Allicin (BioDeep_00000000766)

   

human metabolite PANOMIX_OTCML-2023 Volatile Flavor Compounds natural product


代谢物信息卡片


Diallyldisulfid-S-oxid, 3-prop-2-enylsulfinylsulfanylprop-1-ene

化学式: C6H10OS2 (162.01730500000002)
中文名称: 蒜素, 大蒜素
谱图信息: 最多检出来源 Viridiplantae(plant) 0.67%

分子结构信息

SMILES: C=CCS(SCC=C)=O
InChI: InChI=1S/C6H10OS2/c1-3-5-8-9(7)6-4-2/h3-4H,1-2,5-6H2

描述信息

Allicin is found in garden onion. Allicin is isolated from garlic (Allium sativum). Nutriceutical Allicin is an organic compound obtained from garlic. It is also obtainable from onions, and other species in the family Alliaceae. It was first isolated and studied in the laboratory by Chester J. Cavallito in 1944. This colourless liquid has a distinctively pungent smell. This compound exhibits antibacterial and anti-fungal properties. Allicin is garlics defence mechanism against attacks by pests
Allicin is a sulfoxide and a botanical anti-fungal agent. It has a role as an antibacterial agent.
Allicin has been used in trials studying the treatment of Follicular Lymphoma.
Allicin is a natural product found in Allium chinense, Allium nutans, and other organisms with data available.
See also: Garlic (part of).
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D000975 - Antioxidants > D016166 - Free Radical Scavengers
D020011 - Protective Agents > D000975 - Antioxidants
Isolated from garlic (Allium sativum). Nutriceutical
D009676 - Noxae > D000963 - Antimetabolites
D000890 - Anti-Infective Agents
D007004 - Hypoglycemic Agents
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98\\% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains[1][2].
Allicin (diallyl thiosulfinate) is isolated from garlic including Diallyl monosulfide, Diallyl disulfide, Diallyl trisulfide, Diallyl tetrasulfide, and Methyl allyl disulphide etc. They accounts for 98\% of the extract. Allicin (diallyl thiosulfinate) has highly potent antimicrobial activity, and inhibits growth of a variety of microorganisms, among them antibiotic-resistant strains[1][2].

同义名列表

50 个代谢物同义名

Diallyldisulfid-S-oxid, 3-prop-2-enylsulfinylsulfanylprop-1-ene; Diallyl thiosulfinate and Allylthiosulphinic acid allyl ester; 2-Propene-1-sulfinothioic acid, S-2-propenyl ester (9CI); 2-Propene-1-sulphinothioic acid S-2-propenyl ester; 2-Propene-1-sulfinothioic acid, S-2-propenyl ester; 2-Propene-1-sulfinothioic acid S-2-propenyl ester; 2-Propene-1-sulfinic acid, thio-, S-allyl ester; 2-Propene-1-sulphinothioate S-2-propenyl ester; 2-Propene-1-sulfinothioate S-2-propenyl ester; 3-[(prop-2-ene-1-sulfinyl)sulfanyl]prop-1-ene; Thio-2-propene-1-sulphinic acid S-allyl ester; thio-2-propene-1-sulfinic acid S-allyl ester; S-2-Propenyl 2-propene-1-sulfinothioate, 9CI; S-prop-2-en-1-yl prop-2-ene-1-sulfinothioate; 4-04-00-00007 (Beilstein Handbook Reference); S-2-PROPEN-1-YL 2-PROPENE-1-SULFINOTHIOATE; Thio-2-propene-1-sulphinate S-allyl ester; Thio-2-propene-1-sulfinate S-allyl ester; 3-prop-2-enylsulfinylsulfanylprop-1-ene; ALLICIN (CONSTITUENT OF GARLIC) [DSC]; 3-(prop-2-enylsulfinylthio)-1-propene; allylthiosulphinic acid allyl ester; S-allyl prop-2-ene-1-sulfinothioate; S-allyl 2-propene-1-sulfinothioate; 3-allylsulfinylsulfanyl-prop-1-ene; 3-allylsulfinylsulfanylprop-1-ene; S-Allyl acrylo-1-sulphinothioate; ALLICIN (CONSTITUENT OF GARLIC); JDLKFOPOAOFWQN-UHFFFAOYSA-N; Allicin (Allyl-S(O)S-Allyl); Dianyctrsnlgide;Allisatin; Diallyldisulfid-S-oxide; diallyl disulfide-oxide; Allicin (not validated); Diallyldisulfid-S-oxid; Diallyl thiosulfinate; Allicin, tech. grade; ALLICIN(TECH GRADE); allylthiosulfinate; ALLICIN [WHO-DD]; UNII-3C39BY17Y6; ALLICIN [MI]; Allicin kit; 3C39BY17Y6; allitridi; C6H10OS2; Allicin; allimin; DADSO; Allicin



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(2)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(2)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

66 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wamidh H Talib, Media Mohammed Baban, Aya O Azzam, Jenan J Issa, Alaa Y Ali, Alia Kh AlSuwais, Sana Allala, Lina T Al Kury. Allicin and Cancer Hallmarks. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061320. [PMID: 38542956]
  • Christina Schier, Martin C H Gruhlke, Georg Reucher, Alan J Slusarenko, Lothar Rink. Combating Black Fungus: Using Allicin as a Potent Antifungal Agent against Mucorales. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417519. [PMID: 38139348]
