Ibotenic acid (BioDeep_00000008194)

 

Secondary id: BioDeep_00001873996

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


2-amino-2-(3-hydroxy-1,2-oxazol-5-yl)acetic acid

化学式: C5H6N2O4 (158.0328)
中文名称: 鹅膏氨酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 88.42%

分子结构信息

SMILES: C1=C(ONC1=O)C(C(=O)O)N
InChI: InChI=1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

描述信息

D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018690 - Excitatory Amino Acid Agonists
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.
Ibotenic acid has agonist activity at both the N-methyl-D-aspartate (NMDA) and trans-ACPD or metabolotropic quisqualate (Qm) receptor sites.

同义名列表

10 个代谢物同义名

2-amino-2-(3-hydroxy-1,2-oxazol-5-yl)acetic acid; 2-Amino-2-(3-hydroxy-1,2-oxazol-5-yl)acetate; (+/-)-ibotenic acid; (+/-)-ibotenate; Acid, ibotenic; Ibotenic acid; Ibotenate; (RS)-Ibotenic acid; DL-Ibotenic acid; Ibotenic acid



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 BDNF, CA1, CA3, CHAT, GFAP, HTT, PVALB, TH
Peripheral membrane protein 1 ACHE
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 1 DRD1
Nucleus 7 ACHE, CHAT, DRD1, FOS, GRM1, HTT, TH
autophagosome 1 HTT
cytosol 9 CA1, CA3, CHAT, FOS, GFAP, HTT, NGF, SST, TH
dendrite 6 BDNF, DRD2, GRM1, HTT, NGF, TH
nucleoplasm 2 FOS, HTT
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 7 ACHE, DRD1, DRD2, GRID1, GRM1, HTT, KIAA0319
Cell projection, axon 1 TH
Early endosome membrane 1 KIAA0319
Multi-pass membrane protein 5 DRD1, DRD2, GRID1, GRM1, HTT
Golgi apparatus membrane 1 DRD2
Synapse 6 ACHE, CHAT, DRD2, HTT, PVALB, TAC1
cell surface 1 ACHE
glutamatergic synapse 4 DRD1, DRD2, GRID1, GRM1
Golgi apparatus 2 ACHE, HTT
Golgi membrane 1 DRD2
neuromuscular junction 1 ACHE
neuronal cell body 2 SST, TAC1
presynaptic membrane 3 DRD1, DRD2, HTT
smooth endoplasmic reticulum 1 TH
synaptic vesicle 3 BDNF, NGF, TH
Cytoplasmic vesicle, secretory vesicle 1 NTS
acrosomal vesicle 1 DRD2
plasma membrane 8 ACHE, BCHE, DRD1, DRD2, GRID1, GRM1, HTT, KIAA0319
synaptic vesicle membrane 1 DRD2
terminal bouton 1 TH
Membrane 3 ACHE, BDNF, KIAA0319
axon 7 BDNF, DRD2, HTT, NGF, PVALB, TAC1, TH
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 2 FOS, HTT
extracellular space 6 ACHE, BCHE, BDNF, NGF, SST, TAC1
perinuclear region of cytoplasm 4 ACHE, BDNF, HTT, TH
Schaffer collateral - CA1 synapse 1 GRM1
mitochondrion 1 TH
protein-containing complex 1 HTT
intracellular membrane-bounded organelle 2 KIAA0319, NTS
Single-pass type I membrane protein 1 KIAA0319
Secreted 6 ACHE, BCHE, BDNF, NGF, NTS, SST
extracellular region 7 ACHE, BCHE, BDNF, NGF, NTS, SST, TAC1
cytoplasmic side of plasma membrane 1 TH
astrocyte end-foot 1 GFAP
Extracellular side 1 ACHE
ciliary membrane 2 DRD1, DRD2
dendritic spine 2 DRD1, DRD2
perikaryon 2 DRD2, TH
cytoplasmic vesicle 2 KIAA0319, TH
Melanosome membrane 1 TH
Early endosome 2 HTT, KIAA0319
postsynaptic membrane 4 DRD1, DRD2, GRID1, HTT
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
focal adhesion 1 HTT
GABA-ergic synapse 4 DRD1, DRD2, GRID1, SST
basement membrane 1 ACHE
Cell projection, dendritic spine 1 DRD1
intermediate filament 1 GFAP
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 2 GRID1, GRM1
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 3 CHAT, HTT, TH
cilium 2 DRD1, DRD2
chromatin 1 FOS
cell projection 1 GFAP
centriole 1 HTT
blood microparticle 1 BCHE
non-motile cilium 2 DRD1, DRD2
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
Endomembrane system 1 HTT
endosome lumen 1 NGF
Cytoplasmic vesicle membrane 1 HTT
Cell projection, dendrite 1 DRD1
cell body 1 GFAP
side of membrane 1 ACHE
intermediate filament cytoskeleton 1 GFAP
Golgi lumen 1 NGF
endoplasmic reticulum lumen 2 BCHE, BDNF
nuclear matrix 1 FOS
axon terminus 2 DRD2, NTS
endocytic vesicle 1 DRD2
transport vesicle 1 NTS
postsynaptic density membrane 2 GRID1, GRM1
neuronal dense core vesicle 1 SST
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 KIAA0319
synaptic cleft 1 ACHE
protein-DNA complex 1 FOS
dopaminergic synapse 1 DRD2
postsynaptic cytosol 1 HTT
Cell projection, cilium membrane 1 DRD1
presynaptic cytosol 1 HTT
cytoplasmic side of lysosomal membrane 1 GFAP
transcription factor AP-1 complex 1 FOS
inclusion body 1 HTT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
G protein-coupled receptor complex 2 DRD1, DRD2
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
G protein-coupled receptor dimeric complex 1 GRM1
G protein-coupled receptor homodimeric complex 1 GRM1


文献列表

  • Alexander Dushkov, Zuzana Vosáhlová, Alexander Tzintzarov, Květa Kalíková, Tomáš Křížek, Iva Ugrinova. Analysis of the Ibotenic Acid, Muscimol, and Ergosterol Content of an Amanita Muscaria Hydroalcoholic Extract with an Evaluation of Its Cytotoxic Effect against a Panel of Lung Cell Lines In Vitro. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196824. [PMID: 37836667]
  • Yu-Ting Su, Jie Liu, Dan-Ni Yang, Qing Cai, Zhu L Yang, Zuo-Hong Chen. Determination of ibotenic acid and muscimol in species of the genus Amanita section Amanita from China. Toxicon : official journal of the International Society on Toxinology. 2023 Aug; ?(?):107257. doi: 10.1016/j.toxicon.2023.107257. [PMID: 37611670]
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  • Xiao-Min Xu, Jing-Shun Zhang, Bai-Fen Huang, Jian-Long Han, Qing Chen. Determination of ibotenic acid and muscimol in plasma by liquid chromatography-triple quadrupole mass spectrometry with bimolecular dansylation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122128. doi: 10.1016/j.jchromb.2020.122128. [PMID: 32361630]
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