Cucurbitacin (BioDeep_00000000564)
PANOMIX_OTCML-2023
代谢物信息卡片
(1S,2S,4R,6S,9S,10R,11R,14R,15R)-17-hydroxy-6-(2-hydroxypropan-2-yl)-2,9,11,14,19,19-hexamethyl-5-oxapentacyclo[12.8.0.02,11.04,10.015,20]docosa-16,20-diene-8,13,18-trione
化学式: C30H42O6 (498.2981232)
中文名称: 葫芦素 S, 雪胆素甲, 雪胆甲素
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 1.43%
分子结构信息
SMILES: CC1C(=O)CC(C(C)(C)O)OC2CC3(C)C4CC=C5C(C=C(O)C(=O)C5(C)C)C4(C)C(=O)CC3(C)C21
InChI: InChI=1S/C30H42O6/c1-15-18(31)12-23(27(4,5)35)36-20-13-28(6)21-10-9-16-17(11-19(32)25(34)26(16,2)3)30(21,8)22(33)14-29(28,7)24(15)20/h9,11,15,17,20-21,23-24,32,35H,10,12-14H2,1-8H3/t15-,17-,20-,21+,23+,24+,28+,29-,30+/m1/s1
描述信息
Cucurbitacin S is an 11-oxo steroid.
Cucurbitacin S is a natural product found in Cucurbita foetidissima with data available.
Triterpenes that derive from LANOSTEROL by a shift of the C19 methyl to the C9 position. They are found in seeds and roots of CUCURBITACEAE and other plants and are noted for intense bitterness.
同义名列表
9 个代谢物同义名
(1S,2S,4R,6S,9S,10R,11R,14R,15R)-17-hydroxy-6-(2-hydroxypropan-2-yl)-2,9,11,14,19,19-hexamethyl-5-oxapentacyclo[12.8.0.02,11.04,10.015,20]docosa-16,20-diene-8,13,18-trione; 19-Norlanosta-1,5-diene-3,11,22-trione, 16,24-epoxy-2,25-dihydroxy-9-methyl-, (9beta,10alpha,16alpha,24S)-; 2,25-Dihydroxy-9,10,14-trimethyl-16,24-epoxy-4,9-cyclo-9,10-secocholesta-2,5-diene-1,11,22-trione; Curcurbitacin IIa; Cucurbitacin S; cucurbitacins; Cucurbitacin; ST 30:6;O6; FT-0689389
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:3953
- KEGG: C08806
- PubChem: 119287
- Metlin: METLIN41679
- LipidMAPS: LMST01010116
- MeSH: Cucurbitacins
- ChemIDplus: 0060137066
- CAS: 60137-06-6
- medchemexpress: HY-N0725
- PMhub: MS000020209
- PubChem: 10999
- KNApSAcK: C00003694
- 3DMET: B02425
- NIKKAJI: J18.056D
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 184136 Cucurbita foetidissima: 10.1021/JF60216A022
- 184136 Cucurbita foetidissima: 10.1021/JF60216A022
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Carina Stein, Johanna Voigts, Lisa Niederreiter, Stefanie Kowarschik, Roman Huber, Volker M Lüth. Antiproliferative and immunomodulative potential of Citrullus colocynthis and its bioactive compounds in human lymphocytes and lung cells.
Journal of ethnopharmacology.
2024 Jun; 328(?):118053. doi:
10.1016/j.jep.2024.118053. [PMID: 38499257] - Sujuan Li, Sen Wang, Anping Zhang, Lixia Luo, Jie Song, Guoli Wei, Zhijun Fang. Cucurbitacin IIa promotes the immunogenic cell death‑inducing effect of doxorubicin and modulates immune microenvironment in liver cancer.
International journal of oncology.
2024 04; 64(4):. doi:
10.3892/ijo.2024.5625. [PMID: 38391053] - Muhammed Mehdi Üremiş, Yusuf Türköz, Nuray Üremiş. Investigation of apoptotic effects of Cucurbitacin D, I, and E mediated by Bax/Bcl-xL, caspase-3/9, and oxidative stress modulators in HepG2 cell line.
Drug development research.
2024 Apr; 85(2):e22174. doi:
10.1002/ddr.22174. [PMID: 38494997] - Yan Li, Yingrui Li, Yan Yao, Huayao Li, Chundi Gao, Changgang Sun, Jing Zhuang. Potential of cucurbitacin as an anticancer drug.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Dec; 168(?):115707. doi:
10.1016/j.biopha.2023.115707. [PMID: 37862969] - Fan Xia, Suling Sun, Shuyang Li, Wei Jiang, Li Xia, Hongzhi Wang, Xueran Chen. Chinese herb related molecules Catechins, Caudatin and Cucurbitacin-I inhibit the proliferation of glioblastoma by activating KDELR2-mediated endoplasmic reticulum stress.
Biochemical and biophysical research communications.
2023 Oct; 687(?):149196. doi:
10.1016/j.bbrc.2023.149196. [PMID: 37939504] - Yujiao Jia, Lu Kang, Yangliu Wu, Chunran Zhou, Runze Cai, Hui Zhang, Jiaqi Li, Zhendong Chen, Dexian Kang, Li Zhang, Canping Pan. Nano-selenium Foliar Intervention-induced Resistance of Cucumber to Botrytis cinerea by Activating Jasmonic acid Biosynthesis and Regulating Phenolic acid and Cucurbitacin.
Pest management science.
2023 Sep; ?(?):. doi:
10.1002/ps.7784. [PMID: 37733166] - Dongchao Xu, Ajuan Liu, Qiang Liu, Hongchen Zhang, Mengyao Tian, Ying Bian, Xiaofeng Zhang, Meidan Ying, Hongzhang Shen. Cucurbitacin C suppresses the progression of pancreatic ductal adenocarcinoma via inhibition of the cGMP-PKG-VASP axis.
