Euscaphic acid (BioDeep_00000000563)

   

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(1R,2R,4aS,6aS,6bR,8aR,10S,11R,12aR,12bR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid

化学式: C30H48O5 (488.3502)
中文名称: 野鸦椿酸
谱图信息: 最多检出来源 Homo sapiens(otcml) 42.47%

分子结构信息

SMILES: CC1CCC2(C(=O)O)CCC3(C)C(=CCC4C5(C)CC(O)C(O)C(C)(C)C5CCC43C)C2C1(C)O
InChI: InChI=1S/C30H48O5/c1-17-10-13-30(24(33)34)15-14-27(5)18(22(30)29(17,7)35)8-9-21-26(4)16-19(31)23(32)25(2,3)20(26)11-12-28(21,27)6/h8,17,19-23,31-32,35H,9-16H2,1-7H3,(H,33,34)/t17-,19-,20+,21-,22-,23-,26+,27-,28-,29-,30+/m1/s1

描述信息

Euscaphic acid is a pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata. It has a role as a plant metabolite. It is a pentacyclic triterpenoid, a hydroxy monocarboxylic acid and a triol. It derives from a hydride of an ursane.
Euscaphic acid is a natural product found in Ternstroemia gymnanthera, Rhaphiolepis deflexa, and other organisms with data available.
A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by hydroxy groups at positions 2, 3 and 19 respectively (the 2alpha,3alpha-stereoisomer). It has been isolated from the leaves of Rosa laevigata.
Euscaphic acid is found in herbs and spices. Euscaphic acid is a constituent of Coleus amboinicus (Cuban oregano).
Constituent of Coleus amboinicus (Cuban oregano). Euscaphic acid is found in loquat and herbs and spices.
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].
Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].

同义名列表

23 个代谢物同义名

(1R,2R,4aS,6aS,6bR,8aR,10S,11R,12aR,12bR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-icosahydropicene-4a-carboxylic acid; (1S,2S,4AS,6AS,6AS,6BR,8AR,10S,11R,12AS,14BS)-1,2,6A,6B,9,9,12A-HEPTAMETHYL-1,10,11-TRIS(OXIDANYL)-2,3,4,5,6,6A,7,8,8A,10,11,12,13,14B-TETRADECAHYDROPICENE-4A-CARBOXYLIC ACID; (1R,2R,4aS,6aS,6bR,8aR,10S,11R,12aR,12bR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,7,8,8a,10,11,12,12b,13,14b-tetradecahydropicene-4a-carboxylic acid; (1R,2R,4aS,6aR,6aS,6bR,8aR,10S,11R,12aR,14bS)-1,10,11-trihydroxy-1,2,6a,6b,9,9,12a-heptamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid; Urs-12-en-28-oic acid, 2,3,19-trihydroxy-, (2.alpha.,3.alpha.)-; Urs-12-en-28-oic acid,3,19-trihydroxy-, (2.alpha.,3alpha.)-; (2alpha,3alpha)-2,3,19-trihydroxyurs-12-en-28-oic acid; 2alpha,3alpha,19alpha-Trihydroxyurs-12-en-28-oic acid; Urs-12-en-28-oic acid,2,3,19-trihydroxy-, (2a,3a)-; (2alpha,3beta)-isomer of euscaphic acid; 2alpha-acetyl tormentic acid; Jacarandic acid; Acuminatic acid; Euscaphic acid; Tormentic acid; Euscophic acid; Euscapic acid; Jacarandate; LG23EX5V2J; Tormentate; Euscaphate; SCHEMBL13629631; Euscaphic acid



