Aridanin (BioDeep_00000007055)

   

PANOMIX_OTCML-2023


代谢物信息卡片


Olean-12-en-28-oic acid, 3-[[2-(acetylamino)-2-deoxy-.beta.-D-glucopyranosyl]oxy]-, (3.beta.)-

化学式: C38H61NO8 (659.4397)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 98.44%

分子结构信息

SMILES: CC(=O)NC1C(C(C(OC1OC2CCC3(C(C2(C)C)CCC4(C3CC=C5C4(CCC6(C5CC(CC6)(C)C)C(=O)O)C)C)C)CO)O)O
InChI: InChI=1S/C38H61NO8/c1-21(41)39-28-30(43)29(42)24(20-40)46-31(28)47-27-12-13-35(6)25(34(27,4)5)11-14-37(8)26(35)10-9-22-23-19-33(2,3)15-17-38(23,32(44)45)18-16-36(22,37)7/h9,23-31,40,42-43H,10-20H2,1-8H3,(H,39,41)(H,44,45)/t23-,24+,25-,26+,27-,28+,29+,30+,31-,35-,36+,37+,38-/m0/s1



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ABCB1, ANXA5, BCL2, BRAF, CASP3, CAT, CDK2, EGFR, GLUL, ITGB1, VIM, XDH
Peripheral membrane protein 2 ACHE, ANXA5
Endosome membrane 2 EGFR, ITGB1
Endoplasmic reticulum membrane 2 BCL2, EGFR
Mitochondrion membrane 1 ABCG2
Nucleus 8 ACHE, BCL2, BRAF, CASP3, CDK2, EGFR, GLUL, MPO
cytosol 9 ANXA5, BCL2, BRAF, CASP3, CAT, CDK2, GLUL, VIM, XDH
mitochondrial membrane 1 ABCG2
phagocytic vesicle 1 VIM
centrosome 1 CDK2
nucleoplasm 4 ABCG2, CASP3, CDK2, MPO
Cell membrane 9 ABCB1, ABCG2, ACHE, BRAF, EGFR, GLUL, ITGB1, ITGB4, VIM
Lipid-anchor 1 GLUL
Cleavage furrow 1 ITGB1
lamellipodium 1 ITGB1
ruffle membrane 2 EGFR, ITGB1
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 ABCB1, ABCG2
Synapse 2 ACHE, ITGB1
cell junction 3 EGFR, ITGB1, ITGB4
cell surface 5 ABCB1, ACHE, EGFR, ITGB1, ITGB4
glutamatergic synapse 3 BRAF, CASP3, EGFR
Golgi apparatus 1 ACHE
Golgi membrane 1 EGFR
neuromuscular junction 2 ACHE, ITGB1
neuronal cell body 1 CASP3
postsynapse 1 BRAF
sarcolemma 2 ANXA5, ITGB1
Cytoplasm, cytosol 1 GLUL
Lysosome 1 MPO
Presynapse 1 BRAF
endosome 2 CDK2, EGFR
plasma membrane 9 ABCB1, ABCG2, ACHE, BRAF, EGFR, GLUL, ITGB1, ITGB4, VIM
Membrane 9 ABCB1, ABCG2, ACHE, ANXA5, BCL2, CAT, EGFR, ITGB1, ITGB4
apical plasma membrane 3 ABCB1, ABCG2, EGFR
axon 1 VIM
basolateral plasma membrane 1 EGFR
extracellular exosome 8 ABCB1, ANXA5, CAT, GLUL, ITGB1, ITGB4, MPO, VIM
endoplasmic reticulum 2 BCL2, GLUL
extracellular space 4 ACHE, EGFR, MPO, XDH
perinuclear region of cytoplasm 3 ACHE, EGFR, ITGB1
Schaffer collateral - CA1 synapse 1 ITGB1
intercalated disc 1 ITGB1
mitochondrion 4 BCL2, BRAF, CAT, GLUL
protein-containing complex 3 BCL2, CAT, EGFR
intracellular membrane-bounded organelle 3 BRAF, CAT, MPO
filopodium 1 ITGB1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 3 EGFR, ITGB1, ITGB4
Secreted 1 ACHE
extracellular region 4 ACHE, ANXA5, CAT, MPO
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ITGB1
transcription regulator complex 1 CDK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDK2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 3 BCL2, EGFR, ITGB4
external side of plasma membrane 2 ANXA5, ITGB1
dendritic spine 1 ITGB1
nucleolus 1 ITGB4
recycling endosome 1 ITGB1
integrin alpha3-beta1 complex 1 ITGB1
Apical cell membrane 2 ABCB1, ABCG2
Cell projection, lamellipodium 1 ITGB1
Cell projection, ruffle membrane 1 ITGB1
Membrane raft 3 ABCG2, EGFR, ITGB1
pore complex 1 BCL2
Cell junction, focal adhesion 1 ITGB1
Cytoplasm, cytoskeleton 1 VIM
focal adhesion 6 ANXA5, CAT, EGFR, ITGB1, ITGB4, VIM
Peroxisome 3 CAT, VIM, XDH
basement membrane 2 ACHE, ITGB4
intracellular vesicle 1 EGFR
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 ANXA5
secretory granule 1 MPO
intermediate filament 1 VIM
ruffle 1 ITGB1
receptor complex 3 EGFR, ITGB1, ITGB4
Zymogen granule membrane 1 ANXA5
neuron projection 2 BRAF, VIM
cell leading edge 2 ITGB4, VIM
cytoskeleton 1 VIM
brush border membrane 1 ABCG2
chromosome, telomeric region 1 CDK2
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 CDK2
microtubule organizing center 1 VIM
Melanosome 1 ITGB1
cell body 2 BRAF, GLUL
side of membrane 1 ACHE
myelin sheath 1 BCL2
intermediate filament cytoskeleton 1 VIM
basal plasma membrane 2 EGFR, ITGB4
azurophil granule 1 MPO
synaptic membrane 2 EGFR, ITGB1
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
nuclear matrix 1 VIM
male germ cell nucleus 1 CDK2
azurophil granule lumen 1 MPO
Nucleus matrix 1 VIM
vesicle membrane 1 ANXA5
clathrin-coated endocytic vesicle membrane 1 EGFR
phagocytic vesicle lumen 1 MPO
Cajal body 1 CDK2
synaptic cleft 1 ACHE
external side of apical plasma membrane 2 ABCB1, ABCG2
death-inducing signaling complex 1 CASP3
condensed chromosome 1 CDK2
cerebellar climbing fiber to Purkinje cell synapse 1 ITGB1
Nucleus, Cajal body 1 CDK2
X chromosome 1 CDK2
Y chromosome 1 CDK2
integrin alpha10-beta1 complex 1 ITGB1
integrin complex 2 ITGB1, ITGB4
cyclin-dependent protein kinase holoenzyme complex 1 CDK2
glial cell projection 2 GLUL, ITGB1
cyclin E1-CDK2 complex 1 CDK2
cyclin E2-CDK2 complex 1 CDK2
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
catalase complex 1 CAT
Cell projection, invadopodium membrane 1 ITGB1
[Isoform 5]: Cell membrane, sarcolemma 1 ITGB1
integrin alpha1-beta1 complex 1 ITGB1
integrin alpha11-beta1 complex 1 ITGB1
integrin alpha2-beta1 complex 1 ITGB1
integrin alpha4-beta1 complex 1 ITGB1
integrin alpha5-beta1 complex 1 ITGB1
integrin alpha6-beta1 complex 1 ITGB1
integrin alpha7-beta1 complex 1 ITGB1
integrin alpha8-beta1 complex 1 ITGB1
integrin alpha9-beta1 complex 1 ITGB1
integrin alphav-beta1 complex 1 ITGB1
myelin sheath abaxonal region 1 ITGB1
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
hemidesmosome 1 ITGB4
cyclin A2-CDK2 complex 1 CDK2
[Isoform H]: Cell membrane 1 ACHE
cyclin A1-CDK2 complex 1 CDK2