Biochemical pharmacology.
2023 Sep; ?(?):115810. doi:
10.1016/j.bcp.2023.115810. [PMID: 37717690] - Moritz Benka, Kristof Görlitz, Michael C Schöttgen, Simon Lagies, Daniel A Mohl, Michel Kather, Iwanette Du Preez-Bruwer, Davis Mumbengegwi, Robin Teufel, Stefanie Kowarschik, Roman Huber, Dietmar A Plattner, Bernd Kammerer. Mass Spectrometric Analysis of Cucurbitacins and Dihydrocucurbitacins from the Tuber of Citrullus naudinianus.
Biomolecules.
2023 07; 13(8):. doi:
10.3390/biom13081168. [PMID: 37627233] - Shui-Yuan Yang, Lin-Feng Guo, Yang Liu, Ji-Bin Zou, Hai-Yan Zhu, Yan Lu, Dao-Feng Chen. Trichosanates A-G and cucurbitacins W-Y, anticomplement monoterpenoids and cucurbitane-type triterpenoids from the pericarps of Trichosanthes kirilowii.
Bioorganic chemistry.
2023 Jun; 139(?):106710. doi:
10.1016/j.bioorg.2023.106710. [PMID: 37418785] - Guizhou Hu, Wenya Liu, Liyan Li. Identification and quantification of cucurbitacin in watermelon frost using molecular networking integrated with ultra-high-performance liquid chromatography-tandem mass spectrometry.
Journal of separation science.
2023 Jun; ?(?):e2300019. doi:
10.1002/jssc.202300019. [PMID: 37269211] - Aldo Almeida, Bruno Trevenzoli Favero, Lemeng Dong, Pablo D Cárdenas, Jorge Saenz-Mata, Henrik Lütken, Søren Bak. Lessons learned from metabolic engineering in hairy roots: Transcriptome and metabolic profile changes caused by Rhizobium-mediated plant transformation in Cucurbitaceae species.
Plant physiology and biochemistry : PPB.
2023 May; 201(?):107797. doi:
10.1016/j.plaphy.2023.107797. [PMID: 37302255] - Pierre Sadon, Marie-Noëlle Corre, Raphael Lugan, Nathalie Boissot. Aphid adaptation to cucurbits: sugars, cucurbitacin and phloem structure in resistant and susceptible melons.
BMC plant biology.
2023 May; 23(1):239. doi:
10.1186/s12870-023-04248-1. [PMID: 37147560] - Charlyne Jaccard, Wenfeng Ye, Carlos Bustos-Segura, Gaetan Glauser, Ian Kaplan, Betty Benrey. Consequences of squash (Cucurbita argyrosperma) domestication for plant defence and herbivore interactions.
Planta.
2023 May; 257(6):106. doi:
10.1007/s00425-023-04139-7. [PMID: 37127808] - Qi Wang, Xiaohui Li, Chen Zhang, Ning Yue, Simeng Li, Xueying Chen, Fen Jin, Hua Shao, Jing Wang. Discovery and Identification of the Key Contributor to the Bitter Taste in Oriental Melon after Forchlorfenuron Application.
Journal of agricultural and food chemistry.
2023 Apr; 71(16):6415-6423. doi:
10.1021/acs.jafc.3c00380. [PMID: 37039537] - Gnaoré Yoh Toussaint-Douhoré, Yaya Soro, Noufou Ouédraogo, Carlos Vaca-Garcia, Barthélemy Koffi-Attioua, Maëlle Carraz. Liver cancer antiproliferative activity of a new nor-cucurbitacin from Mareya micrantha Müll. Arg.
Fitoterapia.
2023 Apr; 166(?):105471. doi:
10.1016/j.fitote.2023.105471. [PMID: 36918040] - Pingli Yuan, Congping Xu, Nan He, Xuqiang Lu, Xingping Zhang, Jianli Shang, Hongju Zhu, Chengsheng Gong, Hanhui Kuang, Tang Tang, Yong Xu, Shuangwu Ma, Dexi Sun, Weiqin Zhang, Muhammad J Umer, Jian Shi, Alisdair R Fernie, Wenge Liu, Jie Luo. Watermelon domestication was shaped by stepwise selection and regulation of the metabolome.
Science China. Life sciences.
2023 03; 66(3):579-594. doi:
10.1007/s11427-022-2198-5. [PMID: 36346547] - Yongshuo Ma, Dawei Li, Yang Zhong, Xiaohan Wang, Legong Li, Anne Osbourn, William J Lucas, Sanwen Huang, Yi Shang. Vacuolar MATE/DTX protein-mediated cucurbitacin C transport is co-regulated with bitterness biosynthesis in cucumber.
The New phytologist.
2023 Feb; ?(?):. doi:
10.1111/nph.18786. [PMID: 36732026] - Shu Dai, Cheng Wang, XingTao Zhao, Cheng Ma, Ke Fu, Yanfang Liu, Cheng Peng, Yunxia Li. Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics.
Pharmacological research.
2023 01; 187(?):106587. doi:
10.1016/j.phrs.2022.106587. [PMID: 36460279] - Carla Varela, Catarina Melim, Beatriz G Neves, Javad Sharifi-Rad, Daniela Calina, Assem Mamurova, Célia Cabral. Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms.
Journal of translational medicine.
2022 12; 20(1):630. doi:
10.1186/s12967-022-03828-3. [PMID: 36585670] - Max Vidal-Gutiérrez, Heriberto Torres-Moreno, Víctor Arenas-Luna, María Lilia Loredo-Mendoza, Farid Tejeda-Dominguez, Carlos Velazquez, Wagner Vilegas, Salomón Hernández-Gutiérrez, Ramón E Robles-Zepeda. Standardized phytopreparations and cucurbitacin IIb from Ibervillea sonorae (S. Watson) greene induce apoptosis in cervical cancer cells by Nrf2 inhibition.
