Isomangiferin (BioDeep_00000000057)

 

Secondary id: BioDeep_00000311964

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


1,3,6,7-Tetrahydroxy-4-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-9H-xanthen-9-one

  化学式: C19H18O11 (422.0849)
中文名称: 异杞果素, 异芒果苷
  谱图信息: 最多检出来源 Viridiplantae(otcml) 36.68%

分子结构信息

SMILES: C1=C2C(=CC(=C1O)O)OC3=C(C2=O)C(=CC(=C3C4C(C(C(C(O4)CO)O)O)O)O)O
InChI: InChI=1S/C19H18O11/c20-4-11-15(26)16(27)17(28)19(30-11)13-9(24)2-8(23)12-14(25)5-1-6(21)7(22)3-10(5)29-18(12)13/h1-3,11,15-17,19-24,26-28H,4H2


描述信息

Isomangiferin is a member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 3, 6 and 7 and a 1,5-anhydro-D-glucitol moiety at position 1. It has a role as an anti-HSV-1 agent and a plant metabolite. It is a member of xanthones, a C-glycosyl compound and a polyphenol.
Isomangiferin is a natural product found in Cystopteris moupinensis, Cystopteris montana, and other organisms with data available.
Isomangiferin is found in fruits. Isomangiferin is a constituent of Mangifera indica (mango)
Constituent of Mangifera indica (mango). Isomangiferin is found in fruits.
Isomangiferin, a natural product, is reported to have antiviral activity.
Isomangiferin, a natural product, is reported to have antiviral activity.

同义名列表

13 个代谢物同义名

1,3,6,7-Tetrahydroxy-4-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-9H-xanthen-9-one; 1,3,6,7-tetrahydroxy-4-[(2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one; 1,3,6,7-tetrahydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]-9H-xanthen-9-one; 1,3,6,7-tetrahydroxy-4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]xanthen-9-one; (1S)-1,5-anhydro-1-(1,3,6,7-tetrahydroxy-9-oxo-9H-xanthen-4-yl)-D-glucitol; 9H-Xanthen-9-one, 4-beta-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; 4-b-D-Glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one, 9ci; 9H-Xanthen-9-one, 4-ss-D-glucopyranosyl-1,3,6,7-tetrahydroxy-; 4-beta-d-glucopyranosyl-1,3,6,7-tetrahydroxy-9h-xanthen-9-one; 4-C-Glucosyl-1,3,6,7-tetrahydroxyxanthone; 4-Glucosyl-1,3,6,7-tetrahydroxyxanthone; Isomangiferin; Isomangiferin



