Hernandezine (BioDeep_00000000584)
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C39H44N2O7 (652.3148)
中文名称: 鹤氏唐松草碱
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 76.88%
分子结构信息
SMILES: CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)CC6C7=C(CCN6C)C(=C(C(=C7O3)OC)OC)OC)OC)OC
InChI: InChI=1S/C39H44N2O7/c1-40-16-14-25-21-32(43-4)34-22-28(25)29(40)18-23-8-11-26(12-9-23)47-33-20-24(10-13-31(33)42-3)19-30-35-27(15-17-41(30)2)36(44-5)38(45-6)39(46-7)37(35)48-34/h8-13,20-22,29-30H,14-19H2,1-7H3/t29-,30-/m0/s1
描述信息
Hernandezine is a member of isoquinolines and a bisbenzylisoquinoline alkaloid.
Hernandezine is a natural product found in Thalictrum delavayi, Thalictrum fendleri, and other organisms with data available.
Origin: Plant; SubCategory_DNP: Isoquinoline alkaloids, Benzylisoquinoline alkaloids
同义名列表
14 个代谢物同义名
(1S,14S)-9,19,20,21,25-pentamethoxy-15,30-dimethyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-3(36),4,6(35),8,10,12(34),18(33),19,21,24,26,31-dodecaene; 16H-1,24:6,9-Dietheno-11,15-metheno-2H-pyrido[2,3:17,18][1,11]dioxacycloeicosino[2,3,4-ij]isoquinoline, 3,4,4a,5,16a,17,18,19-octahydro-12,20,21,22,26-pentamethoxy-4,17-dimethyl-, (4aS,16aS)-; (4AS,16AS)-3,4,4A,5,16A,17,18,19-OCTAHYDRO-12,20,21,22,26-PENTAMETHOXY-4,17-DIMETHYL-16H-1,24:6,9-DIETHENO-11,15-METHENO-2H-PYRIDO(2,3:17,18)(1,11)DIOXACYCLOEICOSINO(2,3,4-IJ)ISOQUINOLINE; Berbaman, 5,6,6,7,12-pentamethoxy-2,2-dimethyl-, (1.beta.)-; Berbaman, 5,6,6,7,12-pentamethoxy-2,2-dimethyl-, (1beta)-; pentamethoxy(dimethyl)[?]; (+)-Hernandezine; UNII-HPH24MXX7G; Hernandezine; Thalicsimine; Thaliximine; HPH24MXX7G; Isohernandezine; Hernandezine
数据库引用编号
23 个数据库交叉引用编号
- ChEBI: CHEBI:5677
- ChEBI: CHEBI:184058
- KEGG: C09461
- PubChem: 72343
- PubChem: 308359
- Metlin: METLIN67719
- ChEMBL: CHEMBL504936
- Wikipedia: Hernandezine
- MeSH: hernandezine
- ChemIDplus: 0006681136
- CAS: 6681-13-6
- MoNA: CB000109
- medchemexpress: HY-N6042
- PMhub: MS000014016
- MetaboLights: MTBLC5677
- PubChem: 11652
- KNApSAcK: C00001866
- 3DMET: B02989
- NIKKAJI: J12.754J
- RefMet: Hernandezine
- LOTUS: LTS0040497
- wikidata: Q15410998
- KNApSAcK: 5677
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
17 个相关的物种来源信息
- 527501 - Cocculus pendulus: 10.1055/S-2006-959669
- 395328 - Thalictrum alpinum: 10.1007/BF00568555
- 395328 - Thalictrum alpinum: 10.1021/NP50009A009
- 1277765 - Thalictrum atriplex:
- 1084667 - Thalictrum delavayi:
- 1084669 - Thalictrum fendleri: 10.2307/4117899
- 1084670 - Thalictrum foetidum: 10.1007/BF00579794
- 1277777 - Thalictrum foliolosum:
- 1084676 - Thalictrum hernandezii:
- 1084676 - Thalictrum hernandezii: 10.1021/NP50021A011
- 1277780 - Thalictrum lankesteri: 10.1016/0031-9422(88)80063-3
- 581030 - Thalictrum minus var. hypoleucum:
- 1084684 - Thalictrum petaloideum:
- 1084686 - Thalictrum podocarpum: 10.1007/BF00568555
- 1084686 - Thalictrum podocarpum: 10.1021/NP50009A009
- 495765 - Thalictrum simplex: 10.1007/BF00568555
- 495765 - Thalictrum simplex: 10.1021/NP50009A009
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Chiufai Kuok, Qi Wang, Pedro Fong, Yong Qin, Lirong Meng. Inhibitory Effect of Hernandezine on the Proliferation of Hepatocellular Carcinoma.