Journal of ethnopharmacology.
2022 Nov; 298(?):115606. doi:
10.1016/j.jep.2022.115606. [PMID: 35944738] - Cristina Duarte Silva, Cátia Ramalhete, Gabriella Spengler, Silva Mulhovo, Joseph Molnar, Maria-José U Ferreira. Triterpenes from Momordica balsamina (African pumpkin): ABCB1 inhibition and synergistic interaction with doxorubicin in resistant cancer cells.
Phytochemistry.
2022 Nov; 203(?):113354. doi:
10.1016/j.phytochem.2022.113354. [PMID: 35940427] - Aydın Ş Tunçbilek, Serap Yalçın Azarkan, Fahriye Sümer Ercan. The Determination of Molecular and Toxicological Mechanisms of Cucurbitacine E in Model Organism Drosophila melanogaster and Various Cancer Cell Lines: Molecular modelling, docking and dynamic simulation studies.
Current computer-aided drug design.
2022 Oct; ?(?):. doi:
10.2174/1573409919666221031112223. [PMID: 36321227] - Yingchun Zhang, Yue Zeng, Zhilong An, Dingyue Lian, Hongyu Xiao, Ruikang Wang, Ruizhi Zhang, Fuqiang Zhai, Hanru Liu. Comparative transcriptome analysis and identification of candidate genes involved in cucurbitacin IIa biosynthesis in Hemsleya macrosperma.
Plant physiology and biochemistry : PPB.
2022 Aug; 185(?):314-324. doi:
10.1016/j.plaphy.2022.06.014. [PMID: 35738187] - Yang Zhong, Weibing Xun, Xiaohan Wang, Shouwei Tian, Yancong Zhang, Dawei Li, Yuan Zhou, Yuxuan Qin, Bo Zhang, Guangwei Zhao, Xu Cheng, Yaoguang Liu, Huiming Chen, Legong Li, Anne Osbourn, William J Lucas, Sanwen Huang, Yongshuo Ma, Yi Shang. Root-secreted bitter triterpene modulates the rhizosphere microbiota to improve plant fitness.
Nature plants.
2022 08; 8(8):887-896. doi:
10.1038/s41477-022-01201-2. [PMID: 35915145] - Si-Yuan Chen, Qing Yi-Jun Zhou, Lin Chen, Jia-Yu Li, Tao Xie, Shui-Han Zhang. Screening and identifying cucurbitacins and cucurbitacin glycosides in Cucumis sativus using high-performance liquid chromatography/quadrupole-time-of-flight mass spectrometry combined with in-source fragmentation and alkali adduct ions.
Rapid communications in mass spectrometry : RCM.
2022 Jul; 36(14):e9323. doi:
10.1002/rcm.9323. [PMID: 35560736] - Zhixing Qing, Yao Shi, Lida Han, Pengkun Li, Ziou Zha, Chang Liu, Xiubin Liu, Peng Huang, Yisong Liu, Qi Tang, Kewu Zeng, Jianguo Zeng, Yuan Zhou. Identification of seven undescribed cucurbitacins in Cucumis sativus (cucumber) and their cytotoxic activity.
Phytochemistry.
2022 May; 197(?):113123. doi:
10.1016/j.phytochem.2022.113123. [PMID: 35182783] - Jiayi Sun, Jiaqi Sun, Heping Li, Xiaojie Yan, Dianpeng Li, Fenglai Lu. [Preparation of cucurbitacin compounds in Siraitia grosvenorii roots by high speed countercurrent chromatography].
Se pu = Chinese journal of chromatography.
2022 Apr; 40(4):364-371. doi:
10.3724/sp.j.1123.2021.07010. [PMID: 35362684] - Souichi Nakashima, Yoshimi Oda, Moeko Morita, Ayako Ohta, Toshio Morikawa, Hisashi Matsuda, Seikou Nakamura. Analysis of Active Compounds Using Target Protein Cofilin-Cucurbitacins in Cytotoxic Plant Bryonia cretica.
Toxins.
2022 03; 14(3):. doi:
10.3390/toxins14030212. [PMID: 35324709] - Eun-Seon Cho, Premanand Krishnan, Hwei-San Loh, Janet M Daly, Chee-Onn Leong, Chun-Wai Mai, Yun-Yee Low, Kien-Thai Yong, Kuan-Hon Lim. Pentacyclic and hexacyclic cucurbitacins from Elaeocarpuspetiolatus.
Phytochemistry.
2022 Jan; 193(?):112988. doi:
10.1016/j.phytochem.2021.112988. [PMID: 34717280] - Geovana F Guedes Silvestre, Renally Pereira de Lucena, Harley da Silva Alves. Cucurbitacins and the Immune System: Update in Research on Anti- inflammatory, Antioxidant, and Immunomodulatory Mechanisms.
Current medicinal chemistry.
2022; 29(21):3774-3789. doi:
10.2174/0929867329666220107153253. [PMID: 34994307] - Nashipolo E Uushona, Godwin A Dziwornu, Nonkululeko Mkwanazi, Catherine H Kaschula, Suthananda N Sunassee, André de Villiers. New dihydroxycucurbitacin D's from the Namib desert endemic plant Acanthosicyos horridus (!nara).
Fitoterapia.
2021 Nov; 155(?):105041. doi:
10.1016/j.fitote.2021.105041. [PMID: 34592371] - Lemeng Dong, Aldo Almeida, Jacob Pollier, Bekzod Khakimov, Jean-Etienne Bassard, Karel Miettinen, Dan Stærk, Rahimi Mehran, Carl Erik Olsen, Mohammed Saddik Motawia, Alain Goossens, Søren Bak. An Independent Evolutionary Origin for Insect Deterrent Cucurbitacins in Iberis amara.
