skrofulein (BioDeep_00000865640)

Main id: BioDeep_00000000971

 

PANOMIX_OTCML-2023


代谢物信息卡片


4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-

化学式: C17H14O6 (314.079)
中文名称: 蓟黄素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C(=C2C(=C1)OC(=CC2=O)C3=CC=C(C=C3)O)O)OC
InChI: InChI=1S/C17H14O6/c1-21-14-8-13-15(16(20)17(14)22-2)11(19)7-12(23-13)9-3-5-10(18)6-4-9/h3-8,18,20H,1-2H3

描述信息

同义名列表

17 个代谢物同义名

4H-1-Benzopyran-4-one, 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-; 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-chromen-4-one; 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-4-chromenone; 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxychromen-4-one; 5-hydroxy-2-(4-hydroxyphenyl)-6,7-dimethoxy-chromone; Flavone, 4,5-dihydroxy-6,7-dimethoxy-; 4,5-dihydroxy-6,7-dimethoxyflavone; MEGxp0_000498; Cirsimaritin; SMR000440660; MLS000876998; ACon1_000850; ZINC01081537; Scrophulein; skrofulein; 6601-62-3; 7-Methylcapillarisin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

122 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ANXA5, BCL2, CASP3, CASP7, CASP8, CASP9, MAPK14, PRKAA2, PTGS2, SLC2A2, TP53, TYR
Peripheral membrane protein 3 ANXA5, GORASP1, PTGS2
Endoplasmic reticulum membrane 2 BCL2, PTGS2
Nucleus 8 BCL2, CASP3, CASP7, CASP8, CASP9, MAPK14, PRKAA2, TP53
cytosol 11 ANXA5, BCL2, CASP3, CASP7, CASP8, CASP9, GPT, MAPK14, PRKAA2, SLC2A4, TP53
dendrite 1 PRKAA2
trans-Golgi network 1 SLC2A4
centrosome 1 TP53
nucleoplasm 6 CASP3, CASP7, CASP8, MAPK14, PRKAA2, TP53
Cell membrane 3 SLC2A2, SLC2A4, TNF
Cytoplasmic side 1 GORASP1
lamellipodium 1 CASP8
Multi-pass membrane protein 2 SLC2A2, SLC2A4
Golgi apparatus membrane 1 GORASP1
cell surface 1 TNF
glutamatergic synapse 2 CASP3, MAPK14
Golgi apparatus 2 GORASP1, PRKAA2
Golgi membrane 2 GORASP1, INS
neuronal cell body 3 CASP3, PRKAA2, TNF
sarcolemma 2 ANXA5, SLC2A4
Cytoplasm, cytosol 1 CASP7
Lysosome 1 TYR
Presynapse 1 SLC2A4
plasma membrane 3 SLC2A2, SLC2A4, TNF
Membrane 6 ANXA5, BCL2, PRKAA2, SLC2A2, SLC2A4, TP53
apical plasma membrane 1 SLC2A2
axon 1 PRKAA2
brush border 1 SLC2A2
caveola 1 PTGS2
extracellular exosome 3 ANXA5, GPT, SLC2A4
endoplasmic reticulum 3 BCL2, PTGS2, TP53
extracellular space 6 CASP7, IL10, IL17A, IL6, INS, TNF
perinuclear region of cytoplasm 2 SLC2A4, TYR
mitochondrion 5 BCL2, CASP8, CASP9, MAPK14, TP53
protein-containing complex 5 BCL2, CASP8, CASP9, PTGS2, TP53
intracellular membrane-bounded organelle 1 TYR
Microsome membrane 1 PTGS2
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TYR
Secreted 4 IL10, IL17A, IL6, INS
extracellular region 7 ANXA5, IL10, IL17A, IL6, INS, MAPK14, TNF
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 4 ANXA5, IL17A, SLC2A4, TNF
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
nucleolus 1 TP53
Melanosome membrane 1 TYR
cell-cell junction 1 SLC2A2
clathrin-coated pit 1 SLC2A4
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cell projection, lamellipodium 1 CASP8
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 2 SLC2A4, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
focal adhesion 1 ANXA5
cis-Golgi network 1 GORASP1
sarcoplasmic reticulum 1 SLC2A4
Nucleus, PML body 1 TP53
PML body 1 TP53
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 2 MAPK14, PRKAA2
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 ANXA5
neuron projection 1 PTGS2
chromatin 1 TP53
phagocytic cup 1 TNF
cytoskeleton 1 CASP8
Secreted, extracellular space 1 CASP7
spindle pole 1 MAPK14
site of double-strand break 1 TP53
Endomembrane system 1 SLC2A4
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 SLC2A4
Melanosome 1 TYR
cytoplasmic stress granule 1 PRKAA2
cell body 1 CASP8
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 2 INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
apoptosome 1 CASP9
vesicle membrane 2 ANXA5, SLC2A4
[Isoform 1]: Nucleus 1 TP53
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
nucleotide-activated protein kinase complex 1 PRKAA2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
insulin-responsive compartment 1 SLC2A4
caspase complex 1 CASP9
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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  • Xiaopu Ren, Yingjie Bao, Yuxia Zhu, Shixin Liu, Zengqi Peng, Yawei Zhang, Guanghong Zhou. Isorhamnetin, Hispidulin, and Cirsimaritin Identified in Tamarix ramosissima Barks from Southern Xinjiang and Their Antioxidant and Antimicrobial Activities. Molecules (Basel, Switzerland). 2019 Jan; 24(3):. doi: 10.3390/molecules24030390. [PMID: 30678248]
  • Haiyan Yan, Huiqiang Wang, Linlin Ma, Xueping Ma, Jinqiu Yin, Shuo Wu, Hua Huang, Yuhuan Li. Cirsimaritin inhibits influenza A virus replication by downregulating the NF-κB signal transduction pathway. Virology journal. 2018 05; 15(1):88. doi: 10.1186/s12985-018-0995-6. [PMID: 29783993]
  • Jun Yeon Park, Hyun Young Kim, Takayuki Shibamoto, Tae Su Jang, Sang Cheon Lee, Jae Suk Shim, Dae-Hyun Hahm, Hae-Jeung Lee, Sanghyun Lee, Ki Sung Kang. Beneficial effects of a medicinal herb, Cirsium japonicum var. maackii, extract and its major component, cirsimaritin on breast cancer metastasis in MDA-MB-231 breast cancer cells. Bioorganic & medicinal chemistry letters. 2017 09; 27(17):3968-3973. doi: 10.1016/j.bmcl.2017.07.070. [PMID: 28784292]
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