arcaine (BioDeep_00000005076)

   

natural product


代谢物信息卡片


arcaine

化学式: C6H16N6 (172.1436)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 40.68%

分子结构信息

SMILES: C(CCN=C(N)N)CN=C(N)N
InChI: InChI=1S/C6H16N6/c7-5(8)11-3-1-2-4-12-6(9)10/h1-4H2,(H4,7,8,11)(H4,9,10,12)

描述信息

D007004 - Hypoglycemic Agents > D001645 - Biguanides

同义名列表

2 个代谢物同义名

arcaine; Arcaine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ARG1, AZIN2, CA1, GRIN2B, HTT, ODC1, POMC
Peripheral membrane protein 1 AOC1
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 3 GRIN2A, GRIN2B, HMGCR
Nucleus 3 ARG1, AZIN2, HTT
autophagosome 1 HTT
cytosol 5 ARG1, AZIN2, CA1, HTT, ODC1
dendrite 4 AZIN2, HTT, PDYN, TACR1
trans-Golgi network 1 AZIN2
nucleoplasm 2 ATP2B1, HTT
Cell membrane 7 AOC1, ATP2B1, GRID1, GRIN2A, GRIN2B, HTT, TACR1
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 9 ATP2B1, CACNA1I, CATSPER3, GRID1, GRIN2A, GRIN2B, HMGCR, HTT, TACR1
Synapse 5 ATP2B1, GRIN2A, HTT, PDYN, TAC1
cell surface 3 GRIN2A, GRIN2B, TACR1
glutamatergic synapse 3 ATP2B1, GRID1, GRIN2A
Golgi apparatus 1 HTT
mitochondrial inner membrane 1 OTC
neuronal cell body 2 PDYN, TAC1
presynaptic membrane 3 ATP2B1, GRIN2A, HTT
synaptic vesicle 1 GRIN2A
Lysosome 1 GRIN2B
acrosomal vesicle 1 CATSPER3
plasma membrane 11 AOC1, ATP2B1, CACNA1I, CATSPER3, CD160, GRID1, GRIN2A, GRIN2B, HTT, PDYN, TACR1
synaptic vesicle membrane 1 ATP2B1
Membrane 6 ATP2B1, AZIN2, CACNA1I, GRIN2A, GRIN2B, HMGCR
axon 3 AZIN2, HTT, TAC1
basolateral plasma membrane 1 ATP2B1
extracellular exosome 4 AOC1, ATP2B1, CA1, GRID1
endoplasmic reticulum 4 CATSPER3, GRIN2A, HMGCR, HTT
extracellular space 4 AOC1, ARG1, POMC, TAC1
perinuclear region of cytoplasm 2 AZIN2, HTT
bicellular tight junction 1 AOC1
mitochondrion 3 AGMAT, AZIN2, OTC
protein-containing complex 1 HTT
intracellular membrane-bounded organelle 1 ATP2B1
postsynaptic density 2 GRIN2A, GRIN2B
Secreted 2 PDYN, POMC
extracellular region 6 AOC1, ARG1, CD160, PDYN, POMC, TAC1
hippocampal mossy fiber to CA3 synapse 1 PDYN
Mitochondrion matrix 1 OTC
mitochondrial matrix 1 OTC
Extracellular side 1 AOC1
motile cilium 1 CATSPER3
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
dendritic spine 1 GRIN2A
perikaryon 1 AZIN2
cytoplasmic vesicle 1 AZIN2
Early endosome 1 HTT
postsynaptic membrane 5 GRID1, GRIN2A, GRIN2B, HTT, TACR1
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton 1 GRIN2B
focal adhesion 1 HTT
GABA-ergic synapse 1 GRID1
cis-Golgi network 1 AZIN2
Peroxisome 1 AOC1
peroxisomal membrane 1 HMGCR
Cell projection, dendritic spine 1 GRIN2A
secretory granule 1 POMC
lateral plasma membrane 1 ATP2B1
Postsynaptic cell membrane 3 GRID1, GRIN2A, GRIN2B
Late endosome 2 GRIN2B, HTT
Cell projection, neuron projection 1 HTT
neuron projection 3 GRIN2A, GRIN2B, HTT
cell projection 1 ATP2B1
cytoskeleton 1 GRIN2B
centriole 1 HTT
Secreted, extracellular space 1 AOC1
sperm midpiece 1 TACR1
Basolateral cell membrane 1 ATP2B1
Lipid-anchor, GPI-anchor 1 CD160
sperm flagellum 1 TACR1
Endomembrane system 1 HTT
Cell projection, cilium, flagellum membrane 1 CATSPER3
Cytoplasmic vesicle membrane 2 GRIN2A, HTT
Cell projection, dendrite 1 GRIN2B
Presynaptic cell membrane 1 ATP2B1
cell body 1 TACR1
side of membrane 1 CD160
Peroxisome membrane 1 HMGCR
synaptic membrane 2 GRIN2A, GRIN2B
secretory granule lumen 1 POMC
axon terminus 1 PDYN
voltage-gated calcium channel complex 1 CACNA1I
specific granule lumen 2 AOC1, ARG1
transport vesicle 1 AZIN2
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 AZIN2
postsynaptic density membrane 3 GRID1, GRIN2A, GRIN2B
immunological synapse 1 ATP2B1
neuronal dense core vesicle 1 PDYN
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
NMDA selective glutamate receptor complex 2 GRIN2A, GRIN2B
Golgi apparatus, cis-Golgi network 1 AZIN2
postsynaptic cytosol 1 HTT
presynaptic cytosol 1 HTT
[CD160 antigen]: Cell membrane 1 CD160
sperm head 1 TACR1
inclusion body 1 HTT
photoreceptor ribbon synapse 1 ATP2B1
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
CatSper complex 1 CATSPER3
granular vesicle 1 AZIN2