Molecular biology and evolution.
2021 10; 38(11):4659-4673. doi:
10.1093/molbev/msab213. [PMID: 34264303] - Yijia Zeng, Jin Wang, Qinwan Huang, Yuanyuan Ren, Tingna Li, Xiaorui Zhang, Renchuan Yao, Jilin Sun. Cucurbitacin IIa: A review of phytochemistry and pharmacology.
Phytotherapy research : PTR.
2021 Aug; 35(8):4155-4170. doi:
10.1002/ptr.7077. [PMID: 33724593] - Cinthia Dos S Alves, Humberto V Frias, Leoni V Bonamin, Michelle S F Correia, Monica G Corrêa, Eduardo F Bondan, Maria de Fátima M Martins, Cidéli P Coelho, Maria M Bernardi, Ivana B Suffredini. Luffa operculata at a late period of gestation dysregulates melatonin and cytokines interfering with weight of dams and their male offspring.
Journal of ethnopharmacology.
2021 Jul; 275(?):113867. doi:
10.1016/j.jep.2021.113867. [PMID: 33892067] - Min Liu, Qijia Yan, Bi Peng, Yuan Cai, Shuangshuang Zeng, Zhijie Xu, Yuanliang Yan, Zhicheng Gong. Use of cucurbitacins for lung cancer research and therapy.
Cancer chemotherapy and pharmacology.
2021 07; 88(1):1-14. doi:
10.1007/s00280-021-04265-7. [PMID: 33825035] - Max Vidal-Gutiérrez, Heriberto Torres-Moreno, Salomón Hernández-Gutiérrez, Carlos Velazquez, Ramón E Robles-Zepeda, Wagner Vilegas. Antiproliferative activity of standardized phytopreparations from Ibervillea sonorae (S. Watson) Greene.
Steroids.
2021 05; 169(?):108824. doi:
10.1016/j.steroids.2021.108824. [PMID: 33727120] - María Isabel Iñiguez-Luna, Jorge Cadena-Iñiguez, Ramón Marcos Soto-Hernández, Francisco Javier Morales-Flores, Moisés Cortes-Cruz, Kazuo N Watanabe, Ryoko Machida-Hirano, Jorge David Cadena-Zamudio. Bioprospecting of Sechium spp. varieties for the selection of characters with pharmacological activity.
Scientific reports.
2021 03; 11(1):6185. doi:
10.1038/s41598-021-85676-7. [PMID: 33731771] - Dongke Wu, Dasheng Dong, Xiongjie Bi, Yuping Liu, Yunqing Ma. Cucurbitacin IIb improved active chromatin-induced systemic lupus erythematosus via balancing the percentage of Th17 and Treg cells.
Clinical and experimental pharmacology & physiology.
2021 03; 48(3):329-336. doi:
10.1111/1440-1681.13434. [PMID: 33128285] - Lu-Te Chuang, Wen-Cheng Huang, Yu-Chen Hou, Jong-Ho Chyuan, Hsiang Chang, Chi-I Chang, Tsung-Hsien Tsai, Po-Jung Tsai. Suppressive Effect of Two Cucurbitane-Type Triterpenoids from Momordica charantia on Cutibacterium acnes-Induced Inflammatory Responses in Human THP-1 Monocytic Cell and Mouse Models.
Molecules (Basel, Switzerland).
2021 Jan; 26(3):. doi:
10.3390/molecules26030579. [PMID: 33499307] - Xianjing Zhang, Huihui Li, Wenqiong Wang, Tong Chen, Lijiang Xuan. Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives.
Journal of natural products.
2020 12; 83(12):3536-3544. doi:
10.1021/acs.jnatprod.0c00364. [PMID: 33269591] - Lauren J Brzozowski, Michael A Gore, Anurag A Agrawal, Michael Mazourek. Divergence of defensive cucurbitacins in independent Cucurbita pepo domestication events leads to differences in specialist herbivore preference.
Plant, cell & environment.
2020 11; 43(11):2812-2825. doi:
10.1111/pce.13844. [PMID: 32666553] - Young-Cheon Kim, Daeun Choi, Ahra Cha, Yeong-Geun Lee, Nam-In Baek, Suman Rimal, Jiun Sang, Youngseok Lee, Sanghyeob Lee. Critical enzymes for biosynthesis of cucurbitacin derivatives in watermelon and their biological significance.
Communications biology.
2020 08; 3(1):444. doi:
10.1038/s42003-020-01170-2. [PMID: 32796947] - Gnaoré Yoh Toussaint Douhoré, Koffi Barthélemy Attioua, Yaya Soro, Faustin Aka Kabran, Landry Claude Ahmont Kablan, Marc Vedrenne, Céline Mathieu, Carlos Vaca-Garcia. Nor-cucurbitacins from the leaves of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae).
Fitoterapia.
2020 Jun; 143(?):104538. doi:
10.1016/j.fitote.2020.104538. [PMID: 32151637] - Md Shahiduzzaman, Refaat Ras, Giovanni Widmer. Effect of Ginsenoside-Rh2 and Curcurbitacin-B on Cryptosporidium parvum in vitro.
Experimental parasitology.
2020 May; 212(?):107873. doi:
10.1016/j.exppara.2020.107873. [PMID: 32165146] - Heriberto Torres-Moreno, Maria Carla Marcotullio, Carlos Velázquez, Federica Ianni, Adriana Garibay-Escobar, Ramón Enrique Robles-Zepeda. Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells.
Steroids.
