Hyndarin (BioDeep_00000862849)

Main id: BioDeep_00000000145

 

PANOMIX_OTCML-2023


代谢物信息卡片


InChI=1\C21H25NO4\c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4\h5-6,10-11,17H,7-9,12H2,1-4H3\t17-\m0\s

化学式: C21H25NO4 (355.178349)
中文名称: L-四氢巴马汀
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC1=C(C2=C(CC3C4=CC(=C(C=C4CCN3C2)OC)OC)C=C1)OC
InChI: InChI=1S/C21H25NO4/c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4/h5-6,10-11,17H,7-9,12H2,1-4H3/t17-/m0/s1

描述信息

D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.
Rotundine is an antagonist of dopamine D1, D2 and D3 receptors with IC50s of 166 nM, 1.4 μM and 3.3 μM, respectively. Rotundine is also an antagonist of 5-HT1A with an IC50 of 370 nM.

同义名列表

32 个代谢物同义名

InChI=1\C21H25NO4\c1-23-18-6-5-13-9-17-15-11-20(25-3)19(24-2)10-14(15)7-8-22(17)12-16(13)21(18)26-4\h5-6,10-11,17H,7-9,12H2,1-4H3\t17-\m0\s; (13aS)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline; 6H-dibenzo[a,g]quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (13aS)-; (13aS)-2,3,9,10-tetramethoxy-5,8,13,13a-tetrahydro-6H-isoquino[3,2-a]isoquinoline; 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-, (S)-; 2-(2,3-Dimethoxy-benzyl)-1-ethyl-6,7-dimethoxy-1,2,3,4-tetrahydro-isoquinoline; (S)-5,8,13,13a-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizine; 5,8,13,13a(S)-Tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo[a,g]quinolizine; 6H-Dibenzo(a,g)quinolizine, 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-; 5,8,13,13a-tetrahydro-2,3,9,10-tetramethoxy-6H-dibenzo(a,g)quinolizine; 13a-alpha-Berbine, 2,3,9,10-tetramethoxy-; Berbine, 2,3,9,10-tetramethoxy- (8CI); Tetrahydropalmatine (6CI); (-)-Tetrahydropalmatine; (S)-Tetrahydropalmatine; l-Tetrahydropalmatine; Tetrahydropalmatine; 4880-82-4 (HCL); NSC36363 (HCL); (-)-Corydalis; CHEBI:16563; AIDS-002241; AIDS002241; BB_NC-1018; Gindarine; Hyndarine; Caseanine; rotundine; 483-14-7; Hyndarin; 84-38-8; C02890



