Cleistanthin (BioDeep_00000008149)

 

Secondary id: BioDeep_00000259003

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


9-(1,3-benzodioxol-5-yl)-4-[(3R,4R,5R)-3-hydroxy-4,5-dimethoxy-tetrahydropyran-2-yl]oxy-6,7-dimethoxy-3H-benzo[f]isobenzofuran-1-one

化学式: C28H28O11 (540.1632)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 89.02%

分子结构信息

SMILES: COc1cc2c(OC3OCC(OC)C(OC)C3O)c3c(c(-c4ccc5c(c4)OCO5)c2cc1OC)C(=O)OC3
InChI: InChI=1S/C28H28O11/c1-31-18-8-14-15(9-19(18)32-2)25(39-28-24(29)26(34-4)21(33-3)11-36-28)16-10-35-27(30)23(16)22(14)13-5-6-17-20(7-13)38-12-37-17/h5-9,21,24,26,28-29H,10-12H2,1-4H3/t21-,24-,26+,28?/m1/s1

描述信息

同义名列表

4 个代谢物同义名

9-(1,3-benzodioxol-5-yl)-4-[(3R,4R,5R)-3-hydroxy-4,5-dimethoxy-tetrahydropyran-2-yl]oxy-6,7-dimethoxy-3H-benzo[f]isobenzofuran-1-one; Cleistanthin A; Cleistanthin; Cleistanthin A