  • Liu-Qing Sun, Chao-Feng Zhu, Jiang-Qin He. Effect of Grape Seed Procyanidins Combined with Allicin on Lipid Levels in Hyperlipidemic Rats. Studies in health technology and informatics. 2023 Nov; 308(?):130-136. doi: 10.3233/shti230833. [PMID: 38007734]
  • Hatice Kubra Sasmaz, Eda Adal, Pınar Kadiroğlu, Serkan Selli, Turkan Uzlasir, Hasim Kelebek. Optimization of complex coacervation parameters for the production of encapsulated black garlic using response surface methodology. Journal of food science. 2023 Oct; ?(?):. doi: 10.1111/1750-3841.16768. [PMID: 37786327]
  • George P Burton, Thomas A K Prescott, Rui Fang, Mark A Lee. Regional variation in the antibacterial activity of a wild plant, wild garlic (Allium ursinum L.). Plant physiology and biochemistry : PPB. 2023 Sep; 202(?):107959. doi: 10.1016/j.plaphy.2023.107959. [PMID: 37619271]
  • Fangyuan Sun, Kailiang Xu, Jiayi Zhou, Wei Zhang, Guihe Duan, Ming Lei. Allicin protects against LPS-induced cardiomyocyte injury by activating Nrf2-HO-1 and inhibiting NLRP3 pathways. BMC cardiovascular disorders. 2023 08; 23(1):410. doi: 10.1186/s12872-023-03442-1. [PMID: 37596540]
  • Faris J Alyasiri, Maryam Ghobeh, Masoud Homayouni Tabrizi. Preparation and Characterization of Allicin-Loaded Solid Lipid Nanoparticles Surface-Functionalized with Folic Acid-Bonded Chitosan: In Vitro Anticancer and Antioxidant Activities. Frontiers in bioscience (Landmark edition). 2023 07; 28(7):135. doi: 10.31083/j.fbl2807135. [PMID: 37525919]
  • Ying Yang, Min Li, Hai-Yan Bao, Xin-Xia Li, Jian-Guang Li. [Advances in cardiovascular protection effects and mechanisms of allicin]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Jul; 48(13):3409-3420. doi: 10.19540/j.cnki.cjcmm.20230320.601. [PMID: 37474979]
  • Lingjuan Kong, Xiaoqing Ji, Yan Liu, YingJie Du. Effect of artemisinin combined with allicin on improving cardiac function, fibrosis and NF-κB signaling pathway in rats with diabetic cardiomyopathy. Acta biochimica Polonica. 2023 Jun; 70(2):401-405. doi: 10.18388/abp.2020_6692. [PMID: 37307593]
  • Ioana Andreea Barbu, Alexandra Ciorîță, Rahela Carpa, Augustin Catalin Moț, Anca Butiuc-Keul, Marcel Pârvu. Phytochemical Characterization and Antimicrobial Activity of Several Allium Extracts. Molecules (Basel, Switzerland). 2023 May; 28(10):. doi: 10.3390/molecules28103980. [PMID: 37241721]
  • Ningning Xu, Weinan Han, Guoping Yun, Lulu Shi. Allicin Protects Renal Function, Improves Oxidative Stress and Lipid Peroxidation in Rats with Chronic Renal Failure. Iranian journal of kidney diseases. 2023 May; 17(3):135-140. doi: . [PMID: 37337797]
  • JeongWoo Kang, HyunYoung Chae, Md Akil Hossain. Poultry red mite eradication potential of ivermectin and allicin combination treatment. Veterinary medicine and science. 2023 05; 9(3):1292-1296. doi: 10.1002/vms3.1136. [PMID: 37018122]
  • Penghui Ai, Jundong Xue, Yifei Zhu, Wenchao Tan, Yifei Wu, Ying Wang, Zhongai Li, Zhongya Shi, Dongru Kang, Haoyi Zhang, Liwen Jiang, Zicheng Wang. Comparative analysis of two kinds of garlic seedings: qualities and transcriptional landscape. BMC genomics. 2023 Feb; 24(1):87. doi: 10.1186/s12864-023-09183-x. [PMID: 36829121]
  • Shiyin Xu, Yuxiao Liao, Qi Wang, Liegang Liu, Wei Yang. Current studies and potential future research directions on biological effects and related mechanisms of allicin. Critical reviews in food science and nutrition. 2023; 63(25):7722-7748. doi: 10.1080/10408398.2022.2049691. [PMID: 35293826]
  • Uzair Ali, Martin Wabitsch, Daniel Tews, Monica Colitti. Effects of allicin on human Simpson-Golabi-Behmel syndrome cells in mediating browning phenotype. Frontiers in endocrinology. 2023; 14(?):1141303. doi: 10.3389/fendo.2023.1141303. [PMID: 36936145]
  • Linzehao Li, Qinghe Song, Xiandang Zhang, Yan Yan, Xiaolei Wang. Allicin Alleviates Diabetes Mellitus by Inhibiting the Formation of Advanced Glycation End Products. Molecules (Basel, Switzerland). 2022 Dec; 27(24):. doi: 10.3390/molecules27248793. [PMID: 36557926]
  • Verena Nadin Fritsch, Vu Van Loi, Benno Kuropka, Martin Gruhlke, Christoph Weise, Haike Antelmann. The MarR/DUF24-Family QsrR Repressor Senses Quinones and Oxidants by Thiol Switch Mechanisms in Staphylococcus aureus. Antioxidants & redox signaling. 2022 Nov; ?(?):. doi: 10.1089/ars.2022.0090. [PMID: 36242097]
  • Nan Sheng, Yun-Qiu Wang, Cun-Fu Wang, Meng-Qi Jia, Huan-Min Niu, Qi-Qi Lu, Ya-Nan Wang, Dan Feng, Xiao-Xue Zheng, Hui-Qing Yuan. AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin. Acta pharmacologica Sinica. 2022 Nov; 43(11):2905-2916. doi: 10.1038/s41401-022-00909-3. [PMID: 35459869]