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Song Chen, Cai-Bo Tian, Li-Yu Bai, Xing-Chao He, Qing-Yu Lu, Yun-Li Zhao, Xiao-Dong Luo. Thrombosis inhibited by Corydalis decumbens through regulating PI3K-Akt pathway. Journal of ethnopharmacology. 2024 Jul; 329(?):118177. doi: 10.1016/j.jep.2024.118177. [PMID: 38604510]
  • Jialong Yang, Jiapeng Deng, Kaitao Wang, An Wang, Guodong Chen, Qingyu Chen, Minle Ye, Xinyu Wu, Xinye Wang, Dingsheng Lin. Tetrahydropalmatine promotes random skin flap survival in rats via the PI3K/AKT signaling pathway. Journal of ethnopharmacology. 2024 Jan; 324(?):117808. doi: 10.1016/j.jep.2024.117808. [PMID: 38280663]
  • Xiao Zhao, Yuan Pan, Jun Tan, Hui Lv, Yu Wang, Da-Xia Chen. Metabolomics and transcriptomics reveal the mechanism of alkaloid synthesis in Corydalis yanhusuo bulbs. PloS one. 2024; 19(5):e0304258. doi: 10.1371/journal.pone.0304258. [PMID: 38781178]
  • Po-Li Lin, Jun-Ling Cao, Ping Ren, Jia-Li Chen, Bo-Ya Cao, Ping He, Chang-Hui Zheng, Qi-Wen Li, Wei Wang, Jian Zhang. Network Pharmacology and Experimental Validation to Explore Mechanism of Tetrahydropalmatine on Acute Myocardial Ischemia. Chinese journal of integrative medicine. 2023 Aug; ?(?):. doi: 10.1007/s11655-023-3644-x. [PMID: 37606869]
  • Xunzhe Yin, Zuojia Liu, Jin Wang. Tetrahydropalmatine ameliorates hepatic steatosis in nonalcoholic fatty liver disease by switching lipid metabolism via AMPK-SREBP-1c-Sirt1 signaling axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2023 Aug; 119(?):155005. doi: 10.1016/j.phymed.2023.155005. [PMID: 37562090]
  • Xue-Shan Dai, Qing-Hua Wei, Xin Guo, Yi Ding, Xiao-Qian Yang, Yu-Xin Zhang, Xiao-Yu Xu, Cong Li, Yi Chen. Ferulic acid, ligustrazine, and tetrahydropalmatine display the anti-proliferative effect in endometriosis through regulating Notch pathway. Life sciences. 2023 Jul; 328(?):121921. doi: 10.1016/j.lfs.2023.121921. [PMID: 37429417]
  • Guizhen Zhang, Xuejian Li, Chunyun Huang, Yuanyuan Jiang, Jian Su, Ying Hu. Preparation of the Levo-Tetrahydropalmatine Liposome Gel and Its Transdermal Study. International journal of nanomedicine. 2023; 18(?):4617-4632. doi: 10.2147/ijn.s422305. [PMID: 37600118]
  • Lian-Zhi Cheng, Jia-Mei Zhou, Jun-Long Ma, Fan-Jing Wang, Kai Cheng, Qian Chen, Hui-Lun Yuan, Ai-Juan Jiang. [Tetrahydropalmatine alleviated diabetic neuropathic pain by inhibiting activation of microglia via p38 MAPK signaling pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 May; 47(9):2533-2540. doi: 10.19540/j.cnki.cjcmm.20220119.702. [PMID: 35531701]
  • Bing-Jing Han, Gui-Yun Cao, Li-Ying Jia, Guo Zheng, Liang Zhang, Ping Sheng, Ji-Zhen Xie, Chun-Feng Zhang. Cardioprotective Effects of Tetrahydropalmatine on Acute Myocardial Infarction in Rats. The American journal of Chinese medicine. 2022; 50(7):1887-1904. doi: 10.1142/s0192415x2250080x. [PMID: 36056468]
  • Yan Gou, Zhao Geng, Lian Zhong, Jinchao Wei, Juanru Liu, Xiaohong Deng, Min Li, Jun Yuan, Yitao Wang, Li Guo. A new strategy for quality evaluation and control of Chinese patent medicine based on chiral isomer ratio analysis: With Yuanhuzhitong tablet as an example. Biomedical chromatography : BMC. 2021 Dec; 35(12):e5211. doi: 10.1002/bmc.5211. [PMID: 34216391]