2020 05; 157(?):108597. doi:
10.1016/j.steroids.2020.108597. [PMID: 32068079] - S B Patel, U A Attar, D M Sakate, S G Ghane. Efficient extraction of cucurbitacins from Diplocyclos palmatus (L.) C. Jeffrey: Optimization using response surface methodology, extraction methods and study of some important bioactivities.
Scientific reports.
2020 02; 10(1):2109. doi:
10.1038/s41598-020-58924-5. [PMID: 32034276] - Yueling Zhong, Hong Xu, Yi Zhong, Xuemiao Zhang, Ting Zeng, Limei Li, Gaojie Xu, Minhui Li, Jin Liu, Tai Yang. Identification and characterization of the Cucurbitacins, a novel class of small-molecule inhibitors of Tropomyosin receptor kinase a.
BMC complementary and alternative medicine.
2019 Nov; 19(1):295. doi:
10.1186/s12906-019-2709-z. [PMID: 31694615] - Faraz Ul Haq, Arslan Ali, Muhammad Noman Khan, Syed Muhammad Zaki Shah, Ram Chandra Kandel, Nudrat Aziz, Achyut Adhikari, M Iqbal Choudhary, Atta- Ur-Rahman, Hesham R El-Seedi, Syed Ghulam Musharraf. Metabolite Profiling and Quantitation of Cucurbitacins in Cucurbitaceae Plants by Liquid Chromatography coupled to Tandem Mass Spectrometry.
Scientific reports.
2019 11; 9(1):15992. doi:
10.1038/s41598-019-52404-1. [PMID: 31690753] - Ru-Qiang Yuan, Lei Qian, Wei-Jing Yun, Xiao-Hui Cui, Guang-Xin Lv, Wei-Qi Tang, Ri-Chang Cao, Hu Xu. Cucurbitacins extracted from Cucumis melo L. (CuEC) exert a hypotensive effect via regulating vascular tone.
Hypertension research : official journal of the Japanese Society of Hypertension.
2019 08; 42(8):1152-1161. doi:
10.1038/s41440-019-0258-y. [PMID: 30962520] - Bahare Salehi, Esra Capanoglu, Nabil Adrar, Gizem Catalkaya, Shabnum Shaheen, Mehwish Jaffer, Lalit Giri, Renu Suyal, Arun K Jugran, Daniela Calina, Anca Oana Docea, Senem Kamiloglu, Dorota Kregiel, Hubert Antolak, Ewelina Pawlikowska, Surjit Sen, Krishnendu Acharya, Zeliha Selamoglu, Javad Sharifi-Rad, Miquel Martorell, Célia F Rodrigues, Farukh Sharopov, Natália Martins, Raffaele Capasso. Cucurbits Plants: A Key Emphasis to Its Pharmacological Potential.
Molecules (Basel, Switzerland).
2019 May; 24(10):. doi:
10.3390/molecules24101854. [PMID: 31091784] - Hidayat Hussain, Ivan R Green, Muhammad Saleem, Khanzadi F Khattak, Muhammad Irshad, Maroof Ali. Cucurbitacins as Anticancer Agents: A Patent Review.
Recent patents on anti-cancer drug discovery.
2019; 14(2):133-143. doi:
10.2174/1574892813666181119123035. [PMID: 30451116] - Abdulrhman Alsayari, Lucas Kopel, Mahmoud Salama Ahmed, Hesham S M Soliman, Sivakumar Annadurai, Fathi T Halaweish. Isolation of anticancer constituents from Cucumis prophetarum var. prophetarum through bioassay-guided fractionation.
BMC complementary and alternative medicine.
2018 Oct; 18(1):274. doi:
10.1186/s12906-018-2295-5. [PMID: 30301463] - Elias E Mazokopakis, Christos G Karagiannis. Medical toxicology in the Old Testament. The poisonous pottage.
Internal medicine journal.
2017 12; 47(12):1458-1460. doi:
10.1111/imj.13641. [PMID: 29224210] - Zhibin Wang, Wenbo Zhu, Mingjie Gao, Chengcui Wu, Chunjuan Yang, Jing Yang, Gaosong Wu, Bingyou Yang, Haixue Kuang. Simultaneous determination of cucurbitacin B and cucurbitacin E in rat plasma by UHPLC-MS/MS: A pharmacokinetics study after oral administration of cucurbitacin tablets.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Oct; 1065-1066(?):63-69. doi:
10.1016/j.jchromb.2017.09.024. [PMID: 28946127] - Giovana Maria Lanchoti Fiori, Salvatore D'Agate, Adriana Rocha, Ana Maria Soares Pereira, O Della Pasqua, Norberto Peporine Lopes. Development and validation of a quantification method for cucurbitacins E and I in rat plasma: Application to population pharmacokinetic studies.
Journal of pharmaceutical and biomedical analysis.
2017 Sep; 144(?):99-105. doi:
10.1016/j.jpba.2017.02.021. [PMID: 28274497] - Sandra Salazar-Aguilar, Lucero Del Mar Ruiz-Posadas, Jorge Cadena-Iñiguez, Marcos Soto-Hernández, Edelmiro Santiago-Osorio, Itzen Aguiñiga-Sánchez, Ana Rocío Rivera-Martínez, Juan Francisco Aguirre-Medina. Sechium edule (Jacq.) Swartz, a New Cultivar with Antiproliferative Potential in a Human Cervical Cancer HeLa Cell Line.
Nutrients.
2017 Jul; 9(8):. doi:
10.3390/nu9080798. [PMID: 28757593] - Rachid Chawech, Fatma Njeh, Nejia Hamed, Mohamed Damak, Ali Ayadi, Hayet Hammami, Raoudha Mezghani-Jarraya. A study of the molluscicidal and larvicidal activities of Citrullus colocynthis (L.) leaf extract and its main cucurbitacins against the mollusc Galba truncatula, intermediate host of Fasciola hepatica.
