Pancratistatin (BioDeep_00000000607)

   

PANOMIX_OTCML-2023


代谢物信息卡片


(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1R-(1alpha,2beta,3alpha,4alpha,4aalpha,11bbeta))-

化学式: C14H15NO8 (325.079763)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2%

分子结构信息

SMILES: C1OC2=C(O1)C(=C3C(=C2)C4C(C(C(C(C4O)O)O)O)NC3=O)O
InChI: InChI=1S/C14H15NO8/c16-8-5-3-1-4-13(23-2-22-4)9(17)6(3)14(21)15-7(5)10(18)12(20)11(8)19/h1,5,7-8,10-12,16-20H,2H2,(H,15,21)/t5-,7-,8-,10+,11+,12+/m1/s1

描述信息

Pancratistatin is a citraconoyl group.
Pancratistatin is a natural product found in Delphinium denudatum, Hymenocallis speciosa, and other organisms with data available.
Pancratistatin is a isoquinoline alkaloid from amaryllis with antineoplastic activity.

同义名列表

19 个代谢物同义名

(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1R-(1alpha,2beta,3alpha,4alpha,4aalpha,11bbeta))-; [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, [1R-(1alpha,2beta,3alpha,4alpha,4aalpha,11bbeta)]-; [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1R,2S,3S,4S,4aR,11bR)-; (1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-, (1R,2S,3S,4S,4aR,11bR)-; (1R,2S,3S,4S,4aR,11bR)-1,2,3,4,7-pentahydroxy-2,3,4,4a,5,11b-hexahydro-1H-[1,3]dioxolo[4,5-j]phenanthridin-6-one; (1R,2S,3S,4S,4aR,11bR)-1,3,4,4a,5,11b-Hexahydro-1,2,3,4,7-pentahydroxy[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one; (1R,2S,3S,4S,4aR,11bR)-1,3,4,4a,5,11b-Hexahydro-1,2,3,4,7-pentahydroxy(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one; [1,5-j]phenanthridin-6(2H)-one, 1,3,4,4a,5,11b-hexahydro-1,2,3,4,7-pentahydroxy-,; VREZDOWOLGNDPW-ALTGWBOUSA-N; (+)-Pancratistatin; Pancratistatine; UNII-4GUM4B7K5B; Pancratistatin; NCI60_003105; SMP1_000217; 4GUM4B7K5B; 96203-70-2; NSC349156; C08535



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Deepali Katoch, Dharmesh Kumar, Yogendra S Padwad, Bikram Singh, Upendra Sharma. Narciclasine-4-O-β-D-xylopyranoside, a new narciclasine glycoside from Zephyranthes minuta. Natural product research. 2020 Jan; 34(2):233-240. doi: 10.1080/14786419.2018.1527836. [PMID: 30636443]
  • Jerald J Nair, Johannes van Staden. Pharmacological and toxicological insights to the South African Amaryllidaceae. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2013 Dec; 62(?):262-75. doi: 10.1016/j.fct.2013.08.042. [PMID: 23994658]
  • Jerald J Nair, Lucie Rárová, Miroslav Strnad, Jaume Bastida, Johannes van Staden. Apoptosis-inducing effects of distichamine and narciprimine, rare alkaloids of the plant family Amaryllidaceae. Bioorganic & medicinal chemistry letters. 2012 Oct; 22(19):6195-9. doi: 10.1016/j.bmcl.2012.08.005. [PMID: 22921081]
  • Dennis Ma, Phillip Tremblay, Kevinjeet Mahngar, Pardis Akbari-Asl, Jonathan Collins, Tomas Hudlicky, James McNulty, Siyaram Pandey. A novel synthetic C-1 analogue of 7-deoxypancratistatin induces apoptosis in p53 positive and negative human colorectal cancer cells by targeting the mitochondria: enhancement of activity by tamoxifen. Investigational new drugs. 2012 Jun; 30(3):1012-27. doi: 10.1007/s10637-011-9668-7. [PMID: 21494837]
  • Xiaofan Na, Yanfeng Hu, Kun Yue, Hongxia Lu, Pengfei Jia, Huahua Wang, Xiaomin Wang, Yurong Bi. Concentration-dependent effects of narciclasine on cell cycle progression in Arabidopsis root tips. BMC plant biology. 2011 Dec; 11(?):184. doi: 10.1186/1471-2229-11-184. [PMID: 22204558]
  • S J Chatterjee, P Ovadje, M Mousa, C Hamm, S Pandey. The efficacy of dandelion root extract in inducing apoptosis in drug-resistant human melanoma cells. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):129045. doi: 10.1155/2011/129045. [PMID: 21234313]
  • Carly Griffin, Natasha Sharda, Divya Sood, Jerald Nair, James McNulty, Siyaram Pandey. Selective cytotoxicity of pancratistatin-related natural Amaryllidaceae alkaloids: evaluation of the activity of two new compounds. Cancer cell international. 2007 Jun; 7(?):10. doi: 10.1186/1475-2867-7-10. [PMID: 17550595]
  • Natasha Kekre, Carly Griffin, James McNulty, Siyaram Pandey. Pancratistatin causes early activation of caspase-3 and the flipping of phosphatidyl serine followed by rapid apoptosis specifically in human lymphoma cells. Cancer chemotherapy and pharmacology. 2005 Jul; 56(1):29-38. doi: 10.1007/s00280-004-0941-8. [PMID: 15726366]
  • Motoh Mutsuga, Keisuke Kojima, Miwako Yamashita, Takamasa Ohno, Yukio Ogihara, Makoto Inoue. Inhibition of cell cycle progression through specific phase by pancratistatin derivatives. Biological & pharmaceutical bulletin. 2002 Feb; 25(2):223-8. doi: 10.1248/bpb.25.223. [PMID: 11853171]
  • P Khan, S Abbas, B Petit, R Caffrey, V Megram, A McGown. Development and validation of a high-performance liquid chromatographic assay using solid-phase extraction for the novel antitumor agent pancratistatin in human plasma. Journal of chromatography. B, Biomedical sciences and applications. 1999 Apr; 726(1-2):249-54. doi: 10.1016/s0378-4347(99)00053-5. [PMID: 10348192]
  • G R Pettit, G R Pettit, R A Backhaus, F E Boettner. Antineoplastic agents, 294. Variations in the formation of pancratistatin and related isocarbostyrils in Hymenocallis littoralis. Journal of natural products. 1995 Jan; 58(1):37-43. doi: 10.1021/np50115a004. [PMID: 7760076]