  • Yijia Xu, Jianfang Sun, Wenwen Li, Suli Zhang, Liying Yang, Ying Teng, Kaikai Lv, Yanfeng Liu, Yang Su, Jinghai Zhang, Mingyi Zhao. Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels. Journal of ethnopharmacology. 2021 Nov; 280(?):114457. doi: 10.1016/j.jep.2021.114457. [PMID: 34329712]
  • Yifan Wang, Wen Zhu, Dandan Lu, Chuzhao Zhang, Yue Wang. Tetrahydropalmatine attenuates MSU crystal-induced gouty arthritis by inhibiting ROS-mediated NLRP3 inflammasome activation. International immunopharmacology. 2021 Nov; 100(?):108107. doi: 10.1016/j.intimp.2021.108107. [PMID: 34482265]
  • Xiaohui Zhang, Yule Wang, Kai Zhang, Hongda Sheng, Yuhan Wu, Huimin Wu, Yingchao Wang, Jianli Guan, Qingfen Meng, Huahuan Li, Zhenhao Li, Guanwei Fan, Yi Wang. Discovery of tetrahydropalmatine and protopine regulate the expression of dopamine receptor D2 to alleviate migraine from Yuanhu Zhitong formula. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Oct; 91(?):153702. doi: 10.1016/j.phymed.2021.153702. [PMID: 34419734]
  • Lian Liu, Ming Liu, Wei Zhao, Yuan-Ling Zhao, Yun Wang. Levo-tetrahydropalmatine: A new potential medication for methamphetamine addiction and neurotoxicity. Experimental neurology. 2021 10; 344(?):113809. doi: 10.1016/j.expneurol.2021.113809. [PMID: 34256045]
  • Jinhua Li, Ziqi Yan, Hongmei Li, Qiong Shi, Vidhula Ahire, Shenqiu Zhang, Naganna Nimishetti, Dun Yang, Thaddeus D Allen, Jing Zhang. The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects. Journal of natural products. 2021 08; 84(8):2312-2320. doi: 10.1021/acs.jnatprod.1c00429. [PMID: 34406008]
  • Yaodong Yi, Liping Li, Feifeng Song, Ping Li, Mingyang Chen, Shixin Ni, Hengbin Zhang, Hui Zhou, Su Zeng, Huidi Jiang. L-tetrahydropalmatine reduces oxaliplatin accumulation in the dorsal root ganglion and mitochondria through selectively inhibiting the transporter-mediated uptake thereby attenuates peripheral neurotoxicity. Toxicology. 2021 07; 459(?):152853. doi: 10.1016/j.tox.2021.152853. [PMID: 34252480]
  • Herong Cui, Xuexin Yang, Zhidong Wang, Guoping Li, Lei Li, Su Huo, Beibei Zhang, Rui He, Kedian Chen, Bing Xu, Penglong Wang, Haimin Lei. Tetrahydropalmatine triggers angiogenesis via regulation of arginine biosynthesis. Pharmacological research. 2021 01; 163(?):105242. doi: 10.1016/j.phrs.2020.105242. [PMID: 33075491]
  • Chengling Zhang, Ying Zhang, Haiying Pan, Yi Tan, Qinghua Wei, Xueshan Dai, Jiahui Wei, Yi Chen. Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation via Wnt/β-catenin Pathway in Endometriosis. International journal of biological sciences. 2021; 17(10):2449-2460. doi: 10.7150/ijbs.60167. [PMID: 34326686]
  • Changqiong Xu, Ran Li, Jie Wu. Effects of Yuanhu- Zhitong tablets on alcohol-induced conditioned place preference in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Jan; 133(?):110962. doi: 10.1016/j.biopha.2020.110962. [PMID: 33166765]
  • Soyon Ahn, Maya O Nesbit, Haiyan Zou, Giada Vacca, Peter Axerio-Cilies, Tran Van Sung, Anthony G Phillips. Neural bases for attenuation of morphine withdrawal by Heantos-4: role of l-tetrahydropalmatine. Scientific reports. 2020 12; 10(1):21275. doi: 10.1038/s41598-020-78083-x. [PMID: 33277581]
  • Heng Wen, Hu Zhang, Weina Wang, Yuebing Li. Tetrahydropalmatine protects against acute lung injury induced by limb ischemia/reperfusion through restoring PI3K/AKT/mTOR-mediated autophagy in rats. Pulmonary pharmacology & therapeutics. 2020 10; 64(?):101947. doi: 10.1016/j.pupt.2020.101947. [PMID: 32949703]