Pest management science.
2017 Jul; 73(7):1473-1477. doi:
10.1002/ps.4479. [PMID: 27862897] - A Varricchio, A De Lucia, A M Varricchio, A Della Volpe, N Mansi, V Pastore, G Ciprandi. Sinuclean Nebules treatment in children suffering from otitis media with effusion.
International journal of pediatric otorhinolaryngology.
2017 Mar; 94(?):30-35. doi:
10.1016/j.ijporl.2017.01.001. [PMID: 28167007] - Wen-Dong Wang, Yan Liu, Yuan Su, Xian-Zhi Xiong, Dan Shang, Juan-Juan Xu, Hong-Ju Liu. ANTITUMOR AND APOPTOTIC EFFECTS OF CUCURBITACIN A IN A-549 LUNG CARCINOMA CELLS IS MEDIATED VIA G2/M CELL CYCLE ARREST AND M-TOR/PI3K/AKT SIGNALLING PATHWAY.
African journal of traditional, complementary, and alternative medicines : AJTCAM.
2017; 14(2):75-82. doi:
10.21010/ajtcam.v14i2.9. [PMID: 28573224] - Shougang Wang, Xiaohui Guan, Xiuhong Zhong, Zhiping Yang, Weili Huang, Baoyang Jia, Tao Cui. Simultaneous determination of cucurbitacin IIa and cucurbitacin IIb of Hemsleya amabilis by HPLC-MS/MS and their pharmacokinetic study in normal and indomethacin-induced rats.
Biomedical chromatography : BMC.
2016 Oct; 30(10):1632-40. doi:
10.1002/bmc.3733. [PMID: 27061415] - Edoardo Fabini, Giovana Maria Lanchoti Fiori, Daniele Tedesco, Norberto Peporine Lopes, Carlo Bertucci. Surface plasmon resonance and circular dichroism characterization of cucurbitacins binding to serum albumins for early pharmacokinetic profiling.
Journal of pharmaceutical and biomedical analysis.
2016 Apr; 122(?):166-72. doi:
10.1016/j.jpba.2016.01.051. [PMID: 26856457] - Izabella Thaís Silva, Fabiana Cristina Geller, Lara Persich, Sabine Eva Dudek, Karen Luise Lang, Miguel Soriano Balparda Caro, Fernando Javier Durán, Eloir Paulo Schenkel, Stephan Ludwig, Cláudia Maria Oliveira Simões. Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549.
Investigational new drugs.
2016 Apr; 34(2):139-48. doi:
10.1007/s10637-015-0317-4. [PMID: 26780083] - Rachid Chawech, Raoudha Jarraya, Cynthia Girardi, Marieke Vansteelandt, Guillaume Marti, Imen Nasri, Claire Racaud-Sultan, Nicolas Fabre. Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.
Molecules (Basel, Switzerland).
2015 Sep; 20(10):18001-15. doi:
10.3390/molecules201018001. [PMID: 26437392] - Tony Chien-Yen Kuo, Chuan-Hung Chen, Shu-Hwa Chen, I-Hsuan Lu, Mei-Ju Chu, Li-Chun Huang, Chung-Yen Lin, Chien-Yu Chen, Hsiao-Feng Lo, Shih-Tong Jeng, Long-Fang O Chen. The effect of red light and far-red light conditions on secondary metabolism in agarwood.
BMC plant biology.
2015 Jun; 15(?):139. doi:
10.1186/s12870-015-0537-y. [PMID: 26067652] - Jian Sun, Fang Xia, Shu Wang, Ke-Yuan Wang, Jin-Ming Chen, Peng-Fei Tu. Structural elucidation of two new megastigmane glycosides from the leaves of Aquilaria sinensis.
Chinese journal of natural medicines.
2015 Apr; 13(4):290-4. doi:
10.1016/s1875-5364(15)30016-9. [PMID: 25908626] - Jian-Chao Chen, Clara Bik-San Lau, Judy Yuet-Wa Chan, Kwok-Pui Fung, Ping-Chung Leung, Jie-Qing Liu, Lin Zhou, Ming-Jin Xie, Ming-Hua Qiu. The antigluconeogenic activity of cucurbitacins from Momordica charantia.
Planta medica.
2015 Mar; 81(4):327-32. doi:
10.1055/s-0035-1545695. [PMID: 25760384] - Rachel Davidovich-Rikanati, Lior Shalev, Nadine Baranes, Ayala Meir, Maxim Itkin, Shahar Cohen, Kobi Zimbler, Vitaly Portnoy, Yutaka Ebizuka, Masaaki Shibuya, Yosef Burger, Nurit Katzir, Arthur A Schaffer, Efraim Lewinsohn, Ya'akov Tadmor. Recombinant yeast as a functional tool for understanding bitterness and cucurbitacin biosynthesis in watermelon (Citrullus spp.).
Yeast (Chichester, England).
2015 Jan; 32(1):103-14. doi:
10.1002/yea.3049. [PMID: 25308777] - Yuee Cai, Xiefan Fang, Chengwei He, Peng Li, Fei Xiao, Yitao Wang, Meiwan Chen. Cucurbitacins: A Systematic Review of the Phytochemistry and Anticancer Activity.
The American journal of Chinese medicine.
2015; 43(7):1331-50. doi:
10.1142/s0192415x15500755. [PMID: 26503558] - Nina Theis, Nicholas A Barber, Sandra D Gillespie, Ruth V Hazzard, Lynn S Adler. Attracting mutualists and antagonists: plant trait variation explains the distribution of specialist floral herbivores and pollinators on crops and wild gourds.
American journal of botany.