  • Weiyu Liu, Shaojun Xu, Shuangqin Liang, Changling Duan, Zhilan Xu, Le Zhao, Feifei Wen, Qiuyan Li, Yikui Li, Jinyan Zhang. Hypertensive vascular and cardiac remodeling protection by allicin in spontaneous hypertension rats via CaMK Ⅱ/NF-κB pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Nov; 155(?):113802. doi: 10.1016/j.biopha.2022.113802. [PMID: 36271577]
  • Fabian Piskol, Kerstin Neubauer, Maurice Eggers, Lisa Margarete Bode, Jan Jasper, Alan Slusarenko, Edward Reijerse, Wolfgang Lubitz, Dieter Jahn, Jürgen Moser. Two-component carnitine monooxygenase from Escherichia coli: functional characterization, inhibition and mutagenesis of the molecular interface. Bioscience reports. 2022 09; 42(9):. doi: 10.1042/bsr20221102. [PMID: 36066069]
  • Jing-Ru Wang, Yong-Mei Hu, Han Zhou, An-Ping Li, Shao-Yong Zhang, Xiong-Fei Luo, Bao-Qi Zhang, Jun-Xia An, Zhi-Jun Zhang, Ying-Qian Liu. Allicin-Inspired Heterocyclic Disulfides as Novel Antimicrobial Agents. Journal of agricultural and food chemistry. 2022 Sep; 70(37):11782-11791. doi: 10.1021/acs.jafc.2c03765. [PMID: 36067412]
  • Suhad Sami Humadi, Samir Mohamed Awad, Ahmed Abd Elkader El-Rashedy, Mohamed Fathy El-Shehry. Design, synthesis, ADME, biological evaluation and molecular dynamic studies of natural and synthetic remedy of Herpes simplex virus type-1. Pakistan journal of pharmaceutical sciences. 2022 Jul; 35(4(Special)):1181-1190. doi: . [PMID: 36218096]
  • Xiaoming Wang, Yue Wang, Ci Fang, Qianmei Gong, Jinhu Huang, Yujuan Zhang, Liping Wang. Allicin affects the pharmacokinetics of sulfadiazine and florfenicol by downregulating the expression of jejunum P-gp and BCRP in broilers. Poultry science. 2022 Jul; 101(7):101947. doi: 10.1016/j.psj.2022.101947. [PMID: 35688033]
  • Maolin Li, Jinzhuo Ning, Houbao Huang, Shuchuan Jiang, Dong Zhuo. Allicin protects against renal ischemia-reperfusion injury by attenuating oxidative stress and apoptosis. International urology and nephrology. 2022 Jul; 54(7):1761-1768. doi: 10.1007/s11255-021-03014-2. [PMID: 34825305]
  • Paola Tedeschi, Manuela Nigro, Alessia Travagli, Martina Catani, Alberto Cavazzini, Stefania Merighi, Stefania Gessi. Therapeutic Potential of Allicin and Aged Garlic Extract in Alzheimer's Disease. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23136950. [PMID: 35805955]
  • Christina Schier, Jana Foerster Née Reiter, Monika Heupel, Philipp Dörner, Michael Klaas, Wolfgang Schröder, Lothar Rink, Alan J Slusarenko, Martin C H Gruhlke. Allicin as a Volatile or Nebulisable Antimycotic for the Treatment of Pulmonary Mycoses: In Vitro Studies Using a Lung Flow Test Rig. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126607. [PMID: 35743050]
  • Qiqi Li, Yaping Zhang, Wangchang Li, Ke Yan, Yaru Liu, Huiyan Xu, Yangqing Lu, Xingwei Liang, Xiaogan Yang. Allicin protects porcine oocytes against LPS-induced defects during maturation in vitro. Theriogenology. 2022 Apr; 182(?):138-147. doi: 10.1016/j.theriogenology.2022.02.007. [PMID: 35176679]
  • Zhenglin Chang, Lingyue An, Zhican He, Yuyan Zhang, Shujue Li, Min Lei, Peng Xu, Yongchang Lai, Zheng Jiang, Yapeng Huang, Xiaolu Duan, Wenqi Wu. Allicin suppressed Escherichia coli-induced urinary tract infections by a novel MALT1/NF-κB pathway. Food & function. 2022 Mar; 13(6):3495-3511. doi: 10.1039/d1fo03853b. [PMID: 35246671]
  • Elena Catanzaro, Donatella Canistro, Valentina Pellicioni, Fabio Vivarelli, Carmela Fimognari. Anticancer potential of allicin: A review. Pharmacological research. 2022 03; 177(?):106118. doi: 10.1016/j.phrs.2022.106118. [PMID: 35134476]
  • Babatunde Joseph Oso, Akinwunmi Oluwaseun Adeoye, Ige Francis Olaoye. Pharmacoinformatics and hypothetical studies on allicin, curcumin, and gingerol as potential candidates against COVID-19-associated proteases. Journal of biomolecular structure & dynamics. 2022 Jan; 40(1):389-400. doi: 10.1080/07391102.2020.1813630. [PMID: 32876538]
  • Wenpeng Xie, Wenjie Chang, Xiaole Wang, Fei Liu, Xu Wang, Daotong Yuan, Yongkui Zhang. Allicin Inhibits Osteosarcoma Growth by Promoting Oxidative Stress and Autophagy via the Inactivation of the lncRNA MALAT1-miR-376a-Wnt/β-Catenin Signaling Pathway. Oxidative medicine and cellular longevity. 2022; 2022(?):4857814. doi: 10.1155/2022/4857814. [PMID: 35783190]