Biological & pharmaceutical bulletin.
2023; 46(2):245-256. doi:
10.1248/bpb.b22-00612. [PMID: 36724952] - Chang-Feng Song, Yu-Heng Hu, Zhi-Guo Mang, Zeng Ye, Hai-di Chen, De-Sheng Jing, Gui-Xiong Fan, Shun-Rong Ji, Xian-Jun Yu, Xiao-Wu Xu, Yi Qin. Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway.
Acta pharmacologica Sinica.
2022 Oct; ?(?):. doi:
10.1038/s41401-022-01006-1. [PMID: 36284209] - Jing Bai, Shuai Zhang, Jinjing Cao, Hongbin Sun, Zhiguo Mang, Wei L Shen, Hao Li. Hernandezine, a natural herbal alkaloid, ameliorates type 2 diabetes by activating AMPK in two mouse models.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Oct; 105(?):154366. doi:
10.1016/j.phymed.2022.154366. [PMID: 35933900] - Xiaoting Wang, Xiaojie Li, Yuan Xia, Danyang Wang, Xiaohan Li, Ling Liu, Qiusheng Zheng, Defang Li, Qingling Jiang. Hernandezine Regulates Proliferation and Autophagy-Induced Apoptosis in Melanoma Cells.
Journal of natural products.
2022 05; 85(5):1351-1362. doi:
10.1021/acs.jnatprod.2c00098. [PMID: 35544345] - Yang Song, Yuan Zhang, Wei-Peng Zhang, Bao-Zhen Zhang, Ke-Fei Wang, Xue-Song Feng. Interaction Effects between Doxorubicin and Hernandezine on the Pharmacokinetics by Liquid Chromatography Coupled with Mass Spectrometry.
Molecules (Basel, Switzerland).
2019 Oct; 24(19):. doi:
10.3390/molecules24193622. [PMID: 31597294] - Yang Song, Zhibin Wang, Baozhen Zhang, Yujia Zhang, Weipeng Zhang, Chunjuan Yang, Fanhao Meng, Xuesong Feng. Determination of a novel anticancer AMPK activator hernandezine in rat plasma and tissues with a validated UHPLC-MS/MS method: Application to pharmacokinetics and tissue distribution study.
Journal of pharmaceutical and biomedical analysis.
2017 Jul; 141(?):132-139. doi:
10.1016/j.jpba.2017.03.038. [PMID: 28437720] - Julia Serkedjieva, Maria Velcheva. In vitro anti-influenza virus activity of isoquinoline alkaloids from thalictrum species.
Planta medica.
2003 Feb; 69(2):153-4. doi:
10.1055/s-2003-37720. [PMID: 12624821] - L J Ho, D M Chang, T C Lee, M L Chang, J H Lai. Plant alkaloid tetrandrine downregulates protein kinase C-dependent signaling pathway in T cells.
European journal of pharmacology.
1999 Feb; 367(2-3):389-98. doi:
10.1016/s0014-2999(98)00941-8. [PMID: 10079015] - K Imoto, H Takemura, C Y Kwan, S Sakano, M Kaneko, H Ohshika. Inhibitory effects of tetrandrine and hernandezine on Ca2+ mobilization in rat glioma C6 cells.
Research communications in molecular pathology and pharmacology.
1997 Feb; 95(2):129-46. doi:
. [PMID: 9090750] - A M Low, M Berdik, L Sormaz, S Gataiance, M R Buchanan, C Y Kwan, E E Daniel. Plant alkaloids, tetrandrine and hernandezine, inhibit calcium-depletion stimulated calcium entry in human and bovine endothelial cells.
Life sciences.
1996; 58(25):2327-35. doi:
10.1016/0024-3205(96)00233-0. [PMID: 8649222] - G T Tan, J M Pezzuto, A D Kinghorn, S H Hughes. Evaluation of natural products as inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase.
Journal of natural products.
1991 Jan; 54(1):143-54. doi:
10.1021/np50073a012. [PMID: 1710653] - C X Xu, L Lin, R H Sun, X Liu, R Han. [Anti-tumor effect of hernandezine and other components extracted from Thalictrum glandulosissimum].
Yao xue xue bao = Acta pharmaceutica Sinica.
1990; 25(5):330-5. doi:
. [PMID: 2284950]