  • Yajie Deng, Xianhui Li, Wei Xiao, Zhenzhong Wang, Zhili Xiong, Longshan Zhao. UPLC-MS/MS simultaneous determination of seven active ingredients of Yaobitong capsule in rat plasma and its integrated pharmacokinetic application. Biomedical chromatography : BMC. 2020 Sep; 34(9):e4866. doi: 10.1002/bmc.4866. [PMID: 32330998]
  • Binjun Yan, Zi-Ao Huang, Noorfatimah Yahaya, David Da Yong Chen. Enantioselective analysis in complex matrices using capillary electrophoresis-mass spectrometry: A case study of the botanical drug Corydalis Rhizoma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Sep; 1152(?):122216. doi: 10.1016/j.jchromb.2020.122216. [PMID: 32531643]
  • Cui Li, Liping Li, Yaodong Yi, Wei Wang, Jingqun Yuan, Fuqing Tan, Danbo Fang, Su Zeng, Hui Zhou, Huidi Jiang. L-tetrahydropalmatine attenuates cisplatin-induced nephrotoxicity via selective inhibition of organic cation transporter 2 without impairing its antitumor efficacy. Biochemical pharmacology. 2020 07; 177(?):114021. doi: 10.1016/j.bcp.2020.114021. [PMID: 32389634]
  • Malkanthi Evans, Abdul M Sulley, David C Crowley, Jamie Langston, Najla Guthrie. Pain Bloc-R Alleviates Unresolved, Non-Pathological Aches and Discomfort in Healthy Adults-A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. Nutrients. 2020 Jun; 12(6):. doi: 10.3390/nu12061831. [PMID: 32575480]
  • Lin Zhi, Shangqi Yang, Jiekun Chen, Yuli Lu, Jiahong Chen, Zixi Qin, Xiao-Mei Tang. Tetrahydropalmatine has a therapeutic effect in a lipopolysaccharide-induced disseminated intravascular coagulation model. The Journal of international medical research. 2020 Jun; 48(6):300060519889430. doi: 10.1177/0300060519889430. [PMID: 31830839]
  • Hongliang Su, Tingting Sun, Xiao Wang, Yan Du, Na Zhao, Jie Zhu, Jiangwei Yan, Teng Chen, Keming Yun. Levo-tetrahydropalmatine attenuates methamphetamine reward behavior and the accompanying activation of ERK phosphorylation in mice. Neuroscience letters. 2020 01; 714(?):134416. doi: 10.1016/j.neulet.2019.134416. [PMID: 31398456]
  • Yan Du, Hongliang Su, Jie Cao, Zhiwen Wei, Yujin Wang, Keming Yun. Pharmacokinetic Effects of l-Tetrahydropalmatine on Ketamine in Rat Plasma by Ultraperformance Liquid Chromatography Tandem Mass Spectrometry. BioMed research international. 2020; 2020(?):9259683. doi: 10.1155/2020/9259683. [PMID: 32724819]
  • Zhong-Min Zhao, Xiao-Fei Shang, Raymond Kobla Lawoe, Ying-Qian Liu, Rui Zhou, Yu Sun, Yin-Fang Yan, Jun-Cai Li, Guan-Zhou Yang, Cheng-Jie Yang. Anti-phytopathogenic activity and the possible mechanisms of action of isoquinoline alkaloid sanguinarine. Pesticide biochemistry and physiology. 2019 Sep; 159(?):51-58. doi: 10.1016/j.pestbp.2019.05.015. [PMID: 31400784]
  • Issac Chi-Chung Cheng, Ren-Kai Li, George Pak-Heng Leung, Song-Lin Li, Ming Kong, Li-Xing Lao, Zhang-Jin Zhang, Wai-Ling Lin, Ernest Hung-Yu Ng, Jian-Hui Rong, Jian-Ping Chen, Jing Su, Kalin Yan-Bo Zhang, Wei Meng. Application of UPLC-MS/MS to simultaneously detect four bioactive compounds in the tumour-shrinking decoction (FM1523) for uterine fibroids treatment. Phytochemical analysis : PCA. 2019 Jul; 30(4):447-455. doi: 10.1002/pca.2827. [PMID: 30916852]