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

218 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 AIMP2, AKR1B1, BCL2, CASP3, ESR1, FRK, IL33, MAP3K7, MAPK8, MTOR, PIK3CA, POLB, PTGS2, TLR4, TRAF6
Peripheral membrane protein 6 ACHE, ESR1, GORASP1, MAP3K7, MTOR, PTGS2
Endosome membrane 3 MAP3K7, TLR4, TRAF6
Endoplasmic reticulum membrane 4 BCL2, MAP3K7, MTOR, PTGS2
Nucleus 13 ACHE, AIMP2, BCL2, CASP3, CS, ESR1, FRK, IL33, MAP3K7, MAPK8, MTOR, POLB, TRAF6
cytosol 12 AIMP2, AKR1B1, BCL2, CASP3, ESR1, FRK, GPT, MAP3K7, MAPK8, MTOR, PIK3CA, TRAF6
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
nucleoplasm 8 AKR1B1, CASP3, ESR1, FRK, IL33, MAPK8, MTOR, POLB
Cell membrane 4 ACHE, ESR1, MAP3K7, TLR4
Cytoplasmic side 4 ESR1, GORASP1, MAP3K7, MTOR
lamellipodium 1 PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 2 ACHE, MAPK8
cell cortex 1 TRAF6
cell surface 2 ACHE, TLR4
glutamatergic synapse 2 CASP3, TRAF6
Golgi apparatus 3 ACHE, ESR1, GORASP1
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 2 GAA, MTOR
neuromuscular junction 1 ACHE
neuronal cell body 1 CASP3
Cytoplasm, cytosol 1 AIMP2
Cytoplasmic vesicle, secretory vesicle 1 IL33
Lysosome 2 GAA, MTOR
plasma membrane 8 ACHE, ESR1, FRK, GAA, MAP3K7, PIK3CA, TLR4, TRAF6
Membrane 9 ACHE, AIMP2, BCL2, CS, ESR1, GAA, IL33, MTOR, TLR4
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 5 AKR1B1, CS, FRK, GAA, GPT
Lysosome membrane 2 GAA, MTOR
endoplasmic reticulum 2 BCL2, PTGS2
extracellular space 3 ACHE, AKR1B1, IL33
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 4 ACHE, PIK3CA, TLR4, TRAF6
intercalated disc 1 PIK3CA
mitochondrion 3 AKR1B1, BCL2, CS
protein-containing complex 5 BCL2, ESR1, POLB, PTGS2, TRAF6
intracellular membrane-bounded organelle 2 GAA, IL33
Microsome membrane 2 MTOR, PTGS2
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 TLR4
Secreted 3 ACHE, GAA, IL33
extracellular region 4 ACHE, FRK, GAA, IL33
cytoplasmic side of plasma membrane 1 TRAF6
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, MTOR
Mitochondrion matrix 1 CS
mitochondrial matrix 1 CS
Extracellular side 1 ACHE
transcription regulator complex 1 ESR1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
CD40 receptor complex 1 TRAF6
external side of plasma membrane 1 TLR4
Early endosome 1 TLR4
pore complex 1 BCL2
microtubule 1 POLB
cis-Golgi network 1 GORASP1
basement membrane 1 ACHE
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
neuron projection 1 PTGS2
chromatin 1 ESR1
phagocytic cup 1 TLR4
Chromosome 1 IL33
Cytoplasm, cell cortex 1 TRAF6
Lipid-anchor, GPI-anchor 1 ACHE
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Lipid droplet 1 TRAF6
tertiary granule membrane 1 GAA
euchromatin 1 ESR1
side of membrane 1 ACHE
myelin sheath 1 BCL2
lipopolysaccharide receptor complex 1 TLR4
endoplasmic reticulum lumen 1 PTGS2
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
specific granule lumen 1 FRK
transport vesicle 1 IL33
azurophil granule membrane 1 GAA
azurophil granule lumen 1 FRK
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
[Isoform 1]: Nucleus 1 ESR1
extrinsic component of cytoplasmic side of plasma membrane 1 TRAF6
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
spindle microtubule 1 POLB
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
ATAC complex 1 MAP3K7
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA


文献列表

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  • Yang Yang, Yawei Wang, Meng Zhao, Haobo Jia, Bing Li, Dan Xing. Tormentic acid inhibits IL-1β-induced chondrocyte apoptosis by activating the PI3K/Akt signaling pathway. Molecular medicine reports. 2018 03; 17(3):4753-4758. doi: 10.3892/mmr.2018.8425. [PMID: 29328385]
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  • Jing-jing Li, Yi Li, Min Bai, Jing-fu Tan, Qiang Wang, Jie Yang. Simultaneous determination of corosolic acid and euscaphic acid in the plasma of normal and diabetic rat after oral administration of extract of Potentilla discolor Bunge by high-performance liquid chromatography/electrospray ionization mass spectrometry. Biomedical chromatography : BMC. 2014 May; 28(5):717-24. doi: 10.1002/bmc.3098. [PMID: 24311372]
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