hinesol (BioDeep_00000000857)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Spiro(4.5)dec-6-ene-2-methanol, alpha,alpha,6,10-tetramethyl-, (2R-(2alpha,5alpha(S*)))-

化学式: C15H26O (222.1984)
中文名称: 茅苍术醇
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 100%

分子结构信息

SMILES: CC1=CCCC(C)C12CCC(C(C)(C)O)C2
InChI: InChI=1S/C15H26O/c1-11-6-5-7-12(2)15(11)9-8-13(10-15)14(3,4)16/h6,12-13,16H,5,7-10H2,1-4H3/t12-,13+,15+/m0/s1

描述信息

Hinesol is a sesquiterpenoid.
(-)-Hinesol is a natural product found in Psidium guajava, Cistus creticus, and other organisms with data available.

同义名列表

9 个代谢物同义名

Spiro(4.5)dec-6-ene-2-methanol, alpha,alpha,6,10-tetramethyl-, (2R-(2alpha,5alpha(S*)))-; 2-((2R,5S,10S)-6,10-dimethylspiro[4.5]dec-6-en-2-yl)propan-2-ol; 2-[(3R,5S,6S)-6,10-Dimethylspiro[4.5]dec-9-en-3-yl]propan-2-ol; 2R-(2alpha,5beta)(R*)-isomer of hinesol; agarospirol; (-)-Hinesol; hinesol; Hinesol; CID 10878761



