Berbine (BioDeep_00000005748)
代谢物信息卡片
化学式: C17H17N (235.1361)
中文名称: 小檗碱
谱图信息:
最多检出来源 Viridiplantae(plant) 25%
分子结构信息
SMILES: c1ccc2c(c1)CC1c3ccccc3CCN1C2
InChI: InChI=1S/C17H17N/c1-2-7-15-12-18-10-9-13-5-3-4-8-16(13)17(18)11-14(15)6-1/h1-8,17H,9-12H2
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:35611
- ChEBI: CHEBI:50400
- KEGG: C05204
- PubChem: 101707
- PubChem: 164543
- CAS: 41173-75-5
- CAS: 483-49-8
- CAS: 131-10-2
- PMhub: MS000018611
- MetaboLights: MTBLC35611
- PubChem: 7609
- NIKKAJI: J356.631E
- KNApSAcK: 50400
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 7461 - Apis cerana: 10.1371/JOURNAL.PONE.0175573
- 6669 - Daphnia pulex: 10.1038/SREP25125
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Wanli Zhao, Manyu Liu, Kemeng Liu, Hanqing Liu, Xiufeng Liu, Jihua Liu. An Enzymatic Strategy for the Selective Methylation of High-Value-Added Tetrahydroprotoberberine Alkaloids.
International journal of molecular sciences.
2023 Oct; 24(20):. doi:
10.3390/ijms242015214
. [PMID: 37894895] - Haixia Ge, Weitao Zhang, Kai Yuan, Hanyue Xue, Hao Cheng, Weijiao Chen, Yishi Xie, Jian Zhang, Xiaojun Xu, Peng Yang. Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives to reduce SREBPs expression for the treatment of hyperlipidemia.
European journal of medicinal chemistry.
2021 Oct; 221(?):113522. doi:
10.1016/j.ejmech.2021.113522
. [PMID: 33984804] - Ling-Xian Liu, Liang Cao, Dan-Feng Shi, Zhen-Zhong Wang, Wei Xiao, Xin-Sheng Yao, Hai-Bo Li, Yang Yu. Metabolic profiles of Jin-hong tablets in rats by ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.
Biomedical chromatography : BMC.
2021 Jun; 35(6):e5072. doi:
10.1002/bmc.5072
. [PMID: 33453065] - Dean E Lang, Jeremy S Morris, Michael Rowley, Miguel A Torres, Vook A Maksimovich, Peter J Facchini, Kenneth K S Ng. Structure-function studies of tetrahydroprotoberberine N-methyltransferase reveal the molecular basis of stereoselective substrate recognition.
The Journal of biological chemistry.
2019 10; 294(40):14482-14498. doi:
10.1074/jbc.ra119.009214
. [PMID: 31395658] - Da-Hong Li, Jian-Yong Li, Chun-Mei Xue, Tong Han, Chun-Mei Sai, Kai-Bo Wang, Jin-Cai Lu, Yong-Kui Jing, Hui-Ming Hua, Zhan-Lin Li. Antiproliferative Dimeric Aporphinoid Alkaloids from the Roots of Thalictrum cultratum.
Journal of natural products.
2017 11; 80(11):2893-2904. doi:
10.1021/acs.jnatprod.7b00387
. [PMID: 29131616] - Phuong Mai Le, Vandana Srivastava, Thanh Tam Nguyen, Bruno Pradines, Marylin Madamet, Joel Mosnier, Thi Thuy Trinh, Hoyun Lee. Stephanine from Stephania venosa (Blume) Spreng Showed Effective Antiplasmodial and Anticancer Activities, the Latter by Inducing Apoptosis through the Reverse of Mitotic Exit.
Phytotherapy research : PTR.
2017 Sep; 31(9):1357-1368. doi:
10.1002/ptr.5861
. [PMID: 28703314] - Jiayong He, Ying Liu, Yun Kang, Ping Yang, Yaqin Wang, Jixian Guo, Jianming Huang. Identification of Alkaloids in Stephania hainanensis by Liquid Chromatography Coupled with Quadrupole Time-of-flight Mass Spectrometry.
Phytochemical analysis : PCA.
2016 May; 27(3-4):206-16. doi:
10.1002/pca.2618
. [PMID: 27313158] - Daniel R Callejon, Thalita B Riul, Luis G P Feitosa, Thais Guaratini, Denise B Silva, Achyut Adhikari, Ram L S Shrestha, Lucas M M Marques, Marcelo D Baruffi, João L C Lopes, Norberto P Lopes. Leishmanicidal evaluation of tetrahydroprotoberberine and spirocyclic erythrina-alkaloids.
Molecules (Basel, Switzerland).
2014 May; 19(5):5692-703. doi:
10.3390/molecules19055692
. [PMID: 24802983] - Qiaoxia Liu, Shiyi Qiu, Hui Yu, Yanxiong Ke, Yu Jin, Xinmiao Liang. Selective separation of structure-related alkaloids in Rhizoma coptidis with "click" binaphthyl stationary phase and their structural elucidation with liquid chromatography-mass spectrometry.
The Analyst.
2011 Oct; 136(20):4357-65. doi:
10.1039/c1an15444c
. [PMID: 21881639] - Yiannis C Fiamegos, Panagiotis L Kastritis, Vassiliki Exarchou, Haley Han, Alexandre M J J Bonvin, Jacques Vervoort, Kim Lewis, Michael R Hamblin, George P Tegos. Antimicrobial and efflux pump inhibitory activity of caffeoylquinic acids from Artemisia absinthium against gram-positive pathogenic bacteria.
PloS one.
2011 Apr; 6(4):e18127. doi:
10.1371/journal.pone.0018127
. [PMID: 21483731] - Manoj K Pandey, Bokyung Sung, Ajaikumar B Kunnumakkara, Gautam Sethi, Madan M Chaturvedi, Bharat B Aggarwal. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.
Cancer research.
2008 Jul; 68(13):5370-9. doi:
10.1158/0008-5472.can-08-0511
. [PMID: 18593939] - E K Marinova, D B Nikolova, D N Popova, G B Gallacher, N D Ivanovska. Suppression of experimental autoimmune tubulointerstitial nephritis in BALB/c mice by berberine.
Immunopharmacology.
2000 Jun; 48(1):9-16. doi:
10.1016/s0162-3109(99)00189-7
. [PMID: 10822084] - X L Jin, Y Shao, M J Wang, L J Chen, G Z Jin. Tetrahydroprotoberberines inhibit lipid peroxidation and scavenge hydroxyl free radicals.
Acta pharmacologica Sinica.
2000 May; 21(5):477-80. doi:
"
. [PMID: 11324451]