Erythrodiol (BioDeep_00000604176)

Main id: BioDeep_00000000549

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol

化学式: C30H50O2 (442.3811)
中文名称: 赤藓糖醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(C)CC[C@]2(CO)CC[C@]3(C)C(=CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]2C1
InChI: InChI=1S/C30H50O2/c1-25(2)14-16-30(19-31)17-15-28(6)20(21(30)18-25)8-9-23-27(5)12-11-24(32)26(3,4)22(27)10-13-29(23,28)7/h8,21-24,31-32H,9-19H2,1-7H3/t21-,22-,23+,24-,27-,28+,29+,30+/m0/s1

描述信息

Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1].
Erythrodiol is an olive oil component. Erythrodiol promotes Cholesterol efflux (ChE) by selectively inhibiting the degradation of ABCA1 protein. Erythrodiol is a good candidate to be further explored for therapeutic or preventive application in the context of atherosclerosis[1].

同义名列表

9 个代谢物同义名

(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-8a-(hydroxymethyl)-4,4,6a,6b,11,11,14b-heptamethyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol; (3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-methylol-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-ol; (3beta)-Olean-12-ene-3,28-diol; olean-12-ene-3beta,28-diol; EINECS 208-890-4; Erythrodiol; 09258_FLUKA; 545-48-2; 3beta-Erythrodiol



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

242 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 APOE, CASP7, DMBT1, G6PD, MAPK8, PTGS2, RPS6KA1, RPS6KA2, SCARB1
Peripheral membrane protein 5 ACHE, CYP1B1, G6PD, PRTN3, PTGS2
Endoplasmic reticulum membrane 4 ABCG1, CYP1B1, PTGS2, SEC61G
Nucleus 5 ACHE, APOE, CASP7, MAPK8, RPS6KA2
cytosol 9 APOA1, CASP7, G6PD, GSR, MAPK8, PRTN3, RPS6KA1, RPS6KA2, SEC61G
dendrite 1 APOE
nucleoplasm 4 CASP7, MAPK8, RPS6KA1, RPS6KA2
Cell membrane 4 ABCG1, ACHE, PRTN3, SCARB1
Cytoplasmic granule 1 PRTN3
Multi-pass membrane protein 2 ABCG1, SCARB1
Golgi apparatus membrane 1 ABCG1
Synapse 4 ACHE, MAPK8, RPS6KA1, RPS6KA2
cell surface 2 ACHE, SCARB1
glutamatergic synapse 1 APOE
Golgi apparatus 3 ABCG1, ACHE, APOE
Golgi membrane 1 ABCG1
lysosomal membrane 1 SCARB1
neuromuscular junction 1 ACHE
neuronal cell body 1 APOE
Cytoplasm, cytosol 2 CASP7, G6PD
Lysosome 1 SCARB1
endosome 1 ABCG1
plasma membrane 6 ABCG1, ACHE, APOA1, APOE, PRTN3, SCARB1
Membrane 9 ABCG1, ACHE, APOE, CYP1B1, DMBT1, G6PD, SCARB1, SEC61G, TMEM81
axon 1 MAPK8
caveola 2 PTGS2, SCARB1