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

23 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AIMP2, BCL2, CCND1, CNR1, ESR1, PPARG, PTGS2
Peripheral membrane protein 3 ESR1, GORASP1, PTGS2
Endosome membrane 1 LY96
Endoplasmic reticulum membrane 4 BCL2, HSP90B1, INSIG1, PTGS2
Nucleus 8 AIMP2, BCL2, CCND1, ESR1, HSP90B1, NCOA1, PPARA, PPARG
cytosol 8 AIMP2, ATP12A, BCL2, CCND1, ESR1, HSP90B1, NCOA1, PPARG
centrosome 1 CCND1
nucleoplasm 6 ATP2B1, CCND1, ESR1, NCOA1, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 NCOA1, PPARG
Cell membrane 4 ATP2B1, CNR1, ESR1, TNF
Cytoplasmic side 2 ESR1, GORASP1
Cell projection, axon 1 CNR1
Multi-pass membrane protein 4 ATP12A, ATP2B1, CNR1, INSIG1
Golgi apparatus membrane 1 GORASP1
Synapse 1 ATP2B1
cell surface 1 TNF
glutamatergic synapse 2 ATP2B1, CNR1
Golgi apparatus 2 ESR1, GORASP1
Golgi membrane 1 GORASP1
growth cone 1 CNR1
neuronal cell body 1 TNF
presynaptic membrane 2 ATP2B1, CNR1
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 1 AIMP2
Presynapse 1 CNR1
plasma membrane 7 ATP12A, ATP2B1, CNR1, ESR1, LY96, NCOA1, TNF
synaptic vesicle membrane 1 ATP2B1
Membrane 5 AIMP2, ATP2B1, BCL2, ESR1, HSP90B1
apical plasma membrane 1 ATP12A
axon 1 CNR1
basolateral plasma membrane 2 ATP12A, ATP2B1
caveola 1 PTGS2
extracellular exosome 3 ATP2B1, HSP90B1, LCN2
endoplasmic reticulum 4 BCL2, HSP90B1, INSIG1, PTGS2
extracellular space 2 LCN2, TNF
perinuclear region of cytoplasm 2 HSP90B1, PPARG
bicellular tight junction 1 CCND1
mitochondrion 1 BCL2
protein-containing complex 5 BCL2, ESR1, HSP90B1, NCOA1, PTGS2
intracellular membrane-bounded organelle 2 ATP2B1, PPARG
Microsome membrane 1 PTGS2
Secreted 2 LCN2, LY96
extracellular region 4 HSP90B1, LCN2, LY96, TNF
Mitochondrion outer membrane 2 BCL2, CNR1
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CNR1
Cytoplasmic vesicle lumen 1 LCN2
transcription regulator complex 2 ESR1, NCOA1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
external side of plasma membrane 1 TNF
actin cytoskeleton 2 ATP12A, CNR1
midbody 1 HSP90B1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ATP12A
Membrane raft 2 CNR1, TNF
pore complex 1 BCL2
focal adhesion 1 HSP90B1
GABA-ergic synapse 1 CNR1
cis-Golgi network 1 GORASP1
collagen-containing extracellular matrix 1 HSP90B1
lateral plasma membrane 1 ATP2B1
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 LY96, PPARG
neuron projection 1 PTGS2
chromatin 4 ESR1, NCOA1, PPARA, PPARG
cell projection 1 ATP2B1
phagocytic cup 1 TNF
Secreted, extracellular space 1 LY96
Basolateral cell membrane 1 ATP2B1
Melanosome 1 HSP90B1
euchromatin 1 ESR1
Presynaptic cell membrane 1 ATP2B1
myelin sheath 1 BCL2
sperm plasma membrane 1 HSP90B1
lipopolysaccharide receptor complex 1 LY96
endoplasmic reticulum lumen 2 HSP90B1, PTGS2
transcription repressor complex 1 CCND1
specific granule lumen 1 LCN2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
immunological synapse 1 ATP2B1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Sarcoplasmic reticulum lumen 1 HSP90B1
[Isoform 1]: Nucleus 1 ESR1
SREBP-SCAP-Insig complex 1 INSIG1
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
endocytic vesicle lumen 1 HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endoplasmic reticulum chaperone complex 1 HSP90B1
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
potassium:proton exchanging ATPase complex 1 ATP12A
cyclin D1-CDK6 complex 1 CCND1
Cytoplasmic granule lumen 1 LCN2
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Baohong Song, Wei Wang, Ruipeng Liu, Jinjin Cai, Yuanyuan Jiang, Xuemei Tang, Hongfei Wu, Hui Ao, Lu Chen. Geographic Differentiation of Essential Oil from Rhizome of Cultivated Atractylodes lancea by Using GC-MS and Chemical Pattern Recognition Analysis. Molecules (Basel, Switzerland). 2023 Feb; 28(5):. doi: 10.3390/molecules28052216. [PMID: 36903461]
  • Takahiro Tsusaka, Bunsho Makino, Ryo Ohsawa, Hiroshi Ezura. Evaluation of heritability of β-eudesmol/hinesol content ratio in Atractylodes lancea De Candolle. Hereditas. 2020 Mar; 157(1):7. doi: 10.1186/s41065-020-00123-3. [PMID: 32160928]
  • Da Qing Yu, Xiao Jing Han, Ting Yu Shan, Rui Xu, Jin Hu, Wang Xing Cheng, Liang Ping Zha, Hua Sheng Peng. Microscopic Characteristic and Chemical Composition Analysis of Three Medicinal Plants and Surface Frosts. Molecules (Basel, Switzerland). 2019 Dec; 24(24):. doi: 10.3390/molecules24244548. [PMID: 31842368]
