Oligomycin B (BioDeep_00000008598)

   

natural product


代谢物信息卡片


28-Oxooligomycin A

化学式: C45H72O12 (804.5024)
中文名称: 寡霉素B
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1C=CC=CCC(C)C(O)C(C)(O)C(=O)C(C)C(O)C(C)C(=O)C(C)C(O)C(C)C=CC(=O)OC2C(C)C(CC1)OC1(OC(CC(C)O)C(C)CC1=O)C2C
InChI: InChI=1S/C45H72O12/c1-12-33-17-15-13-14-16-25(3)42(52)44(11,54)43(53)31(9)40(51)30(8)39(50)29(7)38(49)24(2)18-21-37(48)55-41-28(6)34(20-19-33)56-45(32(41)10)36(47)22-26(4)35(57-45)23-27(5)46/h13-15,17-18,21,24-35,38,40-42,46,49,51-52,54H,12,16,19-20,22-23H2,1-11H3/b14-13+,17-15+,21-18+/t24-,25+,26-,27+,28+,29-,30-,31-,32-,33-,34-,35-,38+,40+,41+,42-,44+,45+/m0/s1

描述信息

An oligomycin with formula C45H72O12 that is oligomycin A in which the spirocyclic ring bearing the 2-hydroxypropyl substituent has been substituted by an oxo group at the carbon which is directly attached to the spirocentre. It is a nonselective inhibitor of the mitochondrial F1F0 ATP synthase.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D009840 - Oligomycins

同义名列表

3 个代谢物同义名

28-Oxooligomycin A; Oligomycin B; Oligomycin B



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 CCND1, CTNNB1, ITPR3, MID1
Endosome membrane 1 RHOD
Endoplasmic reticulum membrane 2 HSP90B1, ITPR3
Nucleus 5 CCND1, CTNNB1, HSP90B1, MID1, PCNA
cytosol 5 CCND1, CTNNB1, HSP90B1, MID1, RHOD
nuclear body 1 PCNA
centrosome 3 CCND1, CTNNB1, PCNA
nucleoplasm 6 ATP2B1, CCND1, CTNNB1, ITPR3, MID1, PCNA
Cell membrane 3 ATP2B1, CTNNB1, RHOD
Lipid-anchor 1 RHOD
Cytoplasmic side 1 RHOD
lamellipodium 1 CTNNB1
Multi-pass membrane protein 3 ATP2B1, CACNA1I, ITPR3
Synapse 2 ATP2B1, CTNNB1
cell cortex 1 CTNNB1
cell junction 1 CTNNB1
glutamatergic synapse 2 ATP2B1, CTNNB1
Golgi apparatus 1 MID1
Golgi membrane 2 INS, RHOD
mitochondrial inner membrane 1 ATP5ME
neuronal cell body 1 ITPR3
presynaptic membrane 2 ATP2B1, CTNNB1
smooth endoplasmic reticulum 1 HSP90B1
plasma membrane 5 ATP2B1, CACNA1I, CTNNB1, ITPR3, RHOD
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ATP2B1, CACNA1I, CTNNB1, HSP90B1, ITPR3, MID1
basolateral plasma membrane 2 ATP2B1, CTNNB1
brush border 1 ITPR3
extracellular exosome 4 ATP2B1, CTNNB1, HSP90B1, PCNA
endoplasmic reticulum 2 HSP90B1, ITPR3
extracellular space 1 INS
perinuclear region of cytoplasm 2 CTNNB1, HSP90B1
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 2 ATP5ME, MID1
protein-containing complex 2 CTNNB1, HSP90B1
intracellular membrane-bounded organelle 1 ATP2B1
Secreted 1 INS
extracellular region 2 HSP90B1, INS
mitochondrial outer membrane 1 RHOD
transcription regulator complex 1 CTNNB1
centriolar satellite 1 MID1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
nucleolus 1 ITPR3
Wnt signalosome 1 CTNNB1
midbody 1 HSP90B1
Early endosome 1 RHOD
apical part of cell 2 CTNNB1, ITPR3
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Cytoplasm, cytoskeleton 2 CTNNB1, MID1
Cytoplasm, cytoskeleton, spindle 1 MID1
focal adhesion 2 CTNNB1, HSP90B1
microtubule 1 MID1
spindle 1 MID1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
mitochondrial nucleoid 1 MID1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 HSP90B1
fascia adherens 1 CTNNB1
lateral plasma membrane 2 ATP2B1, CTNNB1
nuclear outer membrane 1 ITPR3
receptor complex 1 ITPR3
chromatin 1 PCNA
microtubule associated complex 1 MID1
cell projection 1 ATP2B1
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 1 CTNNB1
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 ATP2B1
microvillus membrane 1 CTNNB1
Endomembrane system 1 CTNNB1
endosome lumen 1 INS
Melanosome 1 HSP90B1
euchromatin 1 CTNNB1
Presynaptic cell membrane 1 ATP2B1
replication fork 1 PCNA
sperm plasma membrane 1 HSP90B1
secretory granule lumen 1 INS
secretory granule membrane 1 ITPR3
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
voltage-gated calcium channel complex 1 CACNA1I
transport vesicle 1 INS
beta-catenin-TCF complex 1 CTNNB1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 ATP2B1
presynaptic active zone cytoplasmic component 1 CTNNB1
nuclear lamina 1 PCNA
Sarcoplasmic reticulum lumen 1 HSP90B1
platelet dense tubular network membrane 1 ITPR3
protein-DNA complex 1 CTNNB1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
catenin complex 1 CTNNB1
proton-transporting ATP synthase complex 1 ATP5ME
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
endocytic vesicle lumen 1 HSP90B1
proton-transporting ATP synthase complex, coupling factor F(o) 1 ATP5ME
transport vesicle membrane 1 ITPR3
endoplasmic reticulum chaperone complex 1 HSP90B1
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
beta-catenin-TCF7L2 complex 1 CTNNB1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
cyclin D1-CDK6 complex 1 CCND1
Mitochondrion matrix, mitochondrion nucleoid 1 MID1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1