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

232 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ABCB1, ALOX5, CAT, JAK2, MAPK14, MSMP, NLRP3, PTGS2, VEGFA
Peripheral membrane protein 4 ALOX5, GBA1, JAK2, PTGS2
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 5 JAK2, KDR, MAPK14, NLRP3, VEGFA
cytosol 6 ALOX5, CAT, GHR, JAK2, MAPK14, NLRP3
trans-Golgi network 1 GBA1
nucleoplasm 3 ALOX5, JAK2, MAPK14
Cell membrane 5 ABCB1, GHR, KDR, PROKR2, TNF
Multi-pass membrane protein 3 ABCB1, CACNA1E, PROKR2
Golgi apparatus membrane 1 NLRP3
Synapse 1 CACNA1E
cell junction 1 KDR
cell surface 4 ABCB1, GHR, TNF, VEGFA
glutamatergic synapse 2 JAK2, MAPK14
Golgi apparatus 3 GBA1, KDR, VEGFA
Golgi membrane 2 INS, NLRP3
lysosomal membrane 2 GAA, GBA1
neuronal cell body 3 CACNA1E, GHR, TNF
postsynapse 1 JAK2
Cytoplasm, cytosol 2 ALOX5, NLRP3
Lysosome 2 GAA, GBA1
endosome 1 KDR
plasma membrane 8 ABCB1, CACNA1E, GAA, GHR, JAK2, KDR, PROKR2, TNF
Membrane 8 ABCB1, CACNA1E, CAT, GAA, GHR, JAK2, NLRP3, VEGFA
apical plasma membrane 1 ABCB1
axon 1 CCK
caveola 2 JAK2, PTGS2
extracellular exosome 4 ABCB1, CAT, GAA, GBA1
Lysosome membrane 2 GAA, GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 5 GBA1, KDR, NLRP3, PTGS2, VEGFA
extracellular space 9 ALOX5, CCK, GHR, IGF1, IL10, INS, MSMP, TNF, VEGFA
lysosomal lumen 2 GAA, GBA1
perinuclear region of cytoplasm 1 ALOX5
adherens junction 1 VEGFA
mitochondrion 3 CAT, MAPK14, NLRP3
protein-containing complex 2 CAT, PTGS2
intracellular membrane-bounded organelle 2 CAT, GAA
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 GHR
Secreted 9 CCK, GAA, GHR, IGF1, IL10, INS, MSMP, NLRP3, VEGFA
extracellular region 13 ALOX5, CAT, CCK, GAA, GHR, IGF1, IL10, INS, KDR, MAPK14, NLRP3, TNF, VEGFA
cytoplasmic side of plasma membrane 1 JAK2
[Isoform 2]: Secreted 1 KDR
mitochondrial matrix 1 CAT
anchoring junction 1 KDR
Nucleus membrane 1 ALOX5
nuclear membrane 1 ALOX5
external side of plasma membrane 3 GHR, KDR, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Early endosome 1 KDR
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 ALOX5
Membrane raft 3 JAK2, KDR, TNF
focal adhesion 2 CAT, JAK2
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Cytoplasm, cytoskeleton, microtubule organizing center 1 NLRP3
Inflammasome 1 NLRP3
interphase microtubule organizing center 1 NLRP3
NLRP3 inflammasome complex 1 NLRP3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 2 GHR, KDR
neuron projection 1 PTGS2
phagocytic cup 1 TNF
cytoskeleton 1 JAK2
cytoplasmic ribonucleoprotein granule 1 GHR
spindle pole 1 MAPK14
[Isoform 2]: Cell membrane 1 GHR
nuclear envelope 1 ALOX5
Nucleus envelope 1 ALOX5
Endomembrane system 2 JAK2, NLRP3
endosome lumen 2 INS, JAK2
sorting endosome 1 KDR
microtubule organizing center 1 NLRP3
monoatomic ion channel complex 1 CACNA1E
tertiary granule membrane 1 GAA
euchromatin 1 JAK2
exocytic vesicle 1 IGF1
ficolin-1-rich granule lumen 3 ALOX5, CAT, MAPK14
secretory granule lumen 4 ALOX5, CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
nuclear matrix 1 ALOX5
platelet alpha granule lumen 2 IGF1, VEGFA
voltage-gated calcium channel complex 1 CACNA1E
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Nucleus matrix 1 ALOX5
nuclear envelope lumen 1 ALOX5
extrinsic component of cytoplasmic side of plasma membrane 1 JAK2
ficolin-1-rich granule membrane 1 GAA
external side of apical plasma membrane 1 ABCB1
extrinsic component of plasma membrane 1 JAK2
granulocyte macrophage colony-stimulating factor receptor complex 1 JAK2
interleukin-12 receptor complex 1 JAK2
interleukin-23 receptor complex 1 JAK2
growth hormone receptor complex 1 GHR
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
catalase complex 1 CAT
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
Nucleus intermembrane space 1 ALOX5
autolysosome lumen 1 GAA
[Growth hormone-binding protein]: Secreted 1 GHR