  • Yingying Zhang, Yinan Jiang, Ziying Wang, Jiayu Wang, Mingzhen Zhu, Hui Yang. Effects of Dietary Resveratrol, Bile Acids, Allicin, Betaine, and Inositol on Recovering the Lipid Metabolism Disorder in the Liver of Rare Minnow Gobiocypris rarus Caused by Bisphenol A. Aquaculture nutrition. 2022; 2022(?):6082343. doi: 10.1155/2022/6082343. [PMID: 36860429]
  • S Shamshad, K A Rizvi, H Shehnaz, S A Jatoi, L Shahnaz, S M S Naqvi, M Qasim, T Zainab, A Haider. Novel NARC-G1 garlic: comparative allicin quantification with morpho-biochemical & genetic profiling. Brazilian journal of biology = Revista brasleira de biologia. 2022; 84(?):e262697. doi: 10.1590/1519-6984.262697. [PMID: 35976350]
  • Batool Mahdi, Rana Abu-Huwaij, Iqbal Al-Khateeb. Development of topical patches releasing allicin using garlic extract. Journal of cosmetic dermatology. 2022 Jan; 21(1):396-402. doi: 10.1111/jocd.14553. [PMID: 34713965]
  • Hanan A Edres, Nabil M Taha, Mohamed A Lebda, Mohamed S Elfeky. The potential neuroprotective effect of allicin and melatonin in acrylamide-induced brain damage in rats. Environmental science and pollution research international. 2021 Nov; 28(41):58768-58780. doi: 10.1007/s11356-021-14800-x. [PMID: 34120280]
  • Lorena Avila-Carrasco, Elda Araceli García-Mayorga, Daisy L Díaz-Avila, Idalia Garza-Veloz, Margarita L Martinez-Fierro, Guadalupe T González-Mateo. Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease. Molecules (Basel, Switzerland). 2021 Oct; 26(20):. doi: 10.3390/molecules26206096. [PMID: 34684678]
  • Yungang Shan, Deqing Chen, Bo Hu, Guangtao Xu, Wanlu Li, Ye Jin, Xiuhui Jin, Xin Jin, Limin Jin. Allicin ameliorates renal ischemia/reperfusion injury via inhibition of oxidative stress and inflammation in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Oct; 142(?):112077. doi: 10.1016/j.biopha.2021.112077. [PMID: 34426252]
  • Peirong Cai, Qihang Zhu, Qianying Cao, Yuni Bai, Hui Zou, Jianhong Gu, Yan Yuan, Xuezhong Liu, Zongping Liu, Jianchun Bian. Quercetin and Allicin Can Alleviate the Hepatotoxicity of Lead (Pb) through the PI3K Signaling Pathway. Journal of agricultural and food chemistry. 2021 Aug; 69(32):9451-9460. doi: 10.1021/acs.jafc.1c03794. [PMID: 34372660]
  • Dalia O Saleh, Dina F Mansour, Ahmed M Fayez. Thioacetamide-induced acute hepatic encephalopathy: central vs peripheral effect of Allicin. Metabolic brain disease. 2021 08; 36(6):1331-1340. doi: 10.1007/s11011-021-00695-7. [PMID: 33765229]
  • Ali Hussein Abu Almaaty, Hadeer Abd El-Hak Rashed, Maha Farid Mohamed Soliman, Eman Fayad, Fayez Althobaiti, Nahla Soliman El-Shenawy. Parasitological and Biochemical Efficacy of the Active Ingredients of Allium sativum and Curcuma longa in Schistosoma mansoni Infected Mice. Molecules (Basel, Switzerland). 2021 Jul; 26(15):. doi: 10.3390/molecules26154542. [PMID: 34361695]
  • Sunpreet Kaur, Khadga Raj, Y K Gupta, Shamsher Singh. Allicin ameliorates aluminium- and copper-induced cognitive dysfunction in Wistar rats: relevance to neuro-inflammation, neurotransmitters and Aβ(1-42) analysis. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2021 06; 26(4):495-510. doi: 10.1007/s00775-021-01866-8. [PMID: 34023945]
  • Jan Borlinghaus, Jana Foerster Née Reiter, Ulrike Kappler, Haike Antelmann, Ulrike Noll, Martin C H Gruhlke, Alan J Slusarenko. Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin's Effects on Cells. Molecules (Basel, Switzerland). 2021 Mar; 26(6):. doi: 10.3390/molecules26061505. [PMID: 33801955]
  • Heba S Hamed, Somaya M Ismal, Caterina Faggio. Effect of allicin on antioxidant defense system, and immune response after carbofuran exposure in Nile tilapia, Oreochromis niloticus. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2021 Feb; 240(?):108919. doi: 10.1016/j.cbpc.2020.108919. [PMID: 33122135]
  • Bo Nan, Chaoyue Yang, Lu Li, Haiqing Ye, Haiyang Yan, Minghua Wang, Yuan Yuan. Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Feb; 148(?):111937. doi: 10.1016/j.fct.2020.111937. [PMID: 33348049]
  • Shuxue Pang, Min Jia, Jianxin Gao, Xiaoyu Liu, Wenhui Guo, Hongyan Zhang. Effects of dietary patterns combined with dietary phytochemicals on breast cancer metastasis. Life sciences. 2021 Jan; 264(?):118720. doi: 10.1016/j.lfs.2020.118720. [PMID: 33157089]
  • B Rossi, A Toschi, A Piva, E Grilli. Single components of botanicals and nature-identical compounds as a non-antibiotic strategy to ameliorate health status and improve performance in poultry and pigs. Nutrition research reviews. 2020 12; 33(2):218-234. doi: 10.1017/s0954422420000013. [PMID: 32100670]
