Jatrorrhizine (BioDeep_00000000088)
Secondary id: BioDeep_00000859955
PANOMIX_OTCML-2023
代谢物信息卡片
2,9,10-Trimethoxy-5,6-dihydro-7lambda~5~-isoquino[3,2-a]isoquinolin-3-ol hydrochloride
化学式: C20H20NO4+ (338.1392)
中文名称: 药根碱
谱图信息:
最多检出来源 Viridiplantae(otcml) 75.95%
分子结构信息
SMILES: COC1=C(C2=C[N+]3=C(C=C2C=C1)C4=CC(=C(C=C4CC3)O)OC)OC
InChI: InChI=1S/C20H19NO4/c1-23-18-5-4-12-8-16-14-10-19(24-2)17(22)9-13(14)6-7-21(16)11-15(12)20(18)25-3/h4-5,8-11H,6-7H2,1-3H3/p+1
描述信息
Jatrorrhizine is an alkaloid.
同义名列表
31 个代谢物同义名
2,9,10-Trimethoxy-5,6-dihydro-7lambda~5~-isoquino[3,2-a]isoquinolin-3-ol hydrochloride; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino-[3,2-a]isoquinolin-7-ium; 3-Hydroxy-2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium; 2,9,10-trimethoxy-5,6-dihydroisoquinolino[2,1-b]isoquinolin-7-ium-3-ol; 2,9,10-trimethoxy-5,6-dihydroisoquinolino[3,2-a]isoquinolin-7-ium-3-ol; Berbinium, 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxy- (8CI); Dibenzo[a,g]quinolizinium, 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-; 5,6-dihydro-3-hydroxy-2,9,10-trimethoxy-dibenzo[a,g]quinolizinium; 5,6-DIHYDRO-3-HYDROXY-2,9,10-TRIMETHOXYDIBENZO(A,G)QUINOLIZINIUM; 5,6-Dihydro-3-hydroxy-2,9,10-trimethoxydibenzo[a,g]quinolizinium; 7,8,13,13|A-Tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium; 7,8,13,13a-tetradehydro-3-hydroxy-2,9,10-trimethoxyberbinium; 7,8,13,13a-tetrahydro-3-hydroxy-2,9,10-trimethoxyberbinium; 4-trans-n-Pentylcyclohexyl-4-ethylbiphenyl; MXTLAHSTUOXGQF-UHFFFAOYSA-O; Jatrorrhizine (Neprotine); jatrorrhizine chloride; Dehydrocorypalmine; JATRORRHIZINE [MI]; jateorrhizine; Jatrorrhizine; MEGxp0_001765; Jateorhizine; NCI60_042074; Jatrorhizine; Jatrochizine; Yatrorizine; Neprotine; 1ST40301; neprotin; Jatrorrhizine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:6087
- KEGG: C09553
- PubChem: 72323
- ChEMBL: CHEMBL251055
- Wikipedia: Jatrorrhizine
- MeSH: jatrorrhizine
- ChemIDplus: 0003621383
- chemspider: 65269
- CAS: 3621-38-3
- medchemexpress: HY-N0749
- MetaboLights: MTBLC6087
- PubChem: 11744
- KNApSAcK: C00001874
- 3DMET: B03074
- NIKKAJI: J37.067C
- KNApSAcK: 6087
分类词条
相关代谢途径
Reactome(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 33090 - 青牛胆: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lingyu Huang, Yu Sha, Wenken Liang, Chune Mo, Chunhong Li, Yecheng Deng, Weiwei Gong, Xianliang Hou, Minglin Ou. High-throughput sequencing reveals Jatrorrhizine inhibits colorectal cancer growth by ferroptosis-related genes.
BMC medical genomics.
2023 Sep; 16(1):217. doi:
10.1186/s12920-023-01619-3. [PMID: 37710311] - Tianying Hong, Xianmei Pan, Han Xu, Zhijuan Zheng, Lizhen Wen, Jing Li, Mingfeng Xia. Jatrorrhizine inhibits Piezo1 activation and reduces vascular inflammation in endothelial cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Apr; 163(?):114755. doi:
10.1016/j.biopha.2023.114755. [PMID: 37105072] - Huan He, Jianling Deng, Maochun Yang, Linjing An, Xiaoli Ye, Xuegang Li. Jatrorrhizine from Rhizoma Coptidis exerts an anti-obesity effect in db/db mice.
Journal of ethnopharmacology.
2022 Nov; 298(?):115529. doi:
10.1016/j.jep.2022.115529. [PMID: 35835345] - Yan Zhou, Yuehan Wang, Chi Teng Vong, Yanyan Zhu, Baojun Xu, Cheng-Chao Ruan, Yitao Wang, Wai San Cheang. Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress.
International journal of molecular sciences.
2022 Oct; 23(20):. doi:
10.3390/ijms232012064. [PMID: 36292919] - Janiqua Rolle, Dorothy O Asante, Linsey L Kok-Fong, Hamza Boucetta, Theodora A Seidu, Lesieli L K Tai, Raphael N Alolga. Jatrorrhizine: a review of its pharmacological effects.
The Journal of pharmacy and pharmacology.
2021 Apr; 73(6):709-719. doi:
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European journal of medicinal chemistry.