extracellular exosome 8 APOA1, APOE, DMBT1, G6PD, GSR, MMP9, PRTN3, SCARB1
endoplasmic reticulum 2 APOE, PTGS2
extracellular space 7 ACHE, APOA1, APOE, CASP7, DMBT1, MMP9, PRTN3
perinuclear region of cytoplasm 1 ACHE
mitochondrion 3 ABCG1, CYP1B1, GSR
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 4 CYP1B1, G6PD, PRTN3, SCARB1
Microsome membrane 2 CYP1B1, PTGS2
Single-pass type I membrane protein 1 TMEM81
Secreted 5 ACHE, APOA1, APOE, DMBT1, PRTN3
extracellular region 6 ACHE, APOA1, APOE, DMBT1, MMP9, PRTN3
cytoplasmic side of plasma membrane 1 G6PD
Single-pass membrane protein 1 SEC61G
mitochondrial matrix 1 GSR
Extracellular side 2 ACHE, PRTN3
centriolar satellite 1 G6PD
external side of plasma membrane 2 ABCG1, GSR
Endosome, multivesicular body 1 APOE
Extracellular vesicle 2 APOA1, APOE
Secreted, extracellular space, extracellular matrix 2 APOE, MMP9
chylomicron 2 APOA1, APOE
high-density lipoprotein particle 2 APOA1, APOE
low-density lipoprotein particle 2 APOA1, APOE
multivesicular body 1 APOE
very-low-density lipoprotein particle 2 APOA1, APOE
cytoplasmic vesicle 1 APOA1
Early endosome 2 APOA1, APOE
recycling endosome 1 ABCG1
Membrane raft 1 PRTN3
extracellular matrix 2 APOE, DMBT1
basement membrane 1 ACHE
collagen-containing extracellular matrix 3 APOA1, APOE, MMP9
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Zymogen granule membrane 1 DMBT1
neuron projection 1 PTGS2
phagocytic vesicle membrane 1 DMBT1
Secreted, extracellular space 2 APOE, CASP7
blood microparticle 2 APOA1, APOE
Lipid-anchor, GPI-anchor 1 ACHE
Membrane, caveola 1 SCARB1
Melanosome 1 APOE
side of membrane 1 ACHE
plasma membrane raft 1 PRTN3
ficolin-1-rich granule lumen 1 MMP9
secretory granule lumen 1 APOA1
endoplasmic reticulum lumen 3 APOA1, APOE, PTGS2
tertiary granule lumen 1 MMP9
endocytic vesicle membrane 1 SCARB1
endocytic vesicle 1 APOA1
azurophil granule lumen 1 PRTN3
clathrin-coated endocytic vesicle membrane 1 APOE
synaptic cleft 2 ACHE, APOE
basal dendrite 1 MAPK8
discoidal high-density lipoprotein particle 1 APOE
spherical high-density lipoprotein particle 1 APOA1
endocytic vesicle lumen 2 APOA1, APOE
ribosome 1 RPS6KA2
chylomicron remnant 1 APOE
intermediate-density lipoprotein particle 1 APOE
lipoprotein particle 1 APOE
multivesicular body, internal vesicle 1 APOE
[Isoform H]: Cell membrane 1 ACHE
Ssh1 translocon complex 1 SEC61G