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tate N Winter, William F Elmquist, Carolyn A Fairbanks. OCT2 and MATE1 provide bidirectional agmatine transport. Molecular pharmaceutics. 2011 Feb; 8(1):133-42. doi: 10.1021/mp100180a. [PMID: 21128598]
  • Nádia Aléssio Velloso Bellé, Gerusa Duarte Dalmolin, Graciela Fonini, Maribel Antonello Rubin, João Batista Teixeira Rocha. Polyamines reduces lipid peroxidation induced by different pro-oxidant agents. Brain research. 2004 May; 1008(2):245-51. doi: 10.1016/j.brainres.2004.02.036. [PMID: 15145762]
  • Yoko Sakakibara, Hiroshi Yanagisawa. Agmatine deiminase from cucumber seedlings is a mono-specific enzyme: purification and characteristics. Protein expression and purification. 2003 Jul; 30(1):88-93. doi: 10.1016/s1046-5928(03)00071-8. [PMID: 12821325]
  • H Yanagisawa. Agmatine deiminase from maize shoots: purification and properties. Phytochemistry. 2001 Apr; 56(7):643-7. doi: 10.1016/s0031-9422(00)00491-x. [PMID: 11314948]
  • A Padiglia, R Medda, A Lorrai, B Murgia, J Z Pedersen, A F Agrò, G Floris. Interaction of pig kidney and lentil seedling copper-containing amine oxidases with guanidinium compounds. Journal of enzyme inhibition. 2000; 15(1):91-100. doi: . [PMID: 10850957]
  • L Daeffler, K Nadra, V Eichwald, S Ohresser, Y Landry. Effect of NMDA receptor ligands on mast cell histamine release, a reappraisal. Naunyn-Schmiedeberg's archives of pharmacology. 1999 Jun; 359(6):512-8. doi: 10.1007/pl00005384. [PMID: 10431764]
  • L M Zhou, X S He, G Li, B R de Costa, P Skolnick. Synthesis of N,N'-substituted piperazine and homopiperazine derivatives with polyamine-like actions at N-methyl-D-aspartate receptors. Journal of medicinal chemistry. 1995 Dec; 38(25):4891-6. doi: 10.1021/jm00025a006. [PMID: 8523402]
  • P Chandler, M Pennington, M L Maccecchini, N T Nashed, P Skolnick. Polyamine-like actions of peptides derived from conantokin-G, an N-methyl-D-aspartate (NMDA) antagonist. The Journal of biological chemistry. 1993 Aug; 268(23):17173-8. doi: 10.1016/s0021-9258(19)85318-8. [PMID: 8349604]
  • G Floris, A Rinaldi, A Finazzi-Agrò. Heat-denaturation of pig kidney diamine oxidase: effect of arcaine. The Italian journal of biochemistry. 1981 May; 30(3):251-8. doi: . [PMID: 6792107]