  • Sucheta Khubber, Reza Hashemifesharaki, Mehrdad Mohammadi, Seyed Mohammad Taghi Gharibzahedi. Garlic (Allium sativum L.): a potential unique therapeutic food rich in organosulfur and flavonoid compounds to fight with COVID-19. Nutrition journal. 2020 11; 19(1):124. doi: 10.1186/s12937-020-00643-8. [PMID: 33208167]
  • Lei Ding, Jian Wu, Ning Tang, Liming Tao, Wenping Xu, Zhou Lu, Yang Zhang. Antifungal activity of an allicin derivative against Penicillium expansum via induction of oxidative stress. Journal of basic microbiology. 2020 Nov; 60(11-12):962-970. doi: 10.1002/jobm.202000267. [PMID: 33022788]
  • Xiudong Sun, Siyuan Zhu, Ningyang Li, Yi Cheng, Jing Zhao, Xuguang Qiao, Li Lu, Shiqi Liu, Yanzhou Wang, Chan Liu, Benping Li, Wu Guo, Shuang Gao, Zemao Yang, Fu Li, Zheng Zeng, Qing Tang, Yupeng Pan, Mengjiao Guan, Jian Zhao, Xiaoming Lu, Huanwen Meng, Zhenlin Han, Chunsheng Gao, Wenkai Jiang, Xing Zhao, Shilin Tian, Jianguang Su, Zhihui Cheng, Touming Liu. A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis. Molecular plant. 2020 09; 13(9):1328-1339. doi: 10.1016/j.molp.2020.07.019. [PMID: 32730994]
  • Chad R Schultz, Martin C H Gruhlke, Alan J Slusarenko, André S Bachmann. Allicin, a Potent New Ornithine Decarboxylase Inhibitor in Neuroblastoma Cells. Journal of natural products. 2020 08; 83(8):2518-2527. doi: 10.1021/acs.jnatprod.0c00613. [PMID: 32786875]
  • Chuanhai Zhang, Xiaoyun He, Yao Sheng, Cui Yang, Jia Xu, Shujuan Zheng, Junyu Liu, Wentao Xu, Yunbo Luo, Kunlun Huang. Allicin-induced host-gut microbe interactions improves energy homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2020 08; 34(8):10682-10698. doi: 10.1096/fj.202001007r. [PMID: 32619085]
  • Yi Wang, Chaoyi Deng, Keni Cota-Ruiz, Jose R Peralta-Videa, Youping Sun, Swati Rawat, Wenjuan Tan, Andres Reyes, Jose A Hernandez-Viezcas, Genhua Niu, Chunqiang Li, Jorge L Gardea-Torresdey. Improvement of nutrient elements and allicin content in green onion (Allium fistulosum) plants exposed to CuO nanoparticles. The Science of the total environment. 2020 Jul; 725(?):138387. doi: 10.1016/j.scitotenv.2020.138387. [PMID: 32298898]
  • Chang-Ling Li, Xiao-Hong Liu, Yun Qiao, Lu-Ning Ning, Wen-Jing Li, Ying-Shan Sun, De-Shan Liu, Wei Gao, Chun-Mei Ma. Allicin alleviates inflammation of diabetic macroangiopathy via the Nrf2 and NF-kB pathway. European journal of pharmacology. 2020 Jun; 876(?):173052. doi: 10.1016/j.ejphar.2020.173052. [PMID: 32135124]
  • Sulin Choo, Voon Kin Chin, Eng Hwa Wong, Priya Madhavan, Sun Tee Tay, Phelim Voon Chen Yong, Pei Pei Chong. Review: antimicrobial properties of allicin used alone or in combination with other medications. Folia microbiologica. 2020 Jun; 65(3):451-465. doi: 10.1007/s12223-020-00786-5. [PMID: 32207097]
  • Philipp Dörner, Philipp M Müller, Jana Reiter, Martin C Gruhlke, Alan J Slusarenko, Wolfgang Schröder, Michael Klaas. Feasibility study of a surface-coated lung model to quantify active agent deposition for preclinical studies. Clinical biomechanics (Bristol, Avon). 2020 06; 76(?):105029. doi: 10.1016/j.clinbiomech.2020.105029. [PMID: 32422391]
  • Yara A Samra, Mohamed F Hamed, Ahmed R El-Sheakh. Hepatoprotective effect of allicin against acetaminophen-induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration. Journal of biochemical and molecular toxicology. 2020 May; 34(5):e22470. doi: 10.1002/jbt.22470. [PMID: 32040233]
  • Jan Borlinghaus, Anthony Bolger, Christina Schier, Alexander Vogel, Björn Usadel, Martin Ch Gruhlke, Alan J Slusarenko. Genetic and molecular characterization of multicomponent resistance of Pseudomonas against allicin. Life science alliance. 2020 05; 3(5):. doi: 10.26508/lsa.202000670. [PMID: 32234751]
  • Yang Liu, Meigui You, Jianwei Shen, Yaping Xu, Lin Li, Dongtao Wang, Yajun Yang. Allicin Reversed the Process of Frailty in Aging Male Fischer 344 Rats With Osteoporosis. The journals of gerontology. Series A, Biological sciences and medical sciences. 2020 04; 75(5):821-825. doi: 10.1093/gerona/glz205. [PMID: 31541608]
  • Gaber El-Saber Batiha, Amany Magdy Beshbishy, Lamiaa G Wasef, Yaser H A Elewa, Ahmed A Al-Sagan, Mohamed E Abd El-Hack, Ayman E Taha, Yasmina M Abd-Elhakim, Hari Prasad Devkota. Chemical Constituents and Pharmacological Activities of Garlic (Allium sativum L.): A Review. Nutrients. 2020 Mar; 12(3):. doi: 10.3390/nu12030872. [PMID: 32213941]