2014 Aug; 101(8):1314-22. doi:
10.3732/ajb.1400171. [PMID: 25156980] - Chuan-Hung Chen, Tony Chien-Yen Kuo, Meng-Han Yang, Ting-Ying Chien, Mei-Ju Chu, Li-Chun Huang, Chien-Yu Chen, Hsiao-Feng Lo, Shih-Tong Jeng, Long-Fang O Chen. Identification of cucurbitacins and assembly of a draft genome for Aquilaria agallocha.
BMC genomics.
2014 Jul; 15(?):578. doi:
10.1186/1471-2164-15-578. [PMID: 25005802] - Xiao-Ting Xu, Zhi-Peng Deng, Hui-Xia Fan, Hao Zhong, Qing-Qiang Yao. [Study on in vivo pharmacokinetics of cucurbitacin injection in rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2014 Jun; 39(11):2126-30. doi:
NULL. [PMID: 25272856] - Cynthia H Ho, Michael G Ho, Shin-Pin Ho, Helen H Ho. Bitter bottle gourd (Lagenaria siceraria) toxicity.
The Journal of emergency medicine.
2014 Jun; 46(6):772-5. doi:
10.1016/j.jemermed.2013.08.106. [PMID: 24360122] - Xu-Bing Chen, Guang-Yong Chen, Jun-Hua Liu, Min Lei, Yu-Hui Meng, De-An Guo, Xuan Liu, Li-Hong Hu. Cytotoxic cucurbitane triterpenoids isolated from the rhizomes of Hemsleya amabilis.
Fitoterapia.
2014 Apr; 94(?):88-93. doi:
10.1016/j.fitote.2014.01.014. [PMID: 24462673] - Min Bai, Hong-Liang Li, Jian-Chang He, Gong-Hao He, En-Fu Feng, Yue-Qiong Liu, Pan-Pan Shi, Gui-Li Xu. Development and validation of an LC-ESI-MS/MS method for the quantitation of hemslecin A in rhesus monkey plasma and its application in pharmacokinetics.
Biomedical chromatography : BMC.
2014 Mar; 28(3):385-90. doi:
10.1002/bmc.3032. [PMID: 24132644] - Karen Luise Lang, Emilio Deagosto, Lara Almida Zimmermann, Vanessa Rocha Machado, Lílian Sibelle Campos Bernardes, Eloir Paulo Schenkel, Fernando Javier Duran, Jorge Palermo, Carmen Rossini. Chemical modification produces species-specific changes in cucurbitacin antifeedant effect.
Journal of agricultural and food chemistry.
2013 Jun; 61(23):5534-9. doi:
10.1021/jf4002457. [PMID: 23646892] - Rui-Hua Guo, Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Quan Zhang, Li-Jun Wang, Xue-Mei Zhang, Rong-Ping Zhang, Ji-Jun Chen. Synthesis of hemslecin A derivatives: a new class of hepatitis B virus inhibitors.
Bioorganic & medicinal chemistry letters.
2013 Mar; 23(5):1201-5. doi:
10.1016/j.bmcl.2013.01.024. [PMID: 23385212] - Shengping Zhang, Han Miao, Rifei Sun, Xiaowu Wang, Sanwen Huang, Todd C Wehner, Xingfang Gu. Localization of a new gene for bitterness in cucumber.
The Journal of heredity.
2013 Jan; 104(1):134-9. doi:
10.1093/jhered/ess075. [PMID: 23091223] - Xiuping Chen, Jiaolin Bao, Jiajie Guo, Qian Ding, Jinjian Lu, Mingqing Huang, Yitao Wang. Biological activities and potential molecular targets of cucurbitacins: a focus on cancer.
Anti-cancer drugs.
2012 Sep; 23(8):777-87. doi:
10.1097/cad.0b013e3283541384. [PMID: 22561419] - Shuai Ren, Dong-Yun Ouyang, Mark Saltis, Li-Hui Xu, Qing-Bing Zha, Ji-Ye Cai, Xian-Hui He. Anti-proliferative effect of 23,24-dihydrocucurbitacin F on human prostate cancer cells through induction of actin aggregation and cofilin-actin rod formation.
Cancer chemotherapy and pharmacology.
2012 Sep; 70(3):415-24. doi:
10.1007/s00280-012-1921-z. [PMID: 22814677] - Li Pan, Yeonjoong Yong, Ye Deng, Daniel D Lantvit, Tran Ngoc Ninh, Heebyung Chai, Esperanza J Carcache de Blanco, Djaja D Soejarto, Steven M Swanson, A Douglas Kinghorn. Isolation, structure elucidation, and biological evaluation of 16,23-epoxycucurbitacin constituents from Eleaocarpus chinensis.
Journal of natural products.
2012 Mar; 75(3):444-52. doi:
10.1021/np200879p. [PMID: 22239601] - Curtis J Henrich, Cheryl L Thomas, Alan D Brooks, Nancy Lynn Booth, Evan M Lowery, Richard J Pompei, James B McMahon, Thomas J Sayers. Effects of cucurbitacins on cell morphology are associated with sensitization of renal carcinoma cells to TRAIL-induced apoptosis.
Apoptosis : an international journal on programmed cell death.
2012 Jan; 17(1):79-89. doi:
10.1007/s10495-011-0652-7. [PMID: 21928090] - Karen L Lang, Tatiana da Rosa Guimarães, Vanessa Rocha Machado, Lara A Zimmermann, Izabella T Silva, Marina R Teixeira, Fernando J Durán, Jorge A Palermo, Cláudia M O Simões, Miguel S B Caro, Eloir P Schenkel. New cytotoxic cucurbitacins from Wilbrandia ebracteata Cogn.
Planta medica.
