Oligomycin B (BioDeep_00000008598)

   


代谢物信息卡片


28-Oxooligomycin A

化学式: C45H72O12 (804.5023512)
中文名称: 寡霉素B
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C=CC=CCC(C)C(O)C(C)(O)C(=O)C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C=CC(=O)OC2C(C)C(CC1)OC1(OC(CC(C)O)C(C)CC1=O)C2C
InChI: InChI=1S/C45H72O12/c1-12-33-17-15-13-14-16-25(3)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)24(2)18-21-37(48)55-41-28(6)34(20-19-33)56-45(32(41)10)36(47)22-26(4)35(57-45)23-27(5)46/h13-15,17-18,21,24-35,38,40-42,46,49,51-52,54H,12,16,19-20,22-23H2,1-11H3/b14-13+,17-15+,21-18+/t24-,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35-,38+,40+,41+,42-,44+,45+/m0/s1

描述信息

An oligomycin with formula C45H72O12 that is oligomycin A in which the spirocyclic ring bearing the 2-hydroxypropyl substituent has been substituted by an oxo group at the carbon which is directly attached to the spirocentre. It is a nonselective inhibitor of the mitochondrial F1F0 ATP synthase.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D009840 - Oligomycins

同义名列表

2 个代谢物同义名

28-Oxooligomycin A; Oligomycin B



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Moutoshi Chakraborty, Nur Uddin Mahmud, Abu Naim Md Muzahid, S M Fajle Rabby, Tofazzal Islam. Oligomycins inhibit Magnaporthe oryzae Triticum and suppress wheat blast disease. PloS one. 2020; 15(8):e0233665. doi: 10.1371/journal.pone.0233665. [PMID: 32804955]
  • Zerihun T Dame, M Tofazzal Islam, Elisabeth Helmke, Andreas von Tiedemann, Hartmut Laatsch. Oligomycins and pamamycin homologs impair motility and induce lysis of zoospores of the grapevine downy mildew pathogen, Plasmopara viticola. FEMS microbiology letters. 2016 08; 363(16):. doi: 10.1093/femsle/fnw167. [PMID: 27354061]
  • Katherine L Moerman, Christina L L Chai, Paul Waring. Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells. Toxicology and applied pharmacology. 2003 Aug; 190(3):232-40. doi: 10.1016/s0041-008x(03)00189-3. [PMID: 12902194]
  • S F Mahmoud, C Fewtrell. Microdomains of high calcium are not required for exocytosis in RBL-2H3 mucosal mast cells. The Journal of cell biology. 2001 Apr; 153(2):339-49. doi: 10.1083/jcb.153.2.339. [PMID: 11309415]
  • A H Hamrahian, J Z Zhang, F S Elkhairi, R Prasad, F Ismail-Beigi. Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation. Archives of biochemistry and biophysics. 1999 Aug; 368(2):375-9. doi: 10.1006/abbi.1999.1320. [PMID: 10441390]
  • T Joseph-Horne, P M Wood, C K Wood, A L Moore, J Headrick, D Hollomon. Characterization of a split respiratory pathway in the wheat "take-all" fungus, Gaeumannomyces graminis var. tritici. The Journal of biological chemistry. 1998 May; 273(18):11127-33. doi: 10.1074/jbc.273.18.11127. [PMID: 9556599]
  • D A Maddox, W D Barnes, F J Gennari. Effect of acute increases in filtered HCO3- on renal hydrogen transporters: II. H(+)-ATPase. Kidney international. 1997 Aug; 52(2):446-53. doi: 10.1038/ki.1997.351. [PMID: 9264000]
  • A Pontecorvi, M Lakshmanan, J Robbins. Different intracellular and intranuclear transport of triiodothyronine enantiomers in rat skeletal myoblasts. Endocrinology. 1988 Dec; 123(6):2922-9. doi: 10.1210/endo-123-6-2922. [PMID: 3197649]