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

15 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 AXIN2, BCL2, BIRC5, CCND1, CTNNB1, MYC, PTK2, STAT3
Peripheral membrane protein 1 PTK2
Endoplasmic reticulum membrane 1 BCL2
Nucleus 10 AXIN2, BCL2, BIRC5, CCND1, CTNNB1, MMP2, MYC, PCNA, PTK2, STAT3
cytosol 7 AXIN2, BCL2, BIRC5, CCND1, CTNNB1, PTK2, STAT3
nuclear body 1 PCNA
centrosome 5 AXIN2, CCND1, CTNNB1, PCNA, PTK2
nucleoplasm 7 ATP2B1, BIRC5, CCND1, CTNNB1, MYC, PCNA, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 4 ADRB3, ATP2B1, CTNNB1, PTK2
Cytoplasmic side 1 PTK2
lamellipodium 1 CTNNB1
Multi-pass membrane protein 2 ADRB3, ATP2B1
Synapse 2 ATP2B1, CTNNB1
cell cortex 2 CTNNB1, PTK2
cell junction 1 CTNNB1
glutamatergic synapse 2 ATP2B1, CTNNB1
Golgi apparatus 1 ATRN
presynaptic membrane 2 ATP2B1, CTNNB1
plasma membrane 8 ADRB3, ATP2B1, ATRN, AXIN2, CTNNB1, MMP2, PTK2, STAT3
synaptic vesicle membrane 1 ATP2B1
Membrane 4 ATP2B1, BCL2, CTNNB1, MYC
basolateral plasma membrane 2 ATP2B1, CTNNB1
extracellular exosome 4 ATP2B1, ATRN, CTNNB1, PCNA
endoplasmic reticulum 1 BCL2
extracellular space 2 ATRN, MMP2
perinuclear region of cytoplasm 2 CTNNB1, PTK2
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 1 CTNNB1
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 2 CCND1, CTNNB1
mitochondrion 2 BCL2, MMP2
protein-containing complex 4 BCL2, BIRC5, CTNNB1, MYC
intracellular membrane-bounded organelle 2 ATP2B1, PTK2
Single-pass type I membrane protein 1 ATRN
extracellular region 1 MMP2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
[Isoform 2]: Secreted 1 ATRN
anchoring junction 1 PTK2
transcription regulator complex 2 CTNNB1, STAT3
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
Nucleus membrane 2 BCL2, CCND1
Bcl-2 family protein complex 1 BCL2
nuclear membrane 2 BCL2, CCND1
dendritic spine 1 PTK2
Z disc 1 CTNNB1
beta-catenin destruction complex 2 AXIN2, CTNNB1
microtubule cytoskeleton 1 BIRC5
nucleolus 1 MYC
Wnt signalosome 1 CTNNB1
midbody 1 BIRC5
apical part of cell 1 CTNNB1
cell-cell junction 1 CTNNB1
postsynaptic membrane 1 CTNNB1
Cytoplasm, perinuclear region 1 PTK2
pore complex 1 BCL2
Cell junction, focal adhesion 1 PTK2
Cytoplasm, cytoskeleton 2 CTNNB1, PTK2
Cytoplasm, cytoskeleton, spindle 1 BIRC5
focal adhesion 2 CTNNB1, PTK2
microtubule 1 BIRC5
spindle 1 BIRC5
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 MMP2
collagen-containing extracellular matrix 1 MMP2
fascia adherens 1 CTNNB1
lateral plasma membrane 2 ATP2B1, CTNNB1
interphase microtubule organizing center 1 BIRC5
sarcomere 1 MMP2
receptor complex 1 ADRB3
ciliary basal body 1 PTK2
chromatin 3 MYC, PCNA, STAT3
cell projection 2 ATP2B1, PTK2
cell periphery 1 CTNNB1
Chromosome 1 BIRC5
cytoskeleton 1 PTK2
Cytoplasm, cytoskeleton, cilium basal body 2 CTNNB1, PTK2
centriole 1 BIRC5
Nucleus, nucleolus 1 MYC
spindle pole 1 CTNNB1
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
nuclear chromosome 1 BIRC5
Cytoplasm, cell cortex 1 PTK2
postsynaptic density, intracellular component 1 CTNNB1
Basolateral cell membrane 1 ATP2B1
microvillus membrane 1 CTNNB1
[Isoform 3]: Secreted 1 ATRN
nuclear envelope 1 MYC
Endomembrane system 1 CTNNB1
Chromosome, centromere 1 BIRC5
Chromosome, centromere, kinetochore 1 BIRC5
Nucleus, nucleoplasm 1 MYC
euchromatin 1 CTNNB1
Presynaptic cell membrane 1 ATP2B1
replication fork 1 PCNA
myelin sheath 1 BCL2
stress fiber 1 PTK2
transcription repressor complex 1 CCND1
male germ cell nucleus 1 PCNA
kinetochore 1 BIRC5
[Isoform 1]: Secreted, extracellular space, extracellular matrix 1 MMP2
RNA polymerase II transcription repressor complex 1 MYC
beta-catenin-TCF complex 1 CTNNB1
immunological synapse 1 ATP2B1
chromosome, centromeric region 1 BIRC5
presynaptic active zone cytoplasmic component 1 CTNNB1
nuclear lamina 1 PCNA
chromosome passenger complex 1 BIRC5
cytoplasmic microtubule 1 BIRC5
protein-DNA complex 1 CTNNB1
spindle microtubule 1 BIRC5
survivin complex 1 BIRC5
[Isoform 1]: Cell membrane 1 ATRN
Rough endoplasmic reticulum 1 MYC
catenin complex 1 CTNNB1
cyclin-dependent protein kinase holoenzyme complex 2 CCND1, PCNA
Myc-Max complex 1 MYC
BAD-BCL-2 complex 1 BCL2
photoreceptor ribbon synapse 1 ATP2B1
cyclin D1-CDK4 complex 1 CCND1
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
beta-catenin-TCF7L2 complex 1 CTNNB1
cyclin D1-CDK6 complex 1 CCND1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
nucleoplasmic reticulum 1 MYC