  • Suraphan Panyod, Wei-Kai Wu, Kuan-Hung Lu, Chun-Ting Liu, Yung-Lin Chu, Chi-Tang Ho, Wen-Luan Wendy Hsiao, Yi-Syuan Lai, Wei-Cheng Chen, Yu-En Lin, Shi-Hang Lin, Ming-Shiang Wu, Lee-Yan Sheen. Allicin Modifies the Composition and Function of the Gut Microbiota in Alcoholic Hepatic Steatosis Mice. Journal of agricultural and food chemistry. 2020 Mar; 68(10):3088-3098. doi: 10.1021/acs.jafc.9b07555. [PMID: 32050766]
  • Ibrahim T El-Ratel, Abdel-Khalek E Abdel-Khalek, Sherif A Gabr, Mohamed E Hammad, Hanan I El-Morsy. Influence of allicin administration on reproductive efficiency, immunity and lipid peroxidation of rabbit does under high ambient temperature. Journal of animal physiology and animal nutrition. 2020 Mar; 104(2):539-548. doi: 10.1111/jpn.13316. [PMID: 31989705]
  • Mohamed M Said, Cathy Watson, Danilla Grando. Garlic alters the expression of putative virulence factor genes SIR2 and ECE1 in vulvovaginal C. albicans isolates. Scientific reports. 2020 02; 10(1):3615. doi: 10.1038/s41598-020-60178-0. [PMID: 32107396]
  • Keyu Chen, Yasushi Nakasone, Kun Xie, Kozue Sakao, De-Xing Hou. Modulation of Allicin-Free Garlic on Gut Microbiome. Molecules (Basel, Switzerland). 2020 Feb; 25(3):. doi: 10.3390/molecules25030682. [PMID: 32033507]
  • Sahar Hassan Orabi, Doaa Abd Eldaium, Azza Hassan, Hesham Saad El Sabagh, Mabrouk Attia Abd Eldaim. Allicin modulates diclofenac sodium induced hepatonephro toxicity in rats via reducing oxidative stress and caspase 3 protein expression. Environmental toxicology and pharmacology. 2020 Feb; 74(?):103306. doi: 10.1016/j.etap.2019.103306. [PMID: 31812117]
  • Vahid Sayadi, Ghasem Karimzadeh, Sajad Rashidi Monfared, Mohammad Reza Naghavi. Identification and expression analysis of S-alk(en)yl-L-cysteine sulfoxide lyase isoform genes and determination of allicin contents in Allium species. PloS one. 2020; 15(2):e0228747. doi: 10.1371/journal.pone.0228747. [PMID: 32092058]
  • Qian Xiang, Zhangrong Cheng, Juntan Wang, Xiaobo Feng, Wenbin Hua, Rongjin Luo, Bingjin Wang, Zhiwei Liao, Liang Ma, Gaocai Li, Saideng Lu, Kun Wang, Yu Song, Shuai Li, Xinghuo Wu, Cao Yang, Yukun Zhang. Allicin Attenuated Advanced Oxidation Protein Product-Induced Oxidative Stress and Mitochondrial Apoptosis in Human Nucleus Pulposus Cells. Oxidative medicine and cellular longevity. 2020; 2020(?):6685043. doi: 10.1155/2020/6685043. [PMID: 33381267]
  • Jana Reiter, Anna Maria Hübbers, Frank Albrecht, Lars Ingo Ole Leichert, Alan John Slusarenko. Allicin, a natural antimicrobial defence substance from garlic, inhibits DNA gyrase activity in bacteria. International journal of medical microbiology : IJMM. 2020 Jan; 310(1):151359. doi: 10.1016/j.ijmm.2019.151359. [PMID: 31585716]
  • H Z Gong, M Wu, W Y Lang, M Yang, J H Wang, Y Q Wang, Y Zhang, X Zheng. Effects of laying breeder hens dietary β-carotene, curcumin, allicin, and sodium butyrate supplementation on the growth performance, immunity, and jejunum morphology of their offspring chicks. Poultry science. 2020 Jan; 99(1):151-162. doi: 10.3382/ps/pez584. [PMID: 32416796]
  • Xin'e Shi, Xiaomin Zhou, Xinyi Chu, Jie Wang, Baocai Xie, Jing Ge, Yuan Guo, Xiao Li, Gongshe Yang. Allicin Improves Metabolism in High-Fat Diet-Induced Obese Mice by Modulating the Gut Microbiota. Nutrients. 2019 Dec; 11(12):. doi: 10.3390/nu11122909. [PMID: 31810206]
  • Dominik Wüllner, Annika Haupt, Pascal Prochnow, Roman Leontiev, Alan J Slusarenko, Julia E Bandow. Interspecies Comparison of the Bacterial Response to Allicin Reveals Species-Specific Defense Strategies. Proteomics. 2019 12; 19(24):e1900064. doi: 10.1002/pmic.201900064. [PMID: 31622046]
  • Ved Prakash Dwivedi, Debapriya Bhattacharya, Mona Singh, Ashima Bhaskar, Santosh Kumar, Samreen Fatima, Parveen Sobia, Luc Van Kaer, Gobardhan Das. Allicin enhances antimicrobial activity of macrophages during Mycobacterium tuberculosis infection. Journal of ethnopharmacology. 2019 Oct; 243(?):111634. doi: 10.1016/j.jep.2018.12.008. [PMID: 30537531]
  • Yu Chen, Ying Wang, Mei Yang, Meng-Yao Guo. Allicin Inhibited Staphylococcus aureus -Induced Mastitis by Reducing Lipid Raft Stability via LxRα in Mice. Journal of agricultural and food chemistry. 2019 Oct; 67(39):10863-10870. doi: 10.1021/acs.jafc.9b04378. [PMID: 31507180]
  • Vallerinteavide Mavelli Girish, Hongying Liang, Jennifer T Aguilan, Joshua D Nosanchuk, Joel M Friedman, Parimala Nacharaju. Anti-biofilm activity of garlic extract loaded nanoparticles. Nanomedicine : nanotechnology, biology, and medicine. 2019 08; 20(?):102009. doi: 10.1016/j.nano.2019.04.012. [PMID: 31085344]