2011 Sep; 77(14):1648-51. doi:
10.1055/s-0030-1270962. [PMID: 21472651] - Andrew B Pedersen, Larry D Godfrey. Evaluation of cucurbitacin-based gustatory stimulant to facilitate cucumber beetle (Coleoptera: Chrysomelidae) management with foliar insecticides in melons.
Journal of economic entomology.
2011 Aug; 104(4):1294-300. doi:
10.1603/ec10213. [PMID: 21882695] - C Boykin, G Zhang, Y-H Chen, R-W Zhang, X-E Fan, W-M Yang, Q Lu. Cucurbitacin IIa: a novel class of anti-cancer drug inducing non-reversible actin aggregation and inhibiting survivin independent of JAK2/STAT3 phosphorylation.
British journal of cancer.
2011 Mar; 104(5):781-9. doi:
10.1038/bjc.2011.10. [PMID: 21304528] - Rony Abou-Khalil, Alia Jraij, Jacques Magdalou, Naïm Ouaini, Daniel Tome, Hélène Greige-Gerges. Interaction of cucurbitacins with human serum albumin: Thermodynamic characteristics and influence on the binding of site specific ligands.
Journal of photochemistry and photobiology. B, Biology.
2009 Jun; 95(3):189-95. doi:
10.1016/j.jphotobiol.2009.03.005. [PMID: 19380237] - Jianchao Chen, Renrong Tian, Minghua Qiu, Lu Lu, Yongtang Zheng, Zhongquan Zhang. Trinorcucurbitane and cucurbitane triterpenoids from the roots of Momordica charantia.
Phytochemistry.
2008 Feb; 69(4):1043-8. doi:
10.1016/j.phytochem.2007.10.020. [PMID: 18045630] - Pamita Bhandari, Neeraj Kumar, Bikram Singh, Vijay K Kaul. Cucurbitacins from Bacopa monnieri.
Phytochemistry.
2007 May; 68(9):1248-54. doi:
10.1016/j.phytochem.2007.03.013. [PMID: 17442350] - Ik Hwi Kim, Nahoko Uchiyama, Nobuo Kawahara, Yukihiro Goda. Iridoid glycosides and cucurbitacin glycoside from Neopicrorhiza scrophulariiflora.
Phytochemistry.
2006 Dec; 67(24):2691-6. doi:
10.1016/j.phytochem.2006.09.015. [PMID: 17070880] - J-M Zou, L-S Wang, X-M Ma, Y-J Guo, R-B Shi. A new cucurbitacin from Picria fel-terrae.
Journal of Asian natural products research.
2006 Jun; 8(4):367-71. doi:
10.1080/10286020500034998. [PMID: 16864449] - Durey Nayab, Dildar Ali, Nuzhat Arshad, Abdul Malik, M Iqbal Choudhary, Zaheer Ahmed. Cucurbitacin glucosides from Citrullus colocynthis.
Natural product research.
2006 May; 20(5):409-13. doi:
10.1080/14786410500044997. [PMID: 16644537] - M Carmen Recio, Maite Prieto, Marina Bonucelli, Cecilia Orsi, Salvador Máñez, Rosa M Giner, M Cerdá-Nicolás, José-Luis Ríos. Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.
Planta medica.
2004 May; 70(5):414-20. doi:
10.1055/s-2004-818968. [PMID: 15124085] - Kai Yang, Yuming Wen, Changmei Wang. [The study of cucurbitacin BE polylactic acid nanoparticles delivering cucurbitacin BE to metastasized cervical lymph nodes in mice with oral cancer].
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology.
2003 Dec; 21(6):477-80. doi:
NULL. [PMID: 14732987] - Phyllis A W Martin, Michael Blackburn. Inhibition of seed germination by extracts of bitter Hawkesbury watermelon containing cucurbitacin, a feeding stimulant for corn rootworm (Coleoptera: Chrysomelidae).
Journal of economic entomology.
2003 Apr; 96(2):441-5. doi:
10.1603/0022-0493-96.2.441. [PMID: 14994812] - Bolleddula Jayaprakasam, Navindra P Seeram, Muraleedharan G Nair. Anticancer and antiinflammatory activities of cucurbitacins from Cucurbita andreana.
Cancer letters.
2003 Jan; 189(1):11-6. doi:
10.1016/s0304-3835(02)00497-4. [PMID: 12445672] - Aiko Ito, Hee-Byung Chai, Dongho Lee, Leonardus B S Kardono, Soedarsono Riswan, Norman R Farnsworth, Geoffrey A Cordell, John M Pezzuto, A Douglas Kinghorn. Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii.
Phytochemistry.
2002 Sep; 61(2):171-4. doi:
10.1016/s0031-9422(02)00232-7. [PMID: 12169311] - L Dinan, P C Bourne, Y Meng, S D Sarker, R B Tolentino, P Whiting. Assessment of natural products in the Drosophila melanogaster B(II) cell bioassay for ecdysteroid agonist and antagonist activities.
Cellular and molecular life sciences : CMLS.
2001 Feb; 58(2):321-42. doi:
10.1007/pl00000859. [PMID: 11289314] - E G Attard, A Scicluna-Spiteri. Ecballium elaterium: an in vitro source of cucurbitacins.
Fitoterapia.
2001 Jan; 72(1):46-53. doi:
10.1016/s0367-326x(00)00256-2. [PMID: 11163940] - R R Peters, M R Farias, R M Ribeiro-do-Valle. Anti-inflammatory and analgesic effects of cucurbitacins from Wilbrandia ebracteata.
Planta medica.
1997 Dec; 63(6):525-8. doi:
10.1055/s-2006-957755. [PMID: 9434604] - A O Bakhiet, S E Adam. An estimation of Citrullus colocynthis toxicity for chicks.
Veterinary and human toxicology.
1995 Aug; 37(4):356-8. doi:
NULL. [PMID: 8540228]