文献列表

  • Kawin Padmaja, Roshni Parameswaran, G Srisangeetha, Shikha Mary Zachariah, Neetu Prince, Soosai Manickam Amirtham, Uwe Beifuss, Juergen Conrad, Sathya Subramani. Cleistanthin A causes peripheral vasoconstriction and myocardial depression in isolated tissue preparations. Toxicology mechanisms and methods. 2023 Jul; ?(?):1-13. doi: 10.1080/15376516.2023.2237581. [PMID: 37461393]
  • Siddhartha Das, Abdoul Hamide, Manoj K Mohanty, Ravichandran Muthusamy. Fatal Cleistanthus collinus toxicity: a case report and review of literature. Journal of forensic sciences. 2014 Sep; 59(5):1441-7. doi: 10.1111/1556-4029.12519. [PMID: 25040437]
  • Lakana Himakoun, Patoomratana Tuchinda, Pranom Puchadapirom, Ratigon Tammasakchai, Vijittra Leardkamolkarn. Evaluation of genotoxic and anti-mutagenic properties of cleistanthin A and cleistanthoside A tetraacetate. Asian Pacific journal of cancer prevention : APJCP. 2011; 12(12):3271-5. doi: . [PMID: 22471465]
  • S P E Benjamin, M Edwin Fernando, J Jerene Jayanth, B Preetha. Cleistanthus collinus poisoning. The Journal of the Association of Physicians of India. 2006 Sep; 54(?):742-4. doi: . [PMID: 17212028]
  • Patoomratana Tuchinda, Anawat Kumkao, Manat Pohmakotr, Samaisukh Sophasan, Thawatchai Santisuk, Vichai Reutrakul. Cytotoxic arylnaphthalide lignan glycosides from the aerial parts of Phyllanthus taxodiifolius. Planta medica. 2006 Jan; 72(1):60-2. doi: 10.1055/s-2005-873141. [PMID: 16450297]
  • Vinu M Jose, K N Anand, L Jeyaseelan, Kalpana Ernest, Alice Kuruvilla. Effect of potassium channel modulators on toxicity of Cleistanthus collinus. Indian journal of experimental biology. 2004 Jan; 42(1):81-5. doi: NULL. [PMID: 15274486]
  • D K S Subrahmanyam, T Mooney, R Raveendran, B Zachariah. A clinical and laboratory profile of Cleistanthus collinus poisoning. The Journal of the Association of Physicians of India. 2003 Nov; 51(?):1052-4. doi: ". [PMID: 15260387]
  • Shashiraj Eswarappa, Amiya Ranjan Chakraborty, Babu Urumese Palatty, Mabel Vasnaik. Cleistanthus collinus poisoning: case reports and review of the literature. Journal of toxicology. Clinical toxicology. 2003; 41(4):369-72. doi: 10.1081/clt-120022005. [PMID: 12870879]
  • C P Pradheepkumar, G Shanmugam. Anticancer potential of cleistanthin A isolated from the tropical plant Cleistanthus collinus. Oncology research. 1999; 11(5):225-32. doi: . [PMID: 10608617]
  • G Ragupathi, P Prabhasankar, P C Sekharan, K S Annapoorani, C Damodaran. Novel solid-state fluorodensitometric method for the determination of haptens in protein-hapten conjugates. Demonstration with a toxic glycoside of Cleistanthus collinus. Journal of chromatography. 1992 Feb; 574(2):267-71. doi: 10.1016/0378-4347(92)80039-s. [PMID: 1618959]
  • G Ragupathi, P Prabhasankar, P C Sekharan, K S Annapoorani, C Damodaran. Enzyme-linked immunosorbent assay for the phytotoxin cleistanthin A. Journal of immunoassay. 1992; 13(3):321-38. doi: 10.1080/15321819208021236. [PMID: 1506455]
  • K S Annapoorani, P Periakali, S Ilangovan, C Damodaran, P C Sekharan. Spectrofluorometric determination of the toxic constituents of Cleistanthus collinus. Journal of analytical toxicology. 1984 Jul; 8(4):182-6. doi: 10.1093/jat/8.4.182. [PMID: 6471818]