  • Vu Van Loi, Nguyen Thi Thu Huyen, Tobias Busche, Quach Ngoc Tung, Martin Clemens Horst Gruhlke, Jörn Kalinowski, Jörg Bernhardt, Alan John Slusarenko, Haike Antelmann. Staphylococcus aureus responds to allicin by global S-thioallylation - Role of the Brx/BSH/YpdA pathway and the disulfide reductase MerA to overcome allicin stress. Free radical biology & medicine. 2019 08; 139(?):55-69. doi: 10.1016/j.freeradbiomed.2019.05.018. [PMID: 31121222]
  • Shengzhong Liu, Ying He, Jun Shi, Lulu Liu, Hao Ma, Li He, Yingqiang Guo. Allicin Attenuates Myocardial Ischemia Reperfusion Injury in Rats by Inhibition of Inflammation and Oxidative Stress. Transplantation proceedings. 2019 Jul; 51(6):2060-2065. doi: 10.1016/j.transproceed.2019.04.039. [PMID: 31399184]
  • Cheng-Wei Lu, Chi-Feng Hung, Tzu-Yu Lin, Ting Yang Hsieh, Su Jane Wang. Allicin Inhibits Glutamate Release from Rat Cerebral Cortex Nerve Terminals Through Suppressing Ca2+ Influx and Protein Kinase C Activity. Journal of medicinal food. 2019 Jul; 22(7):696-702. doi: 10.1089/jmf.2018.4337. [PMID: 30985232]
  • Hamed Imani Rad, Hadi Peeri, Mojtaba Amani, Alireza Mohammadnia, Abiodun David Ogunniyi, Manouchehr Khazandi, Henrietta Venter, Mohsen Arzanlou. Allicin prevents the formation of Proteus-induced urinary crystals and the blockage of catheter in a bladder model in vitro. Microbial pathogenesis. 2019 Jul; 132(?):293-301. doi: 10.1016/j.micpath.2019.05.016. [PMID: 31082531]
  • Yongchang Lai, Xiongfa Liang, Fangling Zhong, Weizhou Wu, Tao Zeng, Jian Huang, Xiaolu Duan, Shujue Li, Guohua Zeng, Wenqi Wu. Allicin attenuates calcium oxalate crystal deposition in the rat kidney by regulating gap junction function. Journal of cellular physiology. 2019 06; 234(6):9640-9651. doi: 10.1002/jcp.27651. [PMID: 30378099]
  • Qian Jiang, Junquan Tian, Gang Liu, Yulong Yin, Kang Yao. Endoplasmic Reticulum Stress and Unfolded Protein Response Pathways Involved in the Health-Promoting Effects of Allicin on the Jejunum. Journal of agricultural and food chemistry. 2019 May; 67(21):6019-6031. doi: 10.1021/acs.jafc.9b02180. [PMID: 31067048]
  • Mohamed M Abdel-Daim, Abdelrahman Ibrahim Abushouk, Thoria Donia, Saud Alarifi, Saad Alkahtani, Lotfi Aleya, Simona G Bungau. The nephroprotective effects of allicin and ascorbic acid against cisplatin-induced toxicity in rats. Environmental science and pollution research international. 2019 May; 26(13):13502-13509. doi: 10.1007/s11356-019-04780-4. [PMID: 30911969]
  • Ning Shen, Ailing Cheng, Mengru Qiu, Guodong Zang. Allicin Improves Lung Injury Induced by Sepsis via Regulation of the Toll-Like Receptor 4 (TLR4)/Myeloid Differentiation Primary Response 88 (MYD88)/Nuclear Factor kappa B (NF-κB) Pathway. Medical science monitor : international medical journal of experimental and clinical research. 2019 Apr; 25(?):2567-2576. doi: 10.12659/msm.914114. [PMID: 30957795]
  • Chung Gi Lee, Dong Kwon Rhee, Byung Oh Kim, Sung Hee Um, Suhkneung Pyo. Allicin induces beige-like adipocytes via KLF15 signal cascade. The Journal of nutritional biochemistry. 2019 02; 64(?):13-24. doi: 10.1016/j.jnutbio.2018.09.014. [PMID: 30423518]
  • Martin C H Gruhlke, Haike Antelmann, Jörg Bernhardt, Veronika Kloubert, Lothar Rink, Alan J Slusarenko. The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects. Free radical biology & medicine. 2019 02; 131(?):144-153. doi: 10.1016/j.freeradbiomed.2018.11.022. [PMID: 30500420]
  • Zobia Naheed, Zafar Rizwan, Zhihui Cheng, Noor A Khan, Muhammad Hanif. Effect of pre-storage removal of different parts of the scape top on the biochemical changes of two garlic cultivars during controlled atmosphere storage. Journal of the science of food and agriculture. 2019 Jan; 99(2):797-804. doi: 10.1002/jsfa.9248. [PMID: 29998496]
  • Pilong Shi, Yonggang Cao, Jingquan Gao, Bowen Fu, Jing Ren, Lina Ba, Chao Song, Hanping Qi, Wei Huang, Xueying Guan, Hongli Sun. Allicin improves the function of cardiac microvascular endothelial cells by increasing PECAM-1 in rats with cardiac hypertrophy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Dec; 51(?):241-254. doi: 10.1016/j.phymed.2018.10.021. [PMID: 30466623]