  • Qiang Yu, Liwei Wu, Tong Liu, Sainan Li, Jiao Feng, Yuqing Mao, Xiaoming Fan, Chuanyong Guo, Jianye Wu. Protective effects of levo-tetrahydropalmatine on hepatic ischemia/reperfusion injury are mediated by inhibition of the ERK/NF-κB pathway. International immunopharmacology. 2019 May; 70(?):435-445. doi: 10.1016/j.intimp.2019.02.024. [PMID: 30856394]
  • Wang Ping, Zhang Tinglan, Yu Guohua, Li Mengjie, Su Jin, Zhang Jiaqi, Li Ke, Fu Yan, Xu Haiyu, Yang Hongjun. Poly-pharmacokinetic strategy-delineated metabolic fate of bioactive compounds in a traditional Chinese medicine formula, Yuanhu Zhitong tablets, using parallel reaction monitoring mode. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019 Feb; 53(?):53-61. doi: 10.1016/j.phymed.2018.09.026. [PMID: 30668412]
  • Liwei Chai, Paul Owusu Donkor, Kun Wang, Yingjie Sun, Mahmood Brobbey Oppong, Kai Wang, Liqin Ding, Feng Qiu. Metabolic profiles of corydaline in rats by ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Jan; 49(1):80-89. doi: 10.1080/00498254.2017.1416207. [PMID: 29235899]
  • Caihua Sun, Zhiyun Chen, Hui Wang, Ke Ding. Tetrahydropalmatine Prevents High-Fat Diet-Induced Hyperlipidemia in Golden Hamsters (Mesocricetus Auratus). Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6564-6572. doi: 10.12659/msm.910578. [PMID: 30226834]
  • Ruoxi Sun, Yichen Song, Shanshan Li, Zhanqiang Ma, Xueyang Deng, Qiang Fu, Rong Qu, Shiping Ma. Levo-tetrahydropalmatine Attenuates Neuron Apoptosis Induced by Cerebral Ischemia-Reperfusion Injury: Involvement of c-Abl Activation. Journal of molecular neuroscience : MN. 2018 Jul; 65(3):391-399. doi: 10.1007/s12031-018-1063-9. [PMID: 29974381]
  • Hongbing Zhang, Xin Wu, Jun Xu, Suxiao Gong, Yanqi Han, Tiejun Zhang, Changxiao Liu. The comparative pharmacokinetic study of Yuanhu Zhitong prescription based on five quality-markers. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):148-154. doi: 10.1016/j.phymed.2018.02.005. [PMID: 29523382]
  • Ke Li, Junfang Li, Jin Su, Xuefeng Xiao, Xiujuan Peng, Feng Liu, Defeng Li, Yi Zhang, Tao Chong, Haiyu Xu, Changxiao Liu, Hongjun Yang. Identification of quality markers of Yuanhu Zhitong tablets based on integrative pharmacology and data mining. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 May; 44(?):212-219. doi: 10.1016/j.phymed.2018.03.002. [PMID: 29551644]
  • Qiang Yu, Tong Liu, Sainan Li, Jiao Feng, Liwei Wu, Wenwen Wang, Kan Chen, Yujing Xia, Peiqin Niu, Ling Xu, Fan Wang, Weiqi Dai, Yingqun Zhou, Chuanyong Guo. The Protective Effects of Levo-Tetrahydropalmatine on ConA-Induced Liver Injury Are via TRAF6/JNK Signaling. Mediators of inflammation. 2018; 2018(?):4032484. doi: 10.1155/2018/4032484. [PMID: 30622431]
  • Huang Lixia, Chen Jun, Hu Song, Yuan FaHu, Tu Jinwen. Neuroprotective effect of (-)-tetrahydropalmatine in Japanese encephalitis virus strain GP-78 infected mouse model. Microbial pathogenesis. 2018 Jan; 114(?):197-203. doi: 10.1016/j.micpath.2017.11.047. [PMID: 29191708]
  • Phuong Mai Le, Vandana Srivastava, Thanh Tam Nguyen, Bruno Pradines, Marylin Madamet, Joel Mosnier, Thi Thuy Trinh, Hoyun Lee. Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit. Phytotherapy research : PTR. 2017 Sep; 31(9):1357-1368. doi: 10.1002/ptr.5861. [PMID: 28703314]