文献列表

  • Fiammetta Alagna, James Reed, Ornella Calderini, Ramesha Thimmappa, Nicolò G M Cultrera, Alice Cattivelli, Davide Tagliazucchi, Soraya Mousavi, Roberto Mariotti, Anne Osbourn, Luciana Baldoni. OeBAS and CYP716C67 catalyze the biosynthesis of health-beneficial triterpenoids in olive (Olea europaea L.) fruits. The New phytologist. 2023 Mar; ?(?):. doi: 10.1111/nph.18863. [PMID: 36880371]
  • Santosh Kumar Singh, Shailesh Singh, Rajesh Singh. Targeting novel coronavirus SARS-CoV-2 spike protein with phytoconstituents of Momordica charantia. Journal of ovarian research. 2021 Sep; 14(1):126. doi: 10.1186/s13048-021-00872-3. [PMID: 34579761]
  • Roubi Abuobeid, Luis Herrera-Marcos, María A Navarro, Carmen Arnal, Roberto Martínez-Beamonte, Joaquín Surra, Jesús Osada. Dietary Erythrodiol Modifies Hepatic Transcriptome in Mice in a Sex and Dose-Dependent Way. International journal of molecular sciences. 2020 Oct; 21(19):. doi: 10.3390/ijms21197331. [PMID: 33020388]
  • Pingping Shen, Weiwei Wang, Shaohua Xu, Zhichao Du, Wei Wang, Boyang Yu, Jian Zhang. Biotransformation of Erythrodiol for New Food Supplements with Anti-Inflammatory Properties. Journal of agricultural and food chemistry. 2020 May; 68(21):5910-5916. doi: 10.1021/acs.jafc.0c01420. [PMID: 32351112]
  • Yulin Ren, Gerardo D Anaya-Eugenio, Austin A Czarnecki, Tran Ngoc Ninh, Chunhua Yuan, Hee-Byung Chai, Djaja D Soejarto, Joanna E Burdette, Esperanza J Carcache de Blanco, A Douglas Kinghorn. Cytotoxic and NF-κB and mitochondrial transmembrane potential inhibitory pentacyclic triterpenoids from Syzygium corticosum and their semi-synthetic derivatives. Bioorganic & medicinal chemistry. 2018 08; 26(15):4452-4460. doi: 10.1016/j.bmc.2018.07.025. [PMID: 30057155]
  • Kai Liu, Yue-Hong Qin, Jian-Yong Yu, Heng Ma, Xi-Lin Song. 3-β-Εrythrodiol isolated from Conyza canadensis inhibits MKN‑45 human gastric cancer cell proliferation by inducing apoptosis, cell cycle arrest, DNA fragmentation, ROS generation and reduces tumor weight and volume in mouse xenograft model. Oncology reports. 2016 Apr; 35(4):2328-38. doi: 10.3892/or.2016.4610. [PMID: 26846256]
  • Yao-wu Tao, Ye Tian, Wen-dong Xu, Qing-lan Guo, Jian-gong Shi. [Terpenoids from Euphorbia micractina]. Yao xue xue bao = Acta pharmaceutica Sinica. 2016 03; 51(3):411-9. doi: ". [PMID: 29859022]
  • Lamice Habib, Alia Jraij, Nathalie Khreich, Catherine Charcosset, Hélène Greige-Gerges. Effect of Erythrodiol, A Natural Pentacyclic Triterpene from Olive Oil, on the Lipid Membrane Properties. The Journal of membrane biology. 2015 Dec; 248(6):1079-87. doi: 10.1007/s00232-015-9821-x. [PMID: 26141679]
  • Haoxin Li, Stéphanie Jean, Duncan Webster, Gilles A Robichaud, Larry A Calhoun, John A Johnson, Christopher A Gray. Dibenz[b,f]oxepin and Antimycobacterial Chalcone Constituents of Empetrum nigrum. Journal of natural products. 2015 Nov; 78(11):2837-40. doi: 10.1021/acs.jnatprod.5b00627. [PMID: 26473275]
  • Juan José Ramírez-Espinosa, Maria Yolanda Rios, Paolo Paoli, Virginia Flores-Morales, Guido Camici, Vianey de la Rosa-Lugo, Sergio Hidalgo-Figueroa, Gabriel Navarrete-Vázquez, Samuel Estrada-Soto. Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition. European journal of medicinal chemistry. 2014 Nov; 87(?):316-27. doi: 10.1016/j.ejmech.2014.09.036. [PMID: 25264584]
  • Brian Mathison, Dirk Holstege. A rapid method to determine sterol, erythrodiol, and uvaol concentrations in olive oil. Journal of agricultural and food chemistry. 2013 May; 61(19):4506-13. doi: 10.1021/jf400254k. [PMID: 23587059]
  • Nguyen X Nhiem, Phan V Kiem, Chau V Minh, Nanyoung Kim, Seonju Park, Hwa Young Lee, Eun Sil Kim, Young Ho Kim, Sohyun Kim, Young-Sang Koh, Seung Hyun Kim. Diarylheptanoids and flavonoids from viscum album inhibit LPS-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Journal of natural products. 2013 Apr; 76(4):495-502. doi: 10.1021/np300490v. [PMID: 23484668]
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  • Maria Carelli, Elisa Biazzi, Francesco Panara, Aldo Tava, Laura Scaramelli, Andrea Porceddu, Neil Graham, Miriam Odoardi, Efisio Piano, Sergio Arcioni, Sean May, Carla Scotti, Ornella Calderini. Medicago truncatula CYP716A12 is a multifunctional oxidase involved in the biosynthesis of hemolytic saponins. The Plant cell. 2011 Aug; 23(8):3070-81. doi: 10.1105/tpc.111.087312. [PMID: 21821776]
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  • Rubén Martín, Elvira Ibeas, Juliana Carvalho-Tavares, Marita Hernández, Valentina Ruiz-Gutierrez, María Luisa Nieto. Natural triterpenic diols promote apoptosis in astrocytoma cells through ROS-mediated mitochondrial depolarization and JNK activation. PloS one. 2009 Jun; 4(6):e5975. doi: 10.1371/journal.pone.0005975. [PMID: 19543395]
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