  • Abraham Said Arellano Buendía, Montserrat Tostado González, Omegar Sánchez Reyes, Fernando Enrique García Arroyo, Raúl Argüello García, Edilia Tapia, Laura Gabriela Sánchez Lozada, Horacio Osorio Alonso. Immunomodulatory Effects of the Nutraceutical Garlic Derivative Allicin in the Progression of Diabetic Nephropathy. International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103107. [PMID: 30314265]
  • Roman Leontiev, Nils Hohaus, Claus Jacob, Martin C H Gruhlke, Alan J Slusarenko. A Comparison of the Antibacterial and Antifungal Activities of Thiosulfinate Analogues of Allicin. Scientific reports. 2018 04; 8(1):6763. doi: 10.1038/s41598-018-25154-9. [PMID: 29712980]
  • R S Soumya, S Sherin, K G Raghu, Annie Abraham. Allicin functionalized locust bean gum nanoparticles for improved therapeutic efficacy: An in silico, in vitro and in vivo approach. International journal of biological macromolecules. 2018 Apr; 109(?):740-747. doi: 10.1016/j.ijbiomac.2017.11.065. [PMID: 29155156]
  • Rasha T M Alam, Elshaima M Fawzi, Maha I Alkhalf, Wafa S Alansari, Lotfi Aleya, Mohamed M Abdel-Daim. Anti-Inflammatory, Immunomodulatory, and Antioxidant Activities of Allicin, Norfloxacin, or Their Combination against Pasteurella multocida Infection in Male New Zealand Rabbits. Oxidative medicine and cellular longevity. 2018; 2018(?):1780956. doi: 10.1155/2018/1780956. [PMID: 30050645]
  • Nguyen T Le, Jhansi R Kalluri, Armando Loni, Leigh T Canham, Jeffery L Coffer. Biogenic Nanostructured Porous Silicon as a Carrier for Stabilization and Delivery of Natural Therapeutic Species. Molecular pharmaceutics. 2017 12; 14(12):4509-4514. doi: 10.1021/acs.molpharmaceut.7b00638. [PMID: 29111753]
  • R X Lan, J W Park, D W Lee, I H Kim. Effects of Astragalus membranaceus, Codonopsis pilosula and allicin mixture on growth performance, nutrient digestibility, faecal microbial shedding, immune response and meat quality in finishing pigs. Journal of animal physiology and animal nutrition. 2017 Dec; 101(6):1122-1129. doi: 10.1111/jpn.12625. [PMID: 27868250]
  • Jing Lu, Bijun Cheng, Baochen Fang, Zhuoqun Meng, Yiying Zheng, Xiaochen Tian, Shuang Guan. Protective effects of allicin on 1,3-DCP-induced lipid metabolism disorder in HepG2 cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Dec; 96(?):1411-1417. doi: 10.1016/j.biopha.2017.10.125. [PMID: 29169723]
  • Jana Reiter, Natalja Levina, Mark van der Linden, Martin Gruhlke, Christian Martin, Alan J Slusarenko. Diallylthiosulfinate (Allicin), a Volatile Antimicrobial from Garlic (Allium sativum), Kills Human Lung Pathogenic Bacteria, Including MDR Strains, as a Vapor. Molecules (Basel, Switzerland). 2017 Oct; 22(10):. doi: 10.3390/molecules22101711. [PMID: 29023413]
  • Ehécatl Miguel Ángel García Trejo, Abraham Said Arellano Buendía, Omegar Sánchez Reyes, Fernando Enrique García Arroyo, Raúl Arguello García, María Lilia Loredo Mendoza, Edilia Tapia, Laura Gabriela Sánchez Lozada, Horacio Osorio Alonso. The Beneficial Effects of Allicin in Chronic Kidney Disease Are Comparable to Losartan. International journal of molecular sciences. 2017 Sep; 18(9):. doi: 10.3390/ijms18091980. [PMID: 28926934]
  • Martin C H Gruhlke, Ivan Schlembach, Roman Leontiev, Andreas Uebachs, Peter U G Gollwitzer, Alexander Weiss, Agnes Delaunay, Michel Toledano, Alan J Slusarenko. Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic. Free radical biology & medicine. 2017 07; 108(?):793-802. doi: 10.1016/j.freeradbiomed.2017.05.004. [PMID: 28479370]
  • D H El-Kashef, A E El-Kenawi, G M Suddek, H A Salem. Allicin ameliorates kidney function and urinary bladder sensitivity in cyclosporine A-treated rats. Human & experimental toxicology. 2017 Jul; 36(7):681-691. doi: 10.1177/0960327116660864. [PMID: 27596067]
  • Guodong Zhu, Yin Luo, Ming Xue, Fangyuan Zhou, Haipeng Zhao, Guixia Ji, Fang Liu. Resistance of Garlic Cultivars to Bradysia odoriphaga and Its Correlation with Garlic Thiosulfinates. Scientific reports. 2017 06; 7(1):3249. doi: 10.1038/s41598-017-03617-9. [PMID: 28607407]
  • Xiao-Long Lin, Hui-Jun Hu, Yuan-Bo Liu, Xue-Mei Hu, Xiao-Juan Fan, Wei-Wen Zou, Yong-Quan Pan, Wen-Quan Zhou, Min-Wen Peng, Cai-Hong Gu. Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRα signaling in THP-1 macrophage-derived foam cells. International journal of molecular medicine. 2017 Jun; 39(6):1452-1460. doi: 10.3892/ijmm.2017.2949. [PMID: 28440421]
  • Frank Albrecht, Roman Leontiev, Claus Jacob, Alan J Slusarenko. An Optimized Facile Procedure to Synthesize and Purify Allicin. Molecules (Basel, Switzerland). 2017 May; 22(5):. doi: 10.3390/molecules22050770. [PMID: 28489057]