  • Weiqiang Guo, Songbai Liu, Xin Ju, Jiahui Du, Bin Xu, Hongxia Yuan, Fenju Qin, Liangzhi Li. The antitumor effect of hinesol, extract from Atractylodes lancea (Thunb.) DC. by proliferation, inhibition, and apoptosis induction via MEK/ERK and NF-κB pathway in non-small cell lung cancer cell lines A549 and NCI-H1299. Journal of cellular biochemistry. 2019 11; 120(11):18600-18607. doi: 10.1002/jcb.28696. [PMID: 31338882]
  • Yutaka Masuda, Takayuki Kadokura, Maki Ishii, Kimihiko Takada, Junichi Kitajima. Hinesol, a compound isolated from the essential oils of Atractylodes lancea rhizome, inhibits cell growth and induces apoptosis in human leukemia HL-60 cells. Journal of natural medicines. 2015 Jul; 69(3):332-9. doi: 10.1007/s11418-015-0897-5. [PMID: 25833731]
  • Yan Zhang, Sakurai Miki, Mei-lan Chen, Xiuji Takeda, Dong-yue Zhao, Li-ping Kang, Lan-ping Guo. [Effects of Lime on Seedling Growth,Yield and Volatile Constituents of Atractylodes lancea]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Mar; 38(3):429-32. doi: . [PMID: 26495637]
  • Dharmendra K Yadav, Vipin Mudgal, Jyoti Agrawal, Anil K Maurya, Dnyaneshwar U Bawankule, Chandan S Chanotiya, Feroz Khan, Sanjog T Thul. Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity. Current computer-aided drug design. 2013 Sep; 9(3):360-70. doi: 10.2174/1573409911309030012. [PMID: 23566359]
  • Xue-Fei Li, Gen-Ben Bai, Ru-Feng Wang, Ji-Feng Yang, Ming Yuan, Yan-Nan An, Xiu-Wen Wu. [Study on the chemical components of volatile oil from Euphorbia pekinensis radix]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2013 Feb; 36(2):237-9. doi: ". [PMID: 23901651]
  • Lei Zhang, Zhen Ouyang, Ming Zhao, Peixiang Wang, Jing Fang. [Simultaneous determination of atractylone, hinesol, beta-eudesmol, atrctylodin in Atractylodes lancea and hierarchical cluster analysis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2010 Mar; 35(6):725-8. doi: 10.4268/cjcmm20100615. [PMID: 20545197]
  • Zhen Ouyang, Ling Yang, Shu-Lan Su, Xu Feng, Ming Wang. [Fingerprint of volatile oil of Atractylodes lancea by GC-MS]. Yao xue xue bao = Acta pharmaceutica Sinica. 2007 Sep; 42(9):968-72. doi: . [PMID: 18050740]
  • Lan-ping Guo, Jun-ying Liu, Li Ji, Lu-qi Huang. [The naphtha composing characteristics of geoherbs of Atractylodes lancea]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2002 Nov; 27(11):814-9. doi: . [PMID: 12776582]
  • L Ji, P Ao, J G Pan, J Y Yang, J Yang, S L Hu. [GC-MS analysis of essential oils from rhizomes of Atractylodes lancea (Thunb.) DC. and A. chinensis (DC.) Koidz]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2001 Mar; 26(3):182-5. doi: ". [PMID: 12525038]
  • H Okugawa, R Ueda, K Matsumoto, K Kawanishi, K Kato. Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2000 Oct; 7(5):417-22. doi: 10.1016/s0944-7113(00)80063-x. [PMID: 11081993]
  • K Satoh, F Nagai, I Kano. Inhibition of H+,K+ -ATPase by hinesol, a major component of So-jutsu, by interaction with enzyme in the E1 state. Biochemical pharmacology. 2000 Apr; 59(7):881-6. doi: 10.1016/s0006-2952(99)00399-8. [PMID: 10718347]
  • T Hashimoto, Y Noma, S Kato, M Tanaka, S Takaoka, Y Asakawa. Biotransformation of hinesol isolated from the crude drug Atractylodes lancea by Aspergillus niger and Aspergillus cellulosae. Chemical & pharmaceutical bulletin. 1999 May; 47(5):716-7. doi: 10.1248/cpb.47.716. [PMID: 10361702]
  • M Kohjyouma, S Nakajima, A Namera, R Shimizu, H Mizukami, H Kohda. Random amplified polymorphic DNA analysis and variation of essential oil components of Atractylodes plants. Biological & pharmaceutical bulletin. 1997 May; 20(5):502-6. doi: 10.1248/bpb.20.502. [PMID: 9178929]
  • H Okugawa, R Ueda, K Matsumoto, K Kawanishi, A Kato. Effect of jinkoh-eremol and agarospirol from agarwood on the central nervous system in mice. Planta medica. 1996 Feb; 62(1):2-6. doi: 10.1055/s-2006-957784. [PMID: 8720378]
  • J Yamahara, H Matsuda, Q Huang, Y Li, H Fujimura. Intestinal motility enhancing effect of Atractylodes lancea rhizome. Journal of ethnopharmacology. 1990 Jul; 29(3):341-4. doi: 10.1016/0378-8741(90)90044-t. [PMID: 2214818]
  • Y Kiso, M Tohkin, H Hikino. Antihepatotoxic principles of Atractylodes rhizomes. Journal of natural products. 1983 Sep; 46(5):651-4. doi: 10.1021/np50029a010. [PMID: 6418860]