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Neil Miller, Christiaan J Malherbe, Elizabeth Joubert. In vitroα-glucosidase inhibition by honeybush (Cyclopia genistoides) food ingredient extract-potential for dose reduction of acarbose through synergism. Food & function. 2020 Jul; 11(7):6476-6486. doi: 10.1039/d0fo01306d. [PMID: 32627774]
  • Wei Xiao, Yude Peng, Zhexu Tan, Qiuyue Lv, Chi-On Chan, Jingyu Yang, Sibao Chen. Comparative Evaluation of Chemical Profiles of Pyrrosiae Folium Originating from Three Pyrrosia Species by HPLC-DAD Combined with Multivariate Statistical Analysis. Molecules (Basel, Switzerland). 2017 Dec; 22(12):. doi: 10.3390/molecules22122122. [PMID: 29194397]
  • Fengjun Sun, Zhirui Liu, Bo Yang, Peiyuan Xia. Development and validation of a liquid chromatography with tandem mass spectrometry method for the determination of isomangiferin in rat plasma with application to a preclinical pharmacokinetic study. Journal of separation science. 2016 Aug; 39(15):2890-5. doi: 10.1002/jssc.201501408. [PMID: 27257129]
  • Guo-long Li, Jie Yang, Jin-ao Duan, Hong-bo Liu, Zhen-hua Zhu, Da-wei Qian, Zhi-shu Tang. [Quality Analysis and Evaluation of Anemarrhena asphodeloides Rhizome from Different Habitats]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2015 Jun; 38(6):1148-52. doi: . [PMID: 26762052]
  • Nireshni Chellan, Elizabeth Joubert, Hans Strijdom, Candice Roux, Johan Louw, Christo J F Muller. Aqueous extract of unfermented honeybush (Cyclopia maculata) attenuates STZ-induced diabetes and β-cell cytotoxicity. Planta medica. 2014 Jun; 80(8-9):622-9. doi: 10.1055/s-0034-1368457. [PMID: 24853761]
  • Christiaan J Malherbe, Elize Willenburg, Dalene de Beer, Susan L Bonnet, Jan H van der Westhuizen, Elizabeth Joubert. Iriflophenone-3-C-glucoside from Cyclopia genistoides: isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Mar; 951-952(?):164-71. doi: 10.1016/j.jchromb.2014.01.038. [PMID: 24566268]
  • Adam Kokotkiewicz, Malgorzata Wnuk, Adam Bucinski, Maria Luczkiewicz. In vitro cultures of Cyclopia plants (honeybush) as a source of bioactive xanthones and flavanones. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2009 Jul; 64(7-8):533-40. doi: 10.1515/znc-2009-7-812. [PMID: 19791506]
  • Dalene de Beer, Gerold Jerz, Elizabeth Joubert, Victor Wray, Peter Winterhalter. Isolation of isomangiferin from honeybush (Cyclopia subternata) using high-speed counter-current chromatography and high-performance liquid chromatography. Journal of chromatography. A. 2009 May; 1216(19):4282-9. doi: 10.1016/j.chroma.2009.02.056. [PMID: 19272608]
  • Yanguo Sun, Xi Zhang, Xingya Xue, Yan Zhang, Hongbin Xiao, Xinmiao Liang. Rapid identification of polyphenol C-glycosides from Swertia franchetiana by HPLC-ESI-MS-MS. Journal of chromatographic science. 2009 Mar; 47(3):190-6. doi: 10.1093/chromsci/47.3.190. [PMID: 19298704]
  • Jianchen Li, Li Feng, Jing Dai, Runbiao Wang, Toshihiro Nohara. [Chemical constituents from Polygala telephioides]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2009 Feb; 34(4):402-5. doi: . [PMID: 19459299]
  • M Nurul Islam, Hye Hyun Yoo, Jun Lee, Joo Won Nam, Eun Kyoung Seo, Changbae Jin, Dong-Hyun Kim. Simultaneous determination of bioactive xanthone glycosides and norlignans from ethanolic extract of Anemarrhena asphodeloides by liquid chromatography. Journal of AOAC International. 2008 Nov; 91(6):1271-7. doi: . [PMID: 19202786]
  • Frédéric Martin, Anne-Emmanuelle Hay, Delphine Cressend, Marianne Reist, Livia Vivas, Mahabir P Gupta, Pierre-Alain Carrupt, Kurt Hostettmann. Antioxidant C-glucosylxanthones from the leaves of Arrabidaea patellifera. Journal of natural products. 2008 Nov; 71(11):1887-90. doi: 10.1021/np800406q. [PMID: 18950229]
  • J Li, Y Y Tong. [Determination of active constituents in shi-wei (Folium Pyrrosiae) by high performance liquid chromatography]. Yao xue xue bao = Acta pharmaceutica Sinica. 1992; 27(2):153-6. doi: . [PMID: 1414373]