroxy)methyl}-1,3-dimethylimidazol-1-ium
[C56H93N14O10S7]+ (1345.5243778)
n-{1-[4-(5-oxohexa-1,3-dien-1-yl)-1,3-thiazol-2-yl]ethyl}ethanimidic acid
(2r,3'r,6r,9e,11r,13e,15z)-3',4,11-trihydroxy-2,3',9-trimethyl-4',12-dioxo-19-thia-3,20-diazaspiro[bicyclo[15.2.1]icosane-6,2'-[1,5]dithiolane]-1(20),3,9,13,15,17-hexaen-1'-ium-1'-olate
C22H26N2O6S3 (510.09529360000005)
(2r,3'r,6r,9z,11r,13z,15e)-3',4,11-trihydroxy-2,3',9-trimethyl-4',12-dioxo-19-thia-3,20-diazaspiro[bicyclo[15.2.1]icosane-6,2'-[1,5]dithiolane]-1(20),3,9,13,15,17-hexaen-1'-ium-1'-olate
C22H26N2O6S3 (510.09529360000005)
n-[(1r)-1-{4-[(1z,3e)-6-[(1r,2s,5s)-2,5-dihydroxy-2-methylcyclohexyl]-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl]ethanimidic acid
C20H28N2O4S (392.17696880000005)
n-[(1r)-1-{4-[(1e,3e)-6-[(1r,2s)-2-hydroxy-2-methyl-5-oxocyclohexyl]-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl]ethanimidic acid
C20H26N2O4S (390.16131960000007)
n-(1-{4-[(3e)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl)ethanimidic acid
n-[(1r)-1-{4-[(1e,3e)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl]ethanimidic acid
n-(1-{4-[(3e)-6-(2,5-dihydroxy-2-methylcyclohexyl)-5-oxohexa-1,3-dien-1-yl]-1,3-thiazol-2-yl}ethyl)ethanimidic acid
C20H28N2O4S (392.17696880000005)