  • Guang-Chun Piao, Guan-Cheng Liu, Xue-Jun Jin, Dan Jin, Hai-Dan Yuan. Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3‑L1 adipocytes. Molecular medicine reports. 2017 Jun; 15(6):3912-3918. doi: 10.3892/mmr.2017.6473. [PMID: 28440456]
  • Weihui Wang, Jing Liu, Xiaoning Zhao, Yan Peng, Nannan Wang, David Y W Lee, Ronghua Dai. Simultaneous determination of l-tetrahydropalmatine and its active metabolites in rat plasma by a sensitive ultra-high-performance liquid chromatography with tandem mass spectrometry method and its application in a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Jun; 31(6):. doi: 10.1002/bmc.3903. [PMID: 27868218]
  • Dujun Wang, Kai Wang, Danjuan Sui, Zhen Ouyang, Haiyu Xu, Yuan Wei. Effects of tetrahydroberberine and tetrahydropalmatine on hepatic cytochrome P450 expression and their toxicity in mice. Chemico-biological interactions. 2017 Apr; 268(?):47-52. doi: 10.1016/j.cbi.2017.02.019. [PMID: 28257954]
  • Chhavarath Dary, Sok-Siya Bun, Gaëtan Herbette, Fathi Mabrouki, Hot Bun, Sothea Kim, Florian Jabbour, Sovanmoly Hul, Béatrice Baghdikian, Evelyne Ollivier. Chemical profiling of the tuber of Stephania cambodica Gagnep. (Menispermaceae) and analytical control by UHPLC-DAD. Natural product research. 2017 Apr; 31(7):802-809. doi: 10.1080/14786419.2016.1247077. [PMID: 27976592]
  • Inas A Abdallah, Peng Huang, Jing Liu, David Y Lee, Lee-Yuan Liu-Chen, Hazem E Hassan. Development and validation of a high performance liquid chromatography quantification method of levo-tetrahydropalmatine and its metabolites in plasma and brain tissues: application to a pharmacokinetic study. Biomedical chromatography : BMC. 2017 Apr; 31(4):. doi: 10.1002/bmc.3850. [PMID: 27606501]
  • Yan Du, Li Du, Jie Cao, Christian Hölscher, Yongming Feng, Hongliang Su, Yujin Wang, Ke-Ming Yun. Levo-tetrahydropalmatine inhibits the acquisition of ketamine-induced conditioned place preference by regulating the expression of ERK and CREB phosphorylation in rats. Behavioural brain research. 2017 01; 317(?):367-373. doi: 10.1016/j.bbr.2016.10.001. [PMID: 27713001]
  • Jian Wu, Ying Xie, Zheng Xiang, Canjian Wang, Hua Zhou, Liang Liu. Simultaneous Determination of Multiple Components in Guanjiekang in Rat Plasma via the UPLC-MS/MS Method and Its Application in Pharmacokinetic Study. Molecules (Basel, Switzerland). 2016 Dec; 21(12):. doi: 10.3390/molecules21121732. [PMID: 27999285]
  • Weibin Xiao, Guolin Shen, Xiaomei Zhuang, Xiaorong Ran, Mingshe Zhu, Hua Li. Characterization of human metabolism and disposition of levo-tetrahydropalmatine: Qualitative and quantitative determination of oxidative and conjugated metabolites. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 128(?):371-381. doi: 10.1016/j.jpba.2016.06.015. [PMID: 27343900]
  • L P Li, F F Song, Y Y Weng, X Yang, K Wang, H M Lei, J Ma, H Zhou, H D Jiang. Role of OCT2 and MATE1 in renal disposition and toxicity of nitidine chloride. British journal of pharmacology. 2016 08; 173(16):2543-54. doi: 10.1111/bph.13537. [PMID: 27324234]
  • Yong Zhao, Aihua Liang, Yushi Zhang, Chunying Li, Yan Yi, Odd Georg Nilsen. Impact of Tetrahydropalmatine on the Pharmacokinetics of Probe Drugs for CYP1A2, 2D6 and 3A Isoenzymes in Beagle Dogs. Phytotherapy research : PTR. 2016 Jun; 30(6):906-14. doi: 10.1002/ptr.5608. [PMID: 26990021]
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