2021 Mar; 214(?):113254. doi:
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2021 Jan; 890(?):173688. doi:
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Biomedical chromatography : BMC.
2020 Jun; 34(6):e4824. doi:
10.1002/bmc.4824. [PMID: 32154596] - Guanji Wu, Ting Mu, Lihong Zhang, Xiaolin Chen. Jatrorrhizine Hydrochloride alleviates tert-butyl hydroperoxide-induced endothelial cell injury through its anti-inflammatory activity and PPAR-γ activation.
Cellular and molecular biology (Noisy-le-Grand, France).
2020 May; 66(2):125-129. doi:
10.14715/cmb/2020.66.2.20. [PMID: 32415938] - Rui-Feng Liang, Wen-Jing Ge, Xian-Mei Song, Jun-Ping Zhang, Wei-Feng Cui, She-Feng Zhang, Geng-Sheng Li. Involvement of organic anion-transporting polypeptides and organic cation transporter in the hepatic uptake of jatrorrhizine.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Apr; 50(4):479-487. doi:
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Scientific reports.
2019 12; 9(1):19575. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
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Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):152-157. doi:
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Journal of pharmaceutical and biomedical analysis.
2018 May; 153(?):9-15. doi:
10.1016/j.jpba.2018.02.016. [PMID: 29459236] - Shui-Lan Zhu, Ting Lei, Xu Gao, Jun Tu. [Jatrorrhizine regulates GLUTs with multiple manners for hypoglycemic effect in insulin-resistance 3T3-L1 adipocytes].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2018 Mar; 43(6):1215-1220. doi:
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Scientific reports.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Jul; 42(14):2773-2778. doi:
10.19540/j.cnki.cjcmm.20170523.002. [PMID: 29098836] - Tao Luo, Xiu-Yin Shen, Sheng Li, Ting Ouyang, Quan-An Mai, Hua-Qiao Wang. The Protective Effect of Jatrorrhizine Against Oxidative Stress in Primary Rat Cortical Neurons.
CNS & neurological disorders drug targets.
2017; 16(5):617-623. doi:
10.2174/1871527315666160711101210. [PMID: 27401065] - Weiwei Yang, Liping She, Kun Yu, Shan Yan, Xuefeng Zhang, Xiaoyi Tian, Shuren Ma, Xiwen Zhang. Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model.
Molecular medicine reports.
2016 Oct; 14(4):3277-84. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
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Scientific reports.
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Phytomedicine : international journal of phytotherapy and phytopharmacology.
2014 Sep; 21(11):1373-81. doi:
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Talanta.
2014 Aug; 126(?):38-45. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Jan; 118(?):48-54. doi:
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Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Jan; 117(?):163-9. doi:
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Molecular biology reports.
2013 Jul; 40(7):4397-404. doi:
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Biopharmaceutics & drug disposition.
2013 Apr; 34(3):176-85. doi:
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Journal of pharmaceutical sciences.
2013 Apr; 102(4):1333-42. doi:
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2013 Jan; 72(?):80-8. doi:
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PloS one.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Oct; 906(?):41-7. doi:
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Biopharmaceutics & drug disposition.
2012 Apr; 33(3):135-45. doi:
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The Journal of pharmacy and pharmacology.
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Talanta.
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Neuroscience letters.
2011 Jul; 498(3):227-31. doi:
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Biomedical chromatography : BMC.
2011 Jul; 25(7):816-26. doi:
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Evidence-based complementary and alternative medicine : eCAM.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Dec; 35(24):3362-7. doi:
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Journal of pharmaceutical and biomedical analysis.
2010 Nov; 53(3):591-8. doi:
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Planta medica.
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Journal of separation science.
2010 Nov; 33(21):3347-53. doi:
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Journal of occupational medicine and toxicology (London, England).
2010 Oct; 5(?):29. doi:
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Journal of separation science.
2010 Sep; 33(17-18):2714-22. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Aug; 35(16):2061-4. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2010 Aug; 35(15):2017-20. doi:
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Chinese medicine.
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Planta medica.
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Journal of ethnopharmacology.
2010 May; 129(1):121-6. doi:
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Se pu = Chinese journal of chromatography.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
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Chinese medicine.
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Pharmaceutical biology.
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
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Frontiers in physiology.
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Journal of ethnopharmacology.
2009 Sep; 125(2):297-303. doi:
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Phytochemical analysis : PCA.
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Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2009 Sep; 7(9):831-5. doi:
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Journal of pharmaceutical and biomedical analysis.
2009 Jul; 49(5):1272-6. doi:
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Cell biochemistry and function.
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Journal of pharmaceutical and biomedical analysis.
2009 May; 49(4):1101-8. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 May; 34(10):1276-80. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2009 Feb; 34(3):344-8. doi:
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Electrophoresis.
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Journal of ethnobiology and ethnomedicine.
2009 Jan; 5(?):2. doi:
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Biomedical chromatography : BMC.
2008 Dec; 22(12):1360-7. doi:
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Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
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Journal of natural products.
2008 Aug; 71(8):1376-85. doi:
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Ying yong sheng tai xue bao = The journal of applied ecology.
2008 Jul; 19(7):1455-61. doi:
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Analytica chimica acta.
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Yao xue xue bao = Acta pharmaceutica Sinica.
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