文献列表

  • Moutoshi Chakraborty, Nur Uddin Mahmud, Abu Naim Md Muzahid, S M Fajle Rabby, Tofazzal Islam. Oligomycins inhibit Magnaporthe oryzae Triticum and suppress wheat blast disease. PloS one. 2020; 15(8):e0233665. doi: 10.1371/journal.pone.0233665. [PMID: 32804955]
  • Zerihun T Dame, M Tofazzal Islam, Elisabeth Helmke, Andreas von Tiedemann, Hartmut Laatsch. Oligomycins and pamamycin homologs impair motility and induce lysis of zoospores of the grapevine downy mildew pathogen, Plasmopara viticola. FEMS microbiology letters. 2016 08; 363(16):. doi: 10.1093/femsle/fnw167. [PMID: 27354061]
  • Katherine L Moerman, Christina L L Chai, Paul Waring. Evidence that the lichen-derived scabrosin esters target mitochondrial ATP synthase in P388D1 cells. Toxicology and applied pharmacology. 2003 Aug; 190(3):232-40. doi: 10.1016/s0041-008x(03)00189-3. [PMID: 12902194]
  • S F Mahmoud, C Fewtrell. Microdomains of high calcium are not required for exocytosis in RBL-2H3 mucosal mast cells. The Journal of cell biology. 2001 Apr; 153(2):339-49. doi: 10.1083/jcb.153.2.339. [PMID: 11309415]
  • A H Hamrahian, J Z Zhang, F S Elkhairi, R Prasad, F Ismail-Beigi. Activation of Glut1 glucose transporter in response to inhibition of oxidative phosphorylation. Archives of biochemistry and biophysics. 1999 Aug; 368(2):375-9. doi: 10.1006/abbi.1999.1320. [PMID: 10441390]
  • T Joseph-Horne, P M Wood, C K Wood, A L Moore, J Headrick, D Hollomon. Characterization of a split respiratory pathway in the wheat "take-all" fungus, Gaeumannomyces graminis var. tritici. The Journal of biological chemistry. 1998 May; 273(18):11127-33. doi: 10.1074/jbc.273.18.11127. [PMID: 9556599]
  • D A Maddox, W D Barnes, F J Gennari. Effect of acute increases in filtered HCO3- on renal hydrogen transporters: II. H(+)-ATPase. Kidney international. 1997 Aug; 52(2):446-53. doi: 10.1038/ki.1997.351. [PMID: 9264000]
  • A Pontecorvi, M Lakshmanan, J Robbins. Different intracellular and intranuclear transport of triiodothyronine enantiomers in rat skeletal myoblasts. Endocrinology. 1988 Dec; 123(6):2922-9. doi: 10.1210/endo-123-6-2922. [PMID: 3197649]