文献列表

  • Michael Hermann Kengne Kamdem, Stéphane Zingue, Timothy Grein, Sebastian Maxeiner, Jochen Rutz, Edwin Mpho Mmutlane, Dieudonné Njamen, Roman A Blaheta, Derek Tantoh Ndinteh. Aridanin and oleanane-3- O-β-D-glucoside-2'-acetamide obtained from Tetrapleura tetraptera (Schumach. & Thonn) Taub. (Fabaceae) induces potent apoptotic activity in human prostate cancer cells. Journal of ethnopharmacology. 2023 Oct; ?(?):117298. doi: 10.1016/j.jep.2023.117298. [PMID: 37866463]
  • E-Nuo Su, Shi-Shan Yu, Yue-Hu Pei. [Studies on chemical constituents from stems and leaves of Adenanthera pavanina]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2007 Oct; 32(20):2135-8. doi: . [PMID: 18306745]
  • G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase. Journal of natural products. 1991 Jan; 54(1):143-54. doi: 10.1021/np50073a012. [PMID: 1710653]
  • C O Adewunmi, P Furu. Evaluation of aridanin, a glycoside, and Aridan, an aqueous extract of Tetrapleura tetraptera fruit, on Schistosoma mansoni and S. bovis. Journal of ethnopharmacology. 1989 Dec; 27(3):277-83. doi: 10.1016/0378-8741(89)90002-0. [PMID: 2615433]
  • C O Adewunmi, W Becker, G Dörfler. Effect of prolonged administration of sublethal concentrations of aridanin isolated from Tetrapleura tetraptera and bayluscide on the glycogen and protein content of Biomphalaria glabrata. Journal of ethnopharmacology. 1988 Sep; 24(1):107-14. doi: 10.1016/0378-8741(88)90141-